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Ghanshyam Swarup Group`s Publications
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Title Journal Year
Identification of a splice variant of optineurin which is defective in autophagy and phosphorylation. BBA-Mol. Cell Res.1865, 1526-1538.2018
Autophagy receptor optineurin promotes autophagosome formation by potentiating LC3-II production and phagophore maturation. Commun Integr Biol. 11, 1-4. 2018
Altered functions and interactions of glaucoma-associated mutants of optineurin.Frontiers in Immunology 9, 1287.2018
Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein. J Biol Chem. 293, 132-147.2018
661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively.Sci Rep. 7(1):16855. 2017
A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death. Biol Chem. 292(4):1218-1230, 2017. 2017
The Nobel Prize for understanding autophagy, a cellular mechanism of waste disposal that keeps us healthy. J Biosci. 41(4):563-5672016
Defects in autophagy caused by glaucoma-associated mutations in optineurin. Exp Eye Res.144, 54-63.2016
A glaucoma-associated variant of optineurin, M98K, activates Tbk1 to enhance autophagosome formation and retinal cell death dependent on Ser177 phosphorylation of optineurin. PLoS One 2015 Sep 16;10(9):e0138289. doi: 10.1371/journal.pone.0138289. 2015
Functional analysis of optineurin and some of its disease-associated mutants. IUBMB Life. 2015 Feb;67(2):120-128.2015
E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy. PLoS One, 2014 Apr 21; 9(4): e95758. 2014
Emerging role of tyrosine phosphatase, TCPTP, in the organelles of the early secretory pathway. BBA-Molecular Cell Res. 1833, 1125-1132.2013
IRF-1-binding site in the first intron mediates interferon-γ-induced optineurin promoter activation. Biochem Biophys Res Commun. 437, 179-184. 2013
M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells.Autophagy 9:4, 510-527.2013
A cataract-causing connexin-50 mutant is mislocalized to the ER due to loss of the fourth transmembrane domain and cytoplasmic domain. FEBS Open Bio. 3, 22-29.2013
Optineurin mediates negative regulation of Rab8 by the GTPase activating protein TBC1D17.J. Cell Science 125, 5026-5039. 2012
Tyrosine phosphorylation of a SNARE protein, Syntaxin 17: Implications for membrane trafficking in the early secretory pathway. BBA-Molecular Cell Res. 1823, 2109-2119.2012
Optineurin is required for CYLD-dependent inhibition of TNFalpha induced NF-kB activation.PLoS ONE 6(3):e17477.2011
Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi.Biol. Cell103, 333-350.2011
Interaction with Sug1 enables Ipaf ubiquitination leading to caspase-8 activation and cell death. Biochem.J. 427, 91-104.2010
Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant.BMC Cell Biol. 11: 4.2010
Optineurin, a multifunctional protein involved in glaucoma, amyotrophic lateral sclerosis and antiviral signaling.J. Biosci. 35(4), 501-505.2010
NF-kB mediates tumor necrosis factor a-induced expression of optineurin, a negative regulator of NF-kB.PLoS ONE 4(4):e5114.2009
Opineurin and its mutants: molecules associated with some forms of glaucoma.Ophthalmic Res. 42,176-184.2009
Focus on Molecules: Optineurin.Experimental Eye Research 87, 1-2.2008
Sp1-like sequences mediate human caspase-3 promoter activation by p73 and cisplatin.FEBS J. 275, 2200-2213.2008
A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants. Invest. Ophthalmol. Vis Sci. 48, 1607-1614.2007
C3G is required for c-Abl-induced filopodia and its overexpression promotes filopodia formation.Exp. Cell Res. 313, 2476-2492.2007
Regulation of p73 by Hck through kinase-dependent and independent mechanisms.BMC. Mol. Biol. 8, 45.2007
Tumor necrosis factor a-induced caspase-1 gene expression. Role of p73.FEBS Journal 274, 4396-4407.2007
Evidence for a role of transmembrane protein p25 in localization of protein tyrosine phosphatase TC48 to the ER. J. Cell Sci. 119, 1703-1714.2006
Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis.FEBS J. 273, 2766-2778.2006
Caspase-1 activator Ipaf is a p53 inducible gene involved in apoptosis.Oncogene 24, 627-636.2005
Role of p73 in regulating human caspase-1 gene transcription induced by interferon-{gamma} and cisplatin.J. Biol. Chem. 280, 36664-36673.2005
Phosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and SFKs localizes to the Golgi and subcortical actin cytoskeleton.BMC Cell Biol. 5, 31.2004
How to design a highly effective siRNA.J. Biosci. 29,129-131.2004
Physical and functional interaction between Hck tyrosine kinase & guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain.J. Biol. Chem. 278, 52188-52194.2003
Induction of cytochrome c release and apoptosis by Hck-SH3 domain-mediated signaling requires caspase-3.Apoptosis, 7, 195-212.2002
A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis.FEBS Letters, 532, 61-66.2002
A nuclear protein tyrosine phosphatase induces shortening of G1 phase and increase in c-Myc protein level. Experimental Cell Research, 265, 1-10.2001
Nuclear Matrix : Methods of Preparation.Encyclopedia of Life Sciences., A2708: 1-3 (2001).2001
Direct transcriptional activation of human caspase-1 by tumor suppressor p53.J. Biol. Chem. 276, 10585-10588.2001
Inhibition of anchorage independent cell growth, adhesion and cyclin D1 gene expression by a dominant negative mutant of a tyrosine phosphatase.Experimental Cell Research, 270, 32-44.2001
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