Cell division is a fundamental cellular process involved in embryonic development and mitotic aberrations result in disorders such as microcephaly, aneuploidy syndromes and embryonic lethality. We study the molecular mechanisms regulating cell division to understand the basis of these developmental disorders. We use zebrafish as the model system to study cell division dynamics during embryonic development. The zebrafish embryos are amenable to live cell imaging, genetic manipulation and high throughput genetic screens.
My group is also interested in ecotoxicology and embryo toxicology. In one of our projects, we aim to assess the impact of common industrial byproducts on embryonic development. Our long-term goal is to elucidate the molecular mechanisms which form the basis of developmental defects upon exposure to these industrial byproducts.
Sharma A., Shukla A., Attri K., Kumar M., Kumar P., Suttee A., Singh G., Barnwal R. and Singla N. (2020). Global trends in pesticides: A looming threat and viable alternatives. Ecotoxicology and Environmental Safety; 201, 110812.
Mahale P*., Kumar M.*, Sharma A*., Babu A., Ranjan S., Sachidanandan C. and Mylavarapu V. S. (2016). The Light Intermediate Chain 2 Subpopulation of Dynein Regulates Mitotic Spindle Orientation. Scientific Reports 6(1); 22. *- Equal contribution
Kumar M., Pushpa K. and Mylavarapu V. S. (2015). Splitting the cell, building the organism: Mechanisms of cell division in metazoan embryos. (IUBMB Life; 67,7: 575-87)
Kumar M. and Chapman S. (2012). Cloning and expression analysis of Fgf5, 6 and 7 during early chick development. Gene Expression Patterns; 12, 245-253.
Kumar M., Ray P. and Chapman S. (2012). Fibroblast growth factor and Bone morphogenetic protein signaling are required for specifying prechondrogenic identity in neural crest-derived mesenchyme and initiating the chondrogenic program. Developmental Dynamics; 241, 1091-1103.
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|Role of vertebrate GAGA associated factor (vGAF) in early development of zebrafish||Cells and Development, https://doi.org/10.1016/j.cdev.2021.203682||2021|
|Watching the embryo: Evolution of the microscope for the study of embryogenesis.||BioEssays, e2000238. https://doi.org/10.1002/bies.202000238||2021|
|Global trends in pesticides: A looming threat and viable alternatives.||Ecotoxicology and Environmental Safety||2020|