The specific microenvironments regulating stem cells, commonly referred to as niches, comprise multiple cell populations whose precise contributions are under active current exploration. Understanding the cross-talk between stem cells and their niche components is essential for the development of therapies against disorders in which stem cells function is altered.
Currently we are focusing on investigating neuronal injury and its repair mechanisms under various conditions. We use 2D & 3D cell culture platforms and animal model systems. Advanced microscopy and Molecular and cell biology techniques will be used to understand these processes.
Adhatoda Vasica attenuates inflammatory and hypoxic responses in preclinical mouse models: potential for repurposing in COVID-19-like conditions Journal of Respiratory Research, 2021, 6; 22(1): 99.
Long term observation of ocular surface alkali burn in rabbit models: Quantitative analysis of corneal haze, vascularity and self-recovery, Experimental Eye Research, 2021 2;205:108526.
Prevention of corneal myofibroblastic differentiation in vitro using biomimetic ECM hydrogel for corneal tissue regeneration. ACS Applied Biomaterials, 2021, 4, 1, 533–544 HspB5 protects Mouse Neural Stem/Progenitor Cells from Paraquat Toxicity, American Journal of Stem Cells, Dec 25;9(5):68-77. eCollection 2020.
Generation of iPSC from fetal fibroblast cells obtained from an abortus with type-I tri-allelic variants. Stem Cell Research. Volume 48 2020, 101963.
Transfection of arginine decarboxylase gene increases the neuronal differentiation of neural progenitor cells. Stem Cell Research. 17 256–265, 2016.
Education & Experience
|P.G:||Andhra University ; Zoology Spl: Animal Physiology ; 2001|
|Ph.D:||Andhra University ; 2008 ;|
Yonsei University College of Medicine, Department of Neuroscience, Seoul, South Korea ; 2008-2013 ;
|Prevention of corneal myofibroblastic differentiation in vitro using biomimetic ECM hydrogel for corneal tissue regeneration||ACS Applied Biomaterials||2021|
|Long term observation of ocular surface alkali burn in rabbit models: Quantitative analysis of corneal haze, vascularity and self-recovery||Experimental Eye Research||2021|
|Adhatoda Vasica attenuates inflammatory and hypoxic responses in preclinical mouse models: potential for repurposing in COVID-19-like conditions||Journal of Respiratory Research||2021|
|Generation of iPSC from fetal fibroblast cells obtained from an abortus with type-I tri-allelic variants||Stem Cell Research||2020|
|HspB5 protects Mouse Neural Stem/Progenitor Cells from Paraquat Toxicity,||American Journal of Stem Cells||2020|
|Inflammation, vascularization and goblet cell differences in LSCD: Validating animal models of corneal alkali burns||Experimental Eye Research||2019|
|Design and synthesis of substituted dihydropyrimidinone derivatives as cytotoxic and tubulin polymerization inhibitors||Bioorganic Chemistry||2019|
|Gene delivery approaches for mesenchymal stem cell therapy: Strategies to increase efficiency and specificity||Stem Cell Reviews and Reports||2017|
|Anticancer activity of large metalla assemblies built from half sandwich complexes||CrystEngComm||2016|
|Transfection of arginine decarboxylase gene increases the neuronal differentiation of neural progenitor cells||Stem Cell Research.||2016|
|Agmatine Improves Cognitive Dysfunction and Prevents Cell Death in a Streptozotocin-Induced Alzheimer Rat Model||Yonsei Medical Journal||2014|
|Modulation of stem cell differentiation by the influence of nano-bio-materials/carriers||Current Stem Cell Research and Therapy||2014|
|Foil assisted replica molding for fabrication of microfluidic devices and their application in vitro||Lab on a Chip||2014|
|The multifaceted effects of agmatine on functional recovery after contusion spinal cord injury through modulations of BMP-2, 4, 7 expressions in neurons, oligodendrocytes and astrocytes||PLoS ONE||2013|
|Agmatine promotes the migration of murine brain endothelial cells via multiple signaling pathways||Life sciences||2013|
|The Effect of Agmatine on Expression of IL-1β and TLX Which Promotes Neuronal Differentiation in Lipopolysaccharide-Treated Neural Progenitors||Experimental Neurobiology||2013|
|Stem cells and stress injury: Role of arginine decarboxylase(Book Chapter)||Stem Cells and Cancer Stem Cells||2012|
|Genetically modified stem cells and their applications in central nervous system injury models.||Vascular Neurology||2012|
|Carbon nanotubes impregnated with subventricular zone neural progenitor cells promotes recovery from ischemic injury||International Journal of Nanomedicine||2012|
|Biocompatability of carbon nanotubes with stem cells to treat CNS injuries||Anatomy and Cell Biology.||2012|
|Agmatine enhances neurogenesis by increasing ERK1/2 Expression, and suppresses astrogenesis by decreasing BMP2 and BMP4 expression in SVZ Neural Stem Cells||Life sciences||2011|
|Retroviral Expression of Arginine Decarboxylase Rescued Mouse Cortical Neural Stem Cells against H2O2 Injury||Stem Cell and Development||2011|
|The expression of human papillomavirus type 16 (HPV 16 E7) induces cell cycle arrest and apoptosis in radiation and hypoxia resistant glioblastoma cell line (U87 MG).||Molecular Medicine Reports||2011|
|Recombinant hexahistidine arginine decarboxylase (hisADC) induced endogenous agmatine synthesis during stress||Molecular and Cellular Biochemistry||2010|
|Agmatine and Angiogenesis in Cerebral Ischemia: Therapeutic Approaches.||Vascular Neurology||2010|
|Influence of lead on glutathione system in different regions of rat brain||Journal of Applied toxicology||2009|
|Lead-Induced alteration of apoptotic proteins in different regions of adult rat brain.||Toxicology letters||2009|
|Lead-induced increase in antioxidant enzymes and lipid peroxidation products in developing rat brain||Biometals||2008|
|Region specific increase in the antioxidant enzymes and lipid peroxidation products in the brain of rats exposed to lead||Free Radical Research||2006|
|In vitro effect of Lead on Na+ K+ ATPase activity in Different Regions of Adult Rat Brain||Drug and Chemical Toxicology||2003|