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CSIR - Centre for Cellular & Molecular Biology

Council of Scientific and Industrial Research
Ministry of Science & Technology, Govt. of India

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A S Sreedhar

Senior Principal Scientist
Email: assr@ccmb.res.in
Phone: +91-040-27192698

Research Interests

Heat Shock Proteins in Biology and Medicine: Our group is working on stress response and heat shock proteins (Hsps) in biology and medicine. We are studying the molecular basis of stress response and transcriptional regulation of Hsp synthesis during development, differentiation and stress management to identify the unconventional roles of heat shock transcription factors in tumor cells. High expression of Hsps, especially the Hsp90 in tumor cells correlates with poor prognosis and accelerated disease progression. Therefore we are studying effect of Hsp90 inhibition in anticancer treatments and elucidating novel functions of Hsps. Inducing cytostasis or apoptosis in tumor cells may induce unwanted cellular response. We are evaluating stress (physiological or oncogene), or Hsp inhibition or over expression induced cellular senescence as a tumor suppressor mechanism. Our group is also involved in molecular targeting of cancer using natural compounds, and evaluation of combinatorial treatments as beneficial tool for cancer

Selected Publications

Shrikant PD, Paithankar K, Abhijnya KV, Hatim SK, Sreedhar AS
Mitochondrial chaperone, TRAP1 modulates mitochondrial dynamics and promotes tumor metastasis
Mitochondrion. doi: https://doi.org/10.1016/j.mito.2020.08.001

Vijayalakshmi A, Khanderao P, Shrikanth PD, Abirami A, Sreedhar AS.
Development of Nanocarrier-Based Mitochondrial Chaperone, TRAP-1 Inhibitor to Combat Cancer Metabolism.
ACS Appl. Bio Mater. 2020, 3, 7, 4188–4197. https://doi.org/10.1021/acsabm.0c00268

Ramkumar B, Dharaskar SP, Mounika G, Paithankar K, Sreedhar AS.
Mitochondrial chaperone, TRAP1 as a potential pharmacological target to combat cancer metabolism.
Mitochondrion. 2020;50:42-50. doi:10.1016/j.mito.2019.09.011

Kumar P, Devaki B, Jonnala UK, Sreedhar AS.
Hsp90 facilitates acquired drug resistance of tumor cells through cholesterol modulation however independent of tumor progression.
Biochim Biophys Acta Mol Cell Res. 2020;1867(8):118728. doi:10.1016/j.bbamcr.2020.118728

Kanugovi AV, Joseph C, Siripini S, Paithankar K, Sreedhar AS.
Compromising the constitutive p16INK4a expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence.
J Cell Biochem. 2020;121(4):2770-2781. doi:10.1002/jcb.29493

Education & Experiance

Publications

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A S Sreedhar

Senior Principal Scientist

2698

assr@ccmb.res.in

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A Vijaya Lakshmi

Senior Principal Scientist

2555

viji@cccmb.res.in

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K R Paithankar

Principal Tech. Officer

2610

krp@ccmb.res.in

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Akhil Kotwal

Senior Research Fellow

2610

akhil@ccmb.res.in

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Pankaj Kumar

Senior Research Fellow

2610

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Shrikant Dharaskar

Junior Research Fellow

2610