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Research Interests

The interest of the group lies in sequence analysis of genomic and protein sequences. In particular, we have been involved in designing de novo methods for the prediction of protein-coding genes. We are also looking at possible role of SNPs as diagnostic markers or as causative agents for diseases. Given a set of SNPs potentially associated with a phenotype, we have developed an algorithm to prioritise those that are likely to be truly associated. We have also interest in the analysis of non-coding RNAs, prediction of novel miRNAs harboured in genes of interest.

Selected Publications

 

Reddy, B.V.B., Ramesh, P. and Tiwari, S. 1998 “MEICPS: A program to suggest substituted point mutations to engineer intracellular protein stability”, Bioinformatics 14, 225-226.

 

Reddy, B.V.B., Datta S. and Tiwari, S. 1998 “Use of propensities of amino acids to the local structural environments to understand effect of substitution mutations on protein stability”, Protein Engineering 11, 1137-1145.

 

Jehan, Z., Vallinayagam, S., Tiwari, S., Pradhan, S., Singh, L. Suresh, A., Reddy, H.M., Ahuja, Y.R. and Jesudasan, R.A. 2007 “Novel non-coding RNA from human Y distal heterochromatic block (Yq12) generates testis-specific chimeric Cdc2L2”, Genome Research 17, 433-440.

 

A. Bhardwaj, M. Mukherji, S. Sharma, J. Paul, C.S. Gokhale, A.K. Srivastava and S. Tiwari (2009) “MtSNPscore: a combined evidence approach for assessing cumulative impact of mitochondrial variations in disease”, BMC Bioinformatics 10 (Suppl 8), S7.

 

Education & Experiance

P.G: Physics ; IIT Kanpur ; 1990
Ph.D: Studies in complexity: Applications to dynamical systems and genomic sequences ; JNU, New Delhi ; 1996
Post.Doc:

Protein stability and secondary structure prediction ; CCMB, Hyderabad ; 1997-1999

Protein structure analysis ; NCI, NIH, Bethesda, Maryland, USA ; 1999-2001

Publications

TitleJournalYear
Molecular modelling of the human serotonin1A receptor: role of membrane cholesterol in ligand binding of the receptor 1. Mol. Biosys. 7, 224-234 (2011). 2011
Identification of cholesterol recognition amino acid consensus (CRAC) motif in G-protein coupled receptors 1. Biochem. Biophys. Res. Comm. 404, 569-573 (2011). 2011
Structural and antigenic variance between novel influenza A/H1N1/2009 and influenza A/H1N1/2008 viruses 1. J. Infect. Dev. Ctries 4, 001-006 (2010). 2010
Are specific nonannular cholesterol binding sites present in G-protein coupled receptors? Biochimica et Biophysica Acta 1788, 295-302 (2009). 2009
MtSNPscore: a combined evidence approach for assessing cumulative impact of mitochondrial variations in disease BMC Bioinformatics 10 (Suppl 8), S7 (2009). 2009
Genetic landscape of the people of India: a canvas for disease gene exploration Journal of Genetics 87, 3-20 (2008). 2008
Novel non-coding RNA from human Y distal heterochromatic block (Yq12) generates testis-specific chimeric Cdc2L2 Genome Research 17, 433-440 (2007). 2007
The Indian Genome Variation databases (IGVdb): a project review 1. Human Genetics 118, 1-11 (2005). 2005

Shrish Tiwari

Principal Scientist

2777

shrish@ccmb.res.in

Prachi Singh

Scientist

2777

prachisingh@ccmb.res.in

P Ramesh

Principal Technical Officer

2628/2786

rameshp@ccmb.res.in

Deepti Rao

Senior Research Fellow

2961

deeptirao@ccmb.res.in

Tummala Nikhila Sai

Project Assistant-II

2960