Training on Faster COVID-19 Testing
CSIR - Centre for Cellular & Molecular Biology
Council of Scientific and Industrial Research
Ministry of Science & Technology, Govt. of India
Senior Scientist
Email: meghakumar@ccmb.res.in
Phone: +91-040-27192531
Cell division is a fundamental cellular process involved in embryonic development and mitotic aberrations result in disorders such as microcephaly, aneuploidy syndromes and embryonic lethality. We study the molecular mechanisms regulating cell division to understand the basis of these developmental disorders. We use zebrafish as the model system to study cell division dynamics during embryonic development. The zebrafish embryos are amenable to live cell imaging, genetic manipulation and high throughput genetic screens.
My group is also interested in ecotoxicology and embryo toxicology. In one of our projects, we aim to assess the impact of common industrial byproducts on embryonic development. Our long-term goal is to elucidate the molecular mechanisms which form the basis of developmental defects upon exposure to these industrial byproducts.
Selected Publications
Iyer S., Dhiman N., Zade S., Mukherjee S., Singla N., Kumar M. (2023). Exposure to Tetrabutylammonium Bromide Impairs Cranial Neural Crest Specification, Neurogenic Program, and Brain Morphogenesis. ACS Chemical Neuroscience, https://doi.org/10.1021/acschemneuro.2c00728
Prasad, T., Iyer, S., Chatterjee, S., & Kumar, M. (2023). In vivo models to study neurogenesis and associated neurodevelopmental disorders-Microcephaly and autism spectrum disorder. WIREs Mechanisms of Disease;e603 doi: https://doi.org/10.1002/wsbm.603
Mukherjee S., Iyer S., Prasad T., Kumar M.* (2021). Epigenetic regulation of chromatin during mitosis in embryos. Journal of Embryology and Stem Cell Research ;5,1.
Iyer, S., Mukherjee, S., & Kumar, M.* (2021). Watching the embryo: Evolution of the microscope for the study of embryogenesis. BioEssays, e2000238. https://doi.org/10.1002/bies.202000238
Mahale P*., Kumar M.*, Sharma A*.,Babu A., Ranjan S., Sachidanandan C. and Mylavarapu V. S. (2016). The Light Intermediate Chain 2 Subpopulation of Dynein Regulates Mitotic Spindle Orientation. Scientific Reports; 6(1); 22.
Education & Experience
| P.G: | Zoology ; University of Delhi ; 2007 |
| Ph.D: | Specification of the neural crest derived pharyngeal mesenchyme: The role of pharyngeal endoderm, FGF and BMP signaling in the establishment of prechondrogenic identity and initiation of chondrogenesis. ; Clemson University, USA ; 2012 |
| Post.Doc: | Cell and Developmental Biology ; Regional Centre for Biotechnology (RCB) ; 2017 Developmental Biology ; Indian Institute of Technology Kanpur (IITK) ; 2012 |
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| Title | Journal | Year |
|---|---|---|
| Exposure to Tetrabutylammonium Bromide Impairs Cranial Neural Crest Specification, Neurogenic Program, and Brain Morphogenesis | ACS Chemical Neuroscience | 2023 |
| In vivo models to study neurogenesis and associated neurodevelopmental disorders-Microcephaly and autism spectrum disorder. | WIREs Mechanisms of Disease | 2023 |
| Pesticides in the Natural Environment | Elsevier | 2022 |
| Phosphorylation and Pin1 binding to the LIC1 subunit selectively regulate mitotic dynein functions | Journal of Cell Biology | 2021 |
| Epigenetic regulation of chromatin during mitosis in embryos. | Journal of Embryology and Stem Cell Research ;5,1. DOI: 10.23880/jes-16000153 | 2021 |
| Role of vertebrate GAGA associated factor (vGAF) in early development of zebrafish | Cells and Development, https://doi.org/10.1016/j.cdev.2021.203682 | 2021 |
| Watching the embryo: Evolution of the microscope for the study of embryogenesis. | BioEssays, e2000238. https://doi.org/10.1002/bies.202000238 | 2021 |
| Global trends in pesticides: A looming threat and viable alternatives. | Ecotoxicology and Environmental Safety | 2020 |
2531
meghakumar@ccmb.res.in
2511
sharada.iyer@ccmb.res.in
2511
tuhinaprasad@ccmb.res.in
siandsilva@ccmb.res.in
List of shortlisted candidates for the final round of Interview for PhD Jan 2025 session