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CSIR - Centre for Cellular & Molecular Biology

Council of Scientific and Industrial Research
Ministry of Science & Technology, Govt. of India

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Puran Singh Sijwali

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Puran Singh Sijwali-Img

Puran Singh Sijwali

Senior Principal Scientist

Research Interests

Malaria parasite has a wonderfully complex development that involves 15 different forms, disguising the host defence arsenal, to complete its life cycle. Many of these forms reside in different cellular environments and contain stage-specific proteins and functionally specialized organelles, which are produced and disposed off as and when required. Additionally, the parasite not only breaks down host cellular contents to obtain nutrients, it also enslaves many host proteins for its benefit. My lab is investigating the ubiquitin proteasome and lysosomal pathways of malaria parasites, which likely regulate parasite development and disease pathogenesis through degradative and non-degradative functions. We combine gene knock-out/knock-in/knock-down approaches with biochemical and cell biology methods in our studies on both P. falciparum and in vivo models of malaria. We also have a high throughput screening assay for anti-malarial drug discovery.

Selected Publications

Divya N. Nair, Rajesh Prasad, Neha Singhal, Manish Bhattacharjee, Renu Sudhakar, Pushpa Singh, Subramonian Thanumalayan, Uday Kiran, Yogendra Sharma and Puran Singh Sijwali. (2018) A conserved human DJ1-subfamily motif (DJSM) is critical for anti-oxidative and deglycase activities of Plasmodium falciparum DJ1. Molecular & Biochemical Parasitology. 222:70-80. doi:10.1016/j.molbiopara.2018.05.003

Kolla VK, Prasad R, Sayyad Z, Atul, Shah AY, Allanki AD, Navale R, Singhal N, Tanneru N, Sudhakar R, Venkatesan V, Deshmukh MV and Sijwali PS. (2015) Independent amino acid residues in the S2 pocket of falcipain-3 determine its specificity for P2 residues in substrates. Mol Biochem Parasitol. 202(2):11-22. doi: 0.1016/j.molbiopara.2015.09.005.


Navale R, Atul, Allanki AD and Sijwali PS. (2014) Characterization of the autophagy marker protein Atg8 reveals atypical features of autophagy in Plasmodium falciparum. PLoS One 9(11): e113220. doi:10.1371/journal.pone.0113220.

Singhal N, Atul, Mastan B, Arun Kumar K and Sijwali PS. (2014) Genetic ablation of plasmoDJ1, a multi-activity enzyme, attenuates parasite virulence and reduces oocyst production. Biochem. J. 461 (189-203).

Prasad R, Atul, Kolla VK, Legac, J, Singhal N, Navale, R, Rosenthal PJ and Sijwali PS. (2013) Blocking Plasmodium falciparum development via dual inhibition of hemoglobin degradation and the ubiquitin proteasome system by MG132. PLoS One. 8(9):e73530. doi: 10.1371/journal.pone.0073530.


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Publications

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Prajakta Biyani

Junior Research Fellow

2928

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Somesh Gorde

Junior Research Fellow

2928

Puran Singh Sijwali-Img

Puran Singh Sijwali

Senior Principal Scientist

2944

psijwali@ccmb.res.in

Renu Sudhakar-Img

Renu Sudhakar

Senior Research Fellow

2928

renusmenon@ccmb.res.in

Manish Bhattacharjee-Img

Manish Bhattacharjee

Senior Research Fellow

2928

manish.atp29@ccmb.res.in

Deepak Kumar-Img

Deepak Kumar

Senior Research Fellow

2928

deepak.kumar@ccmb.res.in

Zeba Rizvi-Img

Zeba Rizvi

Senior Research Fellow

2928

zeba@ccmb.res.in

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Gangumala Srinivas Reddy

Senior Research Fellow

2928