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Swasti Raychaudhuri

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Swasti Raychaudhuri-Img

Swasti Raychaudhuri

Principal Scientist
Email: rcswasti@ccmb.res.in
Phone: +91-040-27192558

Research Interests

Toxic and beneficial outcome of protein aggregation inside cells

With the increasing life expectancy, developing effective treatments for numerous degenerative, age-related diseases becomes of enormous medical, social and economic relevance. Hence, research on cellular and organismal aging is now the focus of several leading laboratories and has provided different hypotheses about the causes of aging. One prominent hypothesis suggests that a gradual, age-dependent decline of protein homeostasis (proteostasis) accompanied by increasing protein-aggregation is the underlying cause of many age-related loss-of-function diseases. In our lab we perform systemic analysis of protein-aggregation in age-related proteostasis stress models. We are interested to identify the response of the cellular proteome against the newly triggered aggregates due to various stresses. Simultaneously, we investigate how components of the proteostasis network, including molecular chaperones, degradation machinery and others collaborate to maintain the integrity of the proteome in the face of protein-aggregation stresses. The specific questions include:

  • Proteostatic control on protein-complex biogenesis!!
  • Cellular response to protein aggregation!!

We use modern cell biology and state-of-the-art proteomics arsenal to address our questions.

Selected Publications

Widespread Nuclear Lamina injuries defeat proteostatic purposes of ?-Synuclein amyloid Inclusions. Mansuri S, Jain A, Singh R, Rawat S, Mondal D, Raychaudhuri S. J Cell Sci. 2024; doi: 10.1242/jcs.261935. Online ahead of print.

Increased supraorganization of respiratory complexes is a dynamic multistep remodelling in response to proteostasis stress. Rawat S, Ghosh S, Mondal D, Anusha V, Raychaudhuri S. J Cell Sci. 2020;133(18):jcs248492. doi: 10.1242/jcs.248492.

Aggregation of Respiratory Complex Subunits Marks the Onset of Proteotoxicity in Proteasome Inhibited Cells. Rawat S, Anusha V, Jha M, Sreedurgalakshmi K, Raychaudhuri S. J Mol Biol. 2019; 431(5):996-1015.

Interplay of Acetyltransferase EP300 and the Proteasome System in Regulating Heat Shock Transcription Factor 1. Raychaudhuri S, Loew C, Koerner R, Pinkert S, Theis M, Hayer-Hartl M, Buchholz F, Hartl FU. Cell. 2014; 156(5):975-85.

Firefly luciferase mutants as sensors of proteome stress. Gupta R, Kasturi P, Bracher A, Loew C, Zheng M, Villella A, Garza D, Hartl FU, Raychaudhuri S. Nature Methods. 2011; 8(10):879-84.

Education & Experience

Publications

Group Photo
Swasti Raychaudhuri-Img

Swasti Raychaudhuri

Principal Scientist

2558

rcswasti@ccmb.res.in

Harshit Vaish-Img

Harshit Vaish

Senior Research Fellow

2552

harshit@ccmb.res.in

Pooja Gupta-Img

Pooja Gupta

Senior Research Fellow

2556

poojagupta@ccmb.res.in

Suparna Ghosh-Img

Suparna Ghosh

Junior Research Fellow

2552

suparna@ccmb.res.in

Anchal-Img

Anchal

Junior Research Fellow

2552

aanchal@ccmb.res.in

Pallavi Rao T-Img

Pallavi Rao T

Junior Research Fellow

2552

pallavi@ccmb.res.in

Abhishek Aher-Img

Abhishek Aher

Project Research Scientist - I

2556

abhishekaher@ccmb.res.in

Rakhesh K V-Img

Rakhesh K V

Senior Project Associate

2556

rakhesh@ccmb.res.in

Sristi Chakroborty-Img

Sristi Chakroborty

Junior Research Fellow (Project)

2553

sristi@ccmb.res.in

Neha kumari-Img

Neha kumari

Junior Research Fellow (project)

2553

nehakumari@ccmb.res.in

Shreya Tripathi-Img

Shreya Tripathi

Junior Research Fellow (project)

2533

shreya.tripathi@ccmb.res.in

Gururaj kalshetti-Img

Gururaj kalshetti

Junior Research Fellow (Project)

2553

gururajk@ccmb.res.in