About CCMB

Scientist Details

Contact Details

Name : Yogendra Sharma

Room : W206

Telephone :

Fax :

E-mail :
yogendra@ccmb.res.in, yogen.ccmb@gmail.com

Research Interests

The research activities of the laboratory center around the understanding of diverse group of calcium-binding proteins with emphasis on the functional and structural requirement of calcium-binding. The families we are concentrating are neuronal calcium sensors (EF-hand superfamily) and bg-crystallin superfamily.

Selected Publications

  • Aravind, P., Mishra, A., Suman, S. K., Jobby, M. K., Sankaranarayanan, R., and Sharma, Y. (2009) The betagamma-Crystallin superfamily contains a universal motif for binding calcium. Biochemistry 48, 12180–12190.

  • Mikhaylova, M., Reddy, P. P., Munsch, T., Landgraf, P. Suman, S. K., Smalla, K.-H., Gundelfinger, E. D., Sharma, Y. and Kreutz, M. R. (2009) Calneurons provide a Calcium-threshold for trans-Golgi network to plasma membrane trafficking. Proc. Natl. Acad. Sci. USA 106(22), 9093-9098.

  • Aravind, P., Chandra, K., Reddy, P. P., Jeromin, A., Chary, K. V., and Sharma, Y., (2008) Regulatory and structural EF-hand motifs of neuronal calcium sensor-1: Mg2+ modulates Ca2+-binding, Ca2+-induced conformation and equilibrium unfolding transitions. J. Mol. Biol. 376, 1100-1115.

  • Jobby, M. K. and Sharma, Y. (2005) Calcium-binding crystallins from Yersinia pestis: Characterization of two single beta gamma-crystallin domains of a putative exported protein. J. Biol. Chem. 280, 1209-1216.

  • Jeromin, A., Muralidhar, D., Parameswaran, M.N., Roder, J., Fairwell, T., Scarlata S., Dowal, L, Mustafi, S.M., Chary, K.V.R., Sharma, Y. (2004) N-terminal myristoylation regulates calcium-induced conformational changes in neuronal calcium sensor-1. J. Biol. Chem. 279, 27158-27167.

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