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Research Interests

Cellular homeostasis requires coordinated functioning, and regulation of multiple cellular processes. Deregulation often causes severe cell defects or death. Interestingly, cells have evolved various mechanisms to accomplish this task. Such regulations include modulating gene expression, protein activity, protein stability, etc. By using Saccharomyces cerevisiae as a model system, we are interested in understanding the regulatory mechanisms and their principles in eukaryotes. Our particular interest is to study the role of selective protein degradation, translational control of gene expression, in regulating polyamine homeostasis in the cell.

Selected Publications         

Kurian L *, Palanimurugan R *, Godderz D, Dohmen RJ.Polyamine sensing by nascent ornithine decarboxylase antizyme stimulates decoding of its mRNA. Nature. 2011 Sep 7; 477(7365): 490-4 [*Equally contributing first authors ordered alphabetically]        

Godderz D, Schafer E, Palanimurugan R, Dohmen RJ. The N-terminal unstructured domain of yeast ODC functions as a transplantable and replaceable ubiquitin-independent degron.
J Mol Biol. 2011 Apr1;407(3):354-67   

Marques AJ, Palanimurugan R, Matias AC, Ramos PC, Dohmen RJ. Catalytic mechanism and assembly of the proteasome. Chem Rev. 2009 Apr; 109(4): 1509-36       

Palanimurugan R, Scheel H, Hofmann K, Dohmen RJ. Polyamines regulate their synthesis by inducing expression and blocking degradation of ODC antizyme. EMBO J. 2004 Dec 8; 23(24): 4857-67

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Publications

TitleJournalYear
Analysis of Cotranslational Polyamine Sensing During Decoding of ODC Antizyme mRNA. Methods Mol Biol. 2018;1694:309-323. doi: 10.1007/978-1-4939-7398-9_26. 2018
A disease-associated mutant of NLRC4 shows enhanced interaction with SUG1 leading to constitutive FADD dependent caspase-8 activation and cell death. J Biol Chem., 292(4):1218-1230 2016
Identification of urinary proteins potentially associated with diabetic kidney disease. Indian J Nephrol. 2016 Nov-Dec;26(6):434-445 2016
Polyamines directly promote antizyme-mediated degradation of ornithine decarboxylase by the proteasome Microbial Cell, 2(6):197-207 2015
Co-translational polyamine sensing by nascent polypeptide. Springer Book: Regulatory Nascent Polypeptide. DOI 10.1007/978-4-431-55052-5_12 2014
Ultrafiltration based in vitro assay for determining polyamine binding to purified proteins. Nature-Protocol Exchange. DOI10.1038/protex.2012.005 2012
Impaired Glutamatergic and GABAergic Function at Early Age in A?PPswe-PS1dE9 Mice: Implications for Alzheimer's Disease J. Alzheimer's Dis. 28:765-769 2012
Synthesis and characterization of iron-rich FexPt1?x ferrofluid for magnetic resonance imaging Phys. Scr. 30:1200-13 2012
The N-terminal unstructured domain of yeast ODC functions as a transplantable and replaceable ubiquitin-independent degron. J Mol Biol. 407(3):354-67 2011
Polyamine sensing by nascent ornithine decarboxylase antizyme stimulates decoding of its mRNA. Nature. 477(7365):490-4 2011
. Role of 14-bp insertion/deletion polymorphism in HLA-G among Indian women with recurrent spontaneous abortions. Tissue Antigens. 77:131-135. 2011
Genetic Analysis of the Glycoprotein 2 Gene (GP2) in Patients with Chronic Pancreatitis Pancreas. 39(3):353-58 2010
Catalytic mechanism and assembly of the proteasome. Chem Rev. 109(4):1509-36. 2009
Fibrillogenic and non-fibrillogenic ensembles of SDS-bound human a-synuclein, Journal of Molecular Biology Journal of Molecular Biology., 364: 1061-1072 2006
Polyamines regulate their synthesis by inducing expression and blocking degradation of ODC antizyme. EMBO J. 23(24): 4857-67. 2004
Studies on the alpha-crystallin target protein binding sites: sequential binding with two target proteins. Molecular Vision., 7: 114-119 2001
Norbornene-constrained cyclic peptides with hairpin architecture: design, synthesis, conformation, and membrane ion transport J Org Chem., 65(2): 365-74 2000
Correlation between the DNA supercoiling and the initiation of transcription of E. coli RNA polymerase in vitro : role of the sequences upstream of the promoter regions. FEBS Letters 260, 273-276, 1990. 1990
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Palani Murugan Rangasamy

Senior Scientist

2529

murugan@ccmb.res.in

Sanjay Kumar Suman

Technical Officer

2553

sanjaysuman@ccmb.res.in

Ganapathi Kandasamy

Post Doctoral Fellow

2553

ganapathi.k@ccmb.res.in

Ashis Kumar Pradhan

Senior Research Fellow

2553

ashispradhan@ccmb.res.in