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N Nagesh

Chief Scientist
Email: nagesh@ccmb.res.in
Phone: 5563

Research Interests:

  • Biochemical and Biophysical studies involving the interaction of different forms of DNA (double, triple and quadruplex forms) with small molecules, metals and macromolecules.
  • Studies to understand the mechanism of modified, novel organic and inorganic complexes in enhancing anti-cancer/pro-apoptotic activity among cancer cells and reduce cancer cell proliferation both under in vitro and in vivo conditions,
  • Research activity that brings the industry and academics together.

Selected Publications:

Magnetic bead-amplified voltammetric detection for carbohydrate antigen 125 with enzyme labels using aptamer-antigen-antibody sandwiched assay. (2020)
Mohanraj Sadasivam, Arunkumar Sakthivel ??, ?Narayana Nagesh, Shekhar Hansda, Murugan Veerapandian, Subbiah Alwarappan, Pandiaraj Manickam.
Sensors & Actuators: B. Chemical, 312, 127985-127991. https://doi.org/10.1016/j.snb.2020.127985. (IF-6.3).

Design,synthesis and biological evaluation of new ?-carboline-bisindole compounds as DNA binding, photocleavage agents and topoisomerase inhibitors. (2018)
Jeshma Kovvuri , Burri Nagaraju, V. Lakshma Nayak, Ravi kumar Akunuri, M.P.Narasimha Rao, Ayyappan Ajitha, Narayana Nagesh*, Ahmed Kamal*.
European Journal of MedicinalChemistry. Volume 143, 1563-1577. (IF- 4.8).

Telomerase inhibition and human telomeric G-quadruplex DNA stabilization by a ?-carboline–benzimidazole derivative at low concentration.(2017)
Kranthikumar Yadav, Penchala Narasimha Rao Meka, Sudeshna Sadhu, Sravanthi Devi Guggilapu, Jeshma Kovvuri, Ahmed Kamal, Ragampeta Srinivas, Panuganti Devayani, Bathini Nagendra Babu, and Narayana Nagesh*.
ACS Biochemistry, 56 (33), 4392–4404. DOI: 10.1021/acs.biochem.7b00008. (IF-2.9).

Synthesis, DNA binding affinity and anticancer activity of novel 4Hbenzo[g][1,2,3]triazolo [5,1-c][1,4]oxazocines. (2016)
K. N. Visweswara Sastry, Sunitha Routhu, Soma Gupta Datta, Narayana Nagesh,* Bathini Nagendra Babu, Jagadeesh Babu Nanubolu, C. Ganesh Kumar, Ram Awatar Maurya* and Ahmed Kamal*.
Organic Biomolecular Chemistry, 14, 9294–9305. (I.F- 3.6).

Sugar-boronate ester scaffold tethered pyridyl -imine palladium(II) complexes:Synthesis and their in vitro anticancer evaluation. (2015)
Eda Rami Reddy, Rajiv Trivedi*, Akella Venkata Subrahmanya Sarma, Balasubramanian Sridhar,Hasitha Shilpa Anantharaju,Dharmarajan Sriram, Perumal Yogeeswari, Narayana Nagesh*
Dalton Transactions, 44,17600-17616. (IF- 4.1).

A dihydroindolizino indole derivative selectively stabilizes G-quadruplex DNA and down regulates c-MYC expression in human cancer cells. (2015)
Narayana Nagesh*, G. Raju, R. Srinivas, P. Ramesh, M. Damoder Reddy, Ch. Raji Reddy.
Biochimica et Biophysica Acta (BBA)-General Subjects, 1850(1), 129-140. (IF-4.4).

Patents:

  • Title of the Patent: Synthesis of N-((1-pheny1-9H-pyrido[3,4-b]indo1-3- y1) methy1) cinnamamides as potential Anticancer Agents.
    File Reference No: PT-649. CSIR Ref No.: 0272NF2015.
    Inventors: Ahmed Kamal, Manda Sathish, Narayana Nagesh, Nagula Shankaraiah, Sabanis Chetan Dushantrao, Namballa Hari Krishna.
    Countries: India, US, UK, Germany, France.
    International Patent Classification: C07D 471/04(2006.01); A61K 31/437(2006.01).
  • Title of the Patent: A process for preparing 2-pyrimidyl substituted-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazines.
    Application No: 201921033132.
    Inventors: Rakhi Gajanan Gawali, Raghunath Bhikaji Bhosale, Sachin Pandurang Shirame, Narayana Nagesh.
    Countries: India.

Education & Experience

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Publications

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N Nagesh

Chief Scientist

5563

nagesh@ccmb.res.in

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P Kavin Kennedy

Senior Principal Scientist

2643

kavin@ccmb.res.in

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Ira Bhatnagar

Principal Scientist

5534

ira@ccmb.res.in

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Manoj Kumar Balyan

Senior Scientist

2778

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C B Tripura Sundari

Senior Scientist

5541

tripura@ccmb.res.in