CSIR - Centre for Cellular & Molecular Biology
Council of Scientific and Industrial Research
Ministry of Science & Technology, Govt. of India
Chief Scientist
Email: abpatel@ccmb.res.in
Phone: +91-040-27192979/2837
Human brain comprises only ~2% of the body weight but it accounts for ~20% of total oxygen utilization of the whole body, indicating the overwhelming energy demand of the brain. Glutamate and ?-aminobutyric acid (GABA) are the major excitatory and inhibitory neurotransmitters in the matured mammalian central nervous system. These neurotransmitters are involved in many functions such as motor, behavior, cognition, emotion, etc. Majority of brain energy is used to support neurotransmission, and for the processes associated with it. Dysfunction in these pathways is associated with many neurological and neuropsychiatric disorders. Our current research is focused on to understand the energetics of neurotransmission in different neurological and psychiatric disorders such as Alzheimer`s disease, Amyotrophic lateral sclerosis, depression, Parkinson`s disease, and addiction.
The major goals of these studies are following:
Selected Publications
Patel AB, Veeraiah P, Shameem M, Mahesh Kumar M, Saba K (2021) Impaired GABAergic and Glutamatergic Neurometabolic Activity in Aged Mice Brain as Measured by 1H-[13C]-NMR Spectroscopy. FASEB J doi:10.1096/fj.20200 1704RR
Pati S, Saba K, Salvi SS, Tiwari P, Chaudhari PR, Verma V, Mukhopadhyay S, Kapri D, Suryavanshi S, Clement JP, Patel AB, Vaidya VA (2020) Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior. eLife 9:e56171.
Mishra PK, Kumar A, Behar KL, Patel AB (2018) Sub-Anesthetic Ketamine Reverses Neuronal and Astroglial Metabolic Activity Deficits in a Social Defeat Model of Depression. Journal of Neurochemistry 146(6): 722-734.
Patel AB, Tiwari V, Veeraiah P, Saba K (2018) Increased Astroglial Activity and Reduced Neuronal Function Across Brain in A?PP-PS1 Mouse Model of Alzheimer's Disease. J Cereb Blood Flow Metab 38(7):1213-1226.
Patel AB, Lai JCK, Chowdhury GMI, Hyder F, Rothman DL, Shulman RG, Behar KL (2014) Direct Evidence for Activity-Dependent Glucose Phosphorylation in Neurons With Implications for the Astrocyte-to-Neuron Lactate Shuttle. Proc Natl Acad Sci USA 111:5385-5390.
Veeraiah P, Noronha JM, Maitra S, Bagga P, Khandelwal N, Chakravarty S, Kumar A, Patel AB (2014) Dysfunctional Glutamatergic and GABAergic Activities in Prefrontal Cortex of Mice in Social Defeat Model of Depression. Biol Psychiatry 76:231-238.
Education & Experience
P.G: | Chemistry (Specialisation in Physical Chemistry) ; Banaras Hindu University, Varanasi, India ; 1993 |
Ph.D: | NMR Studies of Biomolecular Systems ; TATA Institute of Fundamental Research, Mumbai, India ; 1999 |
Post.Doc: | In vivo NMR Studies of Brain Energy Metabolism in Rat Brain ; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, USA ; 1999-2001 In vivo NMR studies of glutamate metabolism in rat brain ; Department of Psychiatry, Yale University School of Medicine, New Haven, USA ; 2001-2003 |
Experience: | Associate Research Scientist: In vivo NMR studies of GABA metabolism in rats and mice brain; Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, USA; 2003-2006 |
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Title | Journal | Year |
---|---|---|
Pathomechanistic Networks of Motor System Injury in Amyotrophic Lateral Sclerosis | Current Neuropharmacology | 2024 |
Acan downregulation in Parvalbumin GABAergic cells reduces spontaneous recovery of fear memories | Molecular Psychiatry | 2023 |
Differential effects of chronic ethanol use on mouse neuronal and astroglial metabolic activity | Neurochem Res | 2023 |
Chronic Lead Exposure Disrupts Neurometabolic Activity in Mouse Brain: An ex vivo 1H-[13C]-NMR Study | Neurotoxicology | 2023 |
A comparative study of antibody response, virus neutralization efficiency & metabolites in SARS-CoV-2-infected adults & children | Indian Journal of Medical Research | 2022 |
Astroglial Pathology in Major Depressive Disorders: Metabolic and Molecular Aspects in Glial Biology | The Biology of Glial Cells: Recent Advances | 2022 |
Enhanced Cortical Metabolic Activity in Females and Males of a Slow Progressing Mouse Model of Amyotrophic Lateral Sclerosis | Neurochem Res | 2022 |
Discovery of serum biomarkers for diagnosis of tuberculosis by NMR metabolomics including cross-validation with a second cohort. | Biomedical Journal | 2021 |
1H-[13C]-NMR investigation of brain energy metabolism in zebrafish: Impact of acute ethanol | Journal of Magnetic Resonance Open | 2021 |
Brain Energy Metabolism in Intracerebroventricularly Administered Streptozotocin Mouse Model of Alzheimer’s disease: A 1H-[13C]-NMR Study. | J Cereb Blood Flow Metab doi: 10.1177/0271678X21996176 | 2021 |
Impaired GABAergic and Glutamatergic Neurometabolic Activity in Aged Mice Brain as Measured by 1H-[13C]-NMR Spectroscopy. | The FASEB Journal doi:10.1096/fj.20200 1704RR | 2021 |
Glutamate and GABA Homeostasis and Neurometabolism in Major Depressive Disorder. | Front Psychiatry-Molecular Psychiatry (in Press) | 2021 |
Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior | eLife 9 (2020) e56171 | 2020 |
Impaired neuronal and astroglial metabolic activity in chronic unpredictable mild stress model of depression: Reversal of behavioral and metabolic deficit with lanicemine | Neurochemistry Internatal 137:104750 | 2020 |
Active and prospective latent tuberculosis are associated with different metabolomic profiles: Clinical potential for the identification of rapid and non-invasive biomarkers | Emerging Microbes & Infections 9(1): 1131-1139. | 2020 |
Delivery of BACE1 siRNA mediated by TARBP-BTP fusion protein reduces b-amyloid deposits in a transgenic mouse model of Alzheimer`s Disease. | Journal of Biosciences 44:1-9. | 2019 |
Sub-Anesthetic Ketamine Reverses Neuronal and Astroglial Metabolic Activity Deficits in a Social Defeat Model of Depression | Journal Neurochemistry | 2018 |
Increased Astroglial Activity and Reduced Neuronal Function Across Brain in A?PP-PS1 Mouse Model of Alzheimer's Disease. | J Cereb Blood Flow Metab 38(7):1213-1226. DOI: 10.1177/0271678X17709463. | 2018 |
Sub-Anesthetic Ketamine Reverses Neuronal and Astroglial Metabolic Activity Deficits in a Social Defeat Model of Depression. | Journal of Neurochemistry 146(6): 722-734. | 2018 |
Direct one-pot synthesis of glutathione capped hydrophilic FePt-CdS nano probe for efficient bimodal imaging application. | Mat Sci Engg C 72:415-424. | 2017 |
Insights into the epigenetic mechanisms involving histone lysine methylation and demethylation in ischemia induced damage and repair has therapeutic implication. | Biochimica et Biophysica Acta (BBA)-Mol Basis Disease 1863:152-154. | 2017 |
Comparison of Glutamate Turnover in Nerve Terminals and Brain Tissue During [1,6-13C2]Glucose Metabolism in Anesthetized Rats. | Neurochem Res 42(1):173-190.doi: 10.1007/s11064-016-2103-x. | 2017 |
Amalaki Rasayana Improved Memory and Neuronal Metabolic Activity in A?PP-PS1 Mouse Model of Alzheimer's disease. | J Biosci 42(3):363-371. DOI: 10.1007/s12038-017-9692-7. | 2017 |
Energetics of Excitatory and Inhibitory Neurotransmission in Aluminium Chloride model of Alzheimer's Disease: Reversal of Behavioral and Metabolic Deficits by Rasa Sindoor. | Front Mol Neurosci 10:323. doi: 10.3389/fnmol.2017.00323. | 2017 |
A designed recombinant fusion protein for targeted delivery of siRNA to the mouse brain | J Controlled Release 228:120-131. | 2016 |
Pretreatment of caffeine leads to partial neuroprotection in MPTP model of Parkinson`s disease. | Neural Regeneration Res 11:1750-1751. [IF: 1.24] | 2016 |
Facile Development of Iron-Platinum Nanoparticles to Harness Multifunctionality in Single Entity. | Acta Metallurgica Sinica 29:1098-1106. [IF: 1.188] | 2016 |
Effects of GAT1 Inhibition by Tiagabine on Brain Glutamate and GABA Metabolism in the Anesthetized Rat In Vivo. | J Neurosci Res 93:1101-1108 | 2015 |
Direct synthesis of water dispersible superparamagnetic TGA capped FePt nanoparticles: One pot, one shot. | Materials Chemistry and Physics 156: 247-53. | 2015 |
A Water-Soluble and Water-Coordinated Mn(II) Complex: Synthesis, Characterization and Phantom MRI Image Study. | Dalton Transactions 44:12990-12994. | 2015 |
Neuroprotective Effects of Caffeine in MPTP Model of Parkinson's Disease: A 13C NMR Study. | Neuochem Int 93:1101-1108. | 2015 |
Protein-Polymer Functionalized Aqueous Ferrofluids Showing High T 2 Relaxivity | Journal of Biomedical Nanotechnology 10:811-189 | 2014 |
Dysfunctional Glutamatergic and GABAergic Activities in Prefrontal Cortex of Mice in Social Defeat Model of Depression. | Biol Psychiatry 76:231-238 | 2014 |
Engineering of gadofluoroprobes: Broad-spectrum applications from cancer diagnosis to therapy | Applied Physics Letters 104:023703 | 2014 |
Pyruvate Carboxylase and Pentose Phosphate Fluxes are Reduced in A?PP-PS1 Mouse Model of Alzheimer's Disease: A 13C NMR Study. | J Alzheimer's Dis 41:387-399. | 2014 |
Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle. | Proc Natl Acad Sci USA 111:5385-5390 | 2014 |
Characterization of Cerebral Glutamine Uptake from Blood in the Mouse Brain: Implications for Metabolic Modeling of 13C NMR Data. | J Cereb Blood Flow Metab 34:1666-1672 | 2014 |
Oligo(p?phenyleneethynylene)-Derived Porous Luminescent Nanoscale Coordination Polymer of GdIII: Bimodal Imaging and Nitroaromatic Sensing. | J Phys Chem 118:12241-12249. | 2014 |
13C Nuclear Magnetic Resonance Investigations of Neurotransmitter Energetics in Brain | J Indian Inst Sci 94:455-464. | 2014 |
Effect of Biomimetic Templates on the Magneto-Structural Properties of Fe3O4 Nanoparticles | RSC Advances 5:13777-13786 | 2014 |
Multifunctional carbon nanospheres with magnetic and luminescent probes: probable brain theranostic agents. | J Material Chem B 1:939-945. | 2013 |
Simple synthesis of superparamagnetic magnetite nanoparticles as highly efficient contrast agent. | Materials Letters 95:186-189. | 2013 |
Glutamatergic and GABAergic TCA Cycle and Neurotransmitter Cycling Fluxes in Different Regions of Mouse Brain | J Cereb Blood Flow Metab 33:1523-31. | 2013 |
In Vivo NMR Studies of Regional Cerebral Energetics in MPTP Model of Parkinson`s Disease: Recovery of Cerebral Metabolism with Acute Levodopa Treatment. | J Neurochem 127:365-77. | 2013 |
Differential effects of ethanol on regional glutamatergic and GABAergic neurotransmitter pathways in mouse brain. | J Neurochem 128:628-640. | 2013 |
Regional Cerebral Metabolism in Mouse under Chronic Manganese Exposure: Implications for Manganism | Neurochem Int 60:177-185 | 2012 |
Glutamatergic and GABAergic Metabolism in Mouse Brain Under Chronic Nicotine Exposure: Implications for Addiction. | PLos One 7(7): e41824. | 2012 |
Evaluation of cerebral acetate transport and metabolic rates in the rat brain in vivo using 1H-[13C]-NMR | J. Cereb. Blood Flow Metab. 30:1200-13 | 2010 |
Effects of continuous hypoxia on energy metabolism in cultured cerebro-cortical neurons, | Brain Res. 1229:147-54 | 2008 |
Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase-deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling | J. Neurochem. 103:2077-91 | 2007 |
Glutamatergic and GABAergic Neurotransmitter Cycling and Energy Metabolism in Rat Cerebral Cortex During Postnatal Development | J. Cereb. Blood Flow Metab. 27:1895-907 | 2007 |
Evidence that GAD65 Mediates Increased GABA Synthesis during Intense Neuronal Activity In Vivo | J. Neurochem. 97:385-396 | 2006 |
Acute Regulation of Steady-State GABA Levels following GABA-Transaminase Inhibition in Rat Cerebral Cortex | Neurochem. Int. 48:508-514 | 2006 |
Neuronal-glial glucose oxidation and glutamatergic-GABAergic function: 13C MRS studies examining the coupling of glucose metabolism and neuronal activity provides insights into the heterogeneity of neuronal-glial interactions | J. Cereb. Blood Flow Metab. 26:865-877 | 2006 |
Cerebral Pyruvate Carboxylase Flux is Unaltered during Bicuculline-Seizures | J. Neurosci. Res. 79:128-138 | 2005 |
The Contribution of GABA to Glutamate/Glutamine Cycling and Energy Metabolism in the Rat Cortex in vivo | Proc. Natl. Acad. Sci. 102:5588-5593 | 2005 |
Glutamatergic Neurotransmission and Neuronal Glucose Oxidation Are Coupled During Intense Neuronal Activation | J. Cereb. Blood Flow Metab. 24:972-985 | 2004 |
Regional Glucose Metabolism and Glutamatergic Neurotransmission in Rat Brain In Vivo | Proc. Natl. Acad. Sci. 101:12700-12705 | 2004 |
Coupling of Glutamatergic Neurotransmission and Neuronal Glucose Oxidation over the Entire Range of Cerebral Cortex Activity | Ann. N. Y. Acad. Sci. 1003:452-453 | 2003 |
Coupling of Glutamatergic Neurotransmission and Neuronal Glucose Oxidation over the Entire Range of Cerebral Cortex Activity | Ann. N. Y. Acad. Sci. 1003:452-453 | 2003 |
In Vivo 1H-[13C]-NMR Spectroscopy of Cerebral Metabolism | NMR Biomed. 16:339-357 | 2003 |
Determination of liposomal encapsulation efficiency using 1H NMR spectroscopy. | Chem. Phys. Lipids 127:113-120 | 2003 |
Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition | Brain Res. 919:207-220 | 2001 |
Decrease in GABA Synthesis Rate in Rat Cortex following GABA-Transaminase Inhibition Correlates with the Decrease in GAD67 Protein | Brain Res. 914:81-91 | 2001 |
Substance P (free acid) Adopts Different Conformation than Native Peptide in DMSO, Water and DPPC Bilayers | J. Biomol. Struct. Dyn. 19:129-138 | 2001 |
Synthesis, spectroscopic, electrochemical and antibacterial studies of new Ru(II) 1,10-phenanthroline complexes containing aryldiazopentane-2,4-dione as co-ligand | New J. Chem. 24:505-510 | 2000 |
Spectroscopic studies on the conformation and binding characteristic of 7-hydroxy-8-(phenylazo)1,3-naphthalene disulfonate with BPA | J. Biol. Chem. 274:21755-21762 | 1999 |
Identification of low molecular weight compounds in goat epididymis using multinuclear NMR | Anal. Biochem. 266:205-215 | 1999 |
Arginine acts as a protective and reversal agent against glycolytic inhibitors in spermatozoa | Physiol. Chem. Phys. Med. NMR 31:29-40 | 1999 |
Interaction of [Ile7]angiotensin III with dodecylphosphocholine Micelles: NMR and molecular dynamics studies | Magn. Reson. Chem. 37:279-286 | 1999 |
Replacement of Phe8 in Substance P bye Tyr (Tyr8-SP) alters the conformation in DMSO, water and lipid bilayers | Biopolymers 50:602-612 | 1999 |
Arginine activates glycolysis of goat epididymal spermatozoa: a NMR study | Biophys. J. 75:1522-1528 | 1998 |
Conformation of renin substrate (angiotensinogen) in water is different from DMSO: a 1H NMR and MD study | Magn. Reson. Chem. 36:285-295 | 1998 |
Membrane induced conformation of [Val4, Ile7]angiotensin III by NMR and molecular dynamics methods | Magn. Reson. Chem. 36:815-825 | 1998 |
ynthesis characterization and film formation of modified riboflavin | Mat. Sci. Engg. C3:273-276 | 1995 |
Spectroscopic studies on calcium depleted horsheradish peroxidase: observation of tryptophan sensitized Fluorescence | J. Inorg. Biochem. 60:245-255 | 1995 |
Elucidation of self-assembling properties of riboflavin and its derivative when interface with solid supports | Mat. Sci. Engg. C3:263-266 | 1995 |
2979/2837
abpatel@ccmb.res.in
2838
ksvr@ccmb.res.in
2981
bedaballi@ccmb.res.in
2981
akila@ccmb.res.in
2981
ajays@ccmb.res.in
2928
prajakta@ccmb.res.in
2981
chaynita.dashora@ccmb.res.in
2981
vimalakp@ccmb.res.in
2981