Training on Faster COVID-19 Testing
CSIR - Centre for Cellular & Molecular Biology
Council of Scientific and Industrial Research
Ministry of Science & Technology, Govt. of India
Chief Scientist
Email: nagesh@ccmb.res.in
Phone: 5563
Research Interests:
Selected Publications:
Magnetic bead-amplified voltammetric detection for carbohydrate antigen 125 with enzyme labels using aptamer-antigen-antibody sandwiched assay. (2020)
Mohanraj Sadasivam, Arunkumar Sakthivel ??, ?Narayana Nagesh, Shekhar Hansda, Murugan Veerapandian, Subbiah Alwarappan, Pandiaraj Manickam.
Sensors & Actuators: B. Chemical, 312, 127985-127991. https://doi.org/10.1016/j.snb.2020.127985. (IF-6.3).
Design,synthesis and biological evaluation of new ?-carboline-bisindole compounds as DNA binding, photocleavage agents and topoisomerase inhibitors. (2018)
Jeshma Kovvuri , Burri Nagaraju, V. Lakshma Nayak, Ravi kumar Akunuri, M.P.Narasimha Rao, Ayyappan Ajitha, Narayana Nagesh*, Ahmed Kamal*.
European Journal of MedicinalChemistry. Volume 143, 1563-1577. (IF- 4.8).
Telomerase inhibition and human telomeric G-quadruplex DNA stabilization by a ?-carboline–benzimidazole derivative at low concentration.(2017)
Kranthikumar Yadav, Penchala Narasimha Rao Meka, Sudeshna Sadhu, Sravanthi Devi Guggilapu, Jeshma Kovvuri, Ahmed Kamal, Ragampeta Srinivas, Panuganti Devayani, Bathini Nagendra Babu, and Narayana Nagesh*.
ACS Biochemistry, 56 (33), 4392–4404. DOI: 10.1021/acs.biochem.7b00008. (IF-2.9).
Synthesis, DNA binding affinity and anticancer activity of novel 4Hbenzo[g][1,2,3]triazolo [5,1-c][1,4]oxazocines. (2016)
K. N. Visweswara Sastry, Sunitha Routhu, Soma Gupta Datta, Narayana Nagesh,* Bathini Nagendra Babu, Jagadeesh Babu Nanubolu, C. Ganesh Kumar, Ram Awatar Maurya* and Ahmed Kamal*.
Organic Biomolecular Chemistry, 14, 9294–9305. (I.F- 3.6).
Sugar-boronate ester scaffold tethered pyridyl -imine palladium(II) complexes:Synthesis and their in vitro anticancer evaluation. (2015)
Eda Rami Reddy, Rajiv Trivedi*, Akella Venkata Subrahmanya Sarma, Balasubramanian Sridhar,Hasitha Shilpa Anantharaju,Dharmarajan Sriram, Perumal Yogeeswari, Narayana Nagesh*
Dalton Transactions, 44,17600-17616. (IF- 4.1).
A dihydroindolizino indole derivative selectively stabilizes G-quadruplex DNA and down regulates c-MYC expression in human cancer cells. (2015)
Narayana Nagesh*, G. Raju, R. Srinivas, P. Ramesh, M. Damoder Reddy, Ch. Raji Reddy.
Biochimica et Biophysica Acta (BBA)-General Subjects, 1850(1), 129-140. (IF-4.4).
Patents:
Education & Experience
| P.G: | Chemistry ; S. V. University, Tirupati ; 1987 |
| Ph.D: | Studies on the Structure and Interaction of G-Quadruplex DNA with Metal Ions and Drugs ; S. V. University, Tirupati ; 2005 |
| Post.Doc: | Studies on Bcl2 Quadruplex DNA interaction with Porphyrins ; With Prof. Edwin A Lewis, Department of Chemistry at North Arizona University, Flagstaff, Arizona, USA ; 2006 - 2007. |
| Experience: | About 31 years of experience in the fields of Biochemistry, Biophysics, Medicinal Chemistry, Bio-organic Chemistry. |
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| Title | Journal | Year |
|---|---|---|
| Development of β-Carboline-Coumarin Based Hybrids as Potential Cytotoxic and Topoisomerase IIα Inhibitors | ChemistrySelect | 2024 |
| A Hydrogen Bonded Non-Porous Organic-Inorganic Framework for Measuring Cysteine in Blood Plasma and Endogenous Cancer Cell | Chemistry - A European Journal | 2024 |
| Synthesis and antibacterial evaluation of new naphthalimide-coumarin hybrids against multidrug-resistant S. aureus and M. tuberculosis. | Journal of Molecular Structure | 2024 |
| Benzimidazole derivatives as tubulin polymerization inhibitors: Design, synthesis and in vitro cytotoxicity studies | Biorganic Medicinal Chemistry Letters | 2023 |
| Synthesis and Biological Evaluation of 1-Phenyl-4,6-dihydrobenzo[b]pyrazolo[3,4-d] azepin-5(1H)-one/thiones as Anticancer Agents. | Bioorganic Chemistry | 2023 |
| Triazolo-linked benzimidazoles as tubulin polymerization inhibitors and DNA intercalators: Design, synthesis, cytotoxicity and docking studies | Archiv der Pharmazie | 2023 |
| Benzimidazole based bis-carboxamide derivatives as promising cytotoxic agents: Design, synthesis, in silico and tubulin polymerization inhibition. | Journal of Molecular Structure | 2023 |
| Synthesis and cytotoxicity evaluation of DNA-interactive β-carboline indolyl-3-glyoxamide derivatives: Topo-II inhibition and in silico modelling studies. | Bioorganic Chemistry | 2023 |
| 1, 2, 3-Triazolo-2-Aryl-Linked Benzimidazole Derivatives as Tubulin Polymerization Inhibitors and DNA Intercalators: Design, Synthesis, Biological Evaluation and Docking Studies | SSRN Electronic Journal. | 2022 |
| A unique water soluble probe for measuring the cardiac marker homocysteine and its clinical validation | Chemical Communications | 2022 |
| Design, synthesis of DNA-interactive 4-thiazolidinone-based indolo-/ pyrroloazepinone conjugates as potential cytotoxic and topoisomerase I inhibitors | European Journal of Medicinal Chemistry | 2022 |
| Exploration of Mercaptoacetamide-linked Pyrimidine-1,3,4-Oxadiazole Derivatives as DNA Intercalative Topo II inhibitors: Cytotoxicity and Apoptosis Induction. | Bioorganic & Medicinal Chemistry Letters., | 2022 |
| Towards the development of reagent-free and reusable electrochemical aptamer-based cortisol sensor. | Bioelectrochemistry | 2022 |
| Synthesis of indolo/pyrroloazepinone-oxindoles as potential cytotoxic, DNA-intercalating and Topo I inhibitors. | Bioroganic Chemistry | 2022 |
| Ready-to-Use Vertical Flow Paper Device for Instrument-free Room Temperature Reverse Transcription. | New Biotechnology. | 2022 |
| Design, Synthesis and Biological Evaluation of Hybrid C3-Quinazolinone linked β-carboline Conjugates as DNA Intercalative Topoisomerase I Inhibitors | JSM Clinical Pharmaceutics (Accepted) | 2021 |
| Benzimidazole-1,2,3-triazole hybrid molecules: synthesis and study of their interaction with G-quadruplex DNA | RSC Medicinal Chemistry | 2021 |
| Synthesis and biological evaluation of novel imidazo[1,2-a]pyridine-oxadiazole hybrids as anti-proliferative agents: Study of microtubule polymerization inhibition and DNA binding | Bioorganic and Medicinal Chemisry | 2021 |
| Targeting Tubulin Polymerization and DNA Binding of 4-Thiazolidinone -umbelliferone Hybrids: Synthesis and Cytotoxicity Evaluation. | New Journal of Chemistry | 2021 |
| Development of β-carboline -benzothiazole hybrids via carboxamide formation as cytotoxic agents: DNA intercalative topoisomerase II? inhibition and apoptosis induction | Bioorganic Chemistry, Vol. 106, 104481 | 2021 |
| 3-Functionalised Benzenesulphonamide based 1,3,4-oxadiazoles as Selective Carbonic Anhydrase XIII Inhibitors: Design, Synthesis and Biological Evaluation. | Bioorganic Medicinal Chemistry Letters., 37, 127856. | 2021 |
| Magnetic bead-amplified voltammetric detection for carbohydrate antigen 125 with enzyme labels using aptamer-antigen-antibody sandwiched assay. | Sensors & Actuators: B. Chemical. 312, 127985-127991. | 2020 |
| Amberlite IR-120H Catalyzed Synthesis of 1,3-Diphenylpyrazole-chromenoquinolin-6-one Compounds and Their Biological Evaluation. | American Journal of Medicinal Chemistry,2(1), 2-16. | 2020 |
| Design and Synthesis of β-carboline linked aryl sulfonyl piperazine derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability. | Bioorganic Chemistry, 101, 103983. | 2020 |
| The β-carboline alkaloids in cancer therapy- recent advancements in this area. (Review Article) | IOSR Journal Of Pharmacy And Biological Sciences (IOSR-JPBS) | 2020 |
| Design and synthesis of substituted (1-(benzyl)-1H-1,2,3-triazol-4yl)(piperazin-1-yl)methanone conjugates: Study on their apoptosis inducing ability and tubulin polymerization inhibition. | RSC Medicinal Chemistry. | 2020 |
| Recent Insights into β-Carboline Alkaloids with Anticancer Potential. | Modern Approches in Drug Design. 3(1) | 2020 |
| A New Class of Naphthalimides derivatives: Design, synthesis, DNA-interaction and topoisomerase II inhibition studies. | Med. Chem. Commun., 10, 72 ?79. | 2019 |
| Synthesis and Biological Evaluation of Pyrazole Linked Benzothiazole-β-Naphthol Derivatives as Topoisomerase I Inhibitors with DNA Binding Ability. | Bioorganic and Medicinal Chemistry, 27, 708?720. | 2019 |
| Synthesis and in vitro cytotoxicity evaluation of β-carboline-combretastatin carboxamides as apoptosis inducing agents: DNA intercalation and topo- isomerase-II inhibition. | Bioorganic & Medicinal Chemistry, 27, 3285?3298. | 2019 |
| Design and synthesis of substituted dihydropyrimidinone derivatives as cytotoxic and tubulin polymerization inhibitors. | Bioorganic Chemistry 93 (2019) 103317 | 2019 |
| Design,synthesis and biological evaluation of new β-carboline-bisindole compounds as DNA binding, photocleavage agents and topoisomerase inhibitors. | European Journal of Medicinal Chemistry, 143,1563-1577. | 2018 |
| Synthesis of podophyllotoxinlinked β-carboline congeners as potential anticancer agents | European Journal of Medicinal Chemistry, 144,557-571. | 2018 |
| Iodine-mediated one-pot intramolecular decarboxylation domino reaction for accessing functionalized 2-(1,3,4-oxadiazol-2-yl)anilines with carbonic anhydrase inhibitory action | Journal Of Enzyme Inhibition And Medicinal Chemistry, 33(1),615-628. | 2018 |
| BODIPY-based Ir (III) rectangles containing bis-benzimidazole ligands with highly selective toxicity obtained through self-assembly. | Journal of Organometallic Chemistry, 868, 86-94. | 2018 |
| BODIPY-based Ru(II) and Ir(III) organometallic complexes of avobenzone, a sunscreen material: potent anticancer agents. | J Inorg. Biochem., Vol.189, 17-29. | 2018 |
| Synthesis of DNA interactive C3-trans-cinnamide linked β-carboline conjugates as potential cytotoxic and DNA topoisomerase I inhibitors | Bioorganic and Medicinal Chemistry, 26, 4916?4929 | 2018 |
| Novel Amphiphillic G-quadruplex binding synthetic derivative of TMPyP4 and its effect on cancer cell proliferation and apoptosis induction. | ACS Biochemistry, 57 (46), 6514-6527. | 2018 |
| 2-aryl benzimidazole conjugate induced apoptosis in human breast cancer MCF-7 cells through caspase independent pathway. | Apoptosis, 22,118-134. | 2017 |
| Design, Synthesis, in vitro and in vivo Evaluation of (Z)-3,4,5-Trimethoxystyryl Benzenesulfonamides/Sulfonates as Highly Potent Tubulin Polymerization Inhibitors. | ChemMedChem., 12(9), 678?700. | 2017 |
| Forced degradation studies of lansoprazole using LC-ESI HRMS and 1H-NMR experiments: in vitrotoxicity evaluation of major degradation products. | Journal of Mass Spectrometry, 52(7), 459?471. | 2017 |
| An efficient one-pot approach for the regio and diastereoselective synthesis of trans-dihydrofuran derivatives: Cytotoxicity and DNA-binding studies. | Org. Biomol. Chem., 15, 6837-6853. | 2017 |
| Telomerase inhibition and human telomeric G-quadruplex DNA stabilization by a β-carboline βbenzimidazole derivative at low concentration. | ACS Biochemistry, 56 (33), 4392?4404. | 2017 |
| Design and synthesis of C3-tethered 1,2,3-triazolo-β-carboline derivatives: Anticancer activity, DNA-binding ability, viscosity and molecular modeling studies. | Bioorganic Chemistry, 64, 42-50. | 2016 |
| Identification and characte- rization of stressed degrada- tion products of rabeprazole using LC /ESI / MS /MS and 1H-NMR experiments: In vitrotoxicity evaluation of major degradation products | RSC Advances, 6, 10719-10735. | 2016 |
| Anticancer activity of large metalla-assemblies built from half-sandwich complexes. | CrystEngComm. DOI: 10.1039/C6CE00139D. 18, 4952-4957. | 2016 |
| Manganese-superoxide dismutase (Mn-SOD) overexpression is a common event in colorectal cancers with mitochondrial microsatellite instability. | Tumor Biology (DOI: 10.1007/s13277-016-4918-0) | 2016 |
| Association of mitochon- drial displacement loop polymorphisms with risk of colorectal cancer in south Indian population. | Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis, http://dx.doi.org/10.3109/24701394.2016.1160076. | 2016 |
| Benzo[b]furan derivatives induces apoptosis by targeting the PI3K/Akt/ mTOR signaling pathway in human breast cancer cells | Bioorganic Chemistry, 66, 124?131. | 2016 |
| Synthesis, DNA binding affinity and anticancer activity of novel 4H-benzo[g][1,2,3]triazolo[5,1-c][1,4]oxazocines. | Organic & Biomolecular Chemistry, Org. Biomol. Chem., 14, 9294?9305 | 2016 |
| A dihydroindolizino indole derivative selectively stabilizes G-quadruplex DNA and down-regulates c-MYC expression in human cancer cells. | Biochimica et Biophysica Acta (BBA) - General Subjects, 1850 (1), 129?140 | 2015 |
| DNA-Binding Affinity and Anticancer Activity of β-Carboline-Chalcone Conjugates as Potential DNA Intercalators: Molecular Modeling and Synthesis. | Bioorganic Chemistry, 59, 130-139. doi: 10.1016/j.bioorg.2015.02.007 | 2015 |
| Biological activities of pyrenyl-derived thiosemicarbazone half-sandwich complexes. | Journal of Organometallic Chemistry, 794, 104-114. doi:10.1016/j.jorganchem.2015.06.036. | 2015 |
| Design and synthesis of dithiocarbamate linked β-carboline derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability. | Bioorganic Medicinal Chemistry, 23(17), 5511-5526. | 2015 |
| Sugar-boronate ester scaffold tethered pyridyl -imine palladium(II) complexes : Synthesis and their in vitro anticancer evaluation. | Dalton Transactions 44(40):17600-17616. | 2015 |
| Phenotypic Variations in the 22q11 Deletion SyndromeβStudy in a South Indian Population | Indian J Pediatrics., DOI : 10.1007/s12098-015-1954-5. | 2015 |
| Pd-Catalyzed Aryl C-H Activation and Tandem ortho-Hydroxylation/Alkoxylation of 2-aryl benzimidazoles: Cytotoxicity and DNA-Binding Studies. | Asian J. Org. Chem. Vol. 3, Pg. 68 ? 76, doi: 10.1002/ajoc.201300214 | 2014 |
| Design and synthesis of C3-pyrazole/chalcone linked β-carboline hybrids: Antitopoisomerase I, DNA interactive and apoptosis inducing anticancer agents. | Chemmedchem, 9(9), 2084-2098, Doi:10.1002/cmdc.201300406. | 2014 |
| Studies on non-covalent interaction of coumarin attached pyrimidine and 1-methyl indole 1,2,3 triazole analogues with intermolecular telomeric G-quadruplex DNA using ESI-MS and spectroscopy | Nucleosides, Nucleotides and Nucleic Acids,Vol. No. 33 and Page No. 489-506. | 2014 |
| Synthesis of β-carboline-benzimidazole conjugates using lanthanum nitrate as a catalyst and their biological evaluation | Organic & Biomolecular Chemistry, 12(15), 2370-2373. DOI: 10.1039/c3ob42236d. | 2014 |
| Anticancer Activity of Half-Sandwich RhIII and IrIII Metalla-Prisms Containing Lipophilic Side Chains. | Chempluschem DOI: 10.1002/cplu.201300425. Vol. 79, Pages.610-118. | 2014 |
| Incidence of Bcr-Abl kinase domain mutations in imatinib refractory chronic myeloid leukemia patients from South India. | 2014 | |
| Exploiting Natural Products to Build Metalla Assemblies :The Anticancer Activity of Embelin-Derived Rh(III) and Ir(III)Metalla -Rectangles. | Molecules 19, 6031 -6046. doi:10.3390/molecules19056031. | 2014 |
| Antiproliferative activities of trithiolato-bridged dinuclear arene osmium complexes. | Inorganica Chimica Acta (ICA). Vol.423, Pg.31-35. http://dx.doi.org/10.1016/j.ica.2014.07.050 | 2014 |
| Contribution of cyclin D1 (CCND1) and E-cadherin (CDH1) 5 alterations to colorectal cancer susceptibility : a case-control study. | Tumor Biology. DOI 10.1007/s13277-014-2505-9 | 2014 |
| Production of melanin pigment from Pseudomonas stutzeri isolated from red seaweed Hypnea musciformis. | Letters in Applied Microbiology, doi:10.1111/lam.12111. | 2013 |
| Phenyl-1,2,3-triazole thymidine ligands stabilize G-quadruplex DNA, inhibit DNA synthesis and potentially reduce tumor cell proliferation over 3'-Azido deoxythymidine. | PLoS ONE 8(8): e70798. doi:10.1371/journal.pone.0070798. | 2013 |
| Copper oxide Nanoparticles Supported on Graphene oxide Catalyzed S-Arylation: An Efficient and Ligand free Synthesis of Aryl Sulfides. | Advanced Synthesis and Catalysis, doi: 10.1002/adsc.201300416 | 2013 |
| Bcl-2 Promoter Sequence G-Quadruplex Interactions with three Planar and Non-planar Cationic Porphyrins: TMPyP4, TMPyP3, and TMPyP2 | PLoS ONE 8(8): e72462. doi:10.1371/journal.pone.0072462. | 2013 |
| Biological Studies of Chalcogenolato-Bridged Dinuclear Half-Sandwich Complexes. | Inorg. Chem., 52 (23), 13663?13673. doi: 10.1021/ic4022307. | 2013 |
| Genetic variants of thiopurine and folate metabolic pathways determine 6-MP mediated hematological toxicity in childhood ALL. | Future Medicine-Pharmacogenomics:13(9),1001-1008. | 2012 |
| Interaction of Pyrrolobenzodiazepine (PBD) Ligands with Parallel Intermolecular G-Quadruplex Complex Using Spectroscopy and ESI-MS. | PLoS ONE, 2012, 7 (4) e35920.doi:10.1371 /journal.pone.0035920. | 2012 |
| Epistatic interactions between Thiopurine methyltransferase (TPMT) and Inosine triphosphate pyrophosphatase (ITPA) variations determine the 6-Mercaptopurine toxicity in Indian children with acute lymphoblastic leukemia. | European Journal of Clinical Pharmacology. 68:379. doi: 10.1007/s00228-011-1133-1. | 2011 |
| Synthesis of Readily Accessible Triazole Linked Dimer Deoxynucleoside Phosphoramidite for Solid Phase Oligonucleotide Synthesis. | Synthesis. 21:3710-3714. | 2010 |
| Studies on the site and mode of TMPyP4 interactions with Bcl-2 Promoter Sequence G-quadruplexes. | Biophys J. 98 (11): 2628-2633. | 2010 |
| Influence of fermentation metabolites on redox potential in anaerobic digestion of proteinaceous solid wastes by Synergistes sp. | Engineering in Life Sciences. 10(4):1-6. | 2010 |
| Effect of ionic strength on porphyrin drugs interaction with quadruplex DNA formed by the promoter region of C-myc and Bcl2 oncogenes. | Journal of Nucleic Acids. Article ID 146418,9 pages,2010. doi:10.4061/2010/146418. | 2010 |
| In situ immobilization of acid protease on mesoporous activated carbon packed column for the production of protein hydrolysates. | Bioresource Technology.101(4): 1377-1379. | 2010 |
| Characterization of an alkaline active - thiol forming extracellular serine keratinase by the newly isolated Bacillus pumilus. | Journal of Applied Microbiology, 104: 411-419.doi:10.1111 /j.1365-2672.2007. 03564. X | 2008 |
| Purification of extracellular acid protease and analysis of fermentation metabolites by Synergistes sp. utilizing proteinaceous solid waste from tanneries. | Bioresource Technology, 99: 2364-2372. | 2008 |
| Noncovalent Interaction of G-Quadruplex DNA with Acridine at low concentration monitored by MALDI-TOF Mass Spectrometry. | Nucleosides, Nucleotides and Nucleic Acids., 26: 303-315. | 2007 |
| Was elusive carnivore a panther? DNA typing of faeces reveals the mystery. | Forensic Science International. 137 : 16?20. | 2003 |
| Halomonas glacieisp. nov. isolated from fast ice of Adelie Land, Antarctica. | Extremophiles. 7: 55?61. doi: 10.1007/s00792-002-0295-2 | 2003 |
| A comparative study on the interaction of acridine and syntheticbis-acridine with G-quadruplex structure. | J. Biochem. Biophys. Methods, 57:65 ?74. | 2003 |
| A Comparative study on removal of chromium from water effluents by reduction and adsorption over different carbon materials. | Indian J Environmental Protection, 22(11), 1221-1225. | 2002 |
| Genetic Locus Encoding Functions Involved in Biosynthesis and Outer Membrane Localization of Xanthomonadin in Xanthomonas oryzae pv. Oryzae. | Journal of Bacteriology. 184(13):3539?3548. | 2002 |
| A useful method for the synthesis of 8 azidoguanosine tri- and tetraphosphate: important substrates for many enzymatic reaction | J. Biochem. Biophys. Methods.35: 61?66. | 1997 |
| Ammonium ion at low concentration stabilizes the G-quadruplex formation by telomeric sequence. | J. Biochem. Biophys. Methods, 30:1-8. | 1995 |
| Terbium( III )-Induced Fluorescence of Four-Stranded G4-DNA. | Biopolymers. 32: 1421-1424. | 1992 |
| A study on removal of chromium by adsorption on bituminous coal from synthetic effluents. | Indian J Environmental Health, 31(4),304-308. | 1989 |
| A study on removal of chromium by adsorption on activated charcoal from synthetic effluents. | Indian J Environmental Proection, 9(4): 301-303. | 1989 |
| Design, synthesis, docking studies and biological screening of 2-pyrimidinyl-2, 3-dihydro-1H-naphtho [1, 2-e][1,3] oxazines as potent tubulin polymerization inhibitors | Journal of Biomolecular Structure & Dynamics | -1 |
5563
nagesh@ccmb.res.in
2778
manojbalyan@ccmb.res.in
Notice and Lists of provisionally shortlisted and not shortlisted candidates for the post of Senior Technical Officer(1)/Medical Officer against Advt.No.05/2023