We combine biophysical, molecular biological and cell biological approaches to address problems of biomedical importance.
Recent Publications
Mishra P, Prabha CR, Rao ChM, Volety S. Q2N and S65D substitutions of ubiquitin unravel functional significance of the invariant residues Gln2 and Ser65. Cell Biochem Biophys. 2011 Dec;61(3):619-28.
Thakur AK, Srivastava AK, Srinivas V, Chary KV, Rao CM. Copper alters aggregation behavior of prion protein and induces novel interactions between its N- and C-terminal regions. J Biol Chem. Nov 4;286(44):38533-45.2011.
Prabhu S, Srinivas V, Ramakrishna T, Raman B, Rao ChM. Inhibition of Cu(2+)-mediated generation of reactive oxygen species by the small heat shock protein αB-crystallin: The relative contributions of the N- and C-terminal domains. Free Radic Biol Med. 51(3):755-62; 2011
Zhang Q, Wang D, Singh NK, Kundumani-Sridharan V, Gadiparthi L, Rao ChM, Rao GN. Activation of Cytosolic Phospholipase A2 Downstream of the Src-Phospholipase D1 (PLD1)-Protein Kinase C {gamma} (PKC{gamma}) Signaling Axis Is Required for Hypoxia-induced Pathological Retinal Angiogenesis. J Biol Chem. 286(25):22489-98; 2011
Adhikari AS, Singh BN, Rao KS, Rao ChM. αB-crystallin, a small heat shock protein, modulates NF-kB activity in a phosphorylation-dependant manner and protects muscle myoblasts from TNF-α induced cytotoxicity. Biochim Biophys Acta. 1813(8):1532-42; 2011
Taiyab A., Rao ChM. HSP90 modulates actin dynamics: inhibition of HSP90 leads to decreased cell motility and impairs invasion. Biochim Biophys Acta. 1813(1):213-21, 2011
Bhairab N. Singh, K. Sridhar Rao, Ch. Mohan Rao. Ubiquitin–proteasome-mediated degradation and synthesis of MyoD is modulated by αB-crystallin, a small heat shock protein, during muscle differentiation. Biochim Biophys Acta.; 1803(2):288-99, 2010
D. Singh, T. Ramakrishna, B. Raman, Ch. Mohan Rao. Synergistic effects of metal ion and the pre-senile cataract-causing G98R αA-crystallin: self-aggregation propensities and chaperone activity. Mol. Vis.;15:2050-2060, 2009
P Mishra, S Volety, Ch. Mohan Rao, CR Prabha. Glutamate64 to glycine substitution in G1 beta-bulge of ubiquitin impairs function and stabilizes structure of the protein. Journal of Biochemistry, 146, 563-569, 2009
A Taiyab, AS Sreedhar, Ch. Mohan Rao. Hsp90 inhibitors, GA and 17AAG, lead to ER stress-induced apoptosis in rat histiocytoma. Biochemical Pharmacology, 78, 142-152, 2009
MF Ahmad, D Singh, A Taiyab, T Ramakrishna, B Raman, Ch. Mohan Rao. Selective Cu2+ binding, redox silencing, and cytoprotective effects of the small heat shock proteins alphaA- and alphaB-crystallin. Journal of Molecular Biology, 382, 812-824, 2008
AK Thakur, Ch. Mohan Rao. UV-light exposed prion protein fails to form amyloid fibrils. PLoS One, 3, e2688, 2008
MF Ahmad, B Raman, T Ramakrishna, Ch. Mohan Rao. Effect of phosphorylation on alpha B-crystallin: differences in stability, subunit exchange and chaperone activityof homo and mixed oligomers of alpha B-crystallin and its phosphorylation-mimicking mutant. Journal of Molecular Biology, 375, 1040-1051, 2008
