About CCMB

Scientist Details

Contact Details

Name : D P Kasbekar

Room : S205

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Research Interests

We have developed an assay for RIP in Neurospora. The RIP process mutates repeated DNA sequences and thereby protects fungal genomes against parasitic DNA. Using the assay we identified dominant RIP suppressor strains, and found that chromosome segment duplications > 300 kbp dominantly suppress RIP, possibly by titrating out the RIP machinery. We and others have shown that lamin B receptor, a vertebrate protein that tethers the nuclear lamina and chromatin to the inner nuclear membrane possesses sterol biosynthetic activity, and by site-directed mutagenesis we identified the amino acid residues essential for this activity. In other work we have proposed a novel plant-microbe interaction wherein leguminous plants use isoflavonoid phytoalexins to recruit Dictyostelium to clear bacteria from the vicinity of root lesions. Dictyostelium are free-living soil amoebae that feed on bacteria, and isoflavonoids are antimicrobial compounds produced by leguminous plants at sites of microbial infection and injury.

Selected Publications

  • Bhat, A., Noubissi, F. K., Vyas, M. and Kasbekar, D. P. (2003). Genetic analysis of wild-isolated Neurospora crassa strains identified as dominant suppressors of repeat-induced point mutation (RIP). Genetics 164: 947-961.

  • Bhat, A., Tamuli, R. and Kasbekar, D. P. (2004) Genetic transformation of Neurospora tetrasperma, demonstration of repeat-induced point mutation (RIP) in self-crosses, and a screen for recessive RIP-defective mutants. Genetics 167: 1155-1164.

  • Vyas, M., Ravindran, C. and Kasbekar, D. P. (2006) Chromosome segment duplications in Neurospora crassa and their effects on repeat-induced point mutation (RIP) and meiotic silencing by unpaired DNA. Genetics 172: 1511-1519.

  • Tamuli, R. and Kasbekar, D. P. (2008) Dominant suppression of repeat-induced point mutation in Neurospora crassa by a variant catalytic subunit of DNA polymerase-z. Genetics 178:1169-1176.

  • Singh, P. K., Iyer, S. V., Ramakrishnan, M. and Kasbekar, D. P. (2009) Chromosome segment duplications in Neurospora crassa: barren crosses beget fertile science. BioEssays 31: 209-219.

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