First slide

Arvind Kumar

Senior Principal Scientist

Research Interests

Understanding the epigenetic or chromatin remodeling mechanisms in complex disorders of brain and behavior, the neuropsychiatric diseases, in particular, the molecular and cellular mechanisms underlying etiopathophysiology of affective disorders such as depression, anxiety and post-traumatic stress disorder (PTSD). Using rodent models we study how chronic environmental perturbations such as stress cause alterations in circuitry controlling mood and emotions, by inducing lasting changes in function of many genes via events at the chromatin level (i.e., epigenetic mechanisms).Understanding the epigenetic regulatory mechanisms in neural stem cell biology, i.e. neurogenesis and gliogenesis in adult mouse brain, using both in vitro and in situ approach; this approach might also give us clue to the etiopathology of brain tumors such as astrocytoma or glioblastoma, etc. Our earlier expertise in apoptosis and tumor biology research and the latest one in genome-wide epigenenomics come together in zeroing in on the etiopathology of cancer of nervous system origin.

Selected Publications

Pathak SS, Maitra S, Chakravarty S, Kumar A (2017). Histone lysine demethylases of JMJD2 or KDM4 family are important epigenetic regulators in reward circuitry in the etiopathology of depression. Neuropsychopharmacol 42(4):854-863.


Joshi PC, Samineni R, Bhattacharya D, Reddy BR, Veeraval L, Das T, Maitra S, Wahul AB, Karri S, Pabbaraja S, Mehta G, Kumar A, Chakravarty S (2017). A 2-oxa-spiro[5.4]decane scaffold displays neurotrophic, neurogenic and anti-neuroinflammatory activities with high potential for development as a versatile CNS therapeutic. Scientific Reports 7(1):1492.

Chakravarty S, Jhelum P, Bhat UA, Rajan WD, Maitra S, Pathak SS, Patel AB, Kumar A (2017). Insights into the epigenetic mechanisms involving histone lysine methylation and demethylation in ischemia induced damage and repair has therapeutic implication. BBA - Molecular Basis of Disease 1863(1):152-164.

Chakravarty S, Pathak SS, Maitra S, Khandelwal N, Chandra KB, Kumar A (2014). Epigenetic Regulatory Mechanisms in Stress Induced Behavior. Int Rev Neurobiol 115:117-54


Veeraiah P, Noronha JM, Maitra S, Bagga P, Khandelwal N, Chakravarty S, Kumar A*, Patel AB* (2014). Dysfunctional Glutamatergic and ?-Aminobutyric Acidergic Activities in Prefrontal Cortex of Mice in Social Defeat Model of Depression. Biol Psychiatry 76(3):231-8.

Education & Experiance

P.G: Zoology ; University of Bihar ; 1988
Ph.D: The pheromonal block to pregnancy (the Bruce effect) in mice: Role of olfactory experience, familiar males and the vomeronasal organ ; Banaras Hindu University, Varanasi ; 1995

Publications

TitleJournalYear
Advances in Histone Deacetylase Inhibitors in Targeting Glioblastoma Stem Cells Cancer Chemotherapy and Pharmacology 2020
Impaired neuronal and astroglial metabolic activity in chronic unpredictable mild stress model of depression: Reversal of behavioral and metabolic deficit with lanicemine Neurochem Int. 2020
miR-30 Family miRNAs Mediate the Effect of Chronic Social Defeat Stress on Hippocampal Neurogenesis in Mouse Depression Model Front Mol Neurosci. 2019
FTO:An Emerging Molecular Player in Neuropsychiatric Diseases Neurosci. 2019
Disrupting the hippocampal Piwi pathway enhances contextual fear memory in mice Neurobiol Learn mem. 2019
Revealing sex-specific molecular changes in hypoxia-ischemia induced neural damage and subsequent recovery using zebrafish model Neurosci Lett. 2019
Crafting Carbazole Based Vorinostat and TubastatinA-like Histone Deacetylase (HDAC) Inhibitors With Potent in Vitro and in Vivo Neuroactive Functions ACS Omega 2019
Increased stress and altered expression of histone modifying enzymes in brain are associated with aberrant behaviour in vitamin B12 deficient female mice. Nutr Neurosci. (in press) 2019
Fellutamide B Synthetic Path Intermediates with in Vitro Neuroactive Function Shows Mood-Elevating Effect in Stress-Induced Zebrafish Model ACS Omega 3, 10534-10544 2018
Sub-Anesthetic Ketamine Reverses Neuronal and Astroglial Metabolic Activity Deficits in a Social Defeat Model of Depression Journal of Neurochemistry 2018 Jul 2. doi: 10.1111/jnc.14544 2018
Transient global cerebral ischemia differentially affects cortex, striatum and hippocampus in bilateral common carotid artery occlusion (BCCAo) mouse model J Chem Neuroanat. 2018 Oct;92:1-15. doi: 10.1016/j.jchemneu.2018.04.006. 2018
Mice with Partial Deletion of Y-heterochromatin Exhibits Stress Vulnerability Frontiers in Behav Neurosci (accepted for publication) 2018
A 2-oxa-spiro[5.4]decane scaffold displays neurotrophic, neurogenic and anti-neuroinflammatory activities with high potential for development as a versatile CNS therapeutic Scientific Reports 2017
Sex difference in mouse hypothalamic transcriptome profile in stress-induced depression model Biochem Biophys Res Comm (in press) 2017
Sex differences in the effect of chronic mild stress on mouse prefrontal cortical BDNF levels: A role of major ovarian hormones Neuroscience 2017
Leucine-rich repeat-containing 8B (LRRC8B) protein is associated with the endoplasmic reticulum calcium leak in HEK293 cells J cell Sci (in press) 2017
A Functional Role for the Epigenetic Regulator ING1 in Activity-induced Gene Expression in Primary Cortical Neurons Neuroscience 2017
Role of Annexin gene and its regulation during Zebrafish caudal fin regeneration. Wound Repair Regen 2016
Natural product based novel small molecules with promising neurotrophic, neurogenic and anti-neuroinflammatory actions can be developed as stroke therapeutics (PERSPECTIVE) NEURAL REGENERATION RESEARCH (in press) 2016
Sirtuin 1 and 7 mediate the resveratrol induced recovery from hyper-anxiety in high fructose fed prediabetic rats. J Biosci. (in Press) 2016
Sameerpannag Ras Mixture (SRM) improved neurobehavioral deficits following acute ischemic stroke by attenuating neuroinflammatory response. J Ethnopharmacol. 2016
nsights into the epigenetic mechanisms involving histone lysine methylation and demethylation in ischemia induced damage and repair has therapeutic implication BBA - Molecular Basis of Disease 2016
Histone lysine demethylases of JMJD2 or KDM4 family are important epigenetic regulators in reward circuitry in the etiopathology of depression. Neuropsychopharmacology (In Press) 2016
Differential effect of chronic stress on mouse hippocampal memory and affective behavior: Role of major ovarian hormones. Behav Brain Res 2016
Implications of Epigenetic Mechanisms and their Targets in Cerebral Ischemia Models Curr. Neuropharmacol. 2016
A novel natural product inspired scaffold with robust neurotrophic, neurogenic and neuroprotective action. Scientific Reports (in Press) 2015
Histone Deacetylase Inhibitors and Psychiatric Disorders Epigenetics in Psychiatry, J. Peedicayil, D. Avramopoulos, D.R. Grayson (edited), Elsevier (in Press) 2014
Epigenetic Regulatory Mechanisms in Stress Induced Behavior. Int Rev Neurosci (in Press) 2014
Prohexadione, a Plant Growth Regulator, Inhibits Histone Lysine Demethylases and Modulates Epigenetics. Toxicology Report, Elsevier (in Press) 2014
Early stress evokes age-dependent biphasic changes in hippocampal neurogenesis, Bdnf expression and cognition Biological Psychiatry 73( 7) , 658-666 2013
Chronic Unpredictable Stress (CUS)-Induced Anxiety and Related Mood Disorders in a Zebrafish Model: Altered Brain Proteome Profile Implicates Mitochondrial Dysfunction PLoS ONE 8(5): e63302. doi:10.1371/journal.pone.0063302 2013
Dysfunctional Glutamatergic and GABAergic Activities in Prefrontal Cortex of Mice in Social Defeat Model of Depression Biol Psychiatry (in Press) 2013
Role of proteomics in biomarker discovery and psychiatric disorders: current status, potentials, limitations and future challenges Expert Rev. Proteomics 9(3), 249-265 (2012) 2012
P2X7 receptor - Pannexin 1 hemichannel association: effect of extracellular calcium on membrane permeabilization J Mol Neurosci. 46(3):585-94. 2012
Insight into cocaine-induced neural and behavioral adaptations using genome-wide expression profiling and epigenomic analysis Curr Psychopharm, 1(4): 332-345. 2012

Arvind Kumar

Senior Principal Scientist

2975

akumar@ccmb.res.in

Sachin Singh

Senior Scientist

2976

sachin@ccmb.res.in

Gajendra Reddy

SERB NPDF

2976

Shams Ul Haq Talee

Senior Research Fellow

2976

shams-ul-haq@ccmb.res.in

Unis Ahmad Bhat

Senior Research Fellow

2976

unis@ccmb.res.in

Aditya Undru

Senior Research Fellow

2940

adityaundru@ccmb.res.in

Annapoorna P K

Senior Research Fellow

2976

annapoornap@ccmb.res.in

Niharika Awasthi

Junior Research Fellow

2976

niharika@ccmb.res.in

Bhanu Pranav N S

Junior Research Fellow

2976

bhanu.pranav@ccmb.res.in

Arpan Mukhoti

Junior Research Fellow

2976

a.mukhoti@ccmb.res.in