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Research Interests

Cell division is a fundamental cellular process involved in embryonic development and mitotic aberrations result in disorders such as microcephaly, aneuploidy syndromes and embryonic lethality. We study the molecular mechanisms regulating cell division to understand the basis of these developmental disorders. We use zebrafish as the model system to study cell division dynamics during embryonic development. The zebrafish embryos are amenable to live cell imaging, genetic manipulation and high throughput genetic screens.

My group is also interested in ecotoxicology and embryo toxicology. In one of our projects, we aim to assess the impact of common industrial byproducts on embryonic development. Our long-term goal is to elucidate the molecular mechanisms which form the basis of developmental defects upon exposure to these industrial byproducts.

Selected Publications

Sharma A., Shukla A., Attri K., Kumar M., Kumar P., Suttee A., Singh G., Barnwal R. and Singla N. (2020). Global trends in pesticides: A looming threat and viable alternatives. Ecotoxicology and Environmental Safety; 201, 110812.

Mahale P*., Kumar M.*, Sharma A*., Babu A., Ranjan S., Sachidanandan C. and Mylavarapu V. S. (2016). The Light Intermediate Chain 2 Subpopulation of Dynein Regulates Mitotic Spindle Orientation. Scientific Reports 6(1); 22. *- Equal contribution

Kumar M., Pushpa K. and Mylavarapu V. S. (2015). Splitting the cell, building the organism: Mechanisms of cell division in metazoan embryos. (IUBMB Life; 67,7: 575-87)

Kumar M. and Chapman S. (2012). Cloning and expression analysis of Fgf5, 6 and 7 during early chick development. Gene Expression Patterns; 12, 245-253.

Kumar M., Ray P. and Chapman S. (2012). Fibroblast growth factor and Bone morphogenetic protein signaling are required for specifying prechondrogenic identity in neural crest-derived mesenchyme and initiating the chondrogenic program. Developmental Dynamics; 241, 1091-1103.

Education & Experiance

P.G: Zoology ; University of Delhi ; 2007
Ph.D: Specification of the neural crest derived pharyngeal mesenchyme: The role of pharyngeal endoderm, FGF and BMP signaling in the establishment of prechondrogenic identity and initiation of chondrogenesis. ; Clemson University, USA ; 2012
Post.Doc:

Cell and Developmental Biology ; Regional Centre for Biotechnology (RCB) ; 2017

Developmental Biology ; Indian Institute of Technology Kanpur (IITK) ; 2012

Publications

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Megha Kumar

DST Inspire Faculty

2531

meghakumar@ccmb.res.in

Sharada Iyer

Junior Research Fellow

2511

Sulagna Mukherjee

Junior Research Fellow (Project)

2511

Suraj Zade

Junior Research Fellow (Project)