Our group focusses on understanding cell cycle regulatory mechanisms underlying normal development and disease manifestation. For this we study genes (i) with mutations linked to microcephaly (small brain) and (ii) whose dysregulation/dysfunction is associated with neural cancers. We use state-of-the-art cell and molecular biology approaches in neural cancer /stem cells and brain organoids, to establish the spatio-temporal roles of such developmentally important proteins.
Chavali PL, Stojic L, Gergely F. Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication. Science. 2017; 357: 83-88.
Chavali S, Chavali PL, Chalancon G, de Groot NS, Gemayel R, Latysheva NS, Ing-Simmons E, Verstrepen KJ, Balaji S, Babu MM. Constraints and consequences of the emergence of amino acid repeats in eukaryotic proteins. Nature Structural & Molecular Biology. 2017; 24:765-777.
Chavali PL, Chandrasekaran G, Barr AR, Tatrai P, Taylor C, Papachristou EK, Woods CG, Chavali S, Gergely F. A CEP215-HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer. Nature Communications. 2016; 7: 11005.
Chavali PL, et al. TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival. Cell Death & Disease. 2014; 5: e1502.
McIntyre RE, Chavali PL, et al. Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome. PLoS Genetics. 2012; 8: e1003022.
Education & Experience
|P.G:||Life Sciences ; Pondicherry University ; 2003|
|Ph.D:||â€˜Regulation of MAR Binding Protein SMAR1 under stress: Implications on the cell cycle by modulation of ATM-p53- MDM2 pathwaysâ€™ ; University of Pune, India (National Centre for Cell Science, Pune) ; 2009|
Adult neural and cancer stem cells ; Sahlgrenska Academy, Gothenburg University, Sweden ; 2009-2010
Cell and developemental biology ; University of Cambridge, cancer Research UK, Cambridge UK ; 2010-2016
Investigator Scientist, MRC Laboratory of Molecular Biology, Cambridge, UK . 2016-2018
|SET7/9 interacts and methylates the ribosomal protein, eL42 and regulates protein synthesis||Biochimica et Biophysica Acta (BBA)-Molecular Cell Research||2020|
|PRMT3 interacts with ALDH1A1 and inhibits retinoic acid signaling.||Communications Biology||2020|
|Functional categories of RNA regulation||RNA based regulation of human health and disease||2020|