Senior Principal Scientist
We are interested in understanding Host Pathogen interactions that dictate the outcome of infection. Our pathogen model system is the protozoan pathogen, Leishmania donovani. Our research work covers three broad areas:Mechanisms of Virulence and Cell survival in Leishmania: identification and analysis of molecules and mechanisms that confer an advantage to the parasite during infection in mammals.Mechanisms of Host Susceptibility/Resistance: We are studying the cellular immune responses in mice of distinct genetic background, to Leishmania infection, over time and in different tissues.Analysis of immunological memory in B-lymphocytes: B-lymphocytes provide immune protection by producing highly specific antibodies in response to foreign antigens and pathogens. While plasma B cells are responsible for the rapid resolution of a current immune challenge, memory B cells are responsible for mounting a rapid response to subsequent exposures. We are currently studying the molecular mechanisms underlying the generation of memory B cells.
Santosh K Panda, Sunil Kumar, Nitin C Tupperwar, Tushar Vaidya, Anna George, Satyajit Rath, Vineeta Bal and Balachandran Ravindran(2012): Chitohexaose activates macrophages by alternate pathway through TLR4 and blocks Endotoxemia. PLOS Pathogens 8 (5) : e1002717
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|Constitutive CD40-signaling calibrates differentiation outcomes in responding B cells via multiple molecular pathways||Journal of Immunology 197:761-770||2016|
|Leishmania donovani Aurora kinase: a promising therapeutic target against visceral leishmaniasis||Biochemica et Biophysica Acta 1860: 1973-1988||2016|
|CD40 Signaling Drives B Lymphocytes into an Intermediate Memory-Like State, Poised Between Na||Journal of Cellular Physiology, 229 (10), 1387-1396.||2014|
|Chitohexaose activates macrophages by alternate pathway through TLR4 and blocks Endotoxemia.||PLOS Pathogens 8 (5) : e1002717||2012|
|Evolutionary and functional insights into Leishmania META1: evidence for lateral gene transfer and a role for META1 in secretion||BMC Evol Biol , 11: 334||2011|
|An endogenous retroviral locus regulates susceptibility to murine leishmanial infection.||The Journal of Infectious Diseases 202(8):1234||2010|
|Inhibition of Terminal Differentiation of B cells mediated by CD27 and CD40 involves signaling through JNK||J Immunology 185;6499-6507||2010|
|Development of a real-time PCR assay for the quantification of Leishmania species and the monitoring of systemic distribution of the pathogen||Diagnostic Microbiology and Infectious Disease 61: 23||2008|
|Induction of autophagic cell death in Leishmania donovani by antimicrobial peptides.||Molecular & Biochemical Parasitology 127: 23||2003|