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Amitabha Chattopadhyay

SERB Distinguished Fellow

Research Interests

The major research interest of our group is centered on membrane and receptor biology using a variety of biophysical, biochemical and cell biological approaches. Fluorescence-based spectroscopic and microscopic approaches are extensively used in our laboratory. The research interest of our group can be broadly categorized as follows:

  • Membrane Organization and Dynamics using the Wavelength-Selective Fluorescence Approach.
  • Novel Organization of Cholesterol in Membranes at Low Concentrations: Effects of Curvature Stress and Membrane Thickness.
  • Organization, Dynamics and Lipid-protein Interactions of the Serotonin1A (5-HT1A) Receptor.
  • Monitoring Organization and Dynamics of the Serotonin1A (5-HT1A) Receptor in Live Cells utilizing Dynamic Fluorescence Microscopy (FRAP and FCS).
  • Role of Membrane Cholesterol in Leishmaniasis.
  • Selected Publications

    Chakraborty, H., and Chattopadhyay, A. (2015) `Excitements and Challenges in GPCR Oligomerization: Molecular Insight from FRET` (invited review) ACS Chem. Neurosci. 6: 199-206.

    Viswanathan, G., Jafurulla, M., Kumar, G.A., Raghunand, T.R., and Chattopadhyay, A. (2015) `Dissecting the Membrane Cholesterol Requirement for Mycobacterial Entry into Host Cells` Chem. Phys. Lipids 189: 19-27.

    Chattopadhyay, A., and Haldar, S. (2014) `Dynamic Insight into Protein Structure utilizing Red Edge Excitation Shift` Acc. Chem. Res. 47: 12-19.

    Ganguly, S., Clayton, A.H.A., and Chattopadhyay, A. (2011) `Organization of Higher Order Oligomers of the Serotonin1A Receptor Explored utilizing Homo-FRET in Live Cells` Biophys. J. 100: 361-368.

    Shrivastava, S., Pucadyil, T.J., Paila, Y.D., Ganguly, S., and Chattopadhyay, A. (2010) `Chronic Cholesterol Depletion using Statin Impairs the Function and Dynamics of Human Serotonin1A Receptors` Biochemistry 49: 5426-5435.

    Education & Experiance

    P.G: Chemistry ; Indian Institute of Technology, Kanpur ; 1980
    Ph.D: A Novel Fluorescence Quenching Method for Measurement of Membrane Penetration Depth ; State University of New York at Stony Brook ; 1987
    Post.Doc:

    Lipid-protein Interaction in the Nicotinic Acetylcholine Receptor ; Department of Biochemistry & Biophysics, University of California, Davis, CA, USA ; 1987-1989

    Patents

    InventionCountries of filing the patentApplication numberPublication numberStatusGrant Number
    A composition useful for the treatment of Leishmaniasis India Granted & Active 242180
    Method of treating Leishmaniasis using Methyl-beta-cyclodextrin USA Granted & Active 7186702

    Publications

    TitleJournalYear
    Micellar Dipole Potential is Sensitive to Sphere-to-Rod Transition Chem. Phys. Lipids 195: 34-38. 2016
    Molecular Anatomy of An Ion Channel Explored utilizing Fluorescence Spectroscopy Reviews in Fluorescence 2015 (Geddes, C.D., Ed.), Springer, Heidelberg pp. 353-367. 2016
    What Can Simulations Tell Us About GPCRs: Integrating the Scales Methods Cell Biol. 132: 429-452. 2016
    Molecular Rheology of Neuronal Membranes Explored using A Molecular Rotor: Implications for Receptor Function Chem. Phys. Lipids 196: 69-75. 2016
    Spatiotemporal Control of Transmembrane Proteins Through the Cytoskeleton: An Evolving Story Biophys. J. 110: 1036–1037. 2016
    Journal of Membrane Biology: Membranes in Disease Section J. Membrane Biol. 249:9 2016
    Effect of Local Anesthetics on the Organization and Dynamics in Membranes of Varying Phase: A Fluorescence Approach Chem. Phys. Lipids 198: 21-27. 2016
    Membrane Fluorescent Probes: Insights and Perspectives in Fluorescent Analogues of Biomolecular Building Blocks: Design and Applications (Tor, Y. and Wilhelmsson, M., Eds.) John Wiley pp. 356-366. 2016
    Cholesterol Modulates Bitter Taste Receptor Function Biochim. Biophys. Acta (Biomembranes) 1858: 2081-2087. 2016
    Statin-induced Chronic Cholesterol Depletion Inhibits Leishmania donovani Infection: Relevance of Optimum Host Membrane Cholesterol Biochim. Biophys. Acta (Biomembranes) 1858: 2088-2096. 2016
    The Membrane as the Gatekeeper of Infection: Cholesterol in Host-Pathogen Interaction Chem. Phys. Lipids 199: 179-185 2016
    The Membrane as the Gatekeeper of Infection: Cholesterol in Host-Pathogen Interaction Chem. Phys. Lipids 199: 179-185 2016
    Cholesterol-Dependent Thermotropic Behavior and Organization of Neuronal Membranes Biochim. Biophys. Acta (Biomembranes) 1858: 2611-2616 2016
    Novel Insights in Membrane Biology Utilizing Fluoresence Recovery After Photobleaching Adv. Exp. Med. Biol. 842: 27-40. 2015
    Role of Lipid-mediated Effects in Beta2-adrenergic receptor Dimerization Adv. Exp. Med. Biol. 842: 247-261. 2015
    Excitements and Challenges in GPCR Oligomerization: Molecular Insight from FRET ACS Chem. Neurosci. 6: 199-206. 2015
    Excitements and Challenges in GPCR Oligomerization: Molecular Insight from FRET ACS Chem. Neurosci. 6: 199-206. 2015
    Solubilization of G Protein-Coupled Receptors: A Convenient Strategy to Explore Lipid-Receptor Interaction Methods Enzymol. 557: 117-134. 2015
    Organization and Dynamics of Tryptophan Residues in Brain Spectrin: Novel Insight into Conformational Flexibility J. Fluoresc. 25: 707–717. 2015
    Cholesterol-induced Changes in Hippocampal Membranes Utilizing A Phase-sensitive Fluorescence Probe Biochim. Biophys. Acta (Biomembranes) 1848: 1699-1705. 2015
    Dissecting the Membrane Cholesterol Requirement for Mycobacterial Entry into Host Cells Chem. Phys. Lipids 189: 19-27. 2015
    Get Your kICS by Measuring Membrane Protein Dynamics Biophys. J. 109: 1-2. 2015
    Guest Editor, special issue - Lipid-protein Interaction Biochim. Biophys. Acta (Biomembranes) 1848: 1727-1728. 2015
    Molecular Dynamics Simulations of GPCR-Cholesterol Interaction: An Emerging Paradigm Biochim. Biophys. Acta (Biomembranes) (invited review) 1848: 1775-1782. 2015
    Dipolar Rearrangement During Micellization Explored using A Potential-sensitive Fluorescent Probe Chem. Phys. Lipids 191: 91-95. 2015
    Sphingolipids in the Function of G Protein-Coupled Receptors Eur. J. Pharmacol. 763: 241–246. 2015
    Differential Dynamics of the Serotonin1A Receptor in Membrane Bilayers of Varying Cholesterol Content Revealed by All Atom Molecular Dynamics Simulation Mol. Membr. Biol. 32: 127–137. 2015
    Depth-dependent Organization and Dynamics of Archaeal and Eukaryotic Membranes: Development of Membrane Anisotropy Gradient with Natural Evolution Langmuir 31: 11591-11597. 2015
    Stereospecific requirement of cholesterol in the function of the serotonin1A receptor Biochim. Biophys. Acta (Biomembranes) 1838: 158-163. 2014
    Ion Channel Stability of Gramicidin A in Lipid Bilayers: Effect of Hydrophobic Mismatch Biochim. Biophys. Acta (Biomembranes) 1838: 328-338. 2014
    Importance of Indole N-H Hydrogen Bonding in the Organization and Dynamics of Gramicidin Channels Biochim. Biophys. Acta (Biomembranes) 1838: 419-428. 2014
    Dynamic Insight into Protein Structure utilizing Red Edge Excitation Shift Acc. Chem. Res. 47: 12-19. 2014
    Functional characterization of rare variants in human dopamine receptor D4 gene by genotype-phenotype correlations Neuroscience 262: 176-189. 2014
    Taking Care of Bystander FRET in A Crowded Cell Membrane Environment Biophys. J. 106: 1227-1228. 2014
    Cholesterol Modulates the Dimer Interface of the Beta2-Adrenergic Receptor via Cholesterol Occupancy Sites Biophys. J. 106: 1290-1300. 2014
    Integrity of the Actin Cytoskeleton of Host Macrophages is Essential for Leishmania donovani Infection Biochim. Biophys. Acta (Biomembranes) 1838: 2011-2018. 2014
    Location, Dynamics and Solvent Relaxation of A Nile Red-based Phase-sensitive Fluorescent Membrane Probe Chem. Phys. Lipids 183: 1-8 2014
    Lipid Binding Specificity of Bovine alpha-Lactalbumin: A Multidimensional Approach Biochim. Biophys. Acta (Biomembranes) 1838: 2078-2086 2014
    Membrane Dipole Potential is Sensitive to Cholesterol Stereospecificity: Implications for Receptor Function Chem. Phys. Lipids 184: 25–29. 2014
    GPCRs: Lipid-Dependent Membrane Receptors That Act as Drug Targets Adv. Biol. 2014: 143023. 2014
    Membrane Lipids in the Function of Serotonin and Adrenergic Receptors Curr. Med. Chem. 20: 47-55. 2013
    Application of NBD-labeled lipids in Membrane and Cell Biology Springer Series on Fluorescence (Mely, Y., Duportail, G., Eds.), Springer, Heidelberg, vol. 13, pp. 37-50. 2013
    Application of Quantitative Fluorescence Microscopic approaches to Monitor Organization and Dynamics of the Serotonin1A Receptor Springer Series on Fluorescence (Mely, Y., Duportail, G., Eds.), Springer, Heidelberg, vol. 13, pp. 417-437. 2013
    Differential Effect of Sterols on Dipole Potential in Hippocampal Membranes: Implications for Receptor Function Biochim. Biophys. Acta (Biomembranes) 1828: 917-923. 2013
    Organization and Dynamics of the N-terminal Domain of Chemokine Receptor CXCR1 in Reverse Micelles: Effect of Graded Hydration J. Phys. Chem. B 117: 1225-1233. 2013
    Cholesterol Biosynthesis and Homeostasis in Regulation of the Cell Cycle PLoS One 8: e58833. 2013
    A Toolbox of Fluorescence Microscopic Approaches Reveals Dynamics and Assembly of a Membrane Associated Protein Biophys. J. (New and Notable) 104: 1844-1845. 2013
    Targeted liposomes to deliver DNA to cells expressing 5-HT receptors Int. J. Pharm. 419: 347-354 2012
    Hydration Dynamics of Probes and Peptides in Captivity Reviews in Fluorescence 2010 (Geddes, C.D., Ed.), Springer, New York pp. 155-172 2012
    Removal of sphingomyelin headgroup inhibits the ligand binding function of hippocampal serotonin1A receptors. Biochemical and Biophysical Research Communications 419: 321-325. 2012
    Organization and Dynamics of Hippocampal Membranes in a Depth-dependent Manner: An Electron Spin Resonance Study. J. Phys. Chem. B 116: 2999-3006. 2012
    Differential Effect of Cholesterol and its Biosynthetic Precursors on Membrane Dipole Potential. Biophysical Journal 102: 1561-1569. 2012
    Structural Transition in Micelles: Novel Insight into Microenvironmental Changes in Polarity and Dynamics. Chemistry and Physics of Lipids 165: 497-504. 2012
    Sphingolipid Binding Domain in the Serotonin1A Receptor. Advances in Experimental Medicine and Biology 749: 279-293. 2012
    Membrane Cholesterol: Implications in Receptor Function. Cholesterol Regulation of Ion Channels and Receptors (Levitan, I. and Barrantes, F.J., Eds.), John Wiley, pp. 255-271. 2012
    Role of Membrane Cholesterol in Leishmanial Infection. Advances in Experimental Medicine and Biology 749: 201-213. 2012
    Comparative Analysis of Calcium Spikes upon Activation of Serotonin1A and Purinergic Receptors PLoS One 7: e51857 2012
    Transbilayer Organization of Membrane Cholesterol at Low Concentrations: Implications in Health and Disease. Biochimica et Biophysica Acta (Biomembranes) 1808: 19-25. 2011
    Cholesterol Depletion Enhances Adrenergic Signaling in Cardiac Myocytes. Biochimica et Biophysica Acta (Biomembranes) 1808: 461-465 2011
    Molecular modeling of the human serotonin1A receptor: role of membrane cholesterol in ligand binding of the receptor Molecular BioSystems, 7: 224-234 2011
    Identification of cholesterol recognition amino acid consensus (CRAC) motif in G-protein coupled receptors Biochemical and Biophysical Research Communications, 404: 569-573 2011
    Organization of Higher Order Oligomers of the Serotonin1A Receptor Explored utilizing Homo-FRET in Live Cells Biophysical Journal, 100: 361-368 2011
    Fixation Alters Fluorescence Lifetime and Anisotropy of Cells Expressing EYFP-tagged Serotonin1A Receptor Biochemical and Biophysical Research Communications, 405: 234-237 2011
    Membrane Organization and Dynamics of the Serotonin1A Receptor in Live Cells J. Neurochem. 116: 726-733 2011
    Reorganization of the actin cytoskeleton upon G-protein coupled receptor signaling Biochimica et Biophysica Acta 1808: 1921-1929 2011
    rganization and Dynamics of Membrane Probes and Proteins Utilizing the Red Edge Excitation Shift J. Phys. Chem. B, 115: 5693-5706 2011
    Desmosterol Replaces Cholesterol for Ligand Binding Function of the Serotonin1A Receptor in Solubilized Hippocampal Membranes: Support for Nonannular Binding Sites for Cholesterol? Biochimica et Biophysica Acta 1808: 2428-2434 2011
    Metabolic Depletion of Sphingolipids Enhances the Mobility of the Human Serotonin1A Receptor Biochemical and Biophysical Research Communications 411: 180-184 2011
    Oligomerization of the Serotonin1A Receptor in Live Cells: A Time-Resolved Fluorescence Anisotropy Approach J. Phys. Chem. B 115: 11439-11447 2011
    A Novel Mechanism for an Old Drug: Amphotericin B in the Treatment of Visceral Leishmaniasis Biochemical and Biophysical Research Communications 416: 7-12 2011
    Identification of a red-emitting fluorescent ligand for in vitro visualization of human serotonin 5-HT1A receptors. Bioorganic & Medicinal Chemistry Letters 20: 6628-6632 2010
    Amphotericin B Inhibits Entry of Leishmania donovani into Primary Macrophages Biochem. Biophys. Res. Commun. 399: 429-433 2010
    Cholesterol Depletion Mimics the Effect of Cytoskeletal Destabilization on Membrane Dynamics of the Serotonin1A Receptor: A zFCS Study Biophys. J. 99:1397-1407 2010
    Exploring tryptophan dynamics in acid-induced molten globule state of bovine a-lactalbumin: a wavelength-selective fluorescence approach Eur Biophys J 39:1453-1463 2010
    Membrane Cholesterol in the Function and Organization of G-protein Coupled Receptors in Cholesterol Binding and Cholesterol Transport Proteins: Structure and Function in Health and Disease Subcellular Biochemistry series (Vol. 51, Harris, J.R., Ed.), Springer, New York, pp. 439-466. 2010
    Membrane interaction of the N-terminal domain of chemokine receptor CXCR1 Biochimica et Biophysica Acta,1798: 1056-1061 2010
    Monitoring Membrane Protein Conformational Heterogeneity by Fluorescence Lifetime Distribution Analysis Using the Maximum Entropy Method J. Fluoresc, 20:407-413 2010
    Chronic Cholesterol Depletion Using Statin Impairs the Function and Dynamics of Human Serotonin1A Receptors Biochemistry, 49: 5426-5435 2010
    Organization and dynamics of tryptophans in the molten globule state of bovine alpha-lactalbumin utilizing wavelength-selective ?uorescence approach: Comparisons with native and denatured states Biochemical and Biophysical Research Communications, 394:1082-1086 2010
    Metabolic Depletion of Sphingolipids Impairs Ligand Binding and Signaling of Human Serotonin1A Receptors Biochemistry, 49:2389-2397 2010
    Synthesis and Characterization of Environment-Sensitive Fluorescent Ligands for Human 5-HT1A Receptors with 1-Arylpiperazine Structure. J. Med. Chem., 52: 7892-7896 2009
    Organization and dynamics in micellar structural transition monitored by pyrene fluorescence. Biochemical and Biophysical Research Communications, 390:728-732 2009
    Membrane cholesterol depletion enhances ligand binding function of human serotonin1A receptors in neuronal cells Biochemical and Biophysical Research Communications,390: 93-96 2009
    Differential effects of cholesterol and desmosterol on the ligand binding function of the hippocampal serotonin1A receptor: Implications in desmosterolosis Biochimica et Biophysica Acta, 1788: 2169-2173 2009
    Membrane cholesterol depletion from live cells enhances the function of human serotonin1A receptors Biochemical and Biophysical Research Communications,389:333-337 2009
    Jagadish Chandra Bose: The First Indian Biophysicist Asian Agri-History, 13:315-319 2009
    Differential dynamics of membrane proteins in yeast Biochemical and Biophysical Research Communications,387:661-665 2009
    Effect of capsaicin on ligand binding activity of the hippocampal serotonin1A receptor Glycoconj J,26:733-738 2009
    The function of G-protein coupled receptors and membrane cholesterol: specific or general interaction? Glycoconj J, 26:711-720 2009
    Green ?uorescent protein: a molecular lantern that illuminates the cellular interior J. Biosci.,34(2):169-172 2009
    Orientation and Dynamics of a Novel Fluorescent Cholesterol Analogue in Membranes of Varying Phase J. Phys.Chem. B,113:4475-4481 2009
    The Green Journey Journal of Fluorescence, 19: 1-2 2009
    Are specific nonannular cholesterol binding sites present in G-protein coupled receptors? Biochimica et Biophysica Acta, 1788: 295-302 2009
    Monitoring Orientation and Dynamics of Membrane-Bound Melittin Utilizing Dansyl Fluorescence J. Phys. Chem. B., 112: 14075-14082 2008
    Effect of sphingomyelinase treatment on ligand binding activity of human serotonin1A receptors Biochimica et Biophysica Acta, 1778:2022-2025 2008
    Exploring the Organization and Dynamics of Hippocampal Membranes Utilizing Pyrene Fluorescence J. Phys. Chem. B., 112:12134-12138 2008
    Role of Tryptophan Residues in Gramicidin Channel Organization and Function Biophysical Journal, 95:166-175 2008
    Actin Cytoskeleton-Dependent Dynamics of the Human Serotonin1A Receptor Correlates with Receptor Signaling Biophysical Journal, 95:451-463 2008
    Signalling by the human serotonin1A receptor is impaired in cellular model of Smith-Lemli-Optiz Syndrome Biochimica et Biophysica Acta- Biomembranes, 1778:1508-1516 2008
    Differential Effects of Cholesterol and its Immediate Biosynthetic Precursors on Membrane Organization Biochemistry, 47:5668-5677 2008
    Membrane Organization and Function of the Serotonin1A Receptor Cellular and Molecular Neurobiology, 27:1097-1116 2007
    Dipolar Relaxation within the Protein Matrix of the Green fluorescent Protein: a Red Edge Excitation Shift Study J. Phys. Chem. B., 111:14436-14439 2007
    Differential effects of cholesterol and 7-dehydrocholesterol on ligand binding of solubillized hippocampal serotonin1A receptors: Implications in SLOS Biochemical and Biophysical Research Communications., 363:800-805 2007
    Solubilization of human serotonin1A receptors expressed in neuronal cells Chemistry and Physics of Lipids., 150:244-249 2007
    Dynamics and heterogeneity of bovine hippocampal membranes: Role of cholesterol and proteins Biochimica et Biophysica Acta., 1768:2130-2144 2007
    The gramicidin ion channel: A model membrane protein Biochimica et Biophysica Acta.,1768: 2011-2025 2007
    Melittin: a Membrane-active peptide with Diverse Functions Biosci Rep., 27:189-223 2007
    Effect of structural transition of the host assembly on dynamics of a membrane-bound tryptophan analogue Biophysical Chemistry., 129:172-180 2007
    Differential effects of cholesterol and 7-dehydrcholesterol on the ligand binding activity of the hippocampal serotonin1A receptor: Implications in SLOS Biochemical and Biophysical Reserarch Communications., 358:495-499 2007
    Membrane Organization of the Serotonin1A Receptor Monitored by a Detergent-Free Approach Cellular and Molecular Neurobiology., 27(4):463-474 2007
    Wavelength-selective fluorescence in ion channels formed by gramicidin A in membranes J.Chem.Sci. 119:135-140 2007
    Monitoring the looping up of acyl chain labeled NBD lipids in membranes as a function of membrane phase state Biochimica. et Biophysica Acta - Biomembranes 1768:1258-1267 2007
    Modulation of gramicidin channel conformation and organization by hydrophobic mismatch in saturated phosphatidylcholine bilayers Biochimica. et Biophysica Acta - Biomembranes 1768:1103-1113 2007
    Influence of cholesterol and ergosterol on membrane dynamics using different fluorescent reporter probes Biochem. Biophys. Res. Comm. 56:705-710 2007
    Cholesterol: a potential therapeutic target in Leishmania infection? Trends Parasitol. 23:49-53 2007
    Organization and Dynamics of NBD-Labeled Lipids in Membranes Analyzed by Fluorescence Recovery after Photobleaching J. Phys. Chem. B , 111:1975-1983 2007
    The human serotonin1A receptor exhibits G-protein-dependent cell surface dynamics Glycoconj J 24:25-31 2007
    Orientation and Dynamics of Melittin in Membranes of Varying Composition Utilizing NBD Fluorescence Biophysical Journal 92:1271-1283 2007
    Lipid-protein interactions, regulation and dysfunction of brain cholesterol Biochemical and Biophysical Research Communications 354:627-633 2007
    Cholesterol depletion induces dynamic confinement of the G-protein coupled serotonin1A receptor in the plasma membrane of living cells Biochimica et Biophysica Acta - Biomembrane 1768:655-668 2007
    Membrane localization and dynamics of Nile Red: Effect of cholesterol Biochimica et Biophysica Acta - Biomembrane, 1768:59-66 2007
    Spectrin Organization and Dynamics: New Insights Biosci Rep 26:369-386 2006
    The Human Serotonin 1A Receptor Expressed in Neuronal Cells: Toward a Native Environment for Neuronal Receptors Cell. Mol. Neurobiol., 26: 925-942 2006
    Effect of ionic strength on the organization and dynamics of membrane-bound melittin Biophysical Chemistry,124: 115-124 2006
    Monitoring the organization and dynamics of bovine hippocampal membranes utilizing differentially localized fluorescent membrane probes Molecular Membrane Biology, 23(5): 430-441 2006
    Effect of Ionic Strength on Folding and Aggregation of the Hemolytic Peptide Melittin in Solution Biopolymers 83: 111-121 2006
    Membrane interfacial localization of aromatic amino acids and membrane protein function J. Biosci., 31(3): 297-302 2006
    Effect of cholesterol on lateral diffusion of fluorescent lipid probes in native hippocampal membranes Chemistry and Physics of Lipids 143: 11-21 2006
    The Sterol-Binding Antibiotic Nystatin Inhibits Entry of Non-opsonized Leishmania donovani into Macrophages Biochem. Biophys. Res. Commun., 339:661-666 2006
    Monitoring ion channel conformations in membranes utilizing a novel dual fluorescence quenching approach Biochem. Biophys. Res. Commun.,343:483-488 2006
    Prolonged Treatment with Ligands Affects Ligand Binding to the Human Serotonin 1A Receptor in Chinese Hamster Ovary Cells Cell. Mol. Neurobiol.,26(3): 247-257 2006
    Role of Cholesterol in the Function and Organization of G-protein Coupled Receptors Progress in Lipid Research, 45: 295-333 2006
    Confocal Fluorescence Recovery After Photobleaching of Green Fluorescent Protein in Solution J. Fluorescence, 16: 87-94 2006
    Ligand Binding and G-protein Coupling of the Serotonin 1A Receptor in Cholesterol-enriched Hippocampal Membranes Bioscience Rep., 26:79-87 2006
    aB-crystallin, a small heat-shock protein, prevents the amyloid fibril growth of an amyloid ?peptide and ?-microglobulin Biochemical Journal., 392: 573-581 2005
    The Serotonin1A Receptor and its Interaction with the Membrane Environment Proc. Indian Natl. Sci. Acad. B71 (2): 61-72 2005
    Membrane Protein Solubilization: Recent Advances and Challenges in Solubilization of Serotonin 1A Receptors IUBMB Life, 57:505-512 2005
    Membrane Cholesterol Oxidation Inhibits Ligand Binding Function of Hippocampal Serotonin 1A Receptors Biochem. Biophys. Res. Commun. 331:422-427 2005
    The Serotonin 1A Receptor: A Representative Member of the Serotonin Receptor Family Cell. Mol. Neurobiol. 25: 553-580 2005
    Membrane organization of the human serotonin 1A receptor monitored by detergent insolubility using GFP fluorescence Mol. Membr. Biol., 22:539-547 2005
    Effect of Structural Transition of the Host Assembly on Dynamics of an Ion Channel Peptide: A Fluorescence Approach Biophys. J., 89:3049-3058 2005
    Novel Insights Into Protein Structure and Dynamics Utilizing the Red Edge Excitation Shift Approach Reviews in Fluorescence, pp. 199-222 2005
    Membrane Organization and Dynamics of the G-protein Coupled Serotonin 1A Receptor Monitored using Fluorescence-based Approaches J. Fluoresc.15:785-796 2005
    Dynamics of A Membrane-Bound Tryptophan Analogue in Environments of Varying Hydration: A Fluorescence Approach Eur. Biophys. J. 35:62-71 2005
    Monitoring the organization and dynamics of bovine hippocampal membranes utilizing Laurdan generalized polarization . Biochim. Biophys. Acta - Biomembrane 1714: 43-55. 2005
    Cholesterol Modulates the Antagonist Binding Funtion of Hippocampal Serotonin 1A Receptors Biochim. Biophys. Acta - Biomembrane 1714: 35-42. 2005
    The cholesterol-complexing agent digitonin modulates ligand binding of the bovine hippocampal serotonin 1A receptor Mol. Membr. Biol. 22: 241-249. 2005
    Ion Channels and d-amino acids J. Biosci. 30: 147-149. 2005
    Effect of Ionic Strength on the Organization and Dynamics of Tryptophan Residues in Spectrin: A Fluorescence Approach Biopolymers 77: 325-334 2005
    Cholesterol inhibits the lytic activity of melittin in erythrocytes Chem. Phys. Lipids 134: 183-189 2005
    Monitoring cholesterol organization in membranes at low concentrations utilizing the wavelength-selective fluorescence approach Chem. Phys. Lipids 134: 79-84 2005
    Influence of Ester and Ether Linkage in Phospholipids on the Environment and Dynamics of the Membrane Interface: A Wavelength-Selective Fluorescence Approach Langmuir 21: 287-293 2005
    Effect of Graded Hydration on the Dynamics of an Ion Channel Peptide: A Fluorescence Approach Biophys. J. 88:1070-1080 2005
    Role of cholesterol in ligand binding and G-protein coupling of Serotonin 1A receptors solubilized from bovine hippocampus Biochem. Biophys.Res. Commun. 327: 1036-1041 2005
    Heat stress-induced localization of small heat shock proteins in mouse myoblasts: intranuclear lamin a/c speckles as target for alhpaB-crystallin and hsp25 Experimental Cell Research ., 299: 393-403 2004
    Depth-Dependent Solvent Relaxation in Reverse Micelles: A Fluorescence Approach J. Phys. Chem. B 108: 12151-12158 2004
    Ligand BindingCharacteristics of the Human Serotonin 1A Receptor Heterologously Expressed in CHO Cells Biosci. Rep. 24, 101-115. 2004
    G-protein-dependent Cell Surface Dynamics of the Human Serotonin 1A Receptor Tagged to Yellow Fluorescent Protein Biochemistry 43: 15852-15862 2004
    Effect of Micellar Charge on the Conformation and Dynamics of Melittin Effect of Micellar Charge on the Conformation and Dynamics of Melittin 2004
    A GFP Fluorescence-based Approach to Determine Detergent Insolubility of the Human Serotonin 1A Receptor FEBS Lett. 576: 455-460 2004
    Effect of Mg 2+ on Guanine Nucleotide Sensitivity of Ligand Binding to Serotonin 1A Receptors from Bovine Hippocampus Biochem. Biophys.Res. Commun. 323: 372-376 2004
    Interaction of Melittin with Membrane Cholesterol: A Fluorescence Approach Biophys. J.87: 2419-2432 2004
    Monitoring Gramicidin Conformations in Membranes: A Fluorescence Approach Biophys. J.87: 831-843 2004
    Influence of Lipid Chain Unsaturation on Membrane-Bound Melittin: A Fluorescence Approach Biochim. Biophys. Acta - Biomembrane 1665: 29-39 2004
    The Sterol-Binding Antibiotic Nystatin Differentially Modulates Agonist and Antagonist Binding of the Bovine Hippocampal Serotonin 1A Receptor Biochem. Biophys.Res. Commun. 320: 557-562 2004
    Influence of Cholesterol and Ergosterol on Membrane Dynamics: A Fluorescence Approach Biochem. Biophys.Res. Commun. 318: 920-926 2004
    Cholesterol Modulates Ligand Binding and G-protein Coupling to Serotonin 1A Receptors from Bovine Hippocampus Biochim. Biophys. Acta - Biomembrane 1663: 188-200 2004
    Membrane Sphingolipid-Ergosterol Interactions are Important Determinants of Multi Drug Resistance in Candida albicans Antimicrob. AgentsChemother. 48: 1778-1787 2004
    Interaction of Serotonin 1A Receptors from Bovine Hippocampus with Tertiary Amine Local Anesthetics Cell. Mol. Neurobiol. 24: 403-422 2004
    Serotonin 1A receptor agonist acquires an antimalarial connection J. Biosci. 29: 101-102 2004
    Temperature Dependent Interaction of the Bovine Hippocampal Serotonin 1A Receptor with G-proteins Mol. Membr. Biol. 21: 119-123 2004
    Effect of Urea on the Organization and Dynamics of Triton X-100 Micelles: A Fluorescence Approach J. Phys. Chem. B 108: 2489-2496 2004
    Exploring Detergent Insolubility in Bovine Hippocampal Membranes: A Critical Assessment of the Requirement for Cholesterol Biochim. Biophys. Acta - Biomembrane 166: 9-17 2004
    Cholesterol is Required for Leishmania donovani Infection: Implications in Leishmaniasis Mol.Biochem. Parasitol. 133: 145-152 2004
    Organization and Dynamics of N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-labeled Lipids: A Fluorescence Approach Chem. Phys. Lipids 127: 91-101 2004
    Solubilization of Serotonin 1A Receptors Heterologously Expressed in Chinese Hamster Ovary Cells Cell. Mol. Neurobiol. 24: 293-300 2004
    Application of fluorescence spectroscopy to membrane protein structure and dynamics Current Science, Vol.87, No.2. 2004
    Organization and Dynamics of Melittin in Environments of Graded Hydration: A Fluorescence Approach Langmuir 19: 10332-10341 2003
    Organization and Dynamics of Tryptophan Residues in Erythroid Spectrin: Novel Structural Features of Denatured Spectrin Revealed by the Wavelength-SelectiveFluorescence Approach Protein Sci. 12: 2389-2403 2003
    Modulation of Fluorophore Environment in Host Membranes of Varying Charge J. Fluoresc. 13: 459-466 2003
    Novel Insights into Membrane Protein Structure and Dynamics utilizing the Wavelength-Selective Fluorescence Approach Proc. Ind. Natl. Sci. Acad. A 69: 25-35 2003
    Exploring Membrane Organization and Dynamics by the Wavelength-Selective Fluorescence Approach Chem. Phys. Lipids 122: 3-17 2003
    Reverse Micellar Organization and Dynamics: A Wavelength-Selective Fluorescence Approach J. Phys. Chem. B 106: 13002-13009 2002
    Application of the Wavelength-selective Fluorescence Approach to Monitor Membrane Organization and Dynamics Fluorescence Spectroscopy, Imaging and Probes(Kraayenhof, R., Visser, A.J.W.G., and Gerritsen, H.C., Eds.), pp. 211-224, Springer-Verlag, Heidelberg 2002
    Solubilization of High Affinity G-Protein-Coupled Coupled Serotonin 1A Receptors from Bovine Hippocampus using Pre-Micellar CHAPS at Low Concentration Mol. Membr. Biol. 19: 211-220 2002
    Modulation of Antagonist Binding to Coupled Serotonin 1A Receptors from Bovine Hippocampus by Metal Ions Cell. Mol. Neurobiol. 21: 453-464 2001
    Cholesterol Organization in Membranes at Low Concentrations: Effects of Curvature Stress and Membrane Thickness Biophys. J. 81: 2122-2134 2001
    Effect of Alcohols on G-Protein Coupling of Coupled Serotonin 1A Receptors from Bovine Hippocampus Brain Res. Bull. 52: 597-601 2000
    A New Paradigm in the Functioning of G-Protein-Coupled Receptors Curr. Sci. 79: 402-403 2000
    Role of Disulfides and Sulfhydryl Groups in Agonist and Antagonist Binding in Serotonin 1A Receptors from Bovine Hippocampus Cell. Mol. Neurobiol. 20: 665-681 2000

    Amitabha Chattopadhyay

    SERB Distinguished Fellow

    2578

    amit@ccmb.res.in

    Aritri Dutta

    Research Associate

    Amrita Samanta

    Research Associate-I (DBT)

    Bhagyashree D Rao

    Senior Research Fellow

    2571

    bhagyashree@ccmb.res.in

    Aditya Kumar G

    Senior Research Fellow

    2623

    adityakumar@ccmb.res.in

    Sreetama Pal

    Senior Research Fellow

    2623

    sreetama@ccmb.res.in

    Parijat Sarkar

    Senior Research Fellow

    2571

    parijat@ccmb.res.in

    Ashwani Sharma

    Junior Research Fellow

    Subhashree S Sahu

    Junior Research Fellow

    Sarosh N. Fatakia

    Visiting Scientist