Training on Faster COVID-19 Testing
CSIR - Centre for Cellular & Molecular Biology
Council of Scientific and Industrial Research
Ministry of Science & Technology, Govt. of India
CSIR Bhatnagar Fellow
Email: amit@ccmb.res.in
Phone: +91-040-27192578
Research Interests
The major research interest of our group is centered on membrane and receptor biology using a variety of biophysical, biochemical and cell biological approaches. Fluorescence-based spectroscopic and microscopic approaches are extensively used in our laboratory. The research interest of our group can be broadly categorized as follows:
Selected Publications
Chakraborty, H., and Chattopadhyay, A. (2015) `Excitements and Challenges in GPCR Oligomerization: Molecular Insight from FRET` (invited review) ACS Chem. Neurosci. 6: 199-206.
Viswanathan, G., Jafurulla, M., Kumar, G.A., Raghunand, T.R., and Chattopadhyay, A. (2015) `Dissecting the Membrane Cholesterol Requirement for Mycobacterial Entry into Host Cells` Chem. Phys. Lipids 189: 19-27.
Chattopadhyay, A., and Haldar, S. (2014) `Dynamic Insight into Protein Structure utilizing Red Edge Excitation Shift` Acc. Chem. Res. 47: 12-19.
Ganguly, S., Clayton, A.H.A., and Chattopadhyay, A. (2011) `Organization of Higher Order Oligomers of the Serotonin1A Receptor Explored utilizing Homo-FRET in Live Cells` Biophys. J. 100: 361-368.
Shrivastava, S., Pucadyil, T.J., Paila, Y.D., Ganguly, S., and Chattopadhyay, A. (2010) `Chronic Cholesterol Depletion using Statin Impairs the Function and Dynamics of Human Serotonin1A Receptors` Biochemistry 49: 5426-5435.
Education & Experience
| P.G: | Chemistry ; Indian Institute of Technology, Kanpur ; 1980 |
| Ph.D: | A Novel Fluorescence Quenching Method for Measurement of Membrane Penetration Depth ; State University of New York at Stony Brook ; 1987 |
| Post.Doc: | Lipid-protein Interaction in the Nicotinic Acetylcholine Receptor ; Department of Biochemistry & Biophysics, University of California, Davis, CA, USA ; 1987-1989 |
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| Invention | Countries of filing the patent | Application number | Publication number | Status | Grant Number |
|---|---|---|---|---|---|
| A composition useful for the treatment of Leishmaniasis | India | Granted & Active | 242180 | ||
| Method of treating Leishmaniasis using Methyl-beta-cyclodextrin | USA | Granted & Active | 7186702 |
| Title | Journal | Year |
|---|---|---|
| Editorial | The Journal of Membrane Biology | 2024 |
| Interplay of Cholesterol and Actin in Neurotransmitter GPCR Signaling: Insights from Chronic Cholesterol Depletion using Statin | ACS Chemical Neuroscience | 2023 |
| Palmitoylation of the Glucagon-like Peptide-1 Receptor Modulates Cholesterol Interactions at the Receptor-Lipid Microenvironment | The Journal of Physical Chemistry B | 2023 |
| Smith-Lemli-Opitz Syndrome: A Pathophysiological Manifestation of The Bloch Hypothesis | Frontiers in Molecular Biosciences | 2023 |
| Role of Cholesterol and its Biosynthetic Precursors on Membrane Organization and Dynamics: A Fluorescence Approach | The Journal of Membrane Biology | 2023 |
| Statin-induced Increase in Actin Polymerization Modulates GPCR Dynamics and Compartmentalization | Biophysical Journal | 2023 |
| Effect of Local Anesthetics on Dipole Potential of Different Phase Membranes: A Fluorescence Study | The Journal of Membrane Biology | 2022 |
| Membrane Dipole Potential: An Emerging Approach to Explore Membrane Organization and Function | The Journal of Physical Chemistry B | 2022 |
| Inositol phosphoryl transferase, Ipt1, is a critical determinant of azole resistance and virulence phenotypes in Candida glabrata | Journal of Fungi | 2022 |
| Integrity of the Actin Cytoskeleton of Host Macrophages is Necessary for Mycobacterial Entry | The Journal of Membrane Biology | 2022 |
| Cholesterol-dependent Dynamics of the Serotonin1A Receptor utilizing Single Particle Tracking: Analysis of Diffusion Modes | The Journal of Physical Chemistry B | 2022 |
| Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-induced Thermal Stability to the Serotonin1A Receptor | The Journal of Membrane Biology | 2022 |
| Synergistic and Competitive Lipid Interactions in the Serotonin1A Receptor Microenvironment | ACS Chemical Neuroscience | 2022 |
| Metabolic Depletion of Sphingolipids Inhibits Agonist-induced Endocytosis of the Serotonin1A Receptor | Traffic | 2022 |
| Comparative Analysis of Tryptophan Dynamics in Spectrin and its Constituent Domains: Insights from Fluorescence | The Journal of Physical Chemistry B | 2022 |
| Cholesterol in GPCR Structures: Prevalence and Relevance | The Journal of Membrane Biology | 2022 |
| Chronic Cholesterol Depletion Increases F-actin Levels and Induces Cytoskeletal Reorganization via a Dual Mechanism | The Journal of Lipid Research | 2022 |
| Effect of Hypoxia on the Function of the Human Serotonin1A Receptor | ACS Chemical Neuroscience | 2022 |
| Metabolic Depletion of Sphingolipids Does not Alter Cell Cycle Progression in Chinese Hamster Ovary Cells | Journal of Membrane Biology | 2022 |
| Cholesterol in GPCR Structures: Prevalence and Relevance | Journal of Membrane Biology | 2022 |
| Integrity of the Actin Cytoskeleton of Host Macrophages is Necessary for Mycobacterial Entry | Journal of Membrane Biology | 2022 |
| Cholesterol-dependent Endocytosis of GPCRs: Implications in Pathophysiology and Therapeutics | Biophysical Reviews | 2021 |
| Cholesterol-dependent Endocytosis of GPCRs: Implications in Pathophysiology and Therapeutics | Biophysical Reviews | 2021 |
| Structure, Dynamics and Lipid Interactions of Serotonin Receptors: Excitements and Challenges | Biophysical Reviews | 2021 |
| Metabolic Depletion of Sphingolipids Reduces Cell Surface Population of the Human Serotonin1A Receptor due to Impaired Trafficking | ACS Chemical Neuroscience | 2021 |
| Conformational Plasticity and Dynamic Interactions of the N-terminal Domain of Chemokine Receptor CXCR1 | PLoS Computational Biology | 2021 |
| Environment-sensitive Fluorescence of 7-Nitrobenz-2-oxa-1,3-diazol-4-yl (NBD)-labeled Ligands for Serotonin Receptors | Molecules | 2021 |
| ack of Environmental Sensitivity of a Naturally Occurring Fluorescent Analog of Cholesterol | Journal of Fluorescence | 2021 |
| Molecular Sensor for Cholesterol in the Human Serotonin1A Receptor | Science Advances | 2021 |
| Lipid Headgroup Charge Controls Melittin Oligomerization in Membranes: Implication in Membrane Lysis | The Journal of Physical Chemistry B | 2021 |
| Cholesterol Footprint in High-Resolution Structures of Serotonin Receptors: Where are We Now and What Does It mean | Chemistry and Physics of Lipids | 2021 |
| Hydration Dynamics in Biological Membranes: Emerging Applications of Terahertz Spectroscopy | The Journal of Physical Chemistry Letters | 2021 |
| Late endosomal/lysosomal accumulation of a neurotransmitter receptor in a cellular model of Smith-Lemli-Opitz syndrome | Traffic | 2021 |
| Insights into Cellular Signaling from Membrane Dynamics | Archives of Biochemistry and Biophysics | 2021 |
| Membrane Cholesterol Regulates Endocytosis and Trafficking of the Serotonin1A Receptor: Insights from Acute Cholesterol Depletion | Biochim. Biophys. Acta (Molecular and Cell Biology of Lipids) | 2021 |
| Effect of Tertiary Amine Local Anesthetics on G Protein-coupled Receptor Lateral Diffusion and Actin Cytoskeletal Reorganization | Biochim. Biophys. Acta (Biomembranes) | 2021 |
| Statin-induced Chronic Cholesterol Depletion Switches GPCR Endocytosis and Trafficking: Insights from the Serotonin1A Receptor | ACS Chem. Neurosci. | 2020 |
| Structure, Dynamics and Lipid Interactions of Serotonin Receptors: Excitements and Challenges | Biophys. Rev. | 2020 |
| Differential Sensitivity of pHLIP to Ester and Ether Lipids | Chem. Phys. Lipids | 2020 |
| Cell Cycle Dependent Modulation of Membrane Dipole Potential and Neurotransmitter Receptor Activity: Role of Membrane Cholesterol | ACS Chem. Neurosci. | 2020 |
| Role of Cholesterol and its Immediate Biosynthetic Precursors in Membrane Dynamics and Heterogeneity: Implications for Health and Disease | J. Phys. Chem. B | 2020 |
| Selectivity in Agonist and Antagonist Binding of Serotonin1A Receptors via G-protein Coupling | Biochim. Biophys. Acta (Biomembranes) | 2020 |
| Cholesterol Interaction Motifs in G Protein-coupled Receptors: Slippery Hot Spots? | Wiley Interdiscip. Rev. Syst. Biol. Med. | 2020 |
| Membrane Electrostatics Sensed by Tryptophan Anchors in Hydrophobic Model Peptides Depends on Non-Aromatic Interfacial Amino Acids: Implications in Hydrophobic Mismatch | Faraday Discuss. | 2020 |
| Role of Cholesterol-mediated Effects in GPCR Heterodimers | Chem. Phys. Lipids | 2020 |
| Structural Stringency and Optimal Nature of Cholesterol Requirement in the Function of the Serotonin1A Receptor | J. Membr. Biol. | 2020 |
| Molecular Determinants of GPCR Oligomerization | In: GPCRs - Structure, Function, and Drug Discovery (Jastrzebska, B., and Park, P.S.-H., Eds.), Elsevier | 2020 |
| Molecular Evolution of a Collage of Cholesterol Interaction Motifs in Transmembrane Helix V of the Serotonin1A Receptor | Chem. Phys. Lipids | 2020 |
| Exploring Membrane Lipid and Protein Diffusion by FRAP | Analysis of Membrane Lipids (Prasad, R., and Singh, A., Eds.), Springer | 2020 |
| Role of Actin Cytoskeleton in Dynamics and Function of the Serotonin1A Receptor | Biophys. J. | 2020 |
| A Critical Analysis of Molecular Mechanisms Underlying Membrane Cholesterol Sensitivity of GPCRs | Adv. Exp. Med. Biol. | 2019 |
| Differential Effects of Simvastatin on Membrane Organization and Dynamics in Varying Phases | Chem. Phys. Lipids | 2019 |
| Leishmania donovani Internalizes into Host Cells via Caveolin-mediated Endocytosis | Sci. Rep. | 2019 |
| Exploring Endocytosis and Intracellular Trafficking of the Human Serotonin1A Receptor | Biochemistry | 2019 |
| Effect of Local Anesthetics on the Organization and Dynamics of Hippocampal Membranes: A Fluorescence Approach | J. Phys. Chem. B | 2019 |
| Extramembranous Regions in G Protein-coupled Receptors: Cinderella in Receptor Biology? | J. Membr. Biol. | 2019 |
| Exploring Membrane Organization at Varying Spatiotemporal Resolutions Utilizing Fluorescence-based Approaches: Implications in Membrane Biology | Phys. Chem. Chem. Phys. | 2019 |
| A Collage of Cholesterol Interaction Motifs in the Serotonin1A Receptor: An Evolutionary Implication for Differential Cholesterol Interaction | Chem. Phys. Lipids | 2019 |
| Micellar Dipole Potential is Sensitive to Sphere-to-Rod Transition | Chem. Phys. Lipids 195: 34-38. | 2016 |
| Molecular Anatomy of An Ion Channel Explored utilizing Fluorescence Spectroscopy | Reviews in Fluorescence 2015 (Geddes, C.D., Ed.), Springer, Heidelberg pp. 353-367. | 2016 |
| What Can Simulations Tell Us About GPCRs: Integrating the Scales | Methods Cell Biol. 132: 429-452. | 2016 |
| Molecular Rheology of Neuronal Membranes Explored using A Molecular Rotor: Implications for Receptor Function | Chem. Phys. Lipids 196: 69-75. | 2016 |
| Spatiotemporal Control of Transmembrane Proteins Through the Cytoskeleton: An Evolving Story | Biophys. J. 110: 1036–1037. | 2016 |
| Journal of Membrane Biology: Membranes in Disease Section | J. Membrane Biol. 249:9 | 2016 |
| Effect of Local Anesthetics on the Organization and Dynamics in Membranes of Varying Phase: A Fluorescence Approach | Chem. Phys. Lipids 198: 21-27. | 2016 |
| Membrane Fluorescent Probes: Insights and Perspectives in Fluorescent Analogues of Biomolecular Building Blocks: Design and Applications | (Tor, Y. and Wilhelmsson, M., Eds.) John Wiley pp. 356-366. | 2016 |
| Cholesterol Modulates Bitter Taste Receptor Function | Biochim. Biophys. Acta (Biomembranes) 1858: 2081-2087. | 2016 |
| Statin-induced Chronic Cholesterol Depletion Inhibits Leishmania donovani Infection: Relevance of Optimum Host Membrane Cholesterol | Biochim. Biophys. Acta (Biomembranes) 1858: 2088-2096. | 2016 |
| The Membrane as the Gatekeeper of Infection: Cholesterol in Host-Pathogen Interaction | Chem. Phys. Lipids 199: 179-185 | 2016 |
| The Membrane as the Gatekeeper of Infection: Cholesterol in Host-Pathogen Interaction | Chem. Phys. Lipids 199: 179-185 | 2016 |
| Cholesterol-Dependent Thermotropic Behavior and Organization of Neuronal Membranes | Biochim. Biophys. Acta (Biomembranes) 1858: 2611-2616 | 2016 |
| Novel Insights in Membrane Biology Utilizing Fluoresence Recovery After Photobleaching | Adv. Exp. Med. Biol. 842: 27-40. | 2015 |
| Role of Lipid-mediated Effects in Beta2-adrenergic receptor Dimerization | Adv. Exp. Med. Biol. 842: 247-261. | 2015 |
| Excitements and Challenges in GPCR Oligomerization: Molecular Insight from FRET | ACS Chem. Neurosci. 6: 199-206. | 2015 |
| Excitements and Challenges in GPCR Oligomerization: Molecular Insight from FRET | ACS Chem. Neurosci. 6: 199-206. | 2015 |
| Solubilization of G Protein-Coupled Receptors: A Convenient Strategy to Explore Lipid-Receptor Interaction | Methods Enzymol. 557: 117-134. | 2015 |
| Organization and Dynamics of Tryptophan Residues in Brain Spectrin: Novel Insight into Conformational Flexibility | J. Fluoresc. 25: 707–717. | 2015 |
| Cholesterol-induced Changes in Hippocampal Membranes Utilizing A Phase-sensitive Fluorescence Probe | Biochim. Biophys. Acta (Biomembranes) 1848: 1699-1705. | 2015 |
| Dissecting the Membrane Cholesterol Requirement for Mycobacterial Entry into Host Cells | Chem. Phys. Lipids 189: 19-27. | 2015 |
| Get Your kICS by Measuring Membrane Protein Dynamics | Biophys. J. 109: 1-2. | 2015 |
| Guest Editor, special issue - Lipid-protein Interaction | Biochim. Biophys. Acta (Biomembranes) 1848: 1727-1728. | 2015 |
| Molecular Dynamics Simulations of GPCR-Cholesterol Interaction: An Emerging Paradigm | Biochim. Biophys. Acta (Biomembranes) (invited review) 1848: 1775-1782. | 2015 |
| Dipolar Rearrangement During Micellization Explored using A Potential-sensitive Fluorescent Probe | Chem. Phys. Lipids 191: 91-95. | 2015 |
| Sphingolipids in the Function of G Protein-Coupled Receptors | Eur. J. Pharmacol. 763: 241–246. | 2015 |
| Differential Dynamics of the Serotonin1A Receptor in Membrane Bilayers of Varying Cholesterol Content Revealed by All Atom Molecular Dynamics Simulation | Mol. Membr. Biol. 32: 127–137. | 2015 |
| Depth-dependent Organization and Dynamics of Archaeal and Eukaryotic Membranes: Development of Membrane Anisotropy Gradient with Natural Evolution | Langmuir 31: 11591-11597. | 2015 |
| Stereospecific requirement of cholesterol in the function of the serotonin1A receptor | Biochim. Biophys. Acta (Biomembranes) 1838: 158-163. | 2014 |
| Ion Channel Stability of Gramicidin A in Lipid Bilayers: Effect of Hydrophobic Mismatch | Biochim. Biophys. Acta (Biomembranes) 1838: 328-338. | 2014 |
| Importance of Indole N-H Hydrogen Bonding in the Organization and Dynamics of Gramicidin Channels | Biochim. Biophys. Acta (Biomembranes) 1838: 419-428. | 2014 |
| Dynamic Insight into Protein Structure utilizing Red Edge Excitation Shift | Acc. Chem. Res. 47: 12-19. | 2014 |
| Functional characterization of rare variants in human dopamine receptor D4 gene by genotype-phenotype correlations | Neuroscience 262: 176-189. | 2014 |
| Taking Care of Bystander FRET in A Crowded Cell Membrane Environment | Biophys. J. 106: 1227-1228. | 2014 |
| Cholesterol Modulates the Dimer Interface of the Beta2-Adrenergic Receptor via Cholesterol Occupancy Sites | Biophys. J. 106: 1290-1300. | 2014 |
| Integrity of the Actin Cytoskeleton of Host Macrophages is Essential for Leishmania donovani Infection | Biochim. Biophys. Acta (Biomembranes) 1838: 2011-2018. | 2014 |
| Location, Dynamics and Solvent Relaxation of A Nile Red-based Phase-sensitive Fluorescent Membrane Probe | Chem. Phys. Lipids 183: 1-8 | 2014 |
| Lipid Binding Specificity of Bovine alpha-Lactalbumin: A Multidimensional Approach | Biochim. Biophys. Acta (Biomembranes) 1838: 2078-2086 | 2014 |
| Membrane Dipole Potential is Sensitive to Cholesterol Stereospecificity: Implications for Receptor Function | Chem. Phys. Lipids 184: 25–29. | 2014 |
| GPCRs: Lipid-Dependent Membrane Receptors That Act as Drug Targets | Adv. Biol. 2014: 143023. | 2014 |
| Membrane Lipids in the Function of Serotonin and Adrenergic Receptors | Curr. Med. Chem. 20: 47-55. | 2013 |
| Application of NBD-labeled lipids in Membrane and Cell Biology | Springer Series on Fluorescence (Mely, Y., Duportail, G., Eds.), Springer, Heidelberg, vol. 13, pp. 37-50. | 2013 |
| Application of Quantitative Fluorescence Microscopic approaches to Monitor Organization and Dynamics of the Serotonin1A Receptor | Springer Series on Fluorescence (Mely, Y., Duportail, G., Eds.), Springer, Heidelberg, vol. 13, pp. 417-437. | 2013 |
| Differential Effect of Sterols on Dipole Potential in Hippocampal Membranes: Implications for Receptor Function | Biochim. Biophys. Acta (Biomembranes) 1828: 917-923. | 2013 |
| Organization and Dynamics of the N-terminal Domain of Chemokine Receptor CXCR1 in Reverse Micelles: Effect of Graded Hydration | J. Phys. Chem. B 117: 1225-1233. | 2013 |
| Cholesterol Biosynthesis and Homeostasis in Regulation of the Cell Cycle | PLoS One 8: e58833. | 2013 |
| A Toolbox of Fluorescence Microscopic Approaches Reveals Dynamics and Assembly of a Membrane Associated Protein | Biophys. J. (New and Notable) 104: 1844-1845. | 2013 |
| Targeted liposomes to deliver DNA to cells expressing 5-HT receptors | Int. J. Pharm. 419: 347-354 | 2012 |
| Hydration Dynamics of Probes and Peptides in Captivity | Reviews in Fluorescence 2010 (Geddes, C.D., Ed.), Springer, New York pp. 155-172 | 2012 |
| Removal of sphingomyelin headgroup inhibits the ligand binding function of hippocampal serotonin1A receptors. | Biochemical and Biophysical Research Communications 419: 321-325. | 2012 |
| Organization and Dynamics of Hippocampal Membranes in a Depth-dependent Manner: An Electron Spin Resonance Study. | J. Phys. Chem. B 116: 2999-3006. | 2012 |
| Differential Effect of Cholesterol and its Biosynthetic Precursors on Membrane Dipole Potential. | Biophysical Journal 102: 1561-1569. | 2012 |
| Structural Transition in Micelles: Novel Insight into Microenvironmental Changes in Polarity and Dynamics. | Chemistry and Physics of Lipids 165: 497-504. | 2012 |
| Sphingolipid Binding Domain in the Serotonin1A Receptor. | Advances in Experimental Medicine and Biology 749: 279-293. | 2012 |
| Membrane Cholesterol: Implications in Receptor Function. | Cholesterol Regulation of Ion Channels and Receptors (Levitan, I. and Barrantes, F.J., Eds.), John Wiley, pp. 255-271. | 2012 |
| Role of Membrane Cholesterol in Leishmanial Infection. | Advances in Experimental Medicine and Biology 749: 201-213. | 2012 |
| Comparative Analysis of Calcium Spikes upon Activation of Serotonin1A and Purinergic Receptors | PLoS One 7: e51857 | 2012 |
| Transbilayer Organization of Membrane Cholesterol at Low Concentrations: Implications in Health and Disease. | Biochimica et Biophysica Acta (Biomembranes) 1808: 19-25. | 2011 |
| Cholesterol Depletion Enhances Adrenergic Signaling in Cardiac Myocytes. | Biochimica et Biophysica Acta (Biomembranes) 1808: 461-465 | 2011 |
| Molecular modeling of the human serotonin1A receptor: role of membrane cholesterol in ligand binding of the receptor | Molecular BioSystems, 7: 224-234 | 2011 |
| Identification of cholesterol recognition amino acid consensus (CRAC) motif in G-protein coupled receptors | Biochemical and Biophysical Research Communications, 404: 569-573 | 2011 |
| Organization of Higher Order Oligomers of the Serotonin1A Receptor Explored utilizing Homo-FRET in Live Cells | Biophysical Journal, 100: 361-368 | 2011 |
| Fixation Alters Fluorescence Lifetime and Anisotropy of Cells Expressing EYFP-tagged Serotonin1A Receptor | Biochemical and Biophysical Research Communications, 405: 234-237 | 2011 |
| Membrane Organization and Dynamics of the Serotonin1A Receptor in Live Cells | J. Neurochem. 116: 726-733 | 2011 |
| Reorganization of the actin cytoskeleton upon G-protein coupled receptor signaling | Biochimica et Biophysica Acta 1808: 1921-1929 | 2011 |
| rganization and Dynamics of Membrane Probes and Proteins Utilizing the Red Edge Excitation Shift | J. Phys. Chem. B, 115: 5693-5706 | 2011 |
| Desmosterol Replaces Cholesterol for Ligand Binding Function of the Serotonin1A Receptor in Solubilized Hippocampal Membranes: Support for Nonannular Binding Sites for Cholesterol? | Biochimica et Biophysica Acta 1808: 2428-2434 | 2011 |
| Metabolic Depletion of Sphingolipids Enhances the Mobility of the Human Serotonin1A Receptor | Biochemical and Biophysical Research Communications 411: 180-184 | 2011 |
| Oligomerization of the Serotonin1A Receptor in Live Cells: A Time-Resolved Fluorescence Anisotropy Approach | J. Phys. Chem. B 115: 11439-11447 | 2011 |
| A Novel Mechanism for an Old Drug: Amphotericin B in the Treatment of Visceral Leishmaniasis | Biochemical and Biophysical Research Communications 416: 7-12 | 2011 |
| Identification of a red-emitting fluorescent ligand for in vitro visualization of human serotonin 5-HT1A receptors. | Bioorganic & Medicinal Chemistry Letters 20: 6628-6632 | 2010 |
| Amphotericin B Inhibits Entry of Leishmania donovani into Primary Macrophages | Biochem. Biophys. Res. Commun. 399: 429-433 | 2010 |
| Cholesterol Depletion Mimics the Effect of Cytoskeletal Destabilization on Membrane Dynamics of the Serotonin1A Receptor: A zFCS Study | Biophys. J. 99:1397-1407 | 2010 |
| Exploring tryptophan dynamics in acid-induced molten globule state of bovine a-lactalbumin: a wavelength-selective fluorescence approach | Eur Biophys J 39:1453-1463 | 2010 |
| Membrane Cholesterol in the Function and Organization of G-protein Coupled Receptors in Cholesterol Binding and Cholesterol Transport Proteins: Structure and Function in Health and Disease | Subcellular Biochemistry series (Vol. 51, Harris, J.R., Ed.), Springer, New York, pp. 439-466. | 2010 |
| Membrane interaction of the N-terminal domain of chemokine receptor CXCR1 | Biochimica et Biophysica Acta,1798: 1056-1061 | 2010 |
| Monitoring Membrane Protein Conformational Heterogeneity by Fluorescence Lifetime Distribution Analysis Using the Maximum Entropy Method | J. Fluoresc, 20:407-413 | 2010 |
| Chronic Cholesterol Depletion Using Statin Impairs the Function and Dynamics of Human Serotonin1A Receptors | Biochemistry, 49: 5426-5435 | 2010 |
| Organization and dynamics of tryptophans in the molten globule state of bovine alpha-lactalbumin utilizing wavelength-selective ?uorescence approach: Comparisons with native and denatured states | Biochemical and Biophysical Research Communications, 394:1082-1086 | 2010 |
| Metabolic Depletion of Sphingolipids Impairs Ligand Binding and Signaling of Human Serotonin1A Receptors | Biochemistry, 49:2389-2397 | 2010 |
| Synthesis and Characterization of Environment-Sensitive Fluorescent Ligands for Human 5-HT1A Receptors with 1-Arylpiperazine Structure. | J. Med. Chem., 52: 7892-7896 | 2009 |
| Organization and dynamics in micellar structural transition monitored by pyrene fluorescence. | Biochemical and Biophysical Research Communications, 390:728-732 | 2009 |
| Membrane cholesterol depletion enhances ligand binding function of human serotonin1A receptors in neuronal cells | Biochemical and Biophysical Research Communications,390: 93-96 | 2009 |
| Differential effects of cholesterol and desmosterol on the ligand binding function of the hippocampal serotonin1A receptor: Implications in desmosterolosis | Biochimica et Biophysica Acta, 1788: 2169-2173 | 2009 |
| Membrane cholesterol depletion from live cells enhances the function of human serotonin1A receptors | Biochemical and Biophysical Research Communications,389:333-337 | 2009 |
| Jagadish Chandra Bose: The First Indian Biophysicist | Asian Agri-History, 13:315-319 | 2009 |
| Differential dynamics of membrane proteins in yeast | Biochemical and Biophysical Research Communications,387:661-665 | 2009 |
| Effect of capsaicin on ligand binding activity of the hippocampal serotonin1A receptor | Glycoconj J,26:733-738 | 2009 |
| The function of G-protein coupled receptors and membrane cholesterol: specific or general interaction? | Glycoconj J, 26:711-720 | 2009 |
| Green ?uorescent protein: a molecular lantern that illuminates the cellular interior | J. Biosci.,34(2):169-172 | 2009 |
| Orientation and Dynamics of a Novel Fluorescent Cholesterol Analogue in Membranes of Varying Phase | J. Phys.Chem. B,113:4475-4481 | 2009 |
| The Green Journey | Journal of Fluorescence, 19: 1-2 | 2009 |
| Are specific nonannular cholesterol binding sites present in G-protein coupled receptors? | Biochimica et Biophysica Acta, 1788: 295-302 | 2009 |
| Monitoring Orientation and Dynamics of Membrane-Bound Melittin Utilizing Dansyl Fluorescence | J. Phys. Chem. B., 112: 14075-14082 | 2008 |
| Effect of sphingomyelinase treatment on ligand binding activity of human serotonin1A receptors | Biochimica et Biophysica Acta, 1778:2022-2025 | 2008 |
| Exploring the Organization and Dynamics of Hippocampal Membranes Utilizing Pyrene Fluorescence | J. Phys. Chem. B., 112:12134-12138 | 2008 |
| Role of Tryptophan Residues in Gramicidin Channel Organization and Function | Biophysical Journal, 95:166-175 | 2008 |
| Actin Cytoskeleton-Dependent Dynamics of the Human Serotonin1A Receptor Correlates with Receptor Signaling | Biophysical Journal, 95:451-463 | 2008 |
| Signalling by the human serotonin1A receptor is impaired in cellular model of Smith-Lemli-Optiz Syndrome | Biochimica et Biophysica Acta- Biomembranes, 1778:1508-1516 | 2008 |
| Differential Effects of Cholesterol and its Immediate Biosynthetic Precursors on Membrane Organization | Biochemistry, 47:5668-5677 | 2008 |
| Membrane Organization and Function of the Serotonin1A Receptor | Cellular and Molecular Neurobiology, 27:1097-1116 | 2007 |
| Dipolar Relaxation within the Protein Matrix of the Green fluorescent Protein: a Red Edge Excitation Shift Study | J. Phys. Chem. B., 111:14436-14439 | 2007 |
| Differential effects of cholesterol and 7-dehydrocholesterol on ligand binding of solubillized hippocampal serotonin1A receptors: Implications in SLOS | Biochemical and Biophysical Research Communications., 363:800-805 | 2007 |
| Solubilization of human serotonin1A receptors expressed in neuronal cells | Chemistry and Physics of Lipids., 150:244-249 | 2007 |
| Dynamics and heterogeneity of bovine hippocampal membranes: Role of cholesterol and proteins | Biochimica et Biophysica Acta., 1768:2130-2144 | 2007 |
| The gramicidin ion channel: A model membrane protein | Biochimica et Biophysica Acta.,1768: 2011-2025 | 2007 |
| Melittin: a Membrane-active peptide with Diverse Functions | Biosci Rep., 27:189-223 | 2007 |
| Effect of structural transition of the host assembly on dynamics of a membrane-bound tryptophan analogue | Biophysical Chemistry., 129:172-180 | 2007 |
| Differential effects of cholesterol and 7-dehydrcholesterol on the ligand binding activity of the hippocampal serotonin1A receptor: Implications in SLOS | Biochemical and Biophysical Reserarch Communications., 358:495-499 | 2007 |
| Membrane Organization of the Serotonin1A Receptor Monitored by a Detergent-Free Approach | Cellular and Molecular Neurobiology., 27(4):463-474 | 2007 |
| Wavelength-selective fluorescence in ion channels formed by gramicidin A in membranes | J.Chem.Sci. 119:135-140 | 2007 |
| Monitoring the looping up of acyl chain labeled NBD lipids in membranes as a function of membrane phase state | Biochimica. et Biophysica Acta - Biomembranes 1768:1258-1267 | 2007 |
| Modulation of gramicidin channel conformation and organization by hydrophobic mismatch in saturated phosphatidylcholine bilayers | Biochimica. et Biophysica Acta - Biomembranes 1768:1103-1113 | 2007 |
| Influence of cholesterol and ergosterol on membrane dynamics using different fluorescent reporter probes | Biochem. Biophys. Res. Comm. 56:705-710 | 2007 |
| Cholesterol: a potential therapeutic target in Leishmania infection? | Trends Parasitol. 23:49-53 | 2007 |
| Organization and Dynamics of NBD-Labeled Lipids in Membranes Analyzed by Fluorescence Recovery after Photobleaching | J. Phys. Chem. B , 111:1975-1983 | 2007 |
| The human serotonin1A receptor exhibits G-protein-dependent cell surface dynamics | Glycoconj J 24:25-31 | 2007 |
| Orientation and Dynamics of Melittin in Membranes of Varying Composition Utilizing NBD Fluorescence | Biophysical Journal 92:1271-1283 | 2007 |
| Lipid-protein interactions, regulation and dysfunction of brain cholesterol | Biochemical and Biophysical Research Communications 354:627-633 | 2007 |
| Cholesterol depletion induces dynamic confinement of the G-protein coupled serotonin1A receptor in the plasma membrane of living cells | Biochimica et Biophysica Acta - Biomembrane 1768:655-668 | 2007 |
| Membrane localization and dynamics of Nile Red: Effect of cholesterol | Biochimica et Biophysica Acta - Biomembrane, 1768:59-66 | 2007 |
| Spectrin Organization and Dynamics: New Insights | Biosci Rep 26:369-386 | 2006 |
| The Human Serotonin 1A Receptor Expressed in Neuronal Cells: Toward a Native Environment for Neuronal Receptors | Cell. Mol. Neurobiol., 26: 925-942 | 2006 |
| Effect of ionic strength on the organization and dynamics of membrane-bound melittin | Biophysical Chemistry,124: 115-124 | 2006 |
| Monitoring the organization and dynamics of bovine hippocampal membranes utilizing differentially localized fluorescent membrane probes | Molecular Membrane Biology, 23(5): 430-441 | 2006 |
| Effect of Ionic Strength on Folding and Aggregation of the Hemolytic Peptide Melittin in Solution | Biopolymers 83: 111-121 | 2006 |
| Membrane interfacial localization of aromatic amino acids and membrane protein function | J. Biosci., 31(3): 297-302 | 2006 |
| Effect of cholesterol on lateral diffusion of fluorescent lipid probes in native hippocampal membranes | Chemistry and Physics of Lipids 143: 11-21 | 2006 |
| The Sterol-Binding Antibiotic Nystatin Inhibits Entry of Non-opsonized Leishmania donovani into Macrophages | Biochem. Biophys. Res. Commun., 339:661-666 | 2006 |
| Monitoring ion channel conformations in membranes utilizing a novel dual fluorescence quenching approach | Biochem. Biophys. Res. Commun.,343:483-488 | 2006 |
| Prolonged Treatment with Ligands Affects Ligand Binding to the Human Serotonin 1A Receptor in Chinese Hamster Ovary Cells | Cell. Mol. Neurobiol.,26(3): 247-257 | 2006 |
| Role of Cholesterol in the Function and Organization of G-protein Coupled Receptors | Progress in Lipid Research, 45: 295-333 | 2006 |
| Confocal Fluorescence Recovery After Photobleaching of Green Fluorescent Protein in Solution | J. Fluorescence, 16: 87-94 | 2006 |
| Ligand Binding and G-protein Coupling of the Serotonin 1A Receptor in Cholesterol-enriched Hippocampal Membranes | Bioscience Rep., 26:79-87 | 2006 |
| aB-crystallin, a small heat-shock protein, prevents the amyloid fibril growth of an amyloid ?peptide and ?-microglobulin | Biochemical Journal., 392: 573-581 | 2005 |
| The Serotonin1A Receptor and its Interaction with the Membrane Environment | Proc. Indian Natl. Sci. Acad. B71 (2): 61-72 | 2005 |
| Membrane Protein Solubilization: Recent Advances and Challenges in Solubilization of Serotonin 1A Receptors | IUBMB Life, 57:505-512 | 2005 |
| Membrane Cholesterol Oxidation Inhibits Ligand Binding Function of Hippocampal Serotonin 1A Receptors | Biochem. Biophys. Res. Commun. 331:422-427 | 2005 |
| The Serotonin 1A Receptor: A Representative Member of the Serotonin Receptor Family | Cell. Mol. Neurobiol. 25: 553-580 | 2005 |
| Membrane organization of the human serotonin 1A receptor monitored by detergent insolubility using GFP fluorescence | Mol. Membr. Biol., 22:539-547 | 2005 |
| Effect of Structural Transition of the Host Assembly on Dynamics of an Ion Channel Peptide: A Fluorescence Approach | Biophys. J., 89:3049-3058 | 2005 |
| Novel Insights Into Protein Structure and Dynamics Utilizing the Red Edge Excitation Shift Approach | Reviews in Fluorescence, pp. 199-222 | 2005 |
| Membrane Organization and Dynamics of the G-protein Coupled Serotonin 1A Receptor Monitored using Fluorescence-based Approaches | J. Fluoresc.15:785-796 | 2005 |
| Dynamics of A Membrane-Bound Tryptophan Analogue in Environments of Varying Hydration: A Fluorescence Approach | Eur. Biophys. J. 35:62-71 | 2005 |
| Monitoring the organization and dynamics of bovine hippocampal membranes utilizing Laurdan generalized polarization . | Biochim. Biophys. Acta - Biomembrane 1714: 43-55. | 2005 |
| Cholesterol Modulates the Antagonist Binding Funtion of Hippocampal Serotonin 1A Receptors | Biochim. Biophys. Acta - Biomembrane 1714: 35-42. | 2005 |
| The cholesterol-complexing agent digitonin modulates ligand binding of the bovine hippocampal serotonin 1A receptor | Mol. Membr. Biol. 22: 241-249. | 2005 |
| Ion Channels and d-amino acids | J. Biosci. 30: 147-149. | 2005 |
| Effect of Ionic Strength on the Organization and Dynamics of Tryptophan Residues in Spectrin: A Fluorescence Approach | Biopolymers 77: 325-334 | 2005 |
| Cholesterol inhibits the lytic activity of melittin in erythrocytes | Chem. Phys. Lipids 134: 183-189 | 2005 |
| Monitoring cholesterol organization in membranes at low concentrations utilizing the wavelength-selective fluorescence approach | Chem. Phys. Lipids 134: 79-84 | 2005 |
| Influence of Ester and Ether Linkage in Phospholipids on the Environment and Dynamics of the Membrane Interface: A Wavelength-Selective Fluorescence Approach | Langmuir 21: 287-293 | 2005 |
| Effect of Graded Hydration on the Dynamics of an Ion Channel Peptide: A Fluorescence Approach | Biophys. J. 88:1070-1080 | 2005 |
| Role of cholesterol in ligand binding and G-protein coupling of Serotonin 1A receptors solubilized from bovine hippocampus | Biochem. Biophys.Res. Commun. 327: 1036-1041 | 2005 |
| Heat stress-induced localization of small heat shock proteins in mouse myoblasts: intranuclear lamin a/c speckles as target for alhpaB-crystallin and hsp25 | Experimental Cell Research ., 299: 393-403 | 2004 |
| Depth-Dependent Solvent Relaxation in Reverse Micelles: A Fluorescence Approach | J. Phys. Chem. B 108: 12151-12158 | 2004 |
| Ligand BindingCharacteristics of the Human Serotonin 1A Receptor Heterologously Expressed in CHO Cells | Biosci. Rep. 24, 101-115. | 2004 |
| G-protein-dependent Cell Surface Dynamics of the Human Serotonin 1A Receptor Tagged to Yellow Fluorescent Protein | Biochemistry 43: 15852-15862 | 2004 |
| Effect of Micellar Charge on the Conformation and Dynamics of Melittin | Effect of Micellar Charge on the Conformation and Dynamics of Melittin | 2004 |
| A GFP Fluorescence-based Approach to Determine Detergent Insolubility of the Human Serotonin 1A Receptor | FEBS Lett. 576: 455-460 | 2004 |
| Effect of Mg 2+ on Guanine Nucleotide Sensitivity of Ligand Binding to Serotonin 1A Receptors from Bovine Hippocampus | Biochem. Biophys.Res. Commun. 323: 372-376 | 2004 |
| Interaction of Melittin with Membrane Cholesterol: A Fluorescence Approach | Biophys. J.87: 2419-2432 | 2004 |
| Monitoring Gramicidin Conformations in Membranes: A Fluorescence Approach | Biophys. J.87: 831-843 | 2004 |
| Influence of Lipid Chain Unsaturation on Membrane-Bound Melittin: A Fluorescence Approach | Biochim. Biophys. Acta - Biomembrane 1665: 29-39 | 2004 |
| The Sterol-Binding Antibiotic Nystatin Differentially Modulates Agonist and Antagonist Binding of the Bovine Hippocampal Serotonin 1A Receptor | Biochem. Biophys.Res. Commun. 320: 557-562 | 2004 |
| Influence of Cholesterol and Ergosterol on Membrane Dynamics: A Fluorescence Approach | Biochem. Biophys.Res. Commun. 318: 920-926 | 2004 |
| Cholesterol Modulates Ligand Binding and G-protein Coupling to Serotonin 1A Receptors from Bovine Hippocampus | Biochim. Biophys. Acta - Biomembrane 1663: 188-200 | 2004 |
| Membrane Sphingolipid-Ergosterol Interactions are Important Determinants of Multi Drug Resistance in Candida albicans | Antimicrob. AgentsChemother. 48: 1778-1787 | 2004 |
| Interaction of Serotonin 1A Receptors from Bovine Hippocampus with Tertiary Amine Local Anesthetics | Cell. Mol. Neurobiol. 24: 403-422 | 2004 |
| Serotonin 1A receptor agonist acquires an antimalarial connection | J. Biosci. 29: 101-102 | 2004 |
| Temperature Dependent Interaction of the Bovine Hippocampal Serotonin 1A Receptor with G-proteins | Mol. Membr. Biol. 21: 119-123 | 2004 |
| Effect of Urea on the Organization and Dynamics of Triton X-100 Micelles: A Fluorescence Approach | J. Phys. Chem. B 108: 2489-2496 | 2004 |
| Exploring Detergent Insolubility in Bovine Hippocampal Membranes: A Critical Assessment of the Requirement for Cholesterol | Biochim. Biophys. Acta - Biomembrane 166: 9-17 | 2004 |
| Cholesterol is Required for Leishmania donovani Infection: Implications in Leishmaniasis | Mol.Biochem. Parasitol. 133: 145-152 | 2004 |
| Organization and Dynamics of N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-labeled Lipids: A Fluorescence Approach | Chem. Phys. Lipids 127: 91-101 | 2004 |
| Solubilization of Serotonin 1A Receptors Heterologously Expressed in Chinese Hamster Ovary Cells | Cell. Mol. Neurobiol. 24: 293-300 | 2004 |
| Application of fluorescence spectroscopy to membrane protein structure and dynamics | Current Science, Vol.87, No.2. | 2004 |
| Organization and Dynamics of Melittin in Environments of Graded Hydration: A Fluorescence Approach | Langmuir 19: 10332-10341 | 2003 |
| Organization and Dynamics of Tryptophan Residues in Erythroid Spectrin: Novel Structural Features of Denatured Spectrin Revealed by the Wavelength-SelectiveFluorescence Approach | Protein Sci. 12: 2389-2403 | 2003 |
| Modulation of Fluorophore Environment in Host Membranes of Varying Charge | J. Fluoresc. 13: 459-466 | 2003 |
| Novel Insights into Membrane Protein Structure and Dynamics utilizing the Wavelength-Selective Fluorescence Approach | Proc. Ind. Natl. Sci. Acad. A 69: 25-35 | 2003 |
| Exploring Membrane Organization and Dynamics by the Wavelength-Selective Fluorescence Approach | Chem. Phys. Lipids 122: 3-17 | 2003 |
| Reverse Micellar Organization and Dynamics: A Wavelength-Selective Fluorescence Approach | J. Phys. Chem. B 106: 13002-13009 | 2002 |
| Application of the Wavelength-selective Fluorescence Approach to Monitor Membrane Organization and Dynamics | Fluorescence Spectroscopy, Imaging and Probes(Kraayenhof, R., Visser, A.J.W.G., and Gerritsen, H.C., Eds.), pp. 211-224, Springer-Verlag, Heidelberg | 2002 |
| Solubilization of High Affinity G-Protein-Coupled Coupled Serotonin 1A Receptors from Bovine Hippocampus using Pre-Micellar CHAPS at Low Concentration | Mol. Membr. Biol. 19: 211-220 | 2002 |
| Modulation of Antagonist Binding to Coupled Serotonin 1A Receptors from Bovine Hippocampus by Metal Ions | Cell. Mol. Neurobiol. 21: 453-464 | 2001 |
| Cholesterol Organization in Membranes at Low Concentrations: Effects of Curvature Stress and Membrane Thickness | Biophys. J. 81: 2122-2134 | 2001 |
| Effect of Alcohols on G-Protein Coupling of Coupled Serotonin 1A Receptors from Bovine Hippocampus | Brain Res. Bull. 52: 597-601 | 2000 |
| A New Paradigm in the Functioning of G-Protein-Coupled Receptors | Curr. Sci. 79: 402-403 | 2000 |
| Role of Disulfides and Sulfhydryl Groups in Agonist and Antagonist Binding in Serotonin 1A Receptors from Bovine Hippocampus | Cell. Mol. Neurobiol. 20: 665-681 | 2000 |
2578
amit@ccmb.res.in
ashwani@ccmb.res.in
subhashree@ccmb.res.in
CSIR-CCMB January 2025 PhD Programme