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M V Jaganadham
The release of membrane vesicles is evolutionarily conserved process among different species. Both gram-ve and Gram +ve bacteria release vesicles during all growth stages/conditions. They are 20-300 nm in size and composed of lipopolysaccharides, lipids, proteins and in some cases they carry DNA or RNA. They interact with host by different mechanism like membrane fusion or endocytosis or other mechanisms. They were proposed to be involved in horizontal gene transfer, biofilm formation, intra- and interspecies communication, stress response, delivery of toxins and other biomolecules, killing competing microbial cells, resistance to antibiotics and several other functions. Our laboratory is involved in structural and functional studies of outer membrane vesicles of bacteria and for their potential applications in biotechnology.
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- Jagannadham, M.V., Kameswari, D.B., Gayathri P., and Nagaraj R. (2018) Detection of peptides with intact phosphate groups using MALDI TOF/TOF and comparison with the ESI-MS/MS. Eur. J. Mass spectrometry 24(2): 231-242.
- Krantikumar Yadav., Lakshmikanta Rao J., Srinivas R., Nagaraj R., and Jagannadham M.V. (2018) Characterization ofacetylated histidine b1-ion structure: A competition between oxazolone and sidechain imidazole moity. Eur. J. Mass spectrum 24 (3): 261-268.
- Bhanu Ramanand K; Sankara Rao, K; Jagannadham, M.V; Swamy, CVB; Dhople, VM; and Rao, NM. (2017) Combinatorial labelling method for improving peptide fragmentation in Mass spectrometry. J Amer. Soc. Mass spectrum. 28(6): 1216-1236.
- Chattopadhyay MK and Jagannadham MV (2015) Vesicles-mediated resistance to antibiotics in bacteria. Front. Microbiol. 6:758. Doi: 10.3389/fmicb.2015.00758.
- Kulkarni, H.M., Swamy, Ch V B., Jagannadham, M.V. (2014) Molecular characterization and functional analysis of outer membrane vesicles from the Antarctic bacterium Pseudomonas syringae suggest a possible response to environmental conditions. J Prot res. 13: 1345-1358.