Scientific Research Groups

Amitabha Chattopadhyay Chandak G R Ghanshyam Swarup Gopal Pande Imran Siddiqi Jyotsna Dhawan
Kasbekar D P Kshitish Majumdar Lalji Singh Madhusudhana Rao N Malay K Ray Mohan Rao Ch
Nagaraj R Purnima Bhargava Rakesh Kumar Mishra Ramesh K Aggarwal Ramesh V Sonti Rajan Sankaranarayanan
Satish Kumar Shashidhara L S Shivaji S Sirdeshmukh R Somdatta Sinha Thangaraj K
Utpal Bhadra Veena K Parnaik Yogendra Sharma . . .

 

 

 

Anant B Patel Guruprasad K Jagannadham M V Lakshmi Rao K Murthy B S N Prabir Kumar De
Rachel A J Radha V Ramakrishna Murti T Shailendra K Saxena Shashi Singh Shrish Tiwari
Sreedhar A S Tushar Vaidya . . . .




Amitabha Chattopadhyay Group Publication

Title Journal Year Article
Synthesis and Characterization of Environment-Sensitive Fluorescent Ligands for Human 5-HT1A Receptors with 1-Arylpiperazine Structure. J. Med. Chem., 52: 7892–7896
2009
Organization and dynamics in micellar structural transition monitored by pyrene fluorescence. Biochemical and Biophysical Research Communications, 390: 728–732
2009
Membrane cholesterol depletion enhances ligand binding function of human serotonin1A receptors in neuronal cells Biochemical and Biophysical Research Communications, 390: 93–96
2009
Differential effects of cholesterol and desmosterol on the ligand binding function of the hippocampal serotonin1A receptor: Implications in desmosterolosis Biochimica et Biophysica Acta, 1788: 2169–2173
2009
Membrane cholesterol depletion from live cells enhances the function of human serotonin1A receptors Biochemical and Biophysical Research Communications, 389: 333-337
2009
Jagadish Chandra Bose: The First Indian Biophysicist Asian Agri-History, 13: 315-319
2009
Differential dynamics of membrane proteins in yeast Biochemical and Biophysical Research Communications, 387: 661–665
2009
Effect of capsaicin on ligand binding activity of the hippocampal serotonin1A receptor Glycoconj J, 26: 733–738
2009
The function of G-protein coupled receptors and membrane cholesterol: specific or general interaction? Glycoconj J, 26: 711–720
2009
Green fluorescent protein: a molecular lantern that illuminates the cellular interior J. Biosci., 34(2): 169–172
2009
Orientation and Dynamics of a Novel Fluorescent Cholesterol Analogue in Membranes of Varying Phase J. Phys. Chem. B, 113: 4475–4481
2009
The Green Journey Journal of Fluorescence, 19: 1-2
2009
Are specific nonannular cholesterol binding sites present in G-protein coupled receptors? Biochimica et Biophysica Acta, 1788: 295-302
2009
Monitoring Orientation and Dynamics of Membrane-Bound Melittin Utilizing Dansyl Fluorescence J. Phys. Chem. B., 112: 14075-14082
2008
Effect of sphingomyelinase treatment on ligand binding activity of human serotonin1A receptors Biochimica et Biophysica Acta, 1778: 2022-2025
2008
Exploring the Organization and Dynamics of Hippocampal Membranes Utilizing Pyrene Fluorescence J. Phys. Chem. B., 112: 12134-12138
2008
Role of Tryptophan Residues in Gramicidin Channel Organization and Function Biophysical Journal, 95: 166-175
2008
Actin Cytoskeleton-Dependent Dynamics of the Human Serotonin1A Receptor Correlates with Receptor Signaling Biophysical Journal, 95: 451-463
2008
Signalling by the human serotonin1A receptor is impaired in cellular model of Smith-Lemli-Optiz Syndrome Biochimica et Biophysica Acta- Biomembranes, 1778: 1508-1516
2008
Differential Effects of Cholesterol and its Immediate Biosynthetic Precursors on Membrane Organization Biochemistry, 47: 5668-5677
2008
Membrane Organization and Function of the Serotonin1A Receptor Cellular and Molecular Neurobiology, 27: 1097-1116
2007
Dipolar Relaxation within the Protein Matrix of the Green fluorescent Protein: a Red Edge Excitation Shift Study J. Phys. Chem. B., 111: 14436-14439
2007
Differential effects of cholesterol and 7-dehydrocholesterol on ligand binding of solubillized hippocampal serotonin1A receptors: Implications in SLOS Biochemical and Biophysical Research Communications., 363: 800-805
2007
Solubilization of human serotonin1A receptors expressed in neuronal cells Chemistry and Physics of Lipids., 150: 244-249
2007
Dynamics and heterogeneity of bovine hippocampal membranes: Role of cholesterol and proteins Biochimica et Biophysica Acta., 1768: 2130-2144
2007
The gramicidin ion channel: A model membrane protein Biochimica et Biophysica Acta., 1768: 2011-2025
2007
Melittin: a Membrane-active peptide with Diverse Functions Biosci Rep., 27: 189-223
2007
Effect of structural transition of the host assembly on dynamics of a membrane-bound tryptophan analogue Biophysical Chemistry., 129: 172-180
2007
Differential effects of cholesterol and 7-dehydrcholesterol on the ligand binding activity of the hippocampal serotonin1A receptor: Implications in SLOS Biochemical and Biophysical Reserarch Communications., 358: 495-499
2007
Membrane Organization of the Serotonin1A Receptor Monitored by a Detergent-Free Approach Cellular and Molecular Neurobiology., 27(4): 463-474
2007
Wavelength-selective fluorescence in ion channels formed by gramicidin A in membranes J.Chem.Sci. 119: 135-140
2007
Monitoring the looping up of acyl chain labeled NBD lipids in membranes as a function of membrane phase state Biochimica. et Biophysica Acta - Biomembranes 1768: 1258-1267
2007
Modulation of gramicidin channel conformation and organization by hydrophobic mismatch in saturated phosphatidylcholine bilayers Biochimica. et Biophysica Acta - Biomembranes 1768: 1103-1113
2007
Influence of cholesterol and ergosterol on membrane dynamics using different fluorescent reporter probes Biochem. Biophys. Res. Comm. 356: 705-710
2007
Cholesterol: a potential therapeutic target in Leishmania infection? Trends Parasitol. 23: 49–53
2007
Organization and Dynamics of NBD-Labeled Lipids in Membranes Analyzed by Fluorescence Recovery after Photobleaching J. Phys. Chem. B , 111: 1975-1983
2007
The human serotonin1A receptor exhibits G-protein-dependent cell surface dynamics Glycoconj J 24:25–31
2007
Orientation and Dynamics of Melittin in Membranes of Varying Composition Utilizing NBD Fluorescence Biophysical Journal 92: 1271–1283
2007

Lipid–protein interactions, regulation and dysfunction of brain cholesterol

Biochemical and Biophysical Research Communications 354: 627–633
2007

Cholesterol depletion induces dynamic confinement of the G-protein coupled serotonin1A receptor in the plasma membrane of living cells

Biochimica et Biophysica Acta - Biomembrane 1768: 655–668
2007
Membrane localization and dynamics of Nile Red: Effect of cholesterol Biochimica et Biophysica Acta - Biomembrane 1768: 59–66
2007

Spectrin Organization and Dynamics: New Insights

Biosci Rep 26:369–386
2006
The Human Serotonin 1A Receptor Expressed in Neuronal Cells: Toward a Native Environment for Neuronal Receptors Cell. Mol. Neurobiol., 26: 925-942
2006
Effect of ionic strength on the organization and dynamics of membrane-bound melittin Biophysical Chemistry,124: 115–124
2006
Monitoring the organization and dynamics of bovine hippocampal membranes utilizing differentially localized fluorescent membrane probes Molecular Membrane Biology, 23(5): 430-441
2006
Effect of Ionic Strength on Folding and Aggregation of the Hemolytic Peptide Melittin in Solution Biopolymers 83: 111–121
2006
Membrane interfacial localization of aromatic amino acids and membrane protein function J. Biosci., 31(3): 297–302
2006
Effect of cholesterol on lateral diffusion of fluorescent lipid probes in native hippocampal membranes Chemistry and Physics of Lipids 143: 11–21
2006
The Sterol-Binding Antibiotic Nystatin Inhibits Entry of Non-opsonized Leishmania donovani into Macrophages Biochem. Biophys. Res. Commun., 339:661-666
2006
Monitoring ion channel conformations in membranes utilizing a novel dual fluorescence quenching approach Biochem. Biophys. Res. Commun.,343:483-488
2006
Prolonged Treatment with Ligands Affects Ligand Binding to the Human Serotonin 1A Receptor in Chinese Hamster Ovary Cells Cell. Mol. Neurobiol.,26(3): 247-257
2006
Role of Cholesterol in the Function and Organization of G-protein Coupled Receptors Progress in Lipid Research, 45: 295-333
2006
Confocal Fluorescence Recovery After Photobleaching of Green Fluorescent Protein in Solution J. Fluorescence, 16: 87-94
2006
Ligand Binding and G-protein Coupling of the Serotonin 1A Receptor in Cholesterol-enriched Hippocampal Membranes Bioscience Rep., 26:79-87
2006
The Serotonin1A Receptor and its Interaction with the Membrane Environment Proc. Indian Natl. Sci. Acad. B71 (2): 61-72
2005
Membrane Protein Solubilization: Recent Advances and Challenges in Solubilization of Serotonin 1A Receptors IUBMB Life, 57:505-512
2005
Membrane Cholesterol Oxidation Inhibits Ligand Binding Function of Hippocampal Serotonin 1A Receptors Biochem. Biophys. Res. Commun. 331:422-427
2005
The Serotonin 1A Receptor: A Representative Member of the Serotonin Receptor Family Cell. Mol. Neurobiol. 25: 553-580
2005
Membrane organization of the human serotonin 1A receptor monitored by detergent insolubility using GFP fluorescence Mol. Membr. Biol., 22:539-547
2005
Effect of Structural Transition of the Host Assembly on Dynamics of an Ion Channel Peptide: A Fluorescence Approach Biophys. J., 89:3049-3058
2005
Novel Insights Into Protein Structure and Dynamics Utilizing the Red Edge Excitation Shift Approach Reviews in Fluorescence, pp. 199-222
2005
Membrane Organization and Dynamics of the G-protein Coupled Serotonin 1A Receptor Monitored using Fluorescence-based Approaches J. Fluoresc.15:785-796
2005
Dynamics of A Membrane-Bound Tryptophan Analogue in Environments of Varying Hydration: A Fluorescence Approach Eur. Biophys. J. 35:62-71
2005
Monitoring the organization and dynamics of bovine hippocampal membranes utilizing Laurdan generalized polarization . Biochim. Biophys. Acta - Biomembrane 1714: 43-55.
2005
Cholesterol Modulates the Antagonist Binding Funtion of Hippocampal Serotonin 1A Receptors Biochim. Biophys. Acta - Biomembrane 1714: 35-42.
2005
The cholesterol-complexing agent digitonin modulates ligand binding of the bovine hippocampal serotonin 1A receptor Mol. Membr. Biol. 22: 241-249.
2005
Ion Channels and d-amino acids
J. Biosci. 30: 147-149.
2005
Effect of Ionic Strength on the Organization and Dynamics of Tryptophan Residues in Spectrin: A Fluorescence Approach Biopolymers 77: 325-334
2005
Cholesterol inhibits the lytic activity of melittin in erythrocytes Chem. Phys. Lipids 134: 183-189
2005
Monitoring cholesterol organization in membranes at low concentrations utilizing the wavelength-selective fluorescence approach Chem. Phys. Lipids 134: 79-84
2005
Influence of Ester and Ether Linkage in Phospholipids on the Environment and Dynamics of the Membrane Interface: A Wavelength-Selective Fluorescence Approach Langmuir 21: 287-293
2005
Effect of Graded Hydration on the Dynamics of an Ion Channel Peptide: A Fluorescence Approach Biophys. J. 88:1070-1080
2005
Role of cholesterol in ligand binding and G-protein coupling of Serotonin 1A receptors solubilized from bovine hippocampus Biochem. Biophys.Res. Commun. 327: 1036-1041
2005
Depth-Dependent Solvent Relaxation in Reverse Micelles: A Fluorescence Approach J. Phys. Chem. B 108: 12151-12158
2004
Ligand BindingCharacteristics of the Human Serotonin 1A Receptor Heterologously Expressed in CHO Cells Biosci. Rep. 24, 101-115.
2004
G-protein-dependent Cell Surface Dynamics of the Human Serotonin 1A Receptor Tagged to Yellow Fluorescent Protein Biochemistry 43: 15852-15862
2004
Effect of Micellar Charge on the Conformation and Dynamics of Melittin Eur. Biophys. J. 33: 611-622
2004
A GFP Fluorescence-based Approach to Determine Detergent Insolubility of the Human Serotonin 1A Receptor FEBS Lett. 576: 455-460
2004
Effect of Mg 2+ on Guanine Nucleotide Sensitivity of Ligand Binding to Serotonin 1A Receptors from Bovine Hippocampus Biochem. Biophys.Res. Commun. 323: 372-376
2004
Interaction of Melittin with Membrane Cholesterol: A Fluorescence Approach Biophys. J.87: 2419-2432
2004
Monitoring Gramicidin Conformations in Membranes: A Fluorescence Approach Biophys. J.87: 831-843
2004
Influence of Lipid Chain Unsaturation on Membrane-Bound Melittin: A Fluorescence Approach Biochim. Biophys. Acta - Biomembrane 1665: 29-39
2004
The Sterol-Binding Antibiotic Nystatin Differentially Modulates Agonist and Antagonist Binding of the Bovine Hippocampal Serotonin 1A Receptor Biochem. Biophys.Res. Commun. 320: 557-562
2004
Influence of Cholesterol and Ergosterol on Membrane Dynamics: A Fluorescence Approach Biochem. Biophys.Res. Commun. 318: 920-926
2004
Cholesterol Modulates Ligand Binding and G-protein Coupling to Serotonin 1A Receptors from Bovine Hippocampus Biochim. Biophys. Acta - Biomembrane 1663: 188-200
2004
Membrane Sphingolipid-Ergosterol Interactions are Important Determinants of Multi Drug Resistance in Candida albicans Antimicrob. AgentsChemother. 48: 1778-1787
2004
Interaction of Serotonin 1A Receptors from Bovine Hippocampus with Tertiary Amine Local Anesthetics Cell. Mol. Neurobiol. 24: 403-422
2004
Serotonin 1A receptor agonist acquires an antimalarial connection J. Biosci. 29: 101-102
2004
Temperature Dependent Interaction of the Bovine Hippocampal Serotonin 1A Receptor with G-proteins Mol. Membr. Biol. 21: 119-123
2004
Effect of Urea on the Organization and Dynamics of Triton X-100 Micelles: A Fluorescence Approach J. Phys. Chem. B 108: 2489-2496
2004
Exploring Detergent Insolubility in Bovine Hippocampal Membranes: A Critical Assessment of the Requirement for Cholesterol Biochim. Biophys. Acta - Biomembrane 166: 9-17
2004
Cholesterol is Required for Leishmania donovani Infection: Implications in Leishmaniasis Mol.Biochem. Parasitol. 133: 145-152
2004
Organization and Dynamics of N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-labeled Lipids: A Fluorescence Approach Chem. Phys. Lipids 127: 91-101
2004
Solubilization of Serotonin 1A Receptors Heterologously Expressed in Chinese Hamster Ovary Cells Cell. Mol. Neurobiol. 24: 293-300
2004
Application of fluorescence spectroscopy to membrane protein structure and dynamics Current Science, Vol.87, No.2.
2004
Organization and Dynamics of Melittin in Environments of Graded Hydration: A Fluorescence Approach Langmuir 19: 10332-10341
2003
Organization and Dynamics of Tryptophan Residues in Erythroid Spectrin: Novel Structural Features of Denatured Spectrin Revealed by the Wavelength-SelectiveFluorescence Approach Protein Sci. 12: 2389-2403
2003
Modulation of Fluorophore Environment in Host Membranes of Varying Charge J. Fluoresc. 13: 459-466
2003
Novel Insights into Membrane Protein Structure and Dynamics utilizing the Wavelength-Selective Fluorescence Approach Proc. Ind. Natl. Sci. Acad. A 69: 25-35
2003
Exploring Membrane Organization and Dynamics by the Wavelength-Selective Fluorescence Approach Chem. Phys. Lipids 122: 3-17
2003
Reverse Micellar Organization and Dynamics: A Wavelength-Selective Fluorescence Approach J. Phys. Chem. B 106: 13002-13009
2002
Application of the Wavelength-selective Fluorescence Approach to Monitor Membrane Organization and Dynamics Fluorescence Spectroscopy, Imaging and Probes(Kraayenhof, R., Visser, A.J.W.G., and Gerritsen, H.C., Eds.), pp. 211-224, Springer-Verlag, Heidelberg
2002
Solubilization of High Affinity G-Protein-Coupled Coupled Serotonin 1A Receptors from Bovine Hippocampus using Pre-Micellar CHAPS at Low Concentration Mol. Membr. Biol. 19: 211-220
2002
Modulation of Antagonist Binding to Coupled Serotonin 1A Receptors from Bovine Hippocampus by Metal Ions Cell. Mol. Neurobiol. 21: 453-464
2001
Cholesterol Organization in Membranes at Low Concentrations: Effects of Curvature Stress and Membrane Thickness Biophys. J. 81: 2122-2134
2001
Effect of Alcohols on G-Protein Coupling of Coupled Serotonin 1A Receptors from Bovine Hippocampus Brain Res. Bull. 52: 597-601
2000
A New Paradigm in the Functioning of G-Protein-Coupled Receptors Curr. Sci. 79: 402-403
2000
Role of Disulfides and Sulfhydryl Groups in Agonist and Antagonist Binding in Serotonin 1A Receptors from Bovine Hippocampus Cell. Mol. Neurobiol. 20: 665-681
2000