Senior Principal Scientist
Understanding the epigenetic or chromatin remodeling mechanisms in complex disorders of brain and behavior, the neuropsychiatric diseases, in particular, the molecular and cellular mechanisms underlying etiopathophysiology of affective disorders such as depression, anxiety and post-traumatic stress disorder (PTSD). Using rodent models we study how chronic environmental perturbations such as stress cause alterations in circuitry controlling mood and emotions, by inducing lasting changes in function of many genes via events at the chromatin level (i.e., epigenetic mechanisms).Understanding the epigenetic regulatory mechanisms in neural stem cell biology, i.e. neurogenesis and gliogenesis in adult mouse brain, using both in vitro and in situ approach; this approach might also give us clue to the etiopathology of brain tumors such as astrocytoma or glioblastoma, etc. Our earlier expertise in apoptosis and tumor biology research and the latest one in genome-wide epigenenomics come together in zeroing in on the etiopathology of cancer of nervous system origin.
Maitra S, Khandelwal N, Kootar S, Sant P, Pathak SS, Reddy S, Annapoorna P, Murty US, Chakravarty S, Kumar A (2020). Histone lysine demethylase JMJD2D/KDM4D and family members mediate effects of chronic social defeat stress on mouse hippocampal neurogenesis and mood disorders. Brain Sci. 10: 833.
Khandelwal N, Dey SK, Chakravarty S, Kumar A (2019). miR-30 family miRNAs mediate the effect of chronic social defeat stress on hippocampal neurogenesis in mouse depression model. Front Mol Neurosci. 12:188.
Pathak SS, Maitra S, Chakravarty S, Kumar A (2017). Histone lysine demethylases of JMJD2 or KDM4 family are important epigenetic regulators in reward circuitry in the etiopathology of depression. Neuropsychopharmacol 42(4):854-863.
Chakravarty S, Jhelum P, Bhat UA, Rajan WD, Maitra S, Pathak SS, Patel AB, Kumar A (2017). Insights into the epigenetic mechanisms involving histone lysine methylation and demethylation in ischemia induced damage and repair has therapeutic implication. BBA- Molecular Basis of Disease 1863(1):152-164.
Veeraiah P, Noronha JM, Maitra S, Bagga P, Khandelwal N, Chakravarty S, Kumar A*, Patel AB* (2014). Dysfunctional glutamatergic and Gamma-Aminobutyric acidergic activities in prefrontal cortex of mice in social defeat model of depression. Biol Psychiatry 76(3):231-8.
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|Proteome profile of telencephalon associates attenuated neurogenesis with chronic stress induced mood disorder phenotypes in zebrafish model||Pharmacology Biochemistry & Behaviour||2021|
|Gene Expression analysis identifies cholesterol metabolism dysregulation in hippocampus of phenytoin resistant pentylenetetrazol kindled epileptic mice||Neuromolecular Medicine||2021|
|A BRD’s (BiRD’s) eye view of BET and BRPF bromodomains in neurological disease||Reviews in the Neurosciences||2021|
|Differential modulation of GR signaling and HDACs in the development of resilient/vulnerable phenotype and antidepressant-like response of vorinostat||Psychoneuroendocrinol||2020|
|Histone lysine demethylase JMJD2D/KDM4D and family members mediate effects of chronic social defeat stress on mouse hippocampal neurogenesis and mood disorders||Brain Sci (in press)||2020|
|Molecular Basis of Sex Difference in Neuroprotection induced by Hypoxia Preconditioning in Zebrafish||Mol Neurobiol (in press)||2020|
|Advances in Histone Deacetylase Inhibitors in Targeting Glioblastoma Stem Cells||Cancer Chemotherapy and Pharmacology||2020|
|Impaired neuronal and astroglial metabolic activity in chronic unpredictable mild stress model of depression: Reversal of behavioral and metabolic deficit with lanicemine||Neurochem Int.||2020|
|miR-30 Family miRNAs Mediate the Effect of Chronic Social Defeat Stress on Hippocampal Neurogenesis in Mouse Depression Model||Front Mol Neurosci.||2019|
|FTO:An Emerging Molecular Player in Neuropsychiatric Diseases||Neurosci.||2019|
|Disrupting the hippocampal Piwi pathway enhances contextual fear memory in mice||Neurobiol Learn mem.||2019|
|Revealing sex-specific molecular changes in hypoxia-ischemia induced neural damage and subsequent recovery using zebrafish model||Neurosci Lett.||2019|
|Crafting Carbazole Based Vorinostat and TubastatinA-like Histone Deacetylase (HDAC) Inhibitors With Potent in Vitro and in Vivo Neuroactive Functions||ACS Omega||2019|
|Increased stress and altered expression of histone modifying enzymes in brain are associated with aberrant behaviour in vitamin B12 deficient female mice.||Nutr Neurosci. (in press)||2019|
|Fellutamide B Synthetic Path Intermediates with in Vitro Neuroactive Function Shows Mood-Elevating Effect in Stress-Induced Zebrafish Model||ACS Omega 3, 10534-10544||2018|
|Sub-Anesthetic Ketamine Reverses Neuronal and Astroglial Metabolic Activity Deficits in a Social Defeat Model of Depression||Journal of Neurochemistry 2018 Jul 2. doi: 10.1111/jnc.14544||2018|
|Transient global cerebral ischemia differentially affects cortex, striatum and hippocampus in bilateral common carotid artery occlusion (BCCAo) mouse model||J Chem Neuroanat. 2018 Oct;92:1-15. doi: 10.1016/j.jchemneu.2018.04.006.||2018|
|Mice with Partial Deletion of Y-heterochromatin Exhibits Stress Vulnerability||Frontiers in Behav Neurosci (accepted for publication)||2018|
|A 2-oxa-spiro[5.4]decane scaffold displays neurotrophic, neurogenic and anti-neuroinflammatory activities with high potential for development as a versatile CNS therapeutic||Scientific Reports||2017|
|Sex difference in mouse hypothalamic transcriptome profile in stress-induced depression model||Biochem Biophys Res Comm (in press)||2017|
|Sex differences in the effect of chronic mild stress on mouse prefrontal cortical BDNF levels: A role of major ovarian hormones||Neuroscience||2017|
|Leucine-rich repeat-containing 8B (LRRC8B) protein is associated with the endoplasmic reticulum calcium leak in HEK293 cells||J cell Sci (in press)||2017|
|A Functional Role for the Epigenetic Regulator ING1 in Activity-induced Gene Expression in Primary Cortical Neurons||Neuroscience||2017|
|Role of Annexin gene and its regulation during Zebrafish caudal fin regeneration.||Wound Repair Regen||2016|
|Natural product based novel small molecules with promising neurotrophic, neurogenic and anti-neuroinflammatory actions can be developed as stroke therapeutics (PERSPECTIVE)||NEURAL REGENERATION RESEARCH (in press)||2016|
|Sirtuin 1 and 7 mediate the resveratrol induced recovery from hyper-anxiety in high fructose fed prediabetic rats.||J Biosci. (in Press)||2016|
|Sameerpannag Ras Mixture (SRM) improved neurobehavioral deficits following acute ischemic stroke by attenuating neuroinflammatory response.||J Ethnopharmacol.||2016|
|nsights into the epigenetic mechanisms involving histone lysine methylation and demethylation in ischemia induced damage and repair has therapeutic implication||BBA - Molecular Basis of Disease||2016|
|Histone lysine demethylases of JMJD2 or KDM4 family are important epigenetic regulators in reward circuitry in the etiopathology of depression.||Neuropsychopharmacology (In Press)||2016|
|Differential effect of chronic stress on mouse hippocampal memory and affective behavior: Role of major ovarian hormones.||Behav Brain Res||2016|
|Implications of Epigenetic Mechanisms and their Targets in Cerebral Ischemia Models||Curr. Neuropharmacol.||2016|
|A novel natural product inspired scaffold with robust neurotrophic, neurogenic and neuroprotective action.||Scientific Reports (in Press)||2015|
|Histone Deacetylase Inhibitors and Psychiatric Disorders||Epigenetics in Psychiatry, J. Peedicayil, D. Avramopoulos, D.R. Grayson (edited), Elsevier (in Press)||2014|
|Epigenetic Regulatory Mechanisms in Stress Induced Behavior.||Int Rev Neurosci (in Press)||2014|
|Prohexadione, a Plant Growth Regulator, Inhibits Histone Lysine Demethylases and Modulates Epigenetics.||Toxicology Report, Elsevier (in Press)||2014|
|Early stress evokes age-dependent biphasic changes in hippocampal neurogenesis, Bdnf expression and cognition||Biological Psychiatry 73( 7) , 658-666||2013|
|Chronic Unpredictable Stress (CUS)-Induced Anxiety and Related Mood Disorders in a Zebrafish Model: Altered Brain Proteome Profile Implicates Mitochondrial Dysfunction||PLoS ONE 8(5): e63302. doi:10.1371/journal.pone.0063302||2013|
|Dysfunctional Glutamatergic and GABAergic Activities in Prefrontal Cortex of Mice in Social Defeat Model of Depression||Biol Psychiatry (in Press)||2013|
|Role of proteomics in biomarker discovery and psychiatric disorders: current status, potentials, limitations and future challenges||Expert Rev. Proteomics 9(3), 249-265 (2012)||2012|
|P2X7 receptor - Pannexin 1 hemichannel association: effect of extracellular calcium on membrane permeabilization||J Mol Neurosci. 46(3):585-94.||2012|
|Insight into cocaine-induced neural and behavioral adaptations using genome-wide expression profiling and epigenomic analysis||Curr Psychopharm, 1(4): 332-345.||2012|