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Research Interests

My current research interests concern in understanding the complexity of developmental biology and neuroscience using alternate model animals such as zebrafish (Danio rerio), marine chordates (Ascidians) and echinoderms (Asterias sp). My research activity mainly focuses in understanding the mechanism of regeneration and degeneration in these model animals involving proteomics and transcriptomics approaches. Regeneration of appendages in zebrafish, nervous tissue in ascidians and arms in Asterias sp are the few important ongoing research activities in my lab. I am also interested in understanding the molecular and functional mechanism of neurodegeneration due to the triplet repeat expansion as like in spino cerebellar ataxia and Huntington’s disease using zebrafish as the model animal.

Selected Publications

Saxena S, Singh SK, Meena Lakshmi MG, Meghah V, Bhatti B, Brahmendra Swamy CV, Sundaram CS, Idris MM.Proteomic analysis of zebrafish caudal fin regeneration.Mol Cell Proteomics. 2012 Jan 25.

Singh SK, Saxena S, Meena Lakshmi MG, Saxena P, Idris MM.Proteome Profile of Zebrafish Danio rerio Olfactory Bulb Based on Two-Dimensional Gel Electrophoresis Matrix-Assisted Laser Desorption/Ionization MS/MS Analysis.Zebrafish. 2011 Dec;8(4):183-9.

Saxena S, Meena Lakshmi MG, Meghah M, Singh SK, Sundaram CS, Brahmendra Swamy CV, Idris MM (2011) Proteome profile of zebrafish kidney. Journal of Proteomics.

Singh SK., Meena Lakshmi MG., Saxena S., Brahmendra Swamy CV., Idris MM (2011) Proteome profile of zebrafish caudal fin based one-dimensional gel electrophoresis LCMS/MS and two-dimensional gel electrophoresis MALDI MS/MS analysis. Journal of Separation science 34(2), 225-32.

Singh SK., Sundaram CS., Shanbhag S., Idris MM (2010) Proteomic profile of zebrafish brain based on 2-DE MALDI MS/MS analysis. Zebrafish 7(2) 169-177.

Education & Experiance

P.G: Biochemistry ; University of Madras ; 1998
Ph.D: Evolution, Genetics and Function of Huntingtin in Ciona intestinalis ; Stazione Zoologica 'A. Dohrn ; 2008

Publications

TitleJournalYear
Functional role of Annexins in Zebrafish Caudal fin regeneration - A Gene knockdown approach in regenerating tissue Biochimie (Just accepted) 2020
Toxicity of TiO2, SiO2, ZnO, CuO, Au and Ag engineered nanoparticles on hatching and early nauplii of Artemia sp. Peer J 6: e6138 2019
Role of Annexin gene and its regulation during zebrafish caudal fin regeneration. Wound, Repair and Regen. 24(3): 551-9. 2016
Qauntitative proteomic analysis of normal and degenerated human intervertebral disc. Spine J. 16(8): 989-1000. 2016
MPTP induced Parkinson's disease in zebrafish. Proteomics. 16(9): 1407-20. 2016
Transcriptomic and proteomic analyses of Amphiura filiformis arm tissue-undergoing regeneration. J Proteomics 112: (113-24). 2015
Proteomic and gene expression analysis of zebrafish brain undergoing continuous light/dark stress. J Sleep Res. 24(4): 458-65. 2015
Proteome map of the neural complex of the Tunicate Ciona intestinalis, the closest living relative to vertebrates Proteomics 2013
Chronic Unpredictable Stress (CUS)-Induced Anxiety and Related Mood Disorders in a Zebrafish Model: Altered Brain Proteome Profile Implicates Mitochondrial Dysfunction PLOS One 2013
Evidence for dynamic and multiple roles for huntingtin in Ciona intestinalis. Invertebrate Neuroscience 2013
Proteomic analysis of zebrafish caudal fin regeneration. Molecular and Cellular Proteomics 2012
Proteome profile of zebrafish kidney Journal of Proteomics 2011
Proteome profile of zebrafish caudalfin based on one-dimensional gelelectrophoresis LCMS/MS andtwo-dimensional gel electrophoresisMALDI MS/MS analysis Journal of separation science 2011
Proteome Profile of Zebrafish Danio rerio Olfactory Bulb Based on Two-Dimensional Gel Electrophoresis Matrix-Assisted Laser Desorption/Ionization MS/MS Analysis. Zebrafish 2011
Synthesis of readily accessible triazole linked dimer deoxynucleoside phophoramidite for sold phase oligonucleotide synthesis. Synthesis Journal of synthetic organic chemistry 2010
Novel helical foldamers: Organized heterogeneous backbone folding in 1:1 a/Nucleoside-derived-b-amino acid sequences. Chemical communications 2010
Streptomyces hyderabadensis sp. Nov., a novel actinomycete isolated from soil in Andhra Pradesh, India International Journal of Systemic and Evolutionary Microbiology 2010
Proteome profile of zebrafish brain based on gel LC-ESI MS/MS analysis Journal of Proteomics and Bioinformatics 2010
Streptomyces osmaniensis sp. nov., a novel streptomycetes from soil in south India International Journal of Systemic and Evolutionary Microbiology 2009
The Sea Urchin Genome Sequencing Consortium. The Genome of the Sea Urchin Strongylocentrotus purpuratus. Science 2006

M Mohammed Idris

Senior Principal Scientist

2770

idris@ccmb.res.in

Naga Sowmya Vuppaladadium

Pharmacopeia Scientist

2590

nagasowmya@ccmb.res.in

Sareena Banu

Pharmacopeia Associate

2590

sarena@ccmb.res.in

Bernadette Mathew

Pharmacopeia Associate

2590

mathew.bernadette@ccmb.res.in