The interest of the group lies in sequence analysis of genomic and protein sequences. In particular, we have been involved in designing de novo methods for the prediction of protein-coding genes. We are also looking at possible role of SNPs as diagnostic markers or as causative agents for diseases. Given a set of SNPs potentially associated with a phenotype, we have developed an algorithm to prioritise those that are likely to be truly associated. We have also interest in the analysis of non-coding RNAs, prediction of novel miRNAs harboured in genes of interest.
Reddy, B.V.B., Ramesh, P. and Tiwari, S. 1998 “MEICPS: A program to suggest substituted point mutations to engineer intracellular protein stability”, Bioinformatics 14, 225-226.
Reddy, B.V.B., Datta S. and Tiwari, S. 1998 “Use of propensities of amino acids to the local structural environments to understand effect of substitution mutations on protein stability”, Protein Engineering 11, 1137-1145.
Jehan, Z., Vallinayagam, S., Tiwari, S., Pradhan, S., Singh, L. Suresh, A., Reddy, H.M., Ahuja, Y.R. and Jesudasan, R.A. 2007 “Novel non-coding RNA from human Y distal heterochromatic block (Yq12) generates testis-specific chimeric Cdc2L2”, Genome Research 17, 433-440.
A. Bhardwaj, M. Mukherji, S. Sharma, J. Paul, C.S. Gokhale, A.K. Srivastava and S. Tiwari (2009) “MtSNPscore: a combined evidence approach for assessing cumulative impact of mitochondrial variations in disease”, BMC Bioinformatics 10 (Suppl 8), S7.
Education & Experiance
|P.G:||Physics ; IIT Kanpur ; 1990|
|Ph.D:||Studies in complexity: Applications to dynamical systems and genomic sequences ; JNU, New Delhi ; 1996|
Protein stability and secondary structure prediction ; CCMB, Hyderabad ; 1997-1999
Protein structure analysis ; NCI, NIH, Bethesda, Maryland, USA ; 1999-2001
|Molecular modelling of the human serotonin1A receptor: role of membrane cholesterol in ligand binding of the receptor||1. Mol. Biosys. 7, 224-234 (2011).||2011|
|Identification of cholesterol recognition amino acid consensus (CRAC) motif in G-protein coupled receptors||1. Biochem. Biophys. Res. Comm. 404, 569-573 (2011).||2011|
|Structural and antigenic variance between novel influenza A/H1N1/2009 and influenza A/H1N1/2008 viruses||1. J. Infect. Dev. Ctries 4, 001-006 (2010).||2010|
|Are specific nonannular cholesterol binding sites present in G-protein coupled receptors?||Biochimica et Biophysica Acta 1788, 295-302 (2009).||2009|
|MtSNPscore: a combined evidence approach for assessing cumulative impact of mitochondrial variations in disease||BMC Bioinformatics 10 (Suppl 8), S7 (2009).||2009|
|Genetic landscape of the people of India: a canvas for disease gene exploration||Journal of Genetics 87, 3-20 (2008).||2008|
|Novel non-coding RNA from human Y distal heterochromatic block (Yq12) generates testis-specific chimeric Cdc2L2||Genome Research 17, 433-440 (2007).||2007|
|The Indian Genome Variation databases (IGVdb): a project review||1. Human Genetics 118, 1-11 (2005).||2005|