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Pavithra L Chavali

Project Scientist

Research Interests

Our group focusses on understanding cell cycle regulatory mechanisms underlying normal development and disease manifestation. For this we study genes (i) with mutations linked to microcephaly (small brain) and (ii) whose dysregulation/dysfunction is associated with neural cancers. We use state-of-the-art cell and molecular biology approaches in neural cancer /stem cells and brain organoids, to establish the spatio-temporal roles of such developmentally important proteins.

Scholar profile

Selected Publications

Chavali PL, Stojic L, Gergely F. Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication. Science. 2017; 357: 83-88.

Chavali S, Chavali PL, Chalancon G, de Groot NS, Gemayel R, Latysheva NS, Ing-Simmons E, Verstrepen KJ, Balaji S, Babu MM. Constraints and consequences of the emergence of amino acid repeats in eukaryotic proteins. Nature Structural & Molecular Biology. 2017; 24:765-777.

Chavali PL, Chandrasekaran G, Barr AR, Tatrai P, Taylor C, Papachristou EK, Woods CG, Chavali S, Gergely F. A CEP215-HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer. Nature Communications. 2016; 7: 11005.

Chavali PL, et al. TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival. Cell Death & Disease. 2014; 5: e1502.

McIntyre RE, Chavali PL, et al. Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome. PLoS Genetics. 2012; 8: e1003022.

Education & Experiance

P.G: Life Sciences ; Pondicherry University ; 2003
Ph.D: ‘Regulation of MAR Binding Protein SMAR1 under stress: Implications on the cell cycle by modulation of ATM-p53- MDM2 pathways’ ; University of Pune, India (National Centre for Cell Science, Pune) ; 2009
Post.Doc:

Adult neural and cancer stem cells ; Sahlgrenska Academy, Gothenburg University, Sweden ; 2009-2010

Cell and developemental biology ; University of Cambridge, cancer Research UK, Cambridge UK ; 2010-2016

Experience:

Investigator Scientist, MRC Laboratory of Molecular Biology, Cambridge, UK . 2016-2018

Publications

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First slide

Pavithra L Chavali

Project Scientist

2695

plchavali@ccmb.res.in

Dhruv Kumar Shakyawar

Post-Doctoral Fellow

2695

Sourav Ganguli

Junior Research Fellow

2695

Balaji Prasanna Kumar G

Project Assistant -II

2695

Chavata Naga Ravi Teja

Junior Research Fellow(Project)

2695