A National Facility for Transgenic and Gene Knock-out Mice sponsored by the Department of Science and Technology (DST), Government of India has been set up at the CCMB with the following aims:
- Procurement and maintenance of transgenic and knock-out mouse models of human diseases where such animals are available elsewhere without restriction and provide facility and expertise to use the same in drug screening.
- Breeding of currently available transgenic and knock-out mouse models.
- Development of transgenic and gene knock-out technologies.
- Development of new transgenic and gene knock-out mice models of human diseases.
A modern mouse facility houses
transgenic mice and other experimental mouse strains needed for creation of
transgenic and gene knock-out mice. The mouse genetics laboratory includes
well-furnished infrastructure for culture of embryonic stem cells, cryopreservation
of embryos, micro-manipulation of embryos, animal surgery, construction of
transgenes & gene knock-out vectors, identification of transgenic &
knock-out mice, and analysis of gene expression.
To understand regulation of gene expression and to delineate the
function of mammalian genes, we routinely create transgenic & gene knockout
mice by performing DNA microinjection into mouse eggs, and genetic manipulation
of mouse embryonic stem cells.
For any service/usage of facility, please write to email@example.com