Contact Details |
A S Sreedhar
Heat Shock Proteins in Biology and Medicine: Our group is working on stress response and heat shock proteins (Hsps) in biology and medicine. We are studying the molecular basis of stress response and transcriptional regulation of Hsp synthesis during development, differentiation and stress management to identify the unconventional roles of heat shock transcription factors in tumor cells. High expression of Hsps, especially the Hsp90 in tumor cells correlates with poor prognosis and accelerated disease progression. Therefore we are studying effect of Hsp90 inhibition in anticancer treatments and elucidating novel functions of Hsps. Inducing cytostasis or apoptosis in tumor cells may induce unwanted cellular response. We are evaluating stress (physiological or oncogene), or Hsp inhibition or over expression induced cellular senescence as a tumor suppressor mechanism. Our group is also involved in molecular targeting of cancer using natural compounds, and evaluation of combinatorial treatments as beneficial tool for cancer
| Click here for team members | Click here for publications|
- V. Chaturvedi, J. Ujwal Kumar, Ch. V. B. Swamy, R. Nandini, G. Srinivas, R. Kumaresan, S. Singh and A. S. Sreedhar. Repercussion of mitochondria structural deformity induced by anti-Hsp90 drug 17AAG in human tumor cells. Journal of Drug Target Insights. In Press, 2011.
- A. Taiyab, U. K. Srinivas, A. S. Sreedhar. 17-(Allylamino)-17-demethoxygeldanamycin combination with diferuloylmethane selectively targets mitogen kinase pathway in a human neuroblastoma cell line. J. Cancer Ther. 1: 197-204. 2010
- A. Taiyab, A. S. Sreedhar and Ch. Mohan Rao. Hsp90 inhibitors, GA and 17AAG leads to ER-stress induced apoptosis in rat histiocytoma. Biochem. Pharmacol. 78: 141-152, 2009.
- A. S. Sreedhar, K. Mihaly, B. Pato, T. Schnaider, A. Stetak, K. Kis-Petik, J. Fidy, T. Simonics, A. Maraz and P. Csemerly. Hsp90 inhibition accelerates cell lysis: anti-Hsp90 ribozyme reveals a complex mechanism of Hsp90 inhibitors involving both superoxide- and Hsp90-dependent events. J. Biol. Chem.278: 35231-35240. 2003.
- A. S. Sreedhar, B. V. V. Pardhasaradhi, A. Khar and U. K. Srinivas. Effect of C-terminal deletion of p53 on heat induced CD95 expression and apoptosis in a rat histiocytoma. Oncogene 21: 4042-4049. 2002.