Areas of Research Back

The CCMB is mandated to conduct basic research in frontier and multidisciplinary areas of modern biology and to seek potential applications of this work. Research at CCMB can be grouped under the following broad umbrella themes:

Biology of Cells and Subcellular Complexes: The programs include: cell functions in normal and disease states; cytoskeleton reorganization and regulation of cell functions; nuclear organization and the molecular basis of laminopathies; cell biology of signaling; metabolism and gene regulation in brain disorders; cold adaptation in bacteria; and structure, composition and function of nuclear architecture in chromatin organization and regulation.

Protein and Macromolecular Assemblies: Major activities in this area include: protein folding to understand its various facets, misfolding consequences, chaperone functions and how ions modulate folding; translational proofreading, a process by which incorrect amino acids are removed from tRNA, taking biochemical, structural & in-vivo approaches; and understanding the mechanistic basis of functioning of membrane proteins with a particular focus on receptors. The research activity also includes peptide-membrane interactions to understand biological processes such as sorting of proteins in cells and mechanism of action of membrane-active peptide toxins; structural studies on RNAi machinery; and calcium binding proteins, etc.

Genetic Analysis and Genomics: Research going on this area aims to understand biology in the genome context and to apply this knowledge to uncover the mechanism of epigenetic regulation. Major activities in this area aim to understand: how is the genome packaged with consequences regulation of gene expression; what epigenetic mechanisms are involved in differentiation, growth and regeneration; what implications do sequence variations in Indian populations have in diseases; and what is the role of micronutrients in complex diseases and clinical phenotypes.

Biology of Plant Development and Disease: Plants have unique developmental processes and strategies to deal with biotic and abiotic stresses. Current activity in this are include: Plant reproductive development, plant chromosome organization and control of meiosis, Plant adaptation to stresses, Plant immunity, Molecular markers and map development in crops.

Molecular Basis of Infection and Disease: Infectious organisms such as Leishmania, plasmodium, Mtb, HCV and HIV are responsible for the major load of morbidity and mortality in India. The biology and evolution of these organisms and their interaction with their host is being investigated.

Evolutionary biology and wildlife conservation: Approaches using molecular markers to ascertain the inter- and intra-specific genetic makeup of species and assisted reproductive techniques are being developed in CCMB. Ongoing molecular evolutionary studies will give in-depth knowledge of the phylogenetic relationships among the wild species and help in developing strategies to protect and conserve wild and endangered species and maintain the balance in the ecosystem.

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