CSIR - Centre for Cellular & Molecular Biology
Council of Scientific and Industrial Research
Ministry of Science & Technology, Govt. of India
Senior Scientist
Email: sonalnj@ccmb.res.in
Phone: +91-040-27192574
Research Interests
Neural stem cells self-renew to maintain their pool, yet differentiate into enormous functionally and morphologically distinct neurons and glia. Proper regulation of self-renewal and differentiation has profound consequences in development and homeostasis. Decreased neurogenesis could lead to defects in brain development resulting in neurodevelopmental disorders like microcephaly, epilepsy and autism. On the other hand, an increase in self-renewal could lead to malignancies such as cancer. We are interested in identifying the mechanisms and the molecular players underlying neural stem cell self-renewal and differentiation. To study these processes, we use Drosophila developing brain and human neuronal stem cells as model systems. We utilize state of the art genome editing tools and a diverse set of cell and molecular biology approaches.
Selected Publications
Cheramangalam RN, Anand T, Pandey P, Balasubramanian D, Varghese R, Singhal N, Nagarkar Jaiswal N#, Jaiswal M# (2023) Bendless is essential for PINK1-Park mediated Mitofusin degradation under mitochondrial stress caused by loss of LRPPRC. eLife.88318.3
Nagarkar-Jaiswal S.#, Manivannan SN, Zuo Z., Bellen HJ#. Flip-Flop, a facile, cell cycle-independent, conditional gene inactivation strategy differentially tagging wild-type and mutant cells eLife 6:e26420
Skinner SO*, Xu H*, Nagarkar-Jaiswal S, Freire PR, Zwaka TP, Golding I. Single-cell analysis of transcription kinetics across the cell cycle. eLife 5:e12175
Nagarkar-Jaiswal S*, DeLuca S*, Lee PT, Lin WW, Pan H, Zuo Z, Lv Z, Spradling AC, Bellen HJ (2015). A genetic toolkit for tagging intronic MiMICs containing genes. eLife 4:e08469
Carrillo CA*,Ozkan E*, Menon KP*, Nagarkar-Jaiswal S, Jeon M, Bellen HJ, Garcia CK, Zinn K. Control of synaptic connectivity in Drosophila by a network of IgSF surface proteins. Cell 163:1770-1782 (*equal contribution)
Nagarkar-Jaiswal S, Lee PT, Campbell ME, Chen K, Anguiano-Zarate S, Cantu Gutierrez M, Busby T, Lin WW, He Y, Schulze KL, Booth BW, Evans-Holm M, Venken KJ, Levis RW, Spradling AC, Hoskins RA, Bellen HJ (2015) A library of MiMICs allows tagging of genes and reversible spatial and temporal knockdown of proteins in Drosophila. eLife 4:e05338
(# Co-corresponding authors)(*equal contribution)
Education & Experience
P.G: | Industrial Microbiology ; Devi Ahilya Vishwavidyalaya, Indore, India ; 2003 |
Ph.D: | Chromosome dynamics during cell divisions in Drosophila melanogaster ; University of Bayreuth, Germany ; 2010 |
Post.Doc: | Genetics ; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, USA ; 2012-2017 Stem cells ; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, USA ; 2010-2012 |
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Title | Journal | Year |
---|---|---|
DYRK1A interacts with Tuberous Sclerosis complex and promotes mTORC1 activity. | eLife12:RP88318. | 2023 |
Bendless is essential for PINK1-Park mediated Mitofusin degradation under mitochondrial stress caused by loss of LRPPRC | PLoS Genet 19(4): e1010493 | 2023 |
Methods for Creating Fly Models to Understand the Molecular Mechanisms Underlying Neurological Diseases | Book: Insights into Human Neurodegeneration: Lessons Learnt from Drosophila | 2019 |
Methods for Creating Fly Models to Understand the Molecular Mechanisms Underlying Neurological Diseases | Insights into Human Neurodegeneration: Lessons Learnt from Drosophila, 37-54 | 2019 |
Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-? and Dpr10. | Elife. 2019 Feb 4;8. pii: e42692 | 2019 |
Transsynaptic interactions between IgSF proteins DIP-? and Dpr10 are required for motor neuron targeting specificity in Drosophila. | Elife. 2019 Feb 4;8. pii: e42690 | 2019 |
Flip-flop Mediated Conditional Gene Inactivation in Drosophila. | Bio-protocol 9(3): e3157 (* Corresponding author) | 2019 |
Ari-1 regulates myonuclear organization together with Parkin and is associated with aortic aneurysms. | Developmental Cell 45:226-244. | 2018 |
Neuron-subtype-specific expression, interaction affinities, and specificity determinants of DIP/Dpr cell recognition proteins. | Neuron 6, P1385-1400.E6 | 2018 |
Loss of Nardilysin, a chaperone for a-Ketoglutarate Dehydrogenase, causes neurodegeneration in flies and humans and promotes mTORC1 activation. | Neuron 93:115-131 | 2017 |
Flip-Flop, a facile, cell cycle-independent, conditional gene inactivation strategy differentially tagging wild-type and mutant cells. | eLife 6:e26420 (*Corresponding author) | 2017 |
Single-cell analysis of transcription kinetics across the cell cycle. | eLife5:e12175 | 2016 |
The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals. | eLife 5:e15258 | 2016 |
A library of MiMICs allows tagging of genes and reversible spatial and temporal knockdown of proteins in Drosophila. | eLife 4:e05338 | 2015 |
A voltage gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. | PLoS Biology 13:e1002103 | 2015 |
A genetic toolkit for tagging intronicMiMICs containing genes. | eLife4:e08469 | 2015 |
Complementary Expression of Ig superfamily ligands and receptors in synaptic pairs in the Drosophila visual system. | Cell163:1770-1782 | 2015 |
Control of synaptic connectivity in Drosophila by a network of IgSF surface proteins. | Cell163:1770-1782 | 2015 |
The Cohesin Subunit Rad21 Is Required for Synaptonemal Complex Maintenance, but Not Sister Chromatid Cohesion, during Drosophila Female Meiosis. | PLoS Genetics 10(8):e1004540 (*equal contribution) | 2014 |
Functional dissection of the Drosophila melanogaster condensin subunit Cap-G reveals its exclusive association with condensin I. | PLoS Genetics 9(4):e1003463. | 2013 |
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sonalnj@ccmb.res.in
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nandan@ccmb.res.in
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aishwarya.arun@ccmb.res.in
2576
sachin.gupta@ccmb.res.in
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priyankapandey@ccmb.res.in
ayesha@csirccmb.org