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R Sankaranarayanan Group`s Publications
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Title Journal Year
Fatty acyl-AMP ligases as mechanistic variants of ANL superfamily and molecular determinants dictating substrate specificities. Journal of the Indian Institute of Science 98, 261-272.2018
Enzyme action at RNA-protein interface in DTD-like foldCurr Opin Struct Biol. 53, 107-114.2018
A discriminator code-based DTD surveillance ensures faithful glycine delivery for protein biosynthesis in bacteria.elife doi: 10.7554/eLife.38232.2018
A chiral selectivity relaxed paralog of DTD for proofreading tRNA mischarging in Animalia.Nature Commun. 9:511 DOI: 10.1038/s41467-017-02204-w2018
A mutation in an exoglucanase of Xanthomonas oryzae pv. oryzae, which confers an endo mode of activity, affects bacterial virulence, but not the induction of immune responses, in rice.Mol Plant Pathol. doi: 10.1111/mpp.12620.2017
A Transition Metal-Binding, Trimeric βγ-Crystallin from Methane-Producing Thermophilic Archaea, Methanosaeta thermophila.Biochemistry 56, 1299-13102017
Role of D-aminoacyl-tRNA deacylase beyond chiral proofreading as a cellular defense against glycine mischarging by AlaRS.
(Covered by a Spotlight article in TIBS, September 2017, vol. 42; p684)
Elife pii: e24001 2017
Elongation factor Tu prevents misediting of Gly-tRNA(Gly) caused by the design behind the chiral proofreading site of D-aminoacyl-tRNA deacylase. PLOS Biol. 14(5) e1002465, 1-22.2016
Structural insights into the regulation of NADPH binding to reductase domains of nonribosomal peptide synthetases: A concerted loop movement model.J. Struct. Biol. 194, 368-374.2016
Unsaturated Lipid Assimilation by Mycobacteria Requires Auxiliary cis-trans Enoyl CoA Isomerase. Chemistry & Biology 22, 1577-1587.2015
Specificity and catalysis hardwired at the RNA-protein interface in a translational proofreading enzyme.Nature Commun. 6:7552 doi: 10.1038/ncomms8552. 2015
Mutations in the predicted active site of Xanthomonas oryzae pv. oryzae XopQ differentially affect virulence, suppression of host innate immunity and induction of HR in a non-host plant. Mol. Plant Microbe Interact. 28, 195-206.2015
Delineating the reaction mechanism of reductase domains of Nonribosomal Peptide Synthetases from mycobacteria.J. Struct. Biol. 187, 207-214.2014
Mechanism of chiral proofreading during translation of the genetic codeeLife 2:e01519 2013
Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analyses of threonyl-tRNA synthetase editing domain from Aeropyrum pernix.Acta Cryst. F68, 1390-1393.2012
Aggregation prone near-native intermediate formation during unfolding of a structurally similar nonlenticular bg-crystallin domain.Biochemistry 51, 8502-85132012
Crystallization and preliminary crystallographic studies of CbsA, a secretory exoglucanase from Xanthomonas oryzae pv. oryzaeActa Cryst. F68, 1191-1194.2012
Nonprocessive [2+2]e- off-loading reductase domains from mycobacterial nonribosomal peptide synthetases. Proc. Natl.Acad. Sci. (USA) 109, 5681-5686.2012
Molecular basis of the functional divergence of fatty acyl-AMP ligase biosynthetic enzymes of Mycobacterium tuberculosis.J. Mol. Biol.416, 221-238.2012
Decoding the molecular design principles underlying Ca(2+) binding to bg-crystallin motifs.J. Mol. Biol. 415, 75-91.2012
Evolutionary and functional insights into Leishmania META1:evidence for lateral gene transfer and a role for META1 in secretion.BMC Evol. Biol. 11, 334.2011
In vitro evolved and non-aggregating and thermostable lipase:Structural and thermodynamic investigation.J.Mol.Biol. 413, 726-741.2011
Fatty acyl-AMP ligases and polyketide synthases are unique enzymes of lipid biosynthetic machinery in Mycobacterium tuberculosis. Tuberculosis 91, 448-455.2011
Structural biology of Mycobacterium tuberculosis proteins: The Indian efforts.Tuberculosis 91, 456-468.2011
Signals and Pathways Regulating Nucleolar Retention of Novel Putative Nucleolar GTPase NGP-1(GNL-2).Biochemistry 50, 4521-4536.2011
Cloning, overexpression, purification, crystallization and preliminary X-ray analysis of a female-specific lipocalin (FLP) expressed in the lacrimal glands of Syrian hamsters.Acta Cryst F66, 509-512.2010
Vertebrate homologue of Drosphila GAGA factor.J. Mol. Biol. 400, 434-4472010
Mechanistic insights into cognate substrate discrimination during proofreading in translation.Proc. Natl. Acad. Sci. (USA)107, 22117-22121.2010
Three-Dimensional Domain Swapping in Nitrollin, a Single-Domain -Crystallin from Nitrosospira multiformis, Controls Protein Conformation and Stability but Not Dimerization.J. Mol.Biol., 385, 163-177.2009
Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis.Nature Chem. Biol., 5, 166-173.2009
Crystal structure of a fungal protease inhibitor from Antheraea mylitta.J. Struct. Biol., 166, 79-87.2009
A cell wall degrading esterase of Xanthomonas oryzae requires a unique substrate recognition module for pathogenesis on rice.Plant Cell, 21,1860-1873.2009
Betagamma-Crystallin superfamily contains a universal motif for binding calcium.Biochemistry, 48, 12180-12190.2009
Structural basis for the remarkable stability of Bacillus subtilis lipase at low pH.Biochim. Biophys. Acta., 1784: 302-3112008
ATPase activity of RecD is essential for growth of the Antarctic Pseudomonas syringae Lz4W at low temperatureFEBS J., 27: 1835-18512008
Structural insights into biosynthesis of resorcinolic lipids by a type III polyketide synthase in Neurospora crassa.J Struct. Biol., 162: 411-4212008
Exploring the limits of sequence and structure in a variant betagamma-crystallin domain of the protein absent in melanoma-I (AIMI).J Mol. Biol., 381: 509-5182008
Thermostable Bacillus subtilis lipases: in vitro evolution and structural insight.J Mol. Biol., 381: 324-3402008
Betagamma-crystallins: A universal calcium-binding superfamily.Protein Science, 17, pg.173.2008
Crystallization and preliminary crystallographic studies of LipA, a secretory lipase/esterase from Xanthomonas oryzae pv. oryzae.Acta Cryst., F63: 708-7102007
Versatility of polyketides synthases in generating metabolic diversityCurrent Opin. Struct. Biol., 17: 736-7432007
Crystallization and preliminary X-ray crystallographic investigations on a ??-Crystallin domain of Absent In Melanoma 1 (AIM1), a protein from Homo sapiensActa Cryst. F62: 282-2842006
Crystallization and preliminary X-ray crystallographic studies of the N-terminal domain of FadD28, a fatty acyl AMP ligase from Mycobacterium tuberculosisActa Cryst., F62: 350-3522006
Crystallization and preliminary X-ray diffraction analysis of a protease inhibitor from the haemolymph of the Indian tsar silkwork Antheraea mylittaActa Cryst., F62: 669-6712006
A type III PKS makes the DIFferenceNature Chem. Biol., 2: 451-4522006
Posttransfer editing mechanism of a D-aminoacyl-tRNA deacylase-like domain in threonyl-tRNA synthetase from archaeaEMBO J., 25: 4152-41622006
A Novel Lysine-rich Domain and GTP Binding Motifs Regulate the Nucleolar Retention of Human Guanine Nucleotide Binding Protein, GNL3LJ. Mol. Biol., 364: 637-6542006
Crystal structure of low molecular weight protein tyrosine phosphatase (MPtpA) from Mycobacterium tuberculosis at 1.9 Sresolution.J. Bacteriol., 187: 2175-21812005
A D-amino acid editing module coupled to the translational apparatus in archaeaNature Struct. Mol. Biol., 12:556-5572005
Major histocompatibility complex class I polymorphism in Asiatic lions.Tissue Antigens, 66: 9-182005
Crystallization and preliminary X-ray crystallographic investigations on several thermostable forms of a Bacillus subtilis lipaseActa Cryst., D60: 160-1622004
Crystallization and preliminary X-ray crystallographic investigations of an unusual type III polyketide synthase PKS18 from Mycobacterium tuberculosis.Acta Cryst., D60: 749-7512004
Structural basis for selection and enhanced thermostability of laboratory evolved Bacillus subtilis lipase.J. Mol. Biol., 341: 1271-12812004
Cloning, expression, purification, crystallization and preliminary X-ray crystallographic investigations on a unique editing domain from ArchaebacteriaActa Cryst., D60: 1662-16642004
A novel tunnel in mycobacterial type III polyketide synthase reveals the structural basis for generating diverse metabolites.Nature Struct. Mol. Biol. 11, 894-900.2004
PhyA, a secreted protein of Xanthomonas oryzae pv. oryzae, is required for optimum virulence and growth on phytic acid as a sole phosphate sourceMolecular Plant-Microbe Interactions., 16: 973-9822003
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