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Facilities
Automated Karyotyping
At
CCMB, the karyotyping facility has been set up to
carry out genetic diagnosis at chromosomal level for
the reasons like recurrent miscarriages, male and
female infertility, mental retardation, and other
miscellaneous syndromic and non syndromic cases. The
lab is equipped with advanced karyotyping equipment
and software.
Chromosomal
analysis is carried out using different sample sources like, blood
(lymphocyte culture) - most commonly performed procedure, amniotic fluid
- prenatal diagnosis. Also POC (aborted foetal tissue) is culture to
detect chromosomal anomalies.
GTG banding is the
routinely practiced technique, also advanced techniques like fluorescence
in situ hybridization (FISH) is performed using different probes like
Whole Chromosome Paints (WCP), Locus Specific Identifier (LSI), and
Multicolour fluorescence probes (M-FISH), to further delineate the
anomaly and characterize the break point.
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