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CSIR - Centre for Cellular & Molecular Biology

Council of Scientific and Industrial Research
Ministry of Science & Technology, Govt. of India

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Arvind Kumar

Senior Principal Scientist
Email: akumar@ccmb.res.in
Phone: +91-040-27192975

Research Interests

Understanding the epigenetic or chromatin remodeling mechanisms in complex disorders of brain and behavior, the neuropsychiatric diseases, in particular, the molecular and cellular mechanisms underlying etiopathophysiology of affective disorders such as depression, anxiety and post-traumatic stress disorder (PTSD). Using rodent models we study how chronic environmental perturbations such as stress cause alterations in circuitry controlling mood and emotions, by inducing lasting changes in function of many genes via events at the chromatin level (i.e., epigenetic mechanisms).Understanding the epigenetic regulatory mechanisms in neural stem cell biology, i.e. neurogenesis and gliogenesis in adult mouse brain, using both in vitro and in situ approach; this approach might also give us clue to the etiopathology of brain tumors such as astrocytoma or glioblastoma, etc. Our earlier expertise in apoptosis and tumor biology research and the latest one in genome-wide epigenenomics come together in zeroing in on the etiopathology of cancer of nervous system origin.

Selected Publications

Maitra S, Khandelwal N, Kootar S, Sant P, Pathak SS, Reddy S, Annapoorna P, Murty US, Chakravarty S, Kumar A (2020). Histone lysine demethylase JMJD2D/KDM4D and family members mediate effects of chronic social defeat stress on mouse hippocampal neurogenesis and mood disorders. Brain Sci. 10: 833.

Khandelwal N, Dey SK, Chakravarty S, Kumar A (2019). miR-30 family miRNAs mediate the effect of chronic social defeat stress on hippocampal neurogenesis in mouse depression model. Front Mol Neurosci. 12:188.

Pathak SS, Maitra S, Chakravarty S, Kumar A (2017). Histone lysine demethylases of JMJD2 or KDM4 family are important epigenetic regulators in reward circuitry in the etiopathology of depression. Neuropsychopharmacol 42(4):854-863.

Chakravarty S, Jhelum P, Bhat UA, Rajan WD, Maitra S, Pathak SS, Patel AB, Kumar A (2017). Insights into the epigenetic mechanisms involving histone lysine methylation and demethylation in ischemia induced damage and repair has therapeutic implication. BBA- Molecular Basis of Disease 1863(1):152-164.

Veeraiah P, Noronha JM, Maitra S, Bagga P, Khandelwal N, Chakravarty S, Kumar A*, Patel AB* (2014). Dysfunctional glutamatergic and Gamma-Aminobutyric acidergic activities in prefrontal cortex of mice in social defeat model of depression. Biol Psychiatry 76(3):231-8.

 

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Arvind Kumar

Senior Principal Scientist

2975

akumar@ccmb.res.in

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Sachin Singh

Senior Scientist

2976

sachin@ccmb.res.in

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Gajendra Reddy

SERB NPDF

2976

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Shams Ul Haq Talee

Senior Research Fellow

2976

shams-ul-haq@ccmb.res.in

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Unis Ahmad Bhat

Senior Research Fellow

2976

unis@ccmb.res.in

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Aditya Undru

Senior Research Fellow

2940

adityaundru@ccmb.res.in

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Annapoorna P K

Senior Research Fellow

2976

annapoornap@ccmb.res.in

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Niharika Awasthi

Junior Research Fellow

2976

niharika@ccmb.res.in

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Bhanu Pranav N S

Junior Research Fellow

2976

bhanu.pranav@ccmb.res.in

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Arpan Mukhoti

Junior Research Fellow

2976

a.mukhoti@ccmb.res.in