First slide

Venkat R Chalamcharla

Project Scientist

Research Interests

Research in my lab focuses on the elongation phase of transcription by RNA Polymerase II (Pol II), which is a major mode of eukaryotic gene regulation. Control of Pol II elongation is also important for dynamic organization of chromatin structure and maintenance of genome stability. In humans, misregulation of the transcription elongation phase is implicated in a broad spectrum of pathologies, including cancer, cardiac hypertrophy, viral infections, and inflammatory responses. Using the fission yeast Schizosaccharomyces pombe model system, we aim: 1. To define the basic mechanisms involved in Pol II elongation control. 2. To elucidate molecular pathways for co-transcriptional RNA degradation.

Selected Publications

Folco HD et al., (2017) "Untimely expression of gametogenic genes in vegetative cells causes uniparental disomy" Nature 543(7643):126-130.

Sugiyama T et al., (2016) "Enhancer of rudimentary cooperates with Mmi1 and conserved RNA processing factors to promote meiotic mRNA decay and facultative heterochromatin assembly" Mol. Cell 61(5):747-59.

Chalamcharla VR et al., (2015) "A conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing" PNAS 112(51):15548-55.

Lee N et al., (2013) "Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance" Cell 155(5):1061-74.

Chalamcharla VR et al., (2010) "Nuclear expression of a group II intron is consistent with spliceosomal intron ancestry" Genes Dev. 24(8):827-836.

Education & Experiance

P.G: Biotechnology ; Andhra University ; 2003
Ph.D: Group II Intron Dynamics in Heterologous Hosts ; State University of New York, University at Albany, USA ; 2010
Post.Doc:

Chromatin Biology ; National Cancer Institute (NCI/NIH), USA ; 2011-2016

RNA Biology ; Wadsworth Center, USA ; 2010-2011

Publications

TitleJournalYear
No records found

Venkat R Chalamcharla

Project Scientist

2526

cvraditya@ccmb.res.in

Anubhav Bhardwaj

Technical Officer

2507

anubhav@ccmb.res.in

Annapoorna K P

Junior Research Fellow

2507

annapoorna@ccmb.res.in

Harsh Kapoor

Junior Research Fellow

2507

harsh.kapoor@ccmb.res.in

Mamta Nirmal Barku

Junior Research Fellow (Project)

2507

mamtabn@ccmb.res.in

Shreya Garg

Junior Research Fellow (Project)

2507

shreyagarg@ccmb.res.in