Dr. Mohan Rao Dr. Mohan Rao's Group

Ch. Mohan Rao

Our Team

Click here for profile.

Research Interests

We combine biophysical, molecular biological and cell biological approaches to address problems of biomedical importance.

Research Interest Molecular Chaperones Amyloidogenic Proteins New Initiatives In-Situ Spectroscopy Applied Research

Recent Publications

  • Swamy-Mruthinti S, Srinivas V, Hansen JE, Rao ChM. Thermal Stress Induced Aggregation of Aquaporin 0 (AQP0) and Protection by α-Crystallin via Its Chaperone Function.PLoS One. 2013 Nov 27;8(11):e80404.

  • Sultan A, Raman B, Rao ChM, Tangirala R. The Extracellular Chaperone Haptoglobin Prevents Serum Fatty Acid-promoted Amyloid Fibril Formation of β2-Microglobulin, Resistance to Lysosomal Degradation, and Cytotoxicity. J Biol Chem. 2013 Nov 8;288(45):32326-42.

  • Karunakaran SC, Babu PS, Madhuri B, Marydasan B, Paul AK, Nair AS, Rao KS, Srinivasan A, Chandrashekar TK, Rao CM, Pillai R, Ramaiah D. In vitro Demonstration of Apoptosis Mediated Photodynamic Activity and NIR Nucleus Imaging through a Novel Porphyrin. ACS Chem Biol. 2013 Jan 18;8(1):127-32.

  • Asthana A, Raman B, Ramakrishna T, Rao ChM. Structural aspects and chaperone activity of human HspB3: role of the "C-terminal extension". Cell Biochem Biophys. 2012 Sep;64(1):61-72.

  • Prabhu S, Raman B, Ramakrishna T, Rao ChM. HspB2/myotonic dystrophy protein kinase binding protein (MKBP) as a novel molecular chaperone: structural and functional aspects. PLoS One. 2012;7(1):e29810.

  • Mishra P, Prabha CR, Rao ChM, Volety S. Q2N and S65D substitutions of ubiquitin unravel functional significance of the invariant residues Gln2 and Ser65. Cell Biochem Biophys. 2011 Dec;61(3):619-28.

  • Thakur AK, Srivastava AK, Srinivas V, Chary KV, Rao CM. Copper alters aggregation behavior of prion protein and induces novel interactions between its N- and C-terminal regions. J Biol Chem. Nov 4;286(44):38533-45.2011.

  • Prabhu S, Srinivas V, Ramakrishna T, Raman B, Rao ChM. Inhibition of Cu(2+)-mediated generation of reactive oxygen species by the small heat shock protein αB-crystallin: The relative contributions of the N- and C-terminal domains. Free Radic Biol Med. 51(3):755-62; 2011

  • Zhang Q, Wang D, Singh NK, Kundumani-Sridharan V, Gadiparthi L, Rao ChM, Rao GN. Activation of Cytosolic Phospholipase A2 Downstream of the Src-Phospholipase D1 (PLD1)-Protein Kinase C {gamma} (PKC{gamma}) Signaling Axis Is Required for Hypoxia-induced Pathological Retinal Angiogenesis. J Biol Chem. 286(25):22489-98; 2011

  • Adhikari AS, Singh BN, Rao KS, Rao ChM. αB-crystallin, a small heat shock protein, modulates NF-kB activity in a phosphorylation-dependant manner and protects muscle myoblasts from TNF-α induced cytotoxicity. Biochim Biophys Acta. 1813(8):1532-42; 2011

  • Taiyab A., Rao ChM. HSP90 modulates actin dynamics: inhibition of HSP90 leads to decreased cell motility and impairs invasion. Biochim Biophys Acta. 1813(1):213-21, 2011