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G R Chandak-Img

G R Chandak

J C Bose Fellow
Email: chandakgrc@ccmb.res.in
Phone: +91-040-27192748

Research Interests

Our group is interested in understanding the genetic basis of complex disorders such as type 2 diabetes mellitus and chronic pancreatitis and its interaction with various environmental factors (epigenetic basis). The major focus is on identifying various genetic and nutritional factors (and interaction between them), which influence The Thin Fat Indian Phenotype, and various intermediate traits that predict higher risk of developing diabetes and metabolic syndrome. These determinants could be both maternal and fetal in origin and we believe that the variable clinical phenotype of these complex disorders in Indians has different genetic basis that is regulated differently and is programmed in-utero (Developmental Origins of Adult Common Diseases,). The larger goal is to have comprehensive knowledge of gene-gene and gene-nutrient interaction that will enable to alleviate and/or modulate the clinical course and complications of these disorders by modification of life style and diet, especially micronutrients.

Selected Publications

C S Yajnik, G R Chandak, C Joglekar, P Katre, D S Bhat, S N Singh, C S Janipalli, H Refsum, G Krishnaveni, S Veena, C Osmond, CHD Fall. Maternal homocysteine in pregnancy and offspring birthweight: Epidemiological associations and Mendelian randomizationanalysis. Int J Epidemiology 22 July 2014. Epub ahead of print. PMID: 25052622. 
[Accompanied by Editorial Commentary, Sarah J Lewis (2014). "One-carbon metabolism has major implications for fetal growth and development beyond neural tube defects" Int. J. of Epidemiol., 1-2 doi: 10.1093/ije/dyu175].

Heiko Witt, Sebastian Beer, Jonas Rosendahl, Jian-Min Chen, GirirajRatanChandak, et al. Loss-of-function mutations in CPA1 are strongly associated with early-onset chronic pancreatitis. Nature Genetics 2013 Oct;45(10):1216-20. doi: 10.1038/ng.2730. Epub 2013 Aug 18.

Ganesh Chauhan, Charles J Spurgeon, 12 more authors and G R Chandak (2010). Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC3018, HHEX, CDKN2A, IGF2BP2 AND CDKAL1 on the risk of type 2 diabetes in 5148 Indians. Diabetes ;59(8):2068-74.

P D Gluckman, P Bateson, A S Beedle, Z A Bhutta, M A Hanson, C Law, K V Anokhin, P Bougneres, G R Chandak, P Dasupta, G D Smith, P T Ellison, T Forrester, S F Gilbert, E Jablonka, H Kaplan, A M Prentice, S J Simpson, R Uauy & M J West-Eberhard (2009)."Development and human disease - a synthesis of evolutionary, medical, anthropological, and economic perspectives". Lancet 373(9675):1654-1657.


G R Chandak, C S Janipalli, S Bhaskar, S R Kulkarni, P Mohankrishna, A T Hattersley, T M Frayling, C S Yajnik (2007). Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population. Diabetologia50(1):63-67. 
[This paper is accompanied by an Editorial Commentary, Zeggini E and McCarthy MI "TCF7L2: the biggest story in diabetes genetics since HLA ?" Diabetologia 50: 1-4.]

Education & Experience

Patents


Publications

G R Chandak-Group Pic
G R Chandak-Img

G R Chandak

J C Bose Fellow

2748

chandakgrc@ccmb.res.in

P Ashok-Img

P Ashok

Lab Attendant(2)

2653

Seema Bhaskar-Img

Seema Bhaskar

Project Manager

2653

seema@ccmb.res.in

Suraj Singh Nongmaithem-Img

Suraj Singh Nongmaithem

Project Scientist-II

2549

suraj.nong@ccmb.res.in

Sowmya Mekala-Img

Sowmya Mekala

Project Scientist-II

2549

sowmya@ccmb.res.in

Sumit Paliwal-Img

Sumit Paliwal

Project Scientist-II

2549

sumit-pal@ccmb.res.in

Aditya Naman Soni-Img

Aditya Naman Soni

Project Associate-I

2549

aditya@ccmb.res.in

Sara Sajjadi-Img

Sara Sajjadi

Senior Research Fellow

2653

sara.sajjadi@ccmb.res.in

Swati Bayyana-Img

Swati Bayyana

Senior Research Fellow

2653

swati.bayyana@ccmb.res.in

Alagu Sankareswaran-Img

Alagu Sankareswaran

Senior Project Associate

2655

sankareswaran@ccmb.res.in

Sohail Rafik Mansuri-Img

Sohail Rafik Mansuri

Senior Research Fellow(CSIR)

2607

sohail@ccmb.res.in

Manisha Arumalla-Img

Manisha Arumalla

Project Associate - II

2653

manishaa@ccmb.res.in

P S K D B Punya Sri-Img

P S K D B Punya Sri

Project Assistant

2607

punyasri@ccmb.res.in

Shagufta Tasneem-Img

Shagufta Tasneem

Project Associate-II

2655

shaguftatasneem@ccmb.res.in

Archana D-Img

Archana D

Project Associate-I

2657

archanad@ccmb.res.in

Jukanti Akshitha -Img

Jukanti Akshitha

Project Associate-I

2657

akshithaj@ccmb.res.in

Dimple Lavanuru-Img

Dimple Lavanuru

Project Associate-I

2657

dimple@ccmb.res.in

Jandhyala Vyshnavi -Img

Jandhyala Vyshnavi

Project Associate - I

2655

vyshnavi@ccmb.res.in

Lakshana N-Img

Lakshana N

Project Associate-I

2657

lakshana@ccmb.res.in

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Pranavi Garimella

Project Assistant

2655