My current research interests concern in understanding the complexity of developmental biology and neuroscience using alternate model animals such as zebrafish (Danio rerio), marine chordates (Ascidians) and echinoderms (Asterias sp). My research activity mainly focuses in understanding the mechanism of regeneration and degeneration in these model animals involving proteomics and transcriptomics approaches. Regeneration of appendages in zebrafish, nervous tissue in ascidians and arms in Asterias sp are the few important ongoing research activities in my lab. I am also interested in understanding the molecular and functional mechanism of neurodegeneration due to the triplet repeat expansion as like in spino cerebellar ataxia and Huntington’s disease using zebrafish as the model animal.

Selected Publications

Saxena S, Singh SK, Meena Lakshmi MG, Meghah V, Bhatti B, Brahmendra Swamy CV, Sundaram CS, Idris MM.Proteomic analysis of zebrafish caudal fin regeneration.Mol Cell Proteomics. 2012 Jan 25.

Singh SK, Saxena S, Meena Lakshmi MG, Saxena P, Idris MM.Proteome Profile of Zebrafish Danio rerio Olfactory Bulb Based on Two-Dimensional Gel Electrophoresis Matrix-Assisted Laser Desorption/Ionization MS/MS Analysis.Zebrafish. 2011 Dec;8(4):183-9.

Saxena S, Meena Lakshmi MG, Meghah M, Singh SK, Sundaram CS, Brahmendra Swamy CV, Idris MM (2011) Proteome profile of zebrafish kidney. Journal of Proteomics.

Singh SK., Meena Lakshmi MG., Saxena S., Brahmendra Swamy CV., Idris MM (2011) Proteome profile of zebrafish caudal fin based one-dimensional gel electrophoresis LCMS/MS and two-dimensional gel electrophoresis MALDI MS/MS analysis. Journal of Separation science 34(2), 225-32.

Singh SK., Sundaram CS., Shanbhag S., Idris MM (2010) Proteomic profile of zebrafish brain based on 2-DE MALDI MS/MS analysis. Zebrafish 7(2) 169-177.