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Theme
of the Symposium Last date
for Abstract Submission is Extended up to
Genetic
susceptibility to commonly occurring complex disorders is variable
across
different populations. Asian Indians are known to be at increased risk
of
diabetes mellitus and coronary heart diseases probably due to the
Thin-Fat
phenotype, which predicts higher insulin resistance compared to the
Europeans.
Sedentary life-style and change in food habits, as a result of improved
economy
have added to the recent spurt of these diseases in them. However, we
have
still not understood the genetic susceptibility and the role of
environment in
predicting commonly occurring complex disorders. Genome-wide
association studies (GWAS)
have finally begun to produce
reliable data on associations between common genetic variants and
common
complex diseases and quantitative traits related to these diseases.
GWAS
research in India has, however, been limited to date, which is
disappointing
for several reasons. First, common complex diseases now represent a
considerable proportion of morbidity and mortality in India and
context-specific
research on aetiology, prevention and treatment is urgently required.
Some
conditions – such as insulin resistance, type 2 diabetes, low birth
weight and
1-carbon pathway dysregulation may be of particular importance and have
some
unique elements in their pathogenesis in India. Tremendous
genetic
diversity and a variable phenotype in the Indian population provides a
unique
opportunity to understand the genetic variation in the Indian
subcontinent and
dissecting the role of genes and environment in the manifestation of
complex
diseases and exploit the same for developing personalized medicine.
Furthermore, patterns of linkage
disequilibrium is likely to
be different in the Indian sub-continent than in the populations where
majority
of common disease genetic studies have been performed, allowing for
enhanced
localisation of causal variants.
Finally, some environmental exposures – such as
folate but also
urbanisation and its consequent effects of obesity and down-stream
phenotypes –
are sufficiently different between the Indian sub-continent (or at
least
regions of the Indian sub-continent) and populations in which majority
of
current work has been undertaken to provide considerable additional
power for
informative gene by environment interaction analyses.
The
symposium would
cover topics such as Epidemiology of
complex diseases with special stress on diabetes mellitus and
cardiovascular
diseases, Genetic variation
in the Indian subcontinent, Comparison between
Indians and Europeans, Effect of rural-urban migration on disease
prevalence,
Interaction between genes and the environment, Evolution of complex
diseases,
Developmental origins of adult diseases, Epigenetics, and
Statistics/software
in human genetic analysis.
Pioneers
working in the area of
epidemiology, molecular genetics and epigenetics of complex diseases
will be
delivering lectures on the key areas of the research during the
symposium. It
is open to all the researchers, academicians, students who are willing
to catch
the current trends in the complex disease research and role of genes
and
environment.
Organisers
| G R
Chandak |
CCMB,
Hyderabad, India
|
George
Davey Smith
|
University of Bristol, UK |
| Lalji Singh |
CCMB,
Hyderabad, India |
| Shah
Ebrahim |
LSH
& TM, London, UK |
| Address
for Correspondence |
|
G
R Chandak
Centre for Cellular and
Molecular Biology
Uppal Road.Hyderabad 500 007. India
Tel: +91-40-2716 0222, 2719
2655
Fax:
+91-40-2716 0591, 2719 2748
E-Mail:
ge2009@ccmb.res.in
chandakgrc@ccmb.res.in
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