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G R Chandak Group`s Publications
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Title Journal Year
Effects of autozygosity on a broad range of human phenotypesNature Communications (Accepted)2019
Protease-sensitive pancreatic lipase (PNLIP) variants are associated with early onset chronic pancreatitis Am J Gastroenterol, doi: 10.14309/ajg. 0000000000000051. 2019
Identification and Characterization of cis-Regulatory Elements "Insulator and Repressor " in PPARD GeneEpigenomics,doi: 10.2217/epi-2017-0139. [Epub ahead of print] 2018
Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data (Nature Group). Sci Data., 23;5:180002. doi: 10.1038/sdata.2018.2. 2018
Diet Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: a review of existing evidence in humans with specific focus on one-carbon metabolismInternational Journal of Epidemiology, 2018, 19102018
Adult onset hereditary hemochromatosis is associated with a novel recurrent Hemojuvelin (HJV) gene mutation in north Indians. Blood Cells Mol Dis, 2018 Nov;73:14-21. doi: 10.1016/j.bcmd.2018.08.003. Epub 2018 Aug 27. 2018
Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: a review of existing evidence in humans with specific focus on one-carbon metabolism Int J Epidemiol, 2018 Dec 1;47(6):1910-1937. doi: 10.1093/ije/dyy153. 2018
Vitamin B12 Supplementation Influences Methylation of Genes Associated with Type 2 Diabetes & its Intermediate Traits. Epigenomics (Accepted)2017
Protocol for the EMPHASIS study; epigenetic mechanisms linking maternal pre-conceptional nutrition and children`s health in India and Sub-Saharan Africa.BMC Nutrition (Accepted)2017
Identification of a Functional Enhancer Variant within the Chronic Pancreatitis-Associated SPINK1 c.101A>G (p.Asn34Ser)-Containing Haplotype Hum Mutat. 2017 Aug;38(8):1014-1024. doi: 10.1002/humu.23269. Epub 2017 Jun 15.2017
Hypermethylated CpG sites in the MTR Gene Promoter in Preterm Placenta Epigenomics. 2017 Jul;9(7):985-996. doi: 10.2217/epi-2016-0173. Epub 2017 Jun 15.2017
A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.Diabetes. 2017 Mar 24. pii: db161329. doi: 10.2337/db16-13292017
GWAS Identifies Population Specific New Regulatory Variants in FUT6 Associated with Plasma B12 Concentrations in Indians. Hum Mol Genet. 2017 Feb 27. doi: 10.1093/hmg/ddx071. 2017
Identification of urinary proteins potentially associated with diabetic kidney disease.Indian J Nephrol. 2016 Nov-Dec;26(6):434-4452016
Evolution of Phenotypic and Genetic Profile of Tropical Calcific Pancreatitis(Book Chapter) Evolution of Phenotypic and Genetic Profile of Tropical Calcific Pancreatitis(Book Title), Springer(Accepted) 2016
Birth size, risk factors across life and cognition in late life: Protocol of prospective longitudinal follow-up of the MYNAH (MYsore studies of Natal effects on Ageing and Health) cohort.BMJ Open (Accepted for publication) 2016
The genetic architecture of type 2 diabetesNature, 536(7614):41-7. 2016
No Association Between CEL-HYB Hybrid Allele and Chronic Pancreatitis in Asian PopulationsGasteroenterology,150(7):1558-1560.e5. doi: 10.1053/j.gastro.2016.02.071. Epub 2016 Mar 3. 2016
Lack of replication of association of THSD7A with obesity.Int J Obes (Lond). 2016 Feb 23. doi: 10.1038/ijo.2016.15. [Epub ahead of print] 2016
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function Nat Commun. 2016 Jan 21;7:10023. doi: 10.1038/ncomms100232016
Association Analysis of PRSS1-PRSS2 and CLDN2-MORC4 Variants in Nonalcoholic Chronic Pancreatitis Using Tropical Calcific Pancreatitis as Model. Pancreas, Sep;45(8):1153-7. doi: 10.1097/MPA.0000000000000608. 2016
Intrauterine Programming of Diabetes and Adiposity. Curr Obes Rep. (4):418-28. doi: 10.1007/s13679-015-0175-6. 2015
Directional dominance on stature and cognition in diverse human populations. Nature. 2015 Jul 23;523(7561):459-62. doi: 10.1038/nature14618. Epub 2015 Jul 1. 2015
Maternal micronutrient deficiency leads to alteration in the kidney proteome in rat pups. Journal of Proteomics, 127(Pt A):178-84. doi: 10.1016/j.jprot.2015.04.035. 2015
New insights from monogenic diabetes for "common" type 2 diabetesFrontiers in Genetics, 6:251. doi: 10.3389/fgene.2015.00251. 2015
Genetic studies of body mass index yield new insights for obesity biology Nature (2015 Feb 12;518(7538):197-206. doi: 10.1038/nature14177) 2015
New genetic loci link adipose and insulin biology to body fat distribution Nature (2015 Feb 12;518(7538):187-96. doi: 10.1038/nature14132) 2015
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus PLOS Genetics | DOI:10.1371/journal.pgen.1004876 January 27, 2015 2014
Chronic Maternal Vitamin B12 Restriction Induced Changes In Body Composition & Glucose Metabolism In The Wistar Rat Offspring Are Partly Correctable By Rehabilitation PLoS One. 2014 Nov 14;9(11):e112991. doi: 10.1371/journal.pone.0112991. eCollection 2014. 2014
Genetic and Phenotypic Heterogeneity in Tropical Calcific Pancreatitis World Journal of Gastroenterology, Dec 14;20(46):17314-23. doi: 10.3748/wjg.v20.i46.17314 2014
Association of common genetic variants with lipid traits in the Indian population PLoS One. 2014 Jul 3;9(7):e101688. doi: 10.1371/journal.pone.0101688. eCollection 2014. 2014
Maternal homocysteine in pregnancy and offspring birthweight:Epidemiological associations and Mendelian randomization analysis Int J Epidemiol. 43(5):1487-97. doi: 10.1093/ije/dyu132. Epub 2014 Jul 22. 2014
Altered methylation and expression patterns of genes regulating placental angiogenesis in preterm pregnancy Reprod Sci. 2014 Dec;21(12):1508-17. doi: 10.1177/1933719114532838. Epub 2014 May 6. 2014
FTO gene variant and risk of hypertension: a meta-analysis of 57,464 hypertensive cases and 41,256 controls Metabolism. 2014 May;63(5):633-9. doi: 10.1016/j.metabol.2014.02.008. Epub 2014 Feb 17. 2014
Associations of genetic variants in/near BMI-associated genes with type 2 diabetes: A systematicClin Endocrinol (Oxf). 2014 Nov;81(5):702-10. doi: 10.1111/cen.12428. Epub 2014 Mar 13. 2014
PPAR Signalling Pathway is a Key Modulator of Liver Proteome in Pups Born to B12 Deficient Rats J Proteomics. 2013 Oct 8;91:297-308. doi: 10.1016/j.jprot.2013.07.027. Epub 2013 Aug 6. 2013
Variants in CPA1 are strongly associated with early-onset chronic pancreatitis Nat Genet. 2013 Oct;45(10):1216-20. doi: 10.1038/ng.2730. Epub 2013 Aug 18. 2013
Differential placental methylation and expression of VEGF, FLT-1 and KDR genes in human term and preterm preeclampsia. Clin Epigenetics. 2013 Apr 26;5(1):6. doi: 10.1186/1868-7083-5-6. 2013
Influence of Obesity on Association Between Genetic Variants Identified by Genome-Wide Association Studies and Hypertension Risk in Chinese Children. Am J Hypertens.26(8):990-6. doi: 10.1093/ajh/hpt046. 2013
STK39 Polymorphism Is Associated with Essential Hypertension: A Systematic Review and Meta-Analysis. PLoS One. 2013;8(3):e59584. doi: 10.1371/journal.pone.0059584. Epub 2013 Mar 18. 2013
Migration and DNA methylation: a comparison of methylation patterns in type 2 diabetes Journal of Diabetes Research & Clinical Metabolism;2:6. Epub 2013 Feb 6. 2013
Study of 11 BMI-associated loci identified in GWAS for associations with central obesity in the Chinese children PLoS One. 2013;8(2):e56472. doi: 10.1371/journal.pone.0056472. Epub 2013 Feb 12. 2013
H63D mutation in HFE gene is common in Indians and is associated with the European haplotype. J Genet, 91(2):229-32. 2012
Association study of 25 type 2 diabetes related loci with measures of obesity in Indian sib pairs PLoS ONE 8(1): e53944.doi:10.1371/journal.pone.0053944 2012
Evaluation of seven common lipid associated loci in a large Indian sib pair study Lipids Health Dis. 2012 Nov 14;11:155. doi: 10.1186/1476-511X-11-155. 2012
Proteins with altered levels in plasma from glioblastoma patients as revealed by iTRAQ-based quantitative proteomic analysis PLoS One;7(9):e46153. doi: 10.1371/journal.pone.0046153. Epub 2012 Sep 28. 2012
Association between common polymorphism near the MC4R gene and obesity risk: a systematic review and meta-analysis. PLoS One. 2012;7(9):e45731. doi: 10.1371/journal.pone.0045731. Epub 2012 Sep 25. 2012
Genetic analysis of an Indian family with members affected with Waardenburg syndrome and Duchenne muscular dystrophy Mol Vis;18:2022-32. Epub 2012 Jul 20. 2012
Common polymorphism near the MC4R gene is associated with type 2 diabetes: Data from meta-analysis of 123,373 individuals Diabetologia;55(10):2660-6 2012
Comprehensive Screening of Chymotrypsin C (CTRC) Gene in Tropical Calcific Pancreatitis Identifies Novel Variants Gut Online First, May 12, 2012:10.1136/gutjnl-2012-302448. 2012
Common variants of SLAMF1 and ITLN1 on 1q21 are associated with type 2 diabetes in Indian population. J Hum Genet;57(3):184-90. doi: 10.1038/jhg.2011.150. Epub 2012 Jan 26. 2012
High resolution methylome map of rat indicates role of intragenic DNA methylation in identification of coding region PLoS One;7(2):e31621. Epub 2012 Feb 15 2012
Maternal Dietary Folate and/or Vitamin B12 Restriction alter body composition (Adiposity) and Lipid Metabolism in Wistar Rat Offspring J Nutr Biochem. 24(1):25-31. doi: 10.1016/j.jnutbio.2012.01.004. 2012
LC-MS/MS analysis of differentially expressed glioblastoma membrane proteome reveals altered calcium signalling and other protein groups of regulatory functions Molecular and Cellular Proteomics, M111.013565. doi: 10.1074/mcp.M111.013565 2012
Association of genetic variation in FTO with risk of obesity and type 2 diabetes in up to 96,551 East and South AsiansDiabetologia; 55(4):981-95. Epub 2011 Nov 23. 2012
Association analysis of 32 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairsPLoS One. 2013;8(1):e53944. doi: 10.1371/journal.pone.0053944. Epub 2013 Jan 17. 2012
Genetic variants in novel pathways influence blood pressure and cardiovascular riskNature 478(7367):103-1092011
Maternal One-Carbon Metabolism, MTHFR and TCN2 Genotype and Neural Tube Defects in IndiaBirth Defects Research Part A: Clinical and Molecular Teratology 91(9):848-562011
Analysis of 32 common susceptibility genetic variants and their combined effect in predicting risk of type 2 diabetes and related traits in Indians. Diabetic Medicine 28, 1–72011
Glioblastoma cell secretome: Proteins secreted by three glioblastoma cell lines reveal 148 non-redundant proteinsJ Proteomics 74(10):1918-252011
Assessing the pathological relevance of SPINK1 promoter variants.Eur J Human Genetics 19(10):1066-732011
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource studyHum Mol Genet. 20(11) :2273-842011
Associations of FTO and MC4R variants with obesity traits in Indians and the role of rural/urban environment as a possible effect modifier. J Obes 2011:307542. Epub 2011 May 17 2011
Relationship of APOA5, PPARγ and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood. Lipids in Health and Dis. 10:68 2011
Association of PON1 and APOA5 gene polymorphisms in a cohort of Indian patients having coronary artery disease with and without type 2 diabetes. Genet Test Mol Biomarkers 5(7-8):507-12 2011
A set of five microsatellite markers linked to F8 gene can detect Hemophilia A carriers across IndiaHaemophilia 17(5):e928-35.2011
Common Variants in NOD2 and IL23R are not Associated with Inflammatory Bowel Disease in Indian Patients J Gastroenterology Hepatology; 26:694-99 2011
Genetic Analysis of the Glycoprotein 2 Gene (GP2) in Patients with Chronic PancreatitisPancreas. 39(3):353-582010
Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2 and CDKAL1 on the risk of type 2 diabetes in 5164 Indians Diabetes. 59:2068-20742010
Response to: Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2 and CDKAL1 on the risk of type 2 diabetes in 5164 Indians Diabetes. 59:e162010
What's There in a Name: Tropical Calcific Pancreatitis and Idiopathic Chronic Pancreatitis in India Gut. Oct 27, 10.1136/gut.2010.228452. 2010
Genetic mechanisms underlying the pathogenesis of tropical calcific pancreatitis World J Gastroenterol, January 21; 15(3): 264-2692009
Development and human disease - a synthesis of evolutionary, medical, anthropological, and economic perspectivesLancet, 373:1654-572009
The G191R variant in PRSS2 gene does not play a role in protection against tropical calcific pancreatitisGut, 58:881-822009
Genetic Basis of Tropical Calcific Pancreatitis: Similar Finds, Different MindsChromosomes to Genome. Ed. Rakesh Kumar Mishra, L & G International Publications Ltd., Bangalore, India, pp 155-1752009
Cardiac Beriberi: Often a Missed DiagnosisJ Trop Pediatr. 56(4):284-5. doi: 10.1093/tropej/fmp108. Epub 2009 Nov 24. 2009
Trypsinogen Copy Number Mutations in Patients with Idiopathic Chronic Pancreatitis Clinical Gastroenterology and Hepatology, 6: 82-882008
High Prevalence of Infantile Encephalitic Beriberi with Overlapping Features of Leigh's DiseaseJournal of Tropical Pediatrics, 54(5):328-322008
Genetic landscape of the people of India: a canvas for disease gene explorationJ Genet, 87(1): 3-202008
TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatis but may interact with SPINK1 and CTSB mutations in predicting diabetes BMC Med Genet, 16:9(1): 80-862008
FTO Gene Variants are Associated with Type 2 Diabetes but not with Obesity in South Asian Indians Diabetologia, 52: 247-522008
Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian populationDiabetologia, 50: 63-672007
Remarkable variation in the informativeness of RFLP markers linked to hemophilia B locus in Indian population groups: Implication in the strategy for carrier detectionDisease Markers, 22: 327-3342007
Frequency of primary iron overload and HFE gene mutations (C282Y, H63D and S65C) in chronic liver disease patients in north IndiaWorld Journal of Gastroenterology, 13(21): 2956-29592007
Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitisWorld J Gastroenterol 28;13(44):5938-432007
Biomarkers and Clinical Genomics: Genetic Disorders and Approaches to their PreventionBioArrays: From Basics to Diagnostics. Ed. Krishnarao Appasani, Humana Press Inc, Totowa, NJ, USA, pp 241-2572007
Evaluation of Genetic Markers linked to Hemophilia A Locus: An Indian ExperienceHaematologica, 92: 1725-262007
Leigh`s Syndrome: A Case Report The International Journal of Pediatrics and Neonatology, 7(2): 1-142007
Allelic drop-out may occur with a primer binding site polymorphism for the commonly used RFLP assay for the -1131T>C polymorphism of the Apolipoprotein AV geneLipids Health Dis, 5: 11-162006
Association of Cathepsin B Polymorphisms with Tropical Calcific PancreatitisGut, 55: 1270-12752006
Juvenile Fibrocalculous Pancreatopathy-A Patient ReportJournal of Pediatric Endocrinology & Metabolism, 19: 947-9502006
Genetic Studies in Chronic Pancreatitis in IndiaChronic Pancreatitis and Pancreatic Diabetes in India. Eds V Balakrishnan, Harish kumar, S Sudhindran, A G Unnikrishnan, LG Creations, Bangalore, pp 243-2602006
A novel mutation in STK11 gene is associated with Peutz-Jeghers Syndrome in Indian patientsBMC Medical Genetics, 7: 73-782006
Triglyceride altering polymorphisms of the ApoAV gene have very different allele frequencies in India compared to EuropeansBMC Medical Genetics, 7: 76-812006
Lack of significant association of an insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene with tropical calcific pancreatitisBMC Gastroenterol 6: 42-472006
Mutations in Anionic Trypsinogen Gene are not associated with Tropical calcific PancreatitisGut, 54: 705-7072005
The Indian Genome Variation Consortium The Indian Genome Variation database (IGVdb): a project overviewHuman Genetics, 1: 1-112005
Genotype-phenotype correlation of 5q13 region genes in Spinal Muscular Atrophy patients from IndiaExperimental and Molecular Medicine, 37: 134-1412005
Analysis of Intron 22 Inversion Mutation of Factor VIII Gene in the Patients with Hemophilia-A in J & K State of IndiaJournal of Capital University of Medical Sciences, 26: 677-6802005
Molecular Pathology of Haemophilia-B: Identification of Five Novel Mutations including a LINE1 Insertion in Indian PatientsHaemophilia, 10: 259-2632004
Absence of PRSS1 Mutations and Association of SPINK1 Trypsin Inhibitor Mutations in Hereditary and Non-Hereditary Chronic PancreatitisGut, 53: 722-272004
Dystrophy Gene Deletions in South Indian Duchenne Muscular Dystrophy PatientsInd J Med Sciences, 57: 1-62003
Mutations in Pancreatic Secretory Trypsin Inhibitor (PSTI/SPINK1) rather than Cationic Trypsinogen Gene (PRSS1) are Significantly Associated with Tropical Calcific PancreatitisJ Medical Genetics, 39: 347-3512002
Apolipoprotein E and Presenilin-1 Allelic Variation and Alzheimer's Disease in IndiaHuman Biology, 74: 683-6932002
Consensus Statement on Genetic Testing for Hereditary Pancreatitis: Guidelines for Indications, Counselling, Consent and Privacy IssuesPancreatology, 1: 405-4152001
Pancreatic Cancer in Hereditary Pancreatitis: Consensus Guidelines for Prevention, Screening and TreatmentPancreatology, 1: 416-4222001
Sickle Cell Gene Haplotypes in Relli and Thurpu Kapu Populations of Andhra PradeshHuman Biology, 72: 535-5402000
Fetus-in-fetu: a case report with molecular analysisJ Pediatr Surg;34(4):641-441999
Some atypical and rare sickle cell gene haplotypes in populations of Andhra Pradesh, IndiaHum Biol;71(3):333-401999
Triplet Repeats in Neurological Disorders Reviews in Neurology, Indian Academy of Neurology. Ed. S M Das, R Borgohain, A K Meena. Pp 39-471998
उपयोगी संपर्क संबंधित संपर्क परिसर
कापीराइट 2010 सीसीएमबी,उप्पल रोड,हैदराबाद 500007, तेलंगाना