Jonaki Back

JONAKI, the Labelled Biomolecules Laboratory, is a unit of Board of Radiation & Isotope Technology (BRIT), Department of Atomic Energy. It is situated in the campus of the Centreer for Cellular & Molecular Biology (CCMB). This laboratory is a shining example of BRIT’s commitment to provide labeled biomolecules and different molecular biology kits to the biotechnologists, molecular biologists and other life science research scientists of the country. Over a dozen 32P / 33P labeled nucleotides and molecular biology kits are supplied on a regular basis to various national laboratories, universities and industries across the country. Radioisotopes labeled nucleotides are one of a few essential components of modern research in biology, agriculture, healthcare, medical sciences, biotechnology and genetic engineering. 33P labeled nucleotide, which is also a favoured tool for in situ hybridization, DNA sequencing and DNA chip- based gene expression studies, and is considered as a bridge between radioisotopic and non-isotopic labels, is currently synthesized in this laboratory and supplied to various users.

Jonaki had started a retail outlet for nuclear medicine cold kits one year before to support the hospitals in the city. It had also introduced PCR Amplification kits, nucleotide mix and Taq DNA polymerase to suit individual needs, priced competitively and tested. Both have been a good success.

It is constantly improvising its functioning to maintain an excellent quality of its products and its staff is constantly working in this direction. All the 32P/33P nucleotides are being supplied in very good purity, better stability and specific activity. Its molecular biology products like Taq DNA polymerase and Molecular Biology kits are also being supplied with good stability and very good performance. And for this, Jonaki is rightly placed in the campus of the CCMB, which provides the infrastructure facilities for its good functioning and suitable scientific environment for its growth.

Jonaki has entered into a new business area, in the field of molecular diagnostics through the launch of its Gel based TB-PCR kit in August, 2008. It has also launched nucleic acid purification kits based on silica membrane at affordable prices to serve molecular biologists and molecular diagnostics community across the country without compromising with the quality. It is preparing for extending its activities in the field of DNA diagnostics and ELISA diagnostics. Efforts are on for further improvisation. TB-PCR-ELISA kit and Real Time TB-PCR kit are under clinical trial and are expected to be launched shortly. The ELISA kit for the human thyroid hormone T3 is under clinical trial and is also expected to be launched shortly.

List of Products:

32P Nucleotides:
1. γ 32P ATP LCP 101 2. γ 32P GTP LCP 1011
3. α 32P ATP LCP 106 4. α 32P CTP LCP 109
5. α 32P GTP LCP 107 6. α 32P UTP LCP 108
7. α 32P dATP LCP 103 8. α 32P dCTP LCP 102
9. α 32P dGTP LCP 104 10.3′5′-a 32P pCP LCP 1010
11.32P-Orthophosphoric Acid LCP 32

The above products are available in two formulations twice a month.
33P Nucleotides:
1. γ 33P ATP LCP 331
2. α 33P dATP LCP333 35S Amino Acids:
1. 35S Methionine LCS 1/LCS 2
2. 35S Cystein LCS 3
3. 35S Methionine-Cysteine Eleg mix LCS 7
4. 35S Glutathione LCS 6
5. Protein in vivo twin label mix LCS 8

The following Molecular Biology kits are also available.
CODE PRODUCT
LCK-1 Nick Translation Kit
LCK-2 Random Primer Kit
LCK-3 5′-End Labeling Kit
LCK-1301PCR Amplification Core Kit (100 reaction kit)
LCK-1302PCR Amplification Core Kit (50 reaction kit)
LCK-1303PCR Amplification Core Kit (25 reaction kit)
LCK-1401PCR Amplification Core Kit (100 reaction kit)
LCK-1402PCR Amplification Core Kit (50 reaction kit)
LCK-1403PCR Amplification Core Kit (25 reaction kit)
LCK-1501 PCR DNA Labelling Kit (50 reaction kit)

LCK-1502 PCR DNA Labelling Kit (25 reaction kit)
LCK-1601 dNTP mix for PCR (1 set of 4 dNTPs in 4 x 25 μl)
LCK-1602 dNTP mix for PCR (3 sets of 4 dNTPs in 4 x 25 μl)
LCK-1603 dNTP mix for PCR (5 sets of 4 dNTPs in 4 x 25 μl)
LCK-1604 dNTP mix for PCR (10 sets of 4 dNTPs in 4 x 25 μl)
LCE-101 Taq DNA Polymerase Enzyme (100 Units)
LCE-102 Taq DNA Polymerase Enzyme (250 Units)
LCE-103 Taq DNA Polymerase Enzyme (1000 Units)
LCE-104 Taq DNA Polymerase Enzyme (2000 – 5000 Units)
LCE-105 Taq DNA Polymerase Enzyme (7000 Units)

New Products Introduced:

CODE PRODUCT
LCK1701 M.tuberculosis PCR detection kit (25 reaction kit)
LCK 1702M.tuberculosis PCR detection kit (50 reaction kit)
LCK 18 DNA Isolation kit (Blood) (50 reaction kit)
LCK 19 DNA Isolation kit (Blood) (100 reaction kit)
LCK 20 DNA Isolation kit (Bacteria) (50 reaction kit)
LCK 21 DNA Isolation kit (Bacteria) (100 reaction kit)
LCK 22 DNA Isolation kit (Plasmid) (50 reaction kit)
LCK 23 DNA Isolation kit (Plasmid) (100 reaction kit)
LCK 24 DNA Gel Purification kit (50 reaction kit)
LCK 25 DNA Gel Purification kit (100 reaction kit)
LCK 26 PCR Product Purification kit (50 reaction kit)
LCK 27 PCR Product Purification kit (100 reaction kit)

Cold kits for formulation of 99mTcradiopharmaceuticals

CODE PRODUCT
TCK-5 Kit for Sulphur colloid injection
Use: For scintigraphy of the reticuloendothelial system

TCK-7 Kit for DTPA injection
Use: For renal function studies and brain scintigraphy

TCK-15 Kit for GHA injection
Use: For renal scintigraphy

TCK-16 Kit for Phytate injection
Use: For scintigraphy of liver

TCK-30 Kit for MDP injection
Use: For bone scintigraphy

TCK-35 Kit for DMSA injection
Use: Fjor renal and tumour scintigraphy

TCK-38 Kit for Sn-Pyp injection
Use: For in vivo labeling of RBC

TCK-39 Kit for Mebrofenin injection
Use: For hepatobiliary scintigraphy

TCK-42 Kit for ECD injection
Use: For brain perfusion imaging

TCK-43 Kit for EC injection
Use: For renal dynamic function studies

TCK-50 Kit for MIBI injection
Use: For myocardial perfusion imaging

Products to be introduced shortly

1) Real time TB-PCR kit
2) TB-PCR-ELISA kit

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