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Anant Bahadur Patel

Senior Principal Scientist

Research Interests

Human brain comprises only ~2% of the body weight but it accounts for ~20% of total oxygen utilization of the whole body, indicating the overwhelming energy demand of the brain. Glutamate and ?-aminobutyric acid (GABA) are the major excitatory and inhibitory neurotransmitters in the matured mammalian central nervous system. These neurotransmitters are involved in many functions such as motor, behavior, cognition, emotion, etc. Majority of brain energy is used to support neurotransmission, and for the processes associated with it. Dysfunction in these pathways is associated with many neurological and neuropsychiatric disorders. Our current research is focused on to understand the energetics of neurotransmission in different neurological and psychiatric disorders such as Alzheimer`s disease, Amyotrophic lateral sclerosis, depression, Parkinson`s disease, and addiction.

The major goals of these studies are following:

  • Understand quantitatively the impacts of different neurological disorders on the homeostasis of neurometabolites specific to neurons and astroglia.
  • Evaluate the energetics of glutamatergic and GABAergic neurotransmission, and energy demand of neurons and astrocyctes with progress of these disorders.
  • Evaluate the efficacy of different interventions to improve neural function in different disorders.
  • Develop novel approach to study neurotransmitter metabolism in brain.

Selected Publications

Mishra PK, Kumar A, Behar KL, Patel AB (2018) Sub-Anesthetic Ketamine Reverses Neuronal and Astroglial Metabolic Activity Deficits in a Social Defeat Model of Depression. J Neurochem (in press)DOI:10.1111/jnc.14544.

Patel AB, Tiwari V, Veeraiah P, Saba K (2018) Increased Astroglial Activity and Reduced Neuronal Function Across Brain in A?PP-PS1 Mouse Model of Alzheimer's Disease. J Cereb Blood Flow Metab 38(7):1213-1226.


Patel AB, Lai JCK, Chowdhury GMI, Hyder F, Rothman DL, Shulman RG, Behar KL (2014) Direct Evidence for Activity-Dependent Glucose Phosphorylation in Neurons With Implications for the Astrocyte-to-Neuron Lactate Shuttle. Proc Natl Acad Sci USA 111:5385-5390. doi: 10.1073/pnas. 1403576111 [IF: 9.674]

Veeraiah P, Noronha JM, Maitra S, Bagga P, Khandelwal N, Chakravarty S, Kumar A, Patel AB (2014) Dysfunctional Glutamatergic and GABAergic Activities in Prefrontal Cortex of Mice in Social Defeat Model of Depression. Biol Psychiatry 76:231-238.

Bagga P, Chugani AN, Varadarajan KS, Patel AB (2013) In Vivo NMR Studies of Regional Cerebral Energetics in MPTP Model of Parkinson`s Disease: Recovery of Cerebral Metabolism with Acute Levodopa Treatment. J Neurochem 127:365-77.

Education & Experiance

P.G: Chemistry (Specialisation in Physical Chemistry) ; Banaras Hindu University, Varanasi, India ; 1993
Ph.D: NMR Studies of Biomolecular Systems ; TATA Institute of Fundamental Research, Mumbai, India ; 1999
Post.Doc:

In vivo NMR Studies of Brain Energy Metabolism in Rat Brain ; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, USA ; 1999-2001

In vivo NMR studies of glutamate metabolism in rat brain ; Department of Psychiatry, Yale University School of Medicine, New Haven, USA ; 2001-2003

Experience:

Associate Research Scientist: In vivo NMR studies of GABA metabolism in rats and mice brain; Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, USA; 2003-2006

Publications

TitleJournalYear
Increased Astroglial Activity and Reduced Neuronal Function Across Brain in A?PP-PS1 Mouse Model of Alzheimer's Disease. J Cereb Blood Flow Metab 38(7):1213-1226. DOI: 10.1177/0271678X17709463. 2018
Sub-Anesthetic Ketamine Reverses Neuronal and Astroglial Metabolic Activity Deficits in a Social Defeat Model of Depression. J Neurochem (in press) DOI:10.1111/jnc.14544. 2018
Direct one-pot synthesis of glutathione capped hydrophilic FePt-CdS nano probe for efficient bimodal imaging application. Mat Sci Engg C 72:415-424. 2017
Insights into the epigenetic mechanisms involving histone lysine methylation and demethylation in ischemia induced damage and repair has therapeutic implication. Biochimica et Biophysica Acta (BBA)-Mol Basis Disease 1863:152-154. 2017
Comparison of Glutamate Turnover in Nerve Terminals and Brain Tissue During [1,6-13C2]Glucose Metabolism in Anesthetized Rats. Neurochem Res 42(1):173-190.doi: 10.1007/s11064-016-2103-x. 2017
Amalaki Rasayana Improved Memory and Neuronal Metabolic Activity in A?PP-PS1 Mouse Model of Alzheimer's disease. J Biosci 42(3):363-371. DOI: 10.1007/s12038-017-9692-7. 2017
Energetics of Excitatory and Inhibitory Neurotransmission in Aluminium Chloride model of Alzheimer's Disease: Reversal of Behavioral and Metabolic Deficits by Rasa Sindoor. Front Mol Neurosci 10:323. doi: 10.3389/fnmol.2017.00323. 2017
A designed recombinant fusion protein for targeted delivery of siRNA to the mouse brain J Controlled Release 228:120-131. 2016
Pretreatment of caffeine leads to partial neuroprotection in MPTP model of Parkinson`s disease. Neural Regeneration Res 11:1750-1751. [IF: 1.24] 2016
Facile Development of Iron-Platinum Nanoparticles to Harness Multifunctionality in Single Entity. Acta Metallurgica Sinica 29:1098-1106. [IF: 1.188] 2016
Delivery of BACE1 siRNA mediated by TARBP-BTP fusion protein reduces b-amyloid deposits in a transgenic mouse model of Alzheimer`s Disease. BioRxiv doi.org/10.1101/097121. 2016
Effects of GAT1 Inhibition by Tiagabine on Brain Glutamate and GABA Metabolism in the Anesthetized Rat In Vivo. J Neurosci Res 93:1101-1108 2015
Direct synthesis of water dispersible superparamagnetic TGA capped FePt nanoparticles: One pot, one shot. Materials Chemistry and Physics 156: 247-53. 2015
A Water-Soluble and Water-Coordinated Mn(II) Complex: Synthesis, Characterization and Phantom MRI Image Study. Dalton Transactions 44:12990-12994. 2015
Neuroprotective Effects of Caffeine in MPTP Model of Parkinson's Disease: A 13C NMR Study. Neuochem Int 93:1101-1108. 2015
Protein-Polymer Functionalized Aqueous Ferrofluids Showing High T 2 Relaxivity Journal of Biomedical Nanotechnology 10:811-189 2014
Dysfunctional Glutamatergic and GABAergic Activities in Prefrontal Cortex of Mice in Social Defeat Model of Depression. Biol Psychiatry 76:231-238 2014
Engineering of gadofluoroprobes: Broad-spectrum applications from cancer diagnosis to therapy Applied Physics Letters 104:023703 2014
Pyruvate Carboxylase and Pentose Phosphate Fluxes are Reduced in A?PP-PS1 Mouse Model of Alzheimer's Disease: A 13C NMR Study. J Alzheimer's Dis 41:387-399. 2014
Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle. Proc Natl Acad Sci USA 111:5385-5390 2014
Characterization of Cerebral Glutamine Uptake from Blood in the Mouse Brain: Implications for Metabolic Modeling of 13C NMR Data. J Cereb Blood Flow Metab 34:1666-1672 2014
Oligo(p?phenyleneethynylene)-Derived Porous Luminescent Nanoscale Coordination Polymer of GdIII: Bimodal Imaging and Nitroaromatic Sensing. J Phys Chem 118:12241-12249. 2014
13C Nuclear Magnetic Resonance Investigations of Neurotransmitter Energetics in Brain J Indian Inst Sci 94:455-464. 2014
Effect of Biomimetic Templates on the Magneto-Structural Properties of Fe3O4 Nanoparticles RSC Advances 5:13777-13786 2014
Multifunctional carbon nanospheres with magnetic and luminescent probes: probable brain theranostic agents. J Material Chem B 1:939-945. 2013
Simple synthesis of superparamagnetic magnetite nanoparticles as highly efficient contrast agent. Materials Letters 95:186-189. 2013
Glutamatergic and GABAergic TCA Cycle and Neurotransmitter Cycling Fluxes in Different Regions of Mouse Brain J Cereb Blood Flow Metab 33:1523-31. 2013
In Vivo NMR Studies of Regional Cerebral Energetics in MPTP Model of Parkinson`s Disease: Recovery of Cerebral Metabolism with Acute Levodopa Treatment. J Neurochem 127:365-77. 2013
Differential effects of ethanol on regional glutamatergic and GABAergic neurotransmitter pathways in mouse brain. J Neurochem 128:628-640. 2013
Regional Cerebral Metabolism in Mouse under Chronic Manganese Exposure: Implications for Manganism Neurochem Int 60:177-185 2012
Glutamatergic and GABAergic Metabolism in Mouse Brain Under Chronic Nicotine Exposure: Implications for Addiction. PLos One 7(7): e41824. 2012
Evaluation of cerebral acetate transport and metabolic rates in the rat brain in vivo using 1H-[13C]-NMR J. Cereb. Blood Flow Metab. 30:1200-13 2010
Effects of continuous hypoxia on energy metabolism in cultured cerebro-cortical neurons, Brain Res. 1229:147-54 2008
Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase-deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling J. Neurochem. 103:2077-91 2007
Glutamatergic and GABAergic Neurotransmitter Cycling and Energy Metabolism in Rat Cerebral Cortex During Postnatal Development J. Cereb. Blood Flow Metab. 27:1895-907 2007
Evidence that GAD65 Mediates Increased GABA Synthesis during Intense Neuronal Activity In Vivo J. Neurochem. 97:385-396 2006
Acute Regulation of Steady-State GABA Levels following GABA-Transaminase Inhibition in Rat Cerebral Cortex Neurochem. Int. 48:508-514 2006
Neuronal-glial glucose oxidation and glutamatergic-GABAergic function: 13C MRS studies examining the coupling of glucose metabolism and neuronal activity provides insights into the heterogeneity of neuronal-glial interactions J. Cereb. Blood Flow Metab. 26:865-877 2006
Cerebral Pyruvate Carboxylase Flux is Unaltered during Bicuculline-Seizures J. Neurosci. Res. 79:128-138 2005
The Contribution of GABA to Glutamate/Glutamine Cycling and Energy Metabolism in the Rat Cortex in vivo Proc. Natl. Acad. Sci. 102:5588-5593 2005
Glutamatergic Neurotransmission and Neuronal Glucose Oxidation Are Coupled During Intense Neuronal Activation J. Cereb. Blood Flow Metab. 24:972-985 2004
Regional Glucose Metabolism and Glutamatergic Neurotransmission in Rat Brain In Vivo Proc. Natl. Acad. Sci. 101:12700-12705 2004
Coupling of Glutamatergic Neurotransmission and Neuronal Glucose Oxidation over the Entire Range of Cerebral Cortex Activity Ann. N. Y. Acad. Sci. 1003:452-453 2003
Coupling of Glutamatergic Neurotransmission and Neuronal Glucose Oxidation over the Entire Range of Cerebral Cortex Activity Ann. N. Y. Acad. Sci. 1003:452-453 2003
In Vivo 1H-[13C]-NMR Spectroscopy of Cerebral Metabolism NMR Biomed. 16:339-357 2003
Determination of liposomal encapsulation efficiency using 1H NMR spectroscopy. Chem. Phys. Lipids 127:113-120 2003
Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition Brain Res. 919:207-220 2001
Decrease in GABA Synthesis Rate in Rat Cortex following GABA-Transaminase Inhibition Correlates with the Decrease in GAD67 Protein Brain Res. 914:81-91 2001
Substance P (free acid) Adopts Different Conformation than Native Peptide in DMSO, Water and DPPC Bilayers J. Biomol. Struct. Dyn. 19:129-138 2001
Synthesis, spectroscopic, electrochemical and antibacterial studies of new Ru(II) 1,10-phenanthroline complexes containing aryldiazopentane-2,4-dione as co-ligand New J. Chem. 24:505-510 2000
Spectroscopic studies on the conformation and binding characteristic of 7-hydroxy-8-(phenylazo)1,3-naphthalene disulfonate with BPA J. Biol. Chem. 274:21755-21762 1999
Identification of low molecular weight compounds in goat epididymis using multinuclear NMR Anal. Biochem. 266:205-215 1999
Arginine acts as a protective and reversal agent against glycolytic inhibitors in spermatozoa Physiol. Chem. Phys. Med. NMR 31:29-40 1999
Interaction of [Ile7]angiotensin III with dodecylphosphocholine Micelles: NMR and molecular dynamics studies Magn. Reson. Chem. 37:279-286 1999
Replacement of Phe8 in Substance P bye Tyr (Tyr8-SP) alters the conformation in DMSO, water and lipid bilayers Biopolymers 50:602-612 1999
Arginine activates glycolysis of goat epididymal spermatozoa: a NMR study Biophys. J. 75:1522-1528 1998
Conformation of renin substrate (angiotensinogen) in water is different from DMSO: a 1H NMR and MD study Magn. Reson. Chem. 36:285-295 1998
Membrane induced conformation of [Val4, Ile7]angiotensin III by NMR and molecular dynamics methods Magn. Reson. Chem. 36:815-825 1998
ynthesis characterization and film formation of modified riboflavin Mat. Sci. Engg. C3:273-276 1995
Spectroscopic studies on calcium depleted horsheradish peroxidase: observation of tryptophan sensitized Fluorescence J. Inorg. Biochem. 60:245-255 1995
Elucidation of self-assembling properties of riboflavin and its derivative when interface with solid supports Mat. Sci. Engg. C3:263-266 1995

Anant Bahadur Patel

Senior Principal Scientist

2838

abpatel@ccmb.res.in

K S Varadarajan

Senior Technical Officer(1)

2837

ksvr@ccmb.res.in

Kamal Saba

Senior Research Fellow (Project)

2517

kamalsaba@ccmb.res.in

Narayan Datt Soni

Senior Research Fellow

2981

narayana.d@ccmb.res.in

Dipak Roy

Senior Research Fellow

2981

dipakroy88@ccmb.res.in

Bedaballi Dey

Senior Research Fellow

2981

bedaballi@ccmb.res.in

Akila Ramesh

Junior Research Fellow (Project)

2981

akila@ccmb.res.in

Ajay Sarawagi

Junior Research Fellow

2981