CSIR - Centre for Cellular & Molecular Biology
Council of Scientific and Industrial Research
Ministry of Science & Technology, Govt. of India
Senior Principal Scientist
Email: mvdesh@ccmb.res.in
Phone: +91-040-27192646/2839
Conformational plasticity in dsRNA binding domains drives functional divergence in RNA recognition
Debadutta Patra, Jaydeep Paul, Upasana Rai, Aravind P. S., and Mandar V. Deshmukh
Journal of the American Chemical Society, 2025. In Press, doi: 10.1021/jacs.5c02057.
The mechanism of DRB7.2:DRB4 mediated sequestering of endogenous inverted-repeat dsRNA precursors in plants.
Sneha Paturi, Debadutta Patra, Priti Chanda Behera, Ramdas Aute, Nilam Waghela, Priyadarshan Kinatukara, and Mandar V Deshmukh
eLife, 14:105762, 2025. Doi: 10.7554/eLife.105762
Crc of Pseudomonas syringae Lz4W utilizes the dominant RNA binding site for mutually exclusive interactions with Hfq:mRNA and CrcY/Z RNA
Rakhi Sharma, Jaydeep Paul, Sneha Paturi, Malay K. Ray, and Mandar V. Deshmukh
Journal of Magnetic Resonance Open, 10–11: 100047, 2022, doi: doi.org/10.1016/j.jmro.2022.100047.
DRB4 dsRBD1 drives dsRNA recognition in Arabidopsis thaliana tasi/siRNA pathway
C. Sai Chaitanya, Ramdas Aute, Upasana Rai, Mandar V. Deshmukh
Nucleic Acids Research, 45(14), 8551-8563, 2017.
Structure of RDE-4 dsRBDs and mutational studies provide insights in the dsRNA recognition in C. elegans RNAi.
C Sai Chaitanya and Mandar V Deshmukh
Biochemical Journal, 458 (1), 119-130, 2014.
Education & Experience
P.G: | Chemistry ; Dr. B. A. M. University, Aurangabad, MS, India ; 1997 |
Ph.D: | : NMR Investigations on Structure, Dynamics and Function of VAT-N & DOTATOC; Advisor: Prof. Dr. Horst Kessler ; Technical University of Munich, Germany ; 2004 |
Post.Doc: | Postdoctoral Scholar, Department of Pharmaceutical Chemistry Structural and functional characterization of the mRNA decapping enzyme, Dcp2, and its complex with RNA Advisor: Prof. John D. Gross ; University of California San Francisco, San Francisco, CA, USA ; 2004-2006 |
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Title | Journal | Year |
---|---|---|
Chemical shift assignments of DRB2 domains, a dsRNA binding protein in A. thaliana RNAi pathway. | Biomolecular NMR Assignment | 2025 |
Chemical shift assignments of N-terminal dsRNA binding domains dsRBD1 and dsRBD2 of Arabidopsis thaliana DRB5. | Biomolecular NMR Assignment | 2025 |
The mechanism of DRB7.2:DRB4 mediated sequestering of endogenous inverted-repeat dsRNA precursors in plants. | eLife | 2025 |
Conformational plasticity in dsRNA binding domains drives functional divergence in RNA recognition | Journal of the American Chemical Society | 2025 |
Key arginine residues in R2D2 dsRBD1 and dsRBD2 lead the siRNA recognition in Drosophila melanogaster RNAi pathway | Biophysical Chemistry | 2024 |
Chemical shift assignment of dsRBD1 and dsRBD2 of Arabidopsis thaliana DRB3, an essential protein involved in RNAi-mediated antiviral defense | Biomolecular NMR Assignment | 2024 |
NMR resonance assignments of 18.5 kDa complex of Arabidopsis thaliana DRB7.2:DRB4 interaction domains | Biomolecular NMR Assignments | 2023 |
Chemical shift assignments of dsRBD1 and linker region of R2D2, a siRNA binding protein in the Drosophila RNAi pathway | Biomolecular NMR Assignment | 2023 |
1. Crc of Pseudomonas syringae Lz4W utilizes the dominant RNA binding site for mutually exclusive interactions with Hfq:mRNA and CrcY/Z RNA | Journal of Magnetic Resonance Open | 2022 |
A glimpse of "Dicer Biology" through the structural and functional perspective | Frontiers in Molecular Biosciences | 2021 |
Dominant mutants of the calcineurin catalytic subunit (CNA-1) showed developmental defects, increased sensitivity to stress conditions, and CNA-1 interacts with CaM and CRZ-1 in Neurospora crassa | Archives of Microbiology, 202(4), 921-934 | 2020 |
Structural and mechanistic insights into EchAMP: A antimicrobial protein from the Echidna milk | BBA – Biomembranes, 1861(6),1260-1274 | 2019 |
Constrained dynamics of the sole tryptophan in the third intracellular loop of the serotonin?1A receptor | Biophysical Chemistry, 240, 34-41, 2018. | 2018 |
Accessing structure determination of biological macromolecules by NMR through advances in isotope labelling | Journal of Indian Institute of Science, https://doi.org/10.1007/s41745-018-0085-1 | 2018 |
DRB4 dsRBD1 drives dsRNA recognition in Arabidopsis thaliana tasi/siRNA pathway | Nucleic Acids Research, 45(14), 8551-8563 | 2017 |
8th RNA Group Meeting: Novelties and Outcome | Indian Natn Sci Acad | 2016 |
Recent Excitements in Protein NMR: Large Proteins and Biologically Relevant Dynamics | Journal of Biosciecnes | 2016 |
Backbone and stereospecific 13C methyl Ile (?1), Leu and Val side-chain chemical shift assignments of Crc | Biomolecular NMR Assignments | 2015 |
Chemical shift assignments of DRB4 (1-153), a dsRNA binding protein in A. thaliana RNAi pathway | Biomolecular NMR Assignment | 2015 |
Independent amino acid residues in the S2 pocket of falcipain-3 determine its distinct activities | Molecular & Biochemical Parasitology | 2015 |
Structure of RDE-4 dsRBDs and mutational studies provide insights in the dsRNA recognition in C. elegans RNAi | Biochemical Journal, 458 (1), 119-130 | 2014 |
Delineating the reaction mechanism of reductase domains of nonribosomal peptide synthetases from Mycobacteria | Journal of Structural Biology | 2014 |
Lipase in aqueous-polar organic solvents: activity, structure, and stability | Protein Science, 22(7), 904-15 | 2013 |
Mechanism of chiral proofreading during translation of the genetic code | Elife. 2:e01519 | 2013 |
Backbone and sidechain methyl Ile(?1), Leu and Val chemical shift assignments of RDE-4 (1-243), an RNA interference initiation protein in C. elegans | Biomolecular NMR Assignments, 6(2), 143-6 | 2012 |
In vitro evolved non-aggregating and thermostable lipase: Structural and thermodynamic investigation. | Journal of Molecular Biology | 2011 |
Mechanistic insights into cognate substrate discrimination during proofreading in translation | Proceedings of the National Academy of Sciences, USA, 107(51), 22117-21 | 2010 |
mRNA decapping is promoted by an RNA binding channel in Dcp2. | Molecular Cell, 29, 324-336, 2008. | 2008 |
Backbone and Ile(?1), Leu and Val Resonance Assignments of the Catalytic Domain of the Yeast mRNA Decapping Enzyme, Dcp2 | Biomolecular NMR Assignments, 1, 17-18. | 2007 |
Inter-domain Orientation and Motions in VAT-N Explored by RDCs and 15N Backbone Relaxation | Magnetic Resonance in Chemistry, 44(S1), S89-S100 | 2006 |
NMR Studies Reveal Structural Differences Between the Gallium and Yttrium Complexes of DOTA-D-Phe1-Tyr3-Octreotide | Journal of Medicinal Chemistry, 48(5), 1506-1514 | 2005 |
Residual Dipolar Coupling Constant: An Elementary Derivation of Key Equations | Concepts in Magnetic Resonance, 21A(1), 10-21 | 2004 |
Design and Evaluation of New Ligands for Lysozyme Recovery by Affinity Thermo-precipitation | Chemical Engineering Science, 56, 5681-5692 | 2001 |
Structural comparison of three DOTATOC metal complexes | European Journal of Nuclear Medicine, 28(8), 1261-1261 | 2001 |
LCST in Poly(N-isopropylacrylamide) Copolymers: High Resolution Proton NMR Investigations | Polymer, 41, 7951-7960 | 2000 |
2646/2839
mvdesh@ccmb.res.in
2917/2517
jaydeep@ccmb.res.in
2917
debadutta@ccmb.res.in
2517
pritichanda@ccmb.res.in
2517
nilam.waghela@ccmb.res.in
2517
aravinduthradam@ccmb.res.in