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CSIR - Centre for Cellular & Molecular Biology

Council of Scientific and Industrial Research
Ministry of Science & Technology, Govt. of India

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Tushar Vaidya

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Research Interests

We are interested in understanding Host Pathogen interactions that dictate the outcome of infection. Our pathogen model system is the protozoan pathogen, Leishmania donovani. Our research work covers three broad areas:Mechanisms of Virulence and Cell survival in Leishmania: identification and analysis of molecules and mechanisms that confer an advantage to the parasite during infection in mammals.Mechanisms of Host Susceptibility/Resistance: We are studying the cellular immune responses in mice of distinct genetic background, to Leishmania infection, over time and in different tissues.Analysis of immunological memory in B-lymphocytes: B-lymphocytes provide immune protection by producing highly specific antibodies in response to foreign antigens and pathogens. While plasma B cells are responsible for the rapid resolution of a current immune challenge, memory B cells are responsible for mounting a rapid response to subsequent exposures. We are currently studying the molecular mechanisms underlying the generation of memory B cells.

Selected Publications

Santosh K Panda, Sunil Kumar, Nitin C Tupperwar, Tushar Vaidya, Anna George, Satyajit Rath, Vineeta Bal and Balachandran Ravindran(2012): Chitohexaose activates macrophages by alternate pathway through TLR4 and blocks Endotoxemia. PLOS Pathogens 8 (5) : e1002717


Vidhi Puri, Aneesh Goyal, Rajan Sankaranarayanan, Anton J Enright and Tushar Vaidya(2011): Evolutionary and functional insights into Leishmania META1: evidence for lateral gene transfer and a role for META1 in secretion. BMC Evol Biol , 11: 334

Shuchismita Satpathy, Gautam Shenoy, Sheetal Kaw, Tushar Vaidya, Vineeta Bal, Satayjit Rath and Anna George(2010): Inhibition of Terminal Differentiation of B cells mediated by CD27 and CD40 involves signaling through JNK. J.Immunology 185;6499-6507

Varanasi Vineeth, Nitin C. Tupperwar, Tushar Vaidya, Vineeta Bal, Anna George, and Satyajit Rath(2010): An endogenous retroviral locus regulates susceptibility to murine leishmanial infection. The Journal of Infectious Diseases 202(8):1234-1245

Nitin Tupperwar, Varanasi Vineeth, Satyajit Rath and Tushar Vaidya (2008): Development of a real-time PCR assay for the quantification of Leishmania species and the monitoring of systemic distribution of the pathogen. Diagnostic Microbiology and Infectious Disease 61: 23-30

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Publications

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Tushar Vaidya

Chief Scientist

2604

tvaidya@ccmb.res.in

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Loka Ram Prasad

Senior Research Fellow

2606

loka_ramprasad@ccmb.res.in

Pradyumna Paranjape-Img

Pradyumna Paranjape

Senior Research Fellow

2606

pradyparanjpe@ccmb.res.in

V Devi Prasad-Img

V Devi Prasad

Senior Research Fellow

2606

vdeviprasad@ccmb.res.in

Satyajeet Salunke-Img

Satyajeet Salunke

Senior Research Fellow

2606

satyajeet@ccmb.res.in

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Srishti Rajkumar Mishra

Project Assistant-II

2606

srishtimishra@ccmb.res.in

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Rati Ranjan Kar

Project Assistant-II

2537

krati@ccmb.res.in

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Kaneez-e-Rabab Khan

Project Assistant-II

2606

kaneez@ccmb.res.in