We combine biophysical, molecular biological and cell biological approaches to address problems of biomedical importance.
Recent Publications
Karunakaran SC, Babu PS, Madhuri B, Marydasan B, Paul AK, Nair AS, Rao KS, Srinivasan A, Chandrashekar TK, Rao CM, Pillai R, Ramaiah D. In vitro Demonstration of Apoptosis Mediated Photodynamic Activity and NIR Nucleus Imaging through a Novel Porphyrin. ACS Chem Biol. 2012 Oct 23. [Epub ahead of print]
Asthana A, Raman B, Ramakrishna T, Rao ChM. Structural aspects and chaperone activity of human HspB3: role of the "C-terminal extension". Cell Biochem Biophys. 2012 Sep;64(1):61-72.
Prabhu S, Raman B, Ramakrishna T, Rao ChM. HspB2/myotonic dystrophy protein kinase binding protein (MKBP) as a novel molecular chaperone: structural and functional aspects. PLoS One. 2012;7(1):e29810. doi: 10.1371/journal.pone.0029810.
Mishra P, Prabha CR, Rao ChM, Volety S. Q2N and S65D substitutions of ubiquitin unravel functional significance of the invariant residues Gln2 and Ser65. Cell Biochem Biophys. 2011 Dec;61(3):619-28.
Thakur AK, Srivastava AK, Srinivas V, Chary KV, Rao CM. Copper alters aggregation behavior of prion protein and induces novel interactions between its N- and C-terminal regions. J Biol Chem. Nov 4;286(44):38533-45.2011.
Prabhu S, Srinivas V, Ramakrishna T, Raman B, Rao ChM. Inhibition of Cu(2+)-mediated generation of reactive oxygen species by the small heat shock protein αB-crystallin: The relative contributions of the N- and C-terminal domains. Free Radic Biol Med. 51(3):755-62; 2011
Zhang Q, Wang D, Singh NK, Kundumani-Sridharan V, Gadiparthi L, Rao ChM, Rao GN. Activation of Cytosolic Phospholipase A2 Downstream of the Src-Phospholipase D1 (PLD1)-Protein Kinase C {gamma} (PKC{gamma}) Signaling Axis Is Required for Hypoxia-induced Pathological Retinal Angiogenesis. J Biol Chem. 286(25):22489-98; 2011
Adhikari AS, Singh BN, Rao KS, Rao ChM. αB-crystallin, a small heat shock protein, modulates NF-kB activity in a phosphorylation-dependant manner and protects muscle myoblasts from TNF-α induced cytotoxicity. Biochim Biophys Acta. 1813(8):1532-42; 2011
Taiyab A., Rao ChM. HSP90 modulates actin dynamics: inhibition of HSP90 leads to decreased cell motility and impairs invasion. Biochim Biophys Acta. 1813(1):213-21, 2011
