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Rajan Sankaranarayanan-Img

Rajan Sankaranarayanan

Outstanding Scientist
Email: sankar@ccmb.res.in
Phone: +91-040-27192832

Research Interests

Our laboratory is interested in exploring the mechanistic basis and functional relevance of unique proofreading mechanisms that are operational in the cell to maintain a high fidelity during translation of the genetic code. We are particularly interested in a D-aminoacyl-tRNA deacylase(DTD)-fold present in two functional contexts a) as an editing module of archaeal threonyl-tRNA synthetases and b) as a free standing domain responsible for 'Chiral proofreading' i.e removal of D-amino acids mistakenly attached to tRNA. We are currently looking at the biological role of DTD using cell biological as well as in vivo approaches using model systems like drosophila and mouse. Structural biology work is underway on a couple of other proofreading systems for which the mechanism is not well understood.

Selected Publications

Kumar P, Babu KSD, Singh AK, Singh DK, Nalli A, Mukul SJ, Roy A, Mazeed M, Raman B, Kruparani SP, Siddiqi I, Sankaranarayanan R.(2023) Distinct localization of chiral proofreaders resolves organellar translation conflict in plants. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2219292120. doi: 10.1073/pnas.2219292120. Epub 2023 Jun 5. PMID: 37276405; PMCID: PMC10268278.

Sivakumar K, Venkadasamy VL, Amudhan G, Ann KJ, Goud GK, Nayani K, Gogoi J, Kuncha SK, Mainkar PS, Kruparani SP, Sankaranarayanan R.(2023) Design principles and functional basis of enantioselectivity of alanyl-tRNA synthetase and a chiral proofreader during protein biosynthesis. Nucleic Acids Res. 2023 Apr 24;51(7):3327-3340. doi: 10.1093/nar/gkad205. PMID: 36951106; PMCID: PMC10123102.

Mondal,S., Kinatukara,P., Singh, S., Shambhavi, S., Patil,G.S., Dubey,N., Singh,S.H., Pal,B., Shekar,P.C., Kamat,S.S., Sankaranarayanan, R. (2022) DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes. elife doi: 10.7554/eLife.77665.

Kumar, P., Bhatnagar, A. & Sankaranarayanan, R. (2022) Chiral Proofreading during protein biosynthesis and its evolutionary implications. FEBS Lett DOI: 10.1002/1873-3468.14419

Gogoi, J., Bhatnagar, A., Ann, K.J., Pottabathini, S., Singh, R., Mazeed, M., Kuncha, S.K., Kruparani, S.P., Sankaranarayanan, R. (2022) Switching a conflicted bacterial DTD-tRNA code is essential for the emergence of mitochondria. Sci. Adv. 8, eabj7307, 1-9. doi: 10.1126/sciadv.abj7307.

Patil G. S. , Kinatukara P., Mondal S., Shambhavi S., Patel K.D., Pramanik S., Dubey N., Narasimhan S., Madduri M K, Pal B, Gokhale R S, & Sankaranarayanan R. (2021) A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation. elife doi: 10.7554/eLife.70067.

Education & Experience

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Publications

Rajan Sankaranarayanan-Group Pic
Rajan Sankaranarayanan-Img

Rajan Sankaranarayanan

Outstanding Scientist

2832

sankar@ccmb.res.in

P Shobha Krupa Rani-Img

P Shobha Krupa Rani

Sr Principal Scientist

2835

pshobha@ccmb.res.in

Biswajit Pal-Img

Biswajit Pal

Principal Scientist

2831

pal@ccmb.res.in

P Sambhavi-Img

P Sambhavi

Sr. Technical Officer (1)

2835

sambavi@ccmb.res.in

Jotin Gogoi-Img

Jotin Gogoi

Senior Research Fellow

2834

jotin@ccmb.res.in

Pradeep Kumar-Img

Pradeep Kumar

Senior Research Fellow

2834

pradeep@ccmb.res.in

Sudipta Mondal-Img

Sudipta Mondal

Senior Research Fellow

2834

sudipta@ccmb.res.in

Koushick S-Img

Koushick S

Senior Research Fellow

2835

koushick@ccmb.res.in

Sakshi Shambhavi-Img

Sakshi Shambhavi

Senior Research Fellow

2834

sakshi@ccmb.res.in

Priyadarshan Kinatukara-Img

Priyadarshan Kinatukara

Research Associate (Project)

2833

priyadarshan@ccmb.res.in

Mukul J S-Img

Mukul J S

Junior Research Fellow

2834

mukuljs@ccmb.res.in

Santhosh K-Img

Santhosh K

Junior Research Fellow

2834

santhosh.k@ccmb.res.in

Suhail Madhar Hanif S -Img

Suhail Madhar Hanif S

Junior Research Fellow

2834

suhailhanif@ccmb.res.in

Nisha Gupta-Img

Nisha Gupta

Junior Research Fellow

2835

nishagupta@ccmb.res.in

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Priyam Chopra

Junior Research Fellow

2834

Nikita Shukla-Img

Nikita Shukla

Project Associate-I

2835

nikita.shukla@ccmb.res.in

Pujaita Banerjee-Img

Pujaita Banerjee

Project Associate-I

2835

pujaita@ccmb.res.in