CSIR - Centre for Cellular & Molecular Biology
Council of Scientific and Industrial Research
Ministry of Science & Technology, Govt. of India
Senior Principal Scientist
Email: schauhan@ccmb.res.in
Phone: 04027192635
Research Interests
Autophagy is one of the most fundamental cell survival processes that executes numerous homeostatic programs of normal and stressed cells. Dysfunctional autophagy is linked to multiple diseases including cancer, infectious diseases and metabolic disorders. Our lab tries to understand the molecular mechanisms by which autophagy executes its functions in healthy and diseased cells.
The major contributor to acute inflammation is the innate immune systems that gets activated upon microbial invasion or sterile tissue damage. Our lab study the mechanisms of innate immune responses to bacteria, viruses and sterile tissue damages.
Also, we are interested in understanding the crosstalk between autophagy and innate immune responses in autoimmune diseases. In addition we are interested in understanding the mechanisms of cancer progression. Especially, we are interested in the immunological response (esp. type 1 interferons) to cancer.
For more details please visit https://www.autophagylab.com/
Selected Publications
Jena KK, Mehto S, Yadav R, Priyadarsini S, Samal P, Krishna S, Dhar K, Jain A, Chauhan NR, Murmu KC, Bal R, Sahu R, Jaiswal P, Sahoo BS, Patnaik S, Kufer TS, Rusten TE, Chauhan S, Prasad P, Chauhan S. Selective Autophagy of RIPosomes Maintains Innate Immune Homeostasis during Bacterial Infection. EMBO J. 2022 Dec 1;41(23):e111289.
Nath P, Chauhan NR, Jena KK, Datey A, Kumar ND, Mehto S, De S, Nayak TK, Priyadarsini S, Rout K, Bal R, Murmu KC, Kalia M, Patnaik S, Prasad P, Reggiori F, Chattopadhyay S*, Chauhan S*. Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses. EMBO Rep. 2021 Sep 1:e52948. (Cover page article)
Kolapalli SP, Sahu R, Chauhan NR, Jena KK, Mehto S, Das SK, Jain A, Rout M, Dash R, Swain R, Lee DY, Rusten TE, Chauhan S*, Chauhan S*. RNA binding RING E3-ligase DZIP3/hRUL138 is a novel driver of cell cycle and cancer progression by employing a unique mechanism to stabilize Cyclin D1. Cancer Research, 2021 Jan 15;81(2):315-331. (Cover page article)
Jena KK, Mehto S, Nath P, Chauhan NR, Sahu R, Dhar K, Das SK, Kolapalli SP, Murmu KC, Jain A, Krishna S, Sahoo BS, Chattopadhyay S, Rusten TE, Prasad P, Chauhan S, Chauhan S*. Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response. EMBO Rep. 2020 Jul 27:e50051.
Mehto S, Jena KK, Nath P, Chauhan S, Kolapalli SP, Das SK, Sahoo PK, Jain A, Taylor GA, Chauhan S*. The Crohn's disease risk factor IRGM limits NLRP3 inflammasome activation by impeding its assembly and by mediating its selective autophagy. Molecular Cell. 2019 Feb 7;73(3):429-445.e7. (Publication highlighted in the issue)
Jena KK, Kolapalli SP, Mehto S, Nath P, Das B, Sahoo PK, Ahad A, Syed GH, Raghav SK, Senapati S, Chauhan S, Chauhan S*. TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. EMBO J. 2018 Sep 14;37(18).
Education & Experience
P.G: | MSc (Biotechnology) ; Guru Nanak Dev University, ; 2004 |
Ph.D: | Molecular Microbiology ; AIIMS, New Delhi, India ; 2009 |
Post.Doc: | MD Anderson Cancer Center, USA ; (2009-2012)
|
Experience: |
|
data Found.... data Found.... data Found.... data Found.... data Found.... data Found.... data Found.... data Found.... data Found.... data Found.... data Found.... data Found.... |
No data Found.... No data Found.... No data Found.... No data Found.... No data Found....No data Found.... No data Found.... No data Found.... No data Found.... No data Found....
Title | Journal | Year |
---|---|---|
SMARCD1 negatively regulates myeloid differentiation of leukemic cells via epigenetic mechanisms. | Blood Adv. 2022. | 2022 |
Selective Autophagy of RIPosomes Maintains Innate Immune Homeostasis during Bacterial Infection. | EMBO J Dec 1;41(23):e111289. (Cover page article) | 2022 |
RNA binding RING E3-ligase DZIP3/hRUL138 is a novel driver of cell cycle and cancer progression by employing a unique mechanism to stabilize Cyclin D1. | Cancer Research,2021 Jan 15;81(2):315-331. (Cover page article) | 2021 |
Inhibition of IRGM establishes a robust antiviral immune state to restrict pathogenic viruses. | EMBO Rep. 2021. | 2021 |
IRGM Links Autoimmunity to Autophagy. | Autophagy.2020 Aug 19. PMID: 32813580. | 2020 |
Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response. | EMBO Rep. 2020 Jul 27:e50051. | 2020 |
TRIM16 governs the biogenesis and disposal of stress-induced protein aggregates to evade cytotoxicity: implication for neurodegeneration and cancer. | Autophagy. 2019 May;15(5):924-926. | 2019 |
IRGM restrains NLRP3 inflammasome activation by mediating its SQSTM1/p62-dependent selective autophagy. | Autophagy.?2019 Jun 20:1-3. | 2019 |
The Crohn's disease risk factor IRGM limits NLRP3 inflammasome activation by impeding its assembly and by mediating its selective autophagy. | Molecular Cell. 2019 Feb 7;73(3):429-445.e7. | 2019 |
TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. | EMBO J. 2018 Sep 14;37(18). | 2018 |
Galectins and TRIMs directly interact and orchestrate autophagic response to endomembrane damage. | Autophagy. 2017 Jun 3;13(6):1086-1087. | 2017 |
TRIMs and Galectins globally cooperate and TRIM16 and Galectin-3 codirect autophagy in endomembrane damage homeostasis. | Developmental Cell, 2016. | 2016 |
Mechanism of action of the tuberculosis and Crohn disease risk factor IRGM in autophagy. | Autophagy. 2015 Aug 27:0. PMID: 26313894 | 2015 |
IRGM governs the core autophagy machinery to conduct antimicrobial defense. | Molecular Cell. Volume 58, Issue 3, p507-521, 7 May, | 2015 |
Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential. | Nature Communication. 2015 Oct 27;6:8620. doi: 10.1038/ncomms9620. | 2015 |
Neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis. | Current Biology (Cell Press). 2014 Mar 17;24 (6):609-20. | 2014 |
TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. | Developmental Cell. 2014 Aug 25; 30(4):394-409. | 2014 |
ZKSCAN3 Is a Master Transcriptional Repressor of Autophagy. | Molecular Cell. Apr 11;50(1):16-28. | 2013 |
Comprehensive insights into Mycobacterium tuberculosis DevR (DosR) regulon activation switch. | Nucleic Acids Research. 2011 Sep 1;39(17):7400-14. | 2012 |
Regulation of u-PAR gene expression by H2A.Z is modulated by the MEK-ERK/AP-1 pathway. | Nucleic Acids Research. 2012 Jan; 40 ?? (2):600-13. | 2012 |
K182G substitution in DevR or C(8) G mutation in the Dev box impairs protein-DNA interaction and abrogates DevR-mediated gene induction in Mycobacterium tuberculosis. | FEBS J. 2011 Jun; 278(12):2131-9. | 2011 |
Analysis of transcription at the oriC locus in Mycobacterium tuberculosis. | Microbiol Res. 2011 Sep 20;166(6):508-14. | 2011 |
A single-nucleotide mutation in the -10 promoter region inactivates the narK2X promoter in Mycobacterium bovis and Mycobacterium bovis BCG and has an application in diagnosis. | FEMS Microbiol Lett.2010, Feb;303(2):190-6. | 2010 |
CmtR, a cadmium-sensing ArsR-SmtB repressor, cooperatively interacts with multiple operator sites to autorepress its transcription in Mycobacterium tuberculosis. | FEBS J. 2009, Jul; 276(13):3428-39. | 2009 |
Powerful induction of divergent tgs1-Rv3131 genes in Mycobacterium tuberculosis is mediated by DevR interaction with a high-affinity site and an adjacent cryptic low-affinity site. | Journal of Bacteriology. 2009, Oct;191(19):6075-81. | 2009 |
Cooperative binding of phosphorylated DevR to upstream sites is necessary and sufficient for activation of the Rv3134c-devRS operon in Mycobacterium tuberculosis: Implication in the induction of DevR target genes. | Journal of Bacteriology, June 2008, p. 4301?4312, 190, No.12. | 2008 |
Interaction of DevR with Multiple Binding Sites Synergistically Activates Divergent Transcription of narK2-Rv1738 Genes in Mycobacterium tuberculosis. | Journal of Bacteriology. Aug 2008, p. 5394-5403, 190, No. 15. | 2008 |
Transcription and autoregulation of Rv3134c-devR-devS operon of Mycobacterium tuberculosis. | Microbiology(2005), 151, 4045-4053. | 2005 |
2635
schauhan@ccmb.res.in
2638
jagamohan@ccmb.res.in
2635
soumyakundu@ccmb.res.in
2635
vennela@ccmb.res.in