About CCMB

Scientist Details

Contact Details

Name : Ghanshyam Swarup

Room : E-206

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Research Interests

My major research interest is to understand the molecular mechanisms involved in the pathogenesis of glaucoma, a complex eye disease which causes blindness. Mutations in optineurin protein (coded by the gene OPTN) are associated with certain glaucomas. What is the normal function of optineurin? How mutations in optineurin affect these functions to cause the disease? We are using several approaches to address these questions. The role of optineurin and its mutants in regulating vesicular membrane trafficking, signaling to NF-kB and gene expression is being invstigated. Our innate immune system responds to invading microorganisms which are recognized by cell surface or cytoplasmic receptors (eg Ipaf), to induce a protective response. We are trying to understand the mechanisms by which activation of Ipaf mediates downstream signaling leading to caspase activation and gene expression.Another research interest involves the study of protein tyrosine phosphatase TCPTP in regulating signaling and membrane trafficking.

Selected Publications

  • S. Sadasivam, S. Gupta, V. Radha, K. Batta, T.K. Kundu and G. Swarup (2005). Caspase-1 activator Ipaf is a p53 inducible gene involved in apoptosis. Oncogene 24, 627-636.

  • V. Gupta and G. Swarup (2006). Evidence for a role of transmembrane protein p25 in localization of protein tyrosine phosphatase TC48 to the ER. J. Cell Sci. 119, 1703-1714.

  • M.L. Chalasani, V. Radha, V. Gupta, N. Agarwal, D. Balasubramanian and G. Swarup (2007). A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants. Invest. Ophthalmol. Vis. Sci. 48, 1607-1614.

  • Y. Kumar, V. Radha and G. Swarup (2010). Interaction with Sug1 enables Ipaf ubiquitination leading to caspase-8 activation and cell death. Biochem. J. (in press).

  • A. Nagabhushana, M.L. Chalasani, N. Jain, V Radha, N. Rangaraj, D. Balasubramanian and G. Swarup (2010). Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant. BMC Cell Biol. (in press).

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