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Puran Singh Sijwali Group`s Publications
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Title Journal Year
Biotransformation of Artemisinin to 14-hydroxydeoxyartemisinin: C-14 hydroxylation by Aspergillus flavus. Journal of Agricultural and Food Chemistry. DOI: 10.1021/acs.jafc.8b035732018
A conserved human DJ1-subfamily motif (DJSM) is critical for anti-oxidative and deglycase activities of Plasmodium falciparum DJ1.Molecular & Biochemical Parasitology. 222:70-80. doi:10.1016/j.molbiopara.2018.05.0032018
A Novel and conserved Plasmodium sporozoite membrane protein SPELD is required for maturation of exo-erythrocytic forms. Sci Rep.7: 40407. doi: 10.1038/srep40407.2017
Synthesis and evaluation of naphthyl bearing 1,2,3-triazole analogs as antiplasmodial agents, cytotoxicity and docking studies. Bioorg Med Chem. 2017;25(1):221-232. doi: 10.1016/j.bmc.2016.10.029.2016
Independent amino acid residues in the S2 pocket of falcipain-3 determine its specificity for P2 residues in substrates.Mol Biochem Parasitol. 202(2):11-22. doi: 0.1016/j.molbiopara.2015.09.005.2015
Characterization of the autophagy marker protein Atg8 reveals atypical features of autophagy in Plasmodium falciparum. PLoS One 9(11): e113220. doi:10.1371/journal.pone.0113220.2014
Genetic ablation of plasmoDJ1, a multi-activity enzyme, attenuates parasite virulence and reduces oocyst production.Biochem. J. 461 (189-203). 2014
Emergence of pyrido quinoxalines as new family of antimalarial agents. Eur J Med Chem. 77C:280-287.2014
Blocking Plasmodium falciparum development via dual inhibition of hemoglobin degradation and the ubiquitin proteasome system by MG132. PLoS One. 8(9):e73530.2013
Synthesis and insight into the structure-activity relationships of chalcones as antimalarial agents.J Med Chem. 2013 Jan 10;56(1):31-45.2013
Expression, Characterization, and Cellular Localization of Knowpains, Papain-Like Cysteine Proteases of the Plasmodium knowlesi Malaria Parasite.PLoS One. 2012;7(12):e51619. 2012
The Ionic and Hydrophobic Interactions Are Required for the Auto Activation of Cysteine Proteases of Plasmodium falciparum.PLoS One. 7(10):e47227. 2012
Functional evaluation of Plasmodium export signals in Plasmodium berghei suggests multiple modes of protein export.PLoS One 19;5(4): e10227.2010
A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2.Protein Engineering, Design and Selection 20(4):171-177.2007
Falcipain cysteine proteases require bipartite motifs for trafficking to the Plasmodium falciparum food vacuole. Journal of Biological Chemistry 282(34):24961-9.2007
Antimalarial effects of human immunodeficiency virus type 1 protease inhibitors differ from those of the aspartic protease inhibitor pepstatin.Antimicrob Agents Chemother 50(6): 2207-2209.2006
Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proceedings of the National Academy of Sciences USA 103(31):11503-8.2006
Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum.Mol Biochem Parasitol 150(1): 96:106.2006
The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif.Proceedings of the National Academy of Sciences USA102(26): 9138-9143.2005
Plasmodium falciparum: Biochemical characterization of the cysteine protease falcipain-2'. Exp Parasitol 112(3):187-192.2005
Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2. Journal of Biological Chemistry 279(5): 3484-3491.2004
Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum. Proceedings of the National Academy of Sciences USA 101(13): 4384-4389.2004
Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax. Biochemical Journal 378(2): 529-538.2004
Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites. Proceedings of the National Academy of Sciences USA 101(23): 8721-8726. *Equal Contribution.2004
Folding of the Plasmodium falciparum cysteine protease falcipain-2 is mediated by a chaperone-like peptide and not the prodomain.Journal of Biological Chemistry 277(17): 14910-14915.2002
Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites. Biochemical Journal 368(1): 273-281.2002
Systematic optimization of expression and refolding of the Plasmodium falciparum cysteine protease falcipain-2. Protein Expression and Purification 22(1): 128-134.2001
Systematic optimization of expression and refolding of the Plasmodium falciparum cysteine protease falcipain-2. Protein Expression and Purification 22(1): 128-134.2001
Recombinant falcipain-2 cleaves erythrocyte membrane ankyrin and protein 4.1.Molecular Biochemical Parasitology 116(1): 95-99.2001
Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3. Biochemical Journal 360(2): 481-489.2001
Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum. Journal of Biological Chemistry 275(37): 29000-29010. *Equal Contribution.2000
Cloning and sequence analysis of the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium cynomolgi bastianelli. Molecular Biochemical Parasitology 90(1): 371-376.1997
Detection and quantitation of Helicoverpa armigera nuclear polyhedrosis virus by ELISA technique. Indian Journal of Microbiology 36: 229-230.1996
Synthesis and evaluation of anti-plasmodial and cytotoxic activities of epoxyazadiradione derivatives. Eur J Med Chem. 134:242-257. doi: 10.1016/j.ejmech.2017.04.016. 0
उपयोगी संपर्क संबंधित संपर्क परिसर
कापीराइट 2010 सीसीएमबी,उप्पल रोड,हैदराबाद 500007, तेलंगाना