First slide

Tushar Vaidya

Senior Principal Scientist

Research Interests

We are interested in understanding Host Pathogen interactions that dictate the outcome of infection. Our pathogen model system is the protozoan pathogen, Leishmania donovani. Our research work covers three broad areas:Mechanisms of Virulence and Cell survival in Leishmania: identification and analysis of molecules and mechanisms that confer an advantage to the parasite during infection in mammals.Mechanisms of Host Susceptibility/Resistance: We are studying the cellular immune responses in mice of distinct genetic background, to Leishmania infection, over time and in different tissues.Analysis of immunological memory in B-lymphocytes: B-lymphocytes provide immune protection by producing highly specific antibodies in response to foreign antigens and pathogens. While plasma B cells are responsible for the rapid resolution of a current immune challenge, memory B cells are responsible for mounting a rapid response to subsequent exposures. We are currently studying the molecular mechanisms underlying the generation of memory B cells.

Selected Publications

Santosh K Panda, Sunil Kumar, Nitin C Tupperwar, Tushar Vaidya, Anna George, Satyajit Rath, Vineeta Bal and Balachandran Ravindran(2012): Chitohexaose activates macrophages by alternate pathway through TLR4 and blocks Endotoxemia. PLOS Pathogens 8 (5) : e1002717


Vidhi Puri, Aneesh Goyal, Rajan Sankaranarayanan, Anton J Enright and Tushar Vaidya(2011): Evolutionary and functional insights into Leishmania META1: evidence for lateral gene transfer and a role for META1 in secretion. BMC Evol Biol , 11: 334

Shuchismita Satpathy, Gautam Shenoy, Sheetal Kaw, Tushar Vaidya, Vineeta Bal, Satayjit Rath and Anna George(2010): Inhibition of Terminal Differentiation of B cells mediated by CD27 and CD40 involves signaling through JNK. J.Immunology 185;6499-6507

Varanasi Vineeth, Nitin C. Tupperwar, Tushar Vaidya, Vineeta Bal, Anna George, and Satyajit Rath(2010): An endogenous retroviral locus regulates susceptibility to murine leishmanial infection. The Journal of Infectious Diseases 202(8):1234-1245

Nitin Tupperwar, Varanasi Vineeth, Satyajit Rath and Tushar Vaidya (2008): Development of a real-time PCR assay for the quantification of Leishmania species and the monitoring of systemic distribution of the pathogen. Diagnostic Microbiology and Infectious Disease 61: 23-30

No data Found....

No data Found.... No data Found.... No data Found.... No data Found.... No data Found....No data Found.... No data Found.... No data Found.... No data Found.... No data Found....

Publications

TitleJournalYear
Constitutive CD40-signaling calibrates differentiation outcomes in responding B cells via multiple molecular pathways Journal of Immunology 197:761-770 2016
Leishmania donovani Aurora kinase: a promising therapeutic target against visceral leishmaniasis Biochemica et Biophysica Acta 1860: 1973-1988 2016
CD40 Signaling Drives B Lymphocytes into an Intermediate Memory-Like State, Poised Between Na Journal of Cellular Physiology, 229 (10), 1387-1396. 2014
Chitohexaose activates macrophages by alternate pathway through TLR4 and blocks Endotoxemia. PLOS Pathogens 8 (5) : e1002717 2012
Evolutionary and functional insights into Leishmania META1: evidence for lateral gene transfer and a role for META1 in secretion BMC Evol Biol , 11: 334 2011
An endogenous retroviral locus regulates susceptibility to murine leishmanial infection. The Journal of Infectious Diseases 202(8):1234 2010
Inhibition of Terminal Differentiation of B cells mediated by CD27 and CD40 involves signaling through JNK J Immunology 185;6499-6507 2010
Development of a real-time PCR assay for the quantification of Leishmania species and the monitoring of systemic distribution of the pathogen Diagnostic Microbiology and Infectious Disease 61: 23 2008
Induction of autophagic cell death in Leishmania donovani by antimicrobial peptides. Molecular & Biochemical Parasitology 127: 23 2003

Tushar Vaidya

Senior Principal Scientist

2604

tvaidya@ccmb.res.in

Loka Ram Prasad

Senior Research Fellow

2606

loka_ramprasad@ccmb.res.in

Pradyumna Paranjape

Senior Research Fellow

2606

pradyparanjpe@ccmb.res.in

V Devi Prasad

Senior Research Fellow

2606

vdeviprasad@ccmb.res.in

Satyajeet Salunke

Senior Research Fellow

2606

satyajeet@ccmb.res.in

Srishti Rajkumar Mishra

Project Assistant-II

2606

srishtimishra@ccmb.res.in

Rati Ranjan Kar

Project Assistant-II

2537

krati@ccmb.res.in

Kaneez-e-Rabab Khan

Project Assistant-II

2606

kaneez@ccmb.res.in