Training on Faster COVID-19 Testing
CSIR - Centre for Cellular & Molecular Biology
Council of Scientific and Industrial Research
Ministry of Science & Technology, Govt. of India
Chief Scientist
Email: assr@ccmb.res.in
Phone: +91-040-27192698
Shrikant PD, Paithankar K, Abhijnya KV, Hatim SK, Sreedhar AS
Mitochondrial chaperone, TRAP1 modulates mitochondrial dynamics and promotes tumor metastasis
Mitochondrion. doi: https://doi.org/10.1016/j.mito.2020.08.001
Vijayalakshmi A, Khanderao P, Shrikanth PD, Abirami A, Sreedhar AS.
Development of Nanocarrier-Based Mitochondrial Chaperone, TRAP-1 Inhibitor to Combat Cancer Metabolism.
ACS Appl. Bio Mater. 2020, 3, 7, 4188–4197. https://doi.org/10.1021/acsabm.0c00268
Ramkumar B, Dharaskar SP, Mounika G, Paithankar K, Sreedhar AS.
Mitochondrial chaperone, TRAP1 as a potential pharmacological target to combat cancer metabolism.
Mitochondrion. 2020;50:42-50. doi:10.1016/j.mito.2019.09.011
Kumar P, Devaki B, Jonnala UK, Sreedhar AS.
Hsp90 facilitates acquired drug resistance of tumor cells through cholesterol modulation however independent of tumor progression.
Biochim Biophys Acta Mol Cell Res. 2020;1867(8):118728. doi:10.1016/j.bbamcr.2020.118728
Kanugovi AV, Joseph C, Siripini S, Paithankar K, Sreedhar AS.
Compromising the constitutive p16INK4a expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence.
J Cell Biochem. 2020;121(4):2770-2781. doi:10.1002/jcb.29493
Education & Experience
| P.G: | Biochemistry ; SV University ; 1991-92 |
| Ph.D: | Hsp90 inhibitors: their effects on redox status and on the cytosrchitecture ; Semmelweis University, Hungary ; 2004 |
| Post.Doc: | Stress Biology ; Kyoto University, Japan ; 2007 ; ; JSPs Fellow, Stress Biology ; Kyoto University, Japan ; 2007 ; ; |
| Experience: | 27 years; Stress Biology, Cell and Developmental Biology, Molecular Biology, Molecular Medicine. |
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| Title | Journal | Year |
|---|---|---|
| The mitochondrial chaperone TRAP-1 regulates the glutamine metabolism in tumor cells | Mitochondrion | 2023 |
| Analysis and functional relevance of the chaperone TRAP-1 interactome in the metabolic regulation and mitochondrial integrity of cancer cells | Scientific Reports | 2023 |
| Heat shock transcription factor HSF2 modulates the autophagy response through the BTG2-SOD2 axis | Biochemical and Biophysical Research Communications (BBRC) | 2022 |
| Hsp90 and its mitochondrial homologue TRAP-1 independently regulate hypoxia adaptations in Caenorhabditis elegans | Mitochondrion | 2021 |
| Hsp90 and its mitochondrial homologue TRAP-1 independently regulate hypoxia adaptations in Caenorhabditis elegans ? | Mitochondrion(Accepted) | 2021 |
| Cancer vs. SARS-CoV-2 induced inflammation, overlapping functions, and pharmacological targeting | Inflammaopharmacology (Accepted) | 2021 |
| Hsp90 chaperone facilitates E2F1/2-dependent gene transcription in human breast cancer cells ? | European Journal of Cell Biology https://doi.org/10.1016/j.ejcb.2020.151148 | 2021 |
| The conformation-specific Hsp90 inhibition interferes with the oncogenic RAF kinase adaptation and triggers premature cellular senescence, hence, acts as a tumor suppressor mechanism. | BBA- Molecular Cell Research https://doi.org/10.1016/j.bbamcr.2020.118943 | 2021 |
| Mitochondrial chaperone, TRAP1 modulates mitochondrial dynamics and promotes tumor metastasis | Mitochondrion, doi: https://doi.org/10.1016/j.mito.2020.08.001 | 2020 |
| Hsp90 regulates HDAC3-dependent gene transcription while HDAC3 regulates the functions of Hsp90 | Cellular Signalling (doi: https://doi.org/10.1016/j.cellsig.2020.109801) | 2020 |
| Mitochondrial chaperone, TRAP1 modulates mitochondrial dynamics and promotes tumor metastasis | Mitochondrion, doi: https://doi.org/10.1016/j.mito.2020.08.001 | 2020 |
| Development of nanocarrier-based mitochondrial chaperone, TRAP-1 inhibitor to combat cancer metabolism. | ACS Appl. Bio Mater. (doi: https://dx.doi.org/10.1021/acsabm.0c00268.) | 2020 |
| The matrix metalloproteinase 7 (MMP7) links Hsp90 chaperone with acquired drug resistance and tumor metastasis | Cancer Reports : doi:10.1002/cnr2.1261 | 2020 |
| Altered molecular pathways decides the treatment outcome of Hsp90 inhibitors against breast cancer cells | Toxicology in Vitro, 2020 https://doi.org/10.1016/j.tiv.2020.104828 | 2020 |
| Hsp90 facilitates acquired drug resistance of tumor cells through cholesterol modulation however independent of tumor progression | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, https://doi.org/10.1016/j.bbamcr.2020.118728 | 2020 |
| Mitochondrial chaperone, TRAP1 as a potential pharmacological target to combat cancer metabolism. | Mitochondrion. 2019 Oct 25. pii: S1567-7249(19)30019-4. doi: 10.1016/j.mito.2019.09.011. | 2019 |
| Compromising the constitutive p16(INK4a) expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence. | J Cell Biochem. 2019 Nov 6. doi:10.1002/jcb.29493. | 2019 |
| The tumor suppressor p16INK4a expression bypasses 17AAG mediated cellular effects in human neuroblastoma, IMR-32 | Transl Med, Vol 6, p 74. 2016,doi: 10.4172/2161-1025.c.1.020 | 2016 |
| The prosurvival activity of HSF2 in response to autophagic stress is triggered by HSF2 - dependent transactivation of BTG2 | Mol Biol Cell, 26(25): 4523,doi: 10.1091/mbc.E15-09-0674 | 2015 |
| Molecular characterization and expression analysis of hsp60 gene homologue of sheep blowfly, Lucilia cuprina | J Therm Biol, Vol 52, p 24-37.,doi: 10.1016/j.jtherbio.2015.05.001. | 2015 |
| Oncogene de-addiction from Hsp90 induces senescence-like phenotype in malignant and metastatic tumor cells | Mol Biol Cell, vol. 25, p 25 3987,doi:10.1091/mbc.E14-10-1437 | 2014 |
| Synthesis, anticancer and antibacterial activities of piplartine derivatives on cell cycle regulation and growth inhibition | Journal of Asian Natural Products Research. 15:658-669, 2013. | 2013 |
| Cipadessin-type limonoids from the leaves of Cipadessa baccifera | Tetrahedron Letters, 54: 2934-2937, 2013. | 2013 |
| Geldanamycin combination with colcemid induces mitotic arrest through stabilization of bubR1 mitotic kinase in human tumor cells | Journal of Cancer Therapy, 4: 709-719, 2013 | 2013 |
| Hsp60 chaperonin acts as barrier to pharmacologically induced oxidative stress mediated apoptosis in tumor cells with differential stress response | Drug Target Insights, Vol 7, p 35-51 doi: 10.4137/DTI.S12513 | 2013 |
| 17AAG treatment accelerates doxorubicin induced cellular senescence: Hsp90 interferes with enforced senescence of tumor cells | Drug Target Insights,6:19-39 | 2012 |
| Glutamete carboxypeptidase II (GCPII) genetic variants as determinants of hyperhomocysteinemia: Implications in stroke susceptibility | Indian J Biochem & Biophys, 49:356-362, 2012. | 2012 |
| Heat shock proteins in the cancer immunity: comprehensive review on potential chemotherapeutic interventions | J. Clin. Cell. Immunol. 6: 1-8, 2012. | 2012 |
| Association of Glutamate Carboxypeptidase II (GCPII) Haplotypes with Breast and Prostate Cancer Risk | Gene, 516: 76-81, 2012. | 2012 |
| Repercussion of mitochondria structural deformity induced by anti-Hsp90 drug 17AAG in human tumor cells | Journal of Drug Target Insights, 5: 1-22,2011 | 2011 |
| Anti-microbial principles of selected remedial plants from southern India | Asian Pacific J Tropical Biomedicine,1: 298-305, 2011 | 2011 |
| Pharmacological inhibition of Hsp90 as a novel antitumor strategy to target cytoarchitecture through extracellular matrix signaling. | Medicinal Chemistry,7:1-12, 2011 | 2011 |
| Synthesis and anticancer effects of pongamol derivatives on mitogen signaling and cell cycle kinases | Medicinal Chemistry Reserach, Published online on 30-Jan-2011 | 2011 |
| Combinatorial effect of 17AAG and doxorubicin on stress induced cellular senescence of human neuroblastoma cells | J. Ind. Acad. Geriatrics. 6: 133, 2010. | 2010 |
| Hsp90 inhibition induces destabilization of actin cytoskeleton in tumor cells: functional significance of Hsp90 interaction with F-actin. | Asian Pacfic Journal of Tropical Medicine, Vol. 3, 715-722 | 2010 |
| 17-(Allylamino)-17-demethoxygeldanamycin combination with diferuloylmethane selectively targets mitogen kinase pathway in a human neuroblastoma cell line | Journal of Cancer Therapy, Vol. 1,197-204. | 2010 |
| p53 pseudogene: potential role in heat shock induced apoptosis in a rat histiocytoma | HEALTH, Vol.2, 1065-1071. | 2010 |
| Hsp70 confines tumor progression of rat histiocytoma and impedes the cytotoxicity induced by natural killer cells and peritoneal macrophages | Asia Pacific J. Trop. Med., Vol. 3 (4): 302-309. | 2010 |
| Stress proteins in biology and medicine: evolution, adaptation and clinical evaluation. | Int. J. Pharma & Biosci. Vol. 1(3): 1-35, 2010. | 2010 |
| Hsp90 inhibitors, GA and 17AAG, leads to ER-stress induced apoptosis in rat histiocytoma. | Biochem. Pharmacol. 78: 141-152 | 2009 |
| Diferuloylmethane augments the cytotoxic effects of piplartine isolated from Piper chaba. | Toxicology in Vitro. Vol.23: 1085-1091 | 2009 |
| Stress response and emerging roles of heat shock proteins: Bench to Bedside. | Icfai J. Bitechnol 2: 31-50 | 2008 |
| Heat shock transcription factors in the regulation of stress induced cell death pathways in a rat histiocytoma | J. Biosci., 32: 585-593 | 2007 |
| Heat shock transcription factors: a comprohensive review. In stress response: a molecular biology approach (Eds. A. S. Sreedhar and Usha K. Srinivas) | ISBN: 81-308-0109-4, Research Signpost. | 2006 |
| Heat shock proteins in the clinical and pharmacological perspective. In stress response: a molecular biology approach (Eds. A. S. Sreedhar and Usha K. Srinivas) | ISBN: 81-308-0109-4, Research Signpost. | 2006 |
| Stress response: a molecular biology approach | ISBN: 81-308-0109-4, Research Signpost. | 2006 |
| Hyperthermia and pharmacological interventions of heat shock proteins in anticancer treatments | Japanese Journal of Hyperthermic Oncology, 22(4): 201-227 | 2006 |
| Effect of unfolded protein accumulation on the redox state of the endoplasmic reticulum. In: Redox regulation (eds: A. Pompella, G. Banhegyi and M. Wellman-Rousseau), | NATO Science Series, 363: 111-119 | 2005 |
| Hidden dimensions of stress response | Everyman`s Science, XL: 179-185 | 2005 |
| Effect of Hsp90 inhibitors, geldanamycin, 17-allylamino-17-demethoxygeldanamycin and curcumin on human neuroblastoma cells, IMR-32. | FEBS J., 272(s1): G1-008P | 2005 |
| Heat Shock Proteins in the regulation of apoptosis: New strategies in tumor therapy | Pharmacol. & Ther., 101: 227-257 | 2004 |
| Inhibition of Hsp90: a new strategy for inhibiting protein kinases | Biochim. Biophys. Acta (Proteins and Proteomics)., 1697: 233-242 | 2004 |
| Enhancement of complement-induced cell lysis. A novel mechanism for the anticancer effects of Hsp90 inhibitors | Immunol. Lett., 92: 157-161 | 2004 |
| Hsp90 isoforms: functions, expression and clinical importance | FEBS Letts., 562: 11-15 | 2004 |
| Effect of potassium application on growth attributes and stem histology of chickpea grown in vertisol | Nat. J. Life Sci., 1: 187-191 | 2004 |
| Apoptosis, necrosis and cellular senescence: chaperone occupancy as a potential switch | Aging Cell, 2: 39-45 | 2003 |
| Novel Roles of Hsp90 inhibitors and Hsp90 in: redox regulation and cytoarchitecture | Rec. Res. Develop. Life Sci., 1: 153-171 | 2003 |
| Hsp90 inhibition accelerates cell lysis: anti-Hsp90 ribozyme reveals a complex mechanism of Hsp90 inhibitors involving both superoxide- and Hsp90-dependent events | J. Biol. Chem., 278: 35231-35240 | 2003 |
| Interaction of neuropeptide Y and Hsp90 through a novel peptide-binding region | Biochemistry (US), 42: 12972-12980 | 2003 |
| Molecular chaperones, evolution and in medicine | J. Mol. Struct. (THEOCHEM), 666-667: 373-380 | 2003 |
| A cross talk between cell signalling and cellular redox state during heat induced apoptosis in a rat histiocytoma | Free Radic. Biol. Med., 32: 221-227 | 2002 |
| Effect of C-terminal deletion of p53 on heat induced CD95 expression and apoptosis in a rat histiocytoma | Oncogene, 21: 4042-4049 | 2002 |
| Activation of stress response by ionomycin in rat hepatoma cells. | J. Cell. Biochem., 86: 154-161 | 2002 |
| Emerging role for Hsp90 in protein folding, evolution, cell organization, and aging | Eur. J. Biochem., 269: 3.3-5 | 2002 |
| Role of stress response proteins in the regulation of cell death process | Cell Stress and Chaperones , 5: 338-338 | 2001 |
| Heat induced expression of CD95 and its correlation with the activation of apoptosis upon heat shock in rat histiocytic tumor cells | FEBS Letts., 472: 271-275 | 2000 |
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assr@ccmb.res.in
2610
priyadarshini.s@ccmb.res.in
2610
prateekshya@ccmb.res.in
2610
vivek.chaudhary@ccmb.res.in
2610
priyanka.gautam@ccmb.res.in
Notice and Lists of provisionally shortlisted and not shortlisted candidates for the post of Senior Technical Officer(1)/Medical Officer against Advt.No.05/2023