We are interested in understanding Host Pathogen interactions that dictate the outcome of infection. Our pathogen model system is the protozoan pathogen, Leishmania donovani. Our research work covers three broad areas:Mechanisms of Virulence and Cell survival in Leishmania: identification and analysis of molecules and mechanisms that confer an advantage to the parasite during infection in mammals.Mechanisms of Host Susceptibility/Resistance: We are studying the cellular immune responses in mice of distinct genetic background, to Leishmania infection, over time and in different tissues.Analysis of immunological memory in B-lymphocytes: B-lymphocytes provide immune protection by producing highly specific antibodies in response to foreign antigens and pathogens. While plasma B cells are responsible for the rapid resolution of a current immune challenge, memory B cells are responsible for mounting a rapid response to subsequent exposures. We are currently studying the molecular mechanisms underlying the generation of memory B cells.
Santosh K Panda, Sunil Kumar, Nitin C Tupperwar, Tushar Vaidya, Anna George, Satyajit Rath, Vineeta Bal and Balachandran Ravindran(2012): Chitohexaose activates macrophages by alternate pathway through TLR4 and blocks Endotoxemia. PLOS Pathogens 8 (5) : e1002717
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|CD40-miRNA axis controls prospective cell fate determinants during B cell differentiation||Molecular Immunology||2020|
|Constitutive CD40-signaling calibrates differentiation outcomes in responding B cells via multiple molecular pathways||Journal of Immunology 197:761-770||2016|
|Leishmania donovani Aurora kinase: a promising therapeutic target against visceral leishmaniasis||Biochemica et Biophysica Acta 1860: 1973-1988||2016|
|CD40 Signaling Drives B Lymphocytes into an Intermediate Memory-Like State, Poised Between Na||Journal of Cellular Physiology, 229 (10), 1387-1396.||2014|
|Chitohexaose activates macrophages by alternate pathway through TLR4 and blocks Endotoxemia.||PLOS Pathogens 8 (5) : e1002717||2012|
|Evolutionary and functional insights into Leishmania META1: evidence for lateral gene transfer and a role for META1 in secretion||BMC Evol Biol , 11: 334||2011|
|An endogenous retroviral locus regulates susceptibility to murine leishmanial infection.||The Journal of Infectious Diseases 202(8):1234||2010|
|Inhibition of Terminal Differentiation of B cells mediated by CD27 and CD40 involves signaling through JNK||J Immunology 185;6499-6507||2010|
|Development of a real-time PCR assay for the quantification of Leishmania species and the monitoring of systemic distribution of the pathogen||Diagnostic Microbiology and Infectious Disease 61: 23||2008|
|Induction of autophagic cell death in Leishmania donovani by antimicrobial peptides.||Molecular & Biochemical Parasitology 127: 23||2003|