Training on Faster COVID-19 Testing
CSIR - Centre for Cellular & Molecular Biology
Council of Scientific and Industrial Research
Ministry of Science & Technology, Govt. of India
Principal Scientist
Email: sst@ccmb.res.in
Phone: 2865
Research Interests:
Cancer is one of the most intricate and life-threatening diseases. Our laboratory would like to understand how does the initiation of cancer happens in the human body. Notably, the mechanistic details and process of cancer initiation are still not well understood. Our research interests involve understanding the initiation of cancers and their progression in cancer development, including metastasis for the childhood and aggressive cancers. We are especially interested in investigating the role of the loss of cancer suppression genes and the involvement of post-translational modifications in the initiation of cancers using cell biology, mouse models, and modern biology approaches including mass spectrometry based quantitative and targeted proteomics. Furthermore, the biomarkers involved in the cancer initiation and progression for childhood and aggressive cancers will serve as targets for developing cancer therapeutics.
Selected Publications:
Chatterjee B, Thakur SS, Single-run mass spectrometry analysis provides deep insight into E. coli proteome J Am Soc Mass Spectrom. 2018 Dec;29(12):2394-2401. doi: 10.1007/s13361-018-2066-z. (Research Highlights of this paper appeared in Nature India)
Kallamadi PR, Dandu K, Kirti PB, Rao CM, Thakur SS, Mulpuri S. An Insight into Powdery Mildew-Infected, Susceptible, Resistant, and Immune Sunflower Genotypes. Proteomics. 2018 Jun 19:e1700418. doi: 10.1002/pmic.201700418 (Selected for Front Cover Page and Research Highlights of this paper appeared in Nature India)
Vardhishna, M.V, Srinivasulu, G, Harikrishna, A., Thakur, SS, Chatterjee, B. Simultaneous Occurrence of Nanospheres and Nanofibers Self-Assembled from Achiral Tripeptides Chemistry Open 2019 Jan 15;8(3):266-270. https://doi.org/10.1002/open.201800258 (Selected for Cover feature)
Sehgal N, Gupta A, Valli RK, Joshi SD, Mills JT, Hamel E, Khanna P, Jain SC, Thakur SS, Ravindranath V. Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver. Proc. Natl. Acad. Sci. U S A. 2012 Feb 28;109(9):3510-5. doi: 10.1073/pnas.1112209109.
Thakur SS, Geiger T, Chatterjee B, Bandilla P, Froehlich F, Cox J, Mann M. Deep and highly sensitive proteome coverage by LC-MS/MS without pre-fractionation. Mol Cell Proteomics. 2011 Aug; 10 (8): M110.003699. doi: 10.1074/mcp.M110.003699. (Most-Read Article in Mol Cell Proteomics during August 2011)
Education & Experience
| P.G: | 1998 ; Ranchi University Ranchi ; |
| Ph.D: | Delhi University, Delhi ; 2002 ; |
| Post.Doc: | Walter Reed Army Institute of Research, Silver Spring, Maryland, MD, USA ; 2002-2004 ; Indian Institute of Science, Bangalore, India ; 2005-2009 ; Max Planck Institute of Biochemistry, Munich, Germany ; 2009-2011 ; |
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| Invention | Countries of filing the patent | Application number | Publication number | Status | Grant Number |
|---|---|---|---|---|---|
| Withania somnifera plant extract and method of preparation thereof | USA | 13/003,758 | WO2010/013254 | Granted | Patent No: US, 8,481,087 B2 |
| Title | Journal | Year |
|---|---|---|
| Valuable Contributions and Lessons Learned from Proteomics and Metabolomics Studies of COVID-19 | J Proteome Research | 2024 |
| Hypothalamic protein profiling from mice subjected to social defeat stress | Molecular Brain | 2024 |
| Cancer stem cell research: A phosphoproteomic approach | Elsevier, Academic Press | 2023 |
| Proteins and Metabolites fingerprints of Gestational Diabetes Mellitus forming Protein-Metabolite Interactomes are its potential biomarkers | Proteomics | 2023 |
| Diverse vaccine platforms safeguarding against SARS-CoV-2 and its variants, | Expert Rev Vaccines | 2022 |
| SARS-CoV-2 Infection Triggers Phosphorylation: Potential Target for Anti-COVID-19 Therapeutics | Front Immunol | 2022 |
| An insight into major signaling pathways and protein-protein interaction networks involved in the pathogenesis of gestational diabetes mellitus | Proteomics | 2022 |
| Remdesivir and its combination with repurposed drugs as COVID-19 therapeutics | Front Immunol | 2022 |
| Editorial: Proteomics and Its Applications in Cancer | Front. Oncol | 2021 |
| Ageing of Hematopoietic Stem Cells: Insight into Mechanisms and Consequences | Elsevier, Academic Press | 2021 |
| Proteomics and its application in endocrine disorders | Biochim Biophys Acta Proteins Proteom, | 2021 |
| Proteomics and Its Application in Pandemic Diseases. | J Proteome Res | 2020 |
| ACE2 as a potential therapeutic target for pandemic COVID-19 | RSC Adv. | 2020 |
| Simultaneous Occurrence of Nanospheres and Nanofibers Self-Assembled from Achiral Tripeptides | Chemistry Open | 2019 |
| Drug Repurposing for Retinoblastoma: Recent Advances | Curr Top Med Chem | 2019 |
| Achievements in cancer research and its therapeutics in hundred years | Curr Top Med Chem | 2019 |
| Studies on the DNA binding and anticancer activity of Ru(II) polypyridyl complexes by using a (2-(4-(diethoxymethyl)-1H-imidazo[4,5-f][1,10] phenanthroline)) intercalative ligand | New J. Chem | 2018 |
| Comparison of Nuclear Matrix and Mitotic Chromosome Scaffold proteins in Drosophila S2 cells - Transmission of hallmarks of nuclear organization through mitosis. | Mol Cell Proteomics | 2018 |
| Absence of?Wdr13?Gene Predisposes Mice to Mild Social Isolation - Chronic Stress, Leading to Depression-Like Phenotype Associated With Differential Expression of Synaptic Proteins. | Front Mol Neurosci | 2018 |
| An Insight into Powdery Mildew-Infected, Susceptible, Resistant, and Immune Sunflower Genotypes. | Proteomics | 2018 |
| Investigation of post-translational modifications in type 2 diabetes | Clinical Proteomics | 2018 |
| Single-run mass spectrometry analysis provides deep insight into E. coli proteome | J Am Soc Mass Spectrom | 2018 |
| Extracellular region of epidermal growth factor receptor: a potential target for anti-EGFR drug discovery | Oncogene | 2017 |
| Human PRE-PIK3C2B, an intronic cis-element with dual function of activation and repression, | Biochimica et BiophysicaActa (BBA) - Gene Regulatory Mechanisms | 2017 |
| Withaniasomniferahas potential to treat cancer | Springer Press | 2017 |
| Proteomics in India: A Report on Brainstorming Meeting at Hyderabad, India | Mol Cell Proteomics | 2016 |
| Identification of components of the SUMOylation machinery in Candida glabrata: role of the deSUMOylation peptidase CgUlp2 in virulence | J Biol Chem | 2016 |
| Implication of Genetic Deletion of Wdr13 in Mice: Mild Anxiety, Better Performance in Spatial Memory Task, With Upregulation of Multiple Synaptic Proteins | Front. Mol. Neurosci | 2016 |
| Withania somnifera Root Extract has Potent Cytotoxic Effect against Human Malignant Melanoma Cells | PLoS ONE | 2015 |
| Lipopeptides from the Banyan Endophyte, Bacillus subtilis K1: Mass Spectrometric Characterization of a Library of Fengycins | J Am Soc Mass Spectrom | 2012 |
| Withani asomnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver. | Proc. Natl. Acad. Sci. U S A | 2012 |
| ? Mechanism of growth inhibition of intraerythrocytic stages of Plasmodium falciparum by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR). | Mol. Biochem. Parasitol | 2011 |
| Deep and highly sensitive proteome coverage by LC-MS/MS without pre-fractionation. | Mol Cell Proteomics | 2011 |
| Detection of the protein dimers, multiple monomeric states and hydrated forms of Plasmodium falciparum triosephosphate isomerase in the gas phase | Protein Eng Des Sel | 2009 |
| Characterization of Alkali Induced Formation of Lanthionine, Trisulfides and Tetasulfides from Peptide Disulfides using Positive and Negative Ion Mass Spectrometry | J Am Soc Mass Spectrom | 2009 |
| Identification of alpha- and beta-hydroxy acid containing cyclodepsipeptides in natural peptide mixtures using negative ion mass spectrometry. | J Am Soc Mass Spectrom | 2009 |
| Role of 16S ribosomal RNA methylations in translation initiation in Escherichia coli. | EMBO J | 2008 |
| Fragmentation of peptide disulfides under conditions of negative ion mass spectrometry: studies of oxidized glutathione and contryphan. | J Am Soc Mass Spectrom | 2008 |
| Rapid mass spectral identification of contryphans. Detection of characteristic peptide ions by fragmentation of intact disulfide-bonded peptides in crude venom | Rapid Commun Mass Spectrom | 2007 |
| De novo sequencing and disulfide mapping of a bromotryptophan-containing conotoxin by Fourier transform ion cyclotron resonance mass spectrometry | Anal Chem | 2006 |
2865
sst@ccmb.res.in
Notice and Lists of provisionally shortlisted and not shortlisted candidates for the post of Senior Technical Officer(1)/Medical Officer against Advt.No.05/2023