| Name | : | Rajan Sankaranarayanan | ||||||
| Date and Place of Birth | : | 28th May 1968, Papanasam Project ,Tamil Nadu, INDIA | ||||||
| Sex/Marital status | : | Male/Married | ||||||
| Nationality | : | Indian | ||||||
| Address | : |
| ||||||
| Telephone | : | |||||||
| Fax | : | +91 (0)40 2716 0252, 2716 0591 | ||||||
| : | sankar@ccmb.res.in , sankarfr@yahoo.com |
1990-1996 Ph.D. from Molecular Biophysics Unit, Indian Institute of Science, Bangalore.
1988-1990 M. Sc. in Physics from Madurai
Kamaraj University.
1985-1988 B.
Sc. in Physics from Madurai Kamaraj University.
March 2002 - present Senior
Scientist and Group Leader, Structural Biology Laboratory, CCMB, Hyderabad.
October 1996 - February 2002 Postdoctoral
research with Prof. Dino Moras, Laboratoire de Biologie Structurale, IGBMC,
Strasbourg, France.
April 1996 - September 1996 Postdoctoral research with Prof. M. Vijayan,
Molecular Biophysics Unit, Indian Institute of Science, Bangalore.
August 1990 - March 1996 Doctoral
research with Prof. M. Vijayan, Molecular Biophysics Unit, Indian Institute of
Science, Bangalore.
2010 Elected as a Fellow of National Academy of Sciences, Allahabad, India.
2010 Elected as a Fellow of Indian Academy of Sciences, Bangalore, India.
2009 Appointed as the Co-Editor of Acta
Crystallographica, an International
Union of Crystallography publication.
2009 Awarded the BM Birla Science Prize for 2008 in Biological Sciences.
2009 Received the National Bioscience Award for the year 2008 from the Department of
Biotechnology, India.
2008 Received the Endeavour Executive Award
from the Department of Education, Science and Training (DEST), Australia.
2007 Editorial board member of the Journal of
Structural Biology, an Elsevier publication.
2007 Awarded the Swarnajayanthi Fellowship
for the year 2005-06 from the Department of Science and Technology, India.
2004 Elected as a member of Guha Research
Conference.
2003 Received an International Senior Research
Fellowship (ISRF) award in Biomedical Science for five years from The
Wellcome Trust, UK.
1996 'Shamrao Kaikini Gold medal and award'
for the best thesis from Indian Institute of Science, Bangalore.
1990 'Gold medal' from Madura College, Madurai for M.Sc. in
Physics branch.
*Corresponding
author(s). If not indicated, the last author is the corresponding author. Research
Articles
26. Acharya, P., Rajakumara, E., Sankaranarayanan, R.* and Rao, N. M.* (2004) Structural basis for selection and enhanced thermostability of laboratory evolved Bacillus subtilis lipase. J. Mol. Biol. 341, 1271-1281.
27. Sankaranarayanan, R.*, Saxena, P.,
Marathe, U., Gokhale, R. S.*, Shanmugam, V. M. and Rukmini, R. (2004) A novel
tunnel in mycobacterial type III polyketide synthase reveals the structural
basis for generating diverse metabolites. Nature Struct. Mol. Biol.
11, 894-900.
28. Rukmini, R., Shanmugam, V. M.,
Saxena, P., Gokhale, R. S. and Sankaranarayanan, R. (2004)
Crystallization and preliminary X-ray crystallographic investigations of an
unusual type III polyketide synthase PKS18 from Mycobacterium tuberculosis.
Acta Cryst. D60, 749-751.
29. Rajakumara, E., Acharya, P., Ahmad, S.,
Shanmugam, V. M., Rao, N. M.* and Sankaranarayanan, R.* (2004)
Crystallization and preliminary X-ray crystallographic investigations on
several thermostable forms of a Bacillus subtilis lipase. Acta Cryst.
D60, 160-162.
30. Chatterjee, S., Sankaranarayanan, R.
and Sonti, R. V. (2003) PhyA, a secreted protein of Xanthomonas oryzae pv.
oryzae, is required for optimum
virulence and growth on phytic acid as a sole phosphate source. Molecular
Plant-Microbe Interactions 16, 973-982.
31. Torres-Larios, A., Sankaranarayanan,
R., Rees, B., Dock-Bregeon, A-C. and Moras, D. (2003) Conformational
movements and cooperativity upon amino acid, ATP and tRNA binding in
threonyl-tRNA synthetase. J. Mol. Biol. 331, 201-211.
32. Caillet, J., Nogueira, T., Masquida, B., Winter, F., Graffe, M., Dock-Bregeon, A-C., Torres-Larios, A., Sankaranarayanan, R., Westhof, E., Ehresmann, B., Ehresmann, C., Romby, P. and Springer, M. (2003) The modular structure of Escherichia coli threonyl-tRNA synthetase as both an enzyme and a regulator of gene expression. Mol. Microbiol. 47, 961-974.
33.
Torres-Larios, A., Dock-Bregeon, A-C., Romby, P., Rees. B., Sankaranarayanan,
R., Caillet, J., Springer, M., Ehresmann, C., Ehresmann, B. and Moras, D.
(2002) Structural basis of translational control by Escherichia coli
threonyl tRNA synthetase. Nature Struct. Biol. 9, 343-347.
34. Sankaranarayanan, R. and Moras, D. (2001) Solution to the double discrimination problem by the class II threonyl-tRNA synthetase. Med Chem Res. 10, 516-523.
35. Dock-Bregeon, A-C., Sankaranarayanan, R., Romby, P., Caillet, J., Springer, M., Rees, B., Francklyn, C. S., Ehresmann, C. and Moras, D. (2000) Transfer RNA-mediated editing in threonyl-tRNA synthetase: The class II solution to the double discrimination problem. Cell 103, 877-884.
36.
Sankaranarayanan, R., Dock-Bregeon, A-C., Rees, B.,
Bovee, M., Caillet, J., Romby, P., Francklyn, C. S. and Moras, D. (2000) Zinc
ion mediated amino acid discrimination by threonyl-tRNA synthetase. Nature
Struct. Biol. 7, 461-465.
37. Sankaranarayanan, R., Dock-Bregeon, A-C., Rees, B., Bovee, M., Caillet, J., Romby, P., Francklyn, C. S. and Moras, D. (2000) Zinc ion mediated amino acid recognition by threonyl-tRNA synthetase. Acta Cryst. A56, S-93.
38.
Arnez, J. G., Sankaranarayanan,
R., Dock-Bregeon, A-C., Francklyn, C. S. and Moras, D. (2000)
Aminoacylation at the atomic level in class IIa aminoacyl-tRNA synthetases. J.
Biomol. Struct. Dyn. 1, 23-27.
39. Sankaranarayanan, R., Dock-Bregeon, A-C., Romby. P., Caillet, J., Springer, M., Rees, B., Ehresmann, C., Ehresmann, B. and Moras, D. (1999) The structure of threonyl-tRNA synthetase-tRNAThr complex enlightens its repressor activity and reveals an essential zinc ion in the active site. Cell 97, 371-381.
40. Prabu, M.M., Sankaranarayanan, R., Puri, K.D., Sharma, V., Surolia, A., Vijayan, M. and Suguna, K. (1998) Carbohydrate specificity and quaternary association in basic winged bean lectin: X-ray analysis of the lectin at 2.5 A resolution. J. Mol. Biol. 276, 787-796.
41. Suresh, S., Rani, P. G., Pratap, J. V., Sankaranarayanan, R., Surolia, A. and Vijayan M. (1997) Homology between jacalin and artocarpin from jackfruit (Artocarpus integrifolia) seeds. Partial sequence and preliminary crystallographic studies of artocarpin. Acta Cryst. D53, 469-471.
42. Sankaranarayanan, R., Sekar, K., Banerjee, R., Sharma, V., Surolia, A. and Vijayan, M. (1996) A novel mode of carbohydrate recognition in jacalin, a Moraceae plant lectin with a b-prism fold. Nature Struct. Biol. 3, 596-603.
43. Vijayan, M.*, Sekar, K., Banerjee, R., Mahanta, S.K., Surolia, A. and Sankaranarayanan, R. (1996) A three-fold symmetric b-prism fold without internal sequence homology in the structure of the two-chain lectin, Jacalin. Acta Cryst. A52, C-147.
44. Sankaranarayanan, R., Puri, K. D., Ganesh, V., Banerjee, R., Surolia, A. and Vijayan, M. (1993) Crystallization and preliminary X-ray studies of the basic lectin from winged bean (Psophocarpus tetragonolobus). J. Mol. Biol. 229, 558-560.
2. Sankaranarayanan, R. (2006) A type III PKS makes the DIFference. Nature Chem. Biol. 2, 451-452 (Invited NEWS and VIEWS article).
3. Sankaranarayanan, R. and Moras, D. (2001) The fidelity of the translation of the genetic code. Acta Biochimica Polonica 48, 323-335.
4. Sankaranarayanan, R. and Moras, D. (1999) Modular organization of aminoacyl-tRNA synthetases. Perspectives in structural biology Ed. Vijayan, M., Yathindra, N. and Kolaskar, A. S. Universities Press (India) Limited, pp 128-138.
Patent
G. Aparna, R. V. Sonti and R.
Sankaranarayanan (2009) A novel plant cell wall degrading enzyme identified
using the crystal structure and applications of the enzyme, thereof. (Patent
Filed).
Presentations
Invited as a Session Organizer for the Indo-American Kavli Frontiers of Science Symposium organized by National Academy of Sciences, USA at Beckman Centre, Irvine from 17th to 20th April, 2011.
Invited speaker at the 'Asian Biophysics Association' meeting held at India Habitat Center, New Delhi from 30th January to 2nd February, 2011.
Invited session chair on 'Combining methods/new tools in structural biology' at the Asian Crystallography Association (AsCA-2010) meeting held at Busan, South Korea from 31st October to 4th November, 2010.
Presented an invited talk entitled 'Evolution of virulence properties using old folds in pathogenic bacteria' at the International conference on Microbial Biotechnology (MICROCON-2009) held at Panjab University, Chandigarh from 3rd to 4th March, 2009.
Invited session chair on 'Protein-Nucleic acid interactions' at the International Union of Crystallography (IUCr) congress and general assembly held at Osaka, Japan from 23rd to 31st of August 2008.
Presented an invited lecture entitled 'Structure-function analysis of enzymes involved in the complex lipid cell wall synthesis of Mycobacterium tuberculosis' at the joint 4th AOHUPO (Asia Oceania Human Proteome Organization) and 2nd PRICPS (Pacific Rim International Conference on Protein Science) held at Cairns Convention Centre, Australia from 22nd to 26th June, 2008.
Presented an invited lecture entitled 'Rational design for enantioselectivity: A lesson from nature' at the 6th Temasek Life Sciences symposium on Biotechnology: Innovative applications from basic research held at Temasek Life Sciences Laboratory, Singapore from 24-25th January, 2008.
Presented a plenary lecture entitled 'Structural basis for proofreading during translation of the genetic code' in the 76th SBC (Society of Biological Chemists, India) meeting held at Sri Venkateshwara University, Tirupati from 25th-27th November, 2007.
Presented an invited talk entitled 'Inverting enantioselectivity in modules responsible for enforcing a high fidelity during translation' at the EMBL, Hamburg, Germany on 14th September, 2007.
Invited popular lecture on 'Physics of Living Matter' on the Indian Academy of Sciences sponsored lecture programme from 19th to 20th July 2007 organized by Aurora Degree and PG College, Hyderabad to Graduate and Post graduate students.
Invited as a session chair and to present a talk on 'Macromolecular Machines' at the Indo-American Frontiers of Science Symposium at University of California, Irvine from 18th to 20th January, 2007.
Invited talk entitled 'Inverting enantioselectivity in modules responsible for enforcing a high fidelity during translation of the genetic code ' at the RNA group, Ohio State University, Columbus, USA on the 10th October, 2006.
Presented an invited talk entitled 'A single residue enantioselectivity switch in a domain enforcing homochirality during translation of the genetic code' in the International Symposium on Recent Trends in Macromolecular Structure and Function (ISRTMSF) held at Guindy Campus, University of Madras, Chennai from 18th to 20th January, 2006.
Invited as a Session Chair and also to present a talk in the '21st International tRNA meeting' held between 2-7, December 2005 at the Indian Institute of Science, Bangalore.
Presented an invited talk entitled 'Structure-function studies on enzymes involved in the complex lipid cell wall biosynthesis of Mycobacterium tuberculosis' in the Symposium on 'Tuberculosis Research - An Indian perspective' organized by Astra Zeneca at Bangalore on the 20th October, 2005.
Presented an invited talk entitled 'A novel substrate binding tunnel reveals the structural basis for generating diverse metabolites by a type III polyketide synthase from Mycobacterium tuberculosis' at IGBMC, Strasbourg, France on 22nd September, 2004.
Presented an invited talk entitled 'A novel tunnel in mycobacterial PKS18 reveals the structural basis for generating diverse metabolites' in the International Conference on 'Structural Biology at Crossroads: From Biological molecules to Biological Systems' held at EMBL, Hamburg, Germany from 15th to 18th of September, 2004.
Presented an invited talk entitled 'Exploring the Structural basis of enhanced thermostability in Bacillus subtilis lipase' in the International Symposium on Recent Trends in Macromolecular Structure and Function (ISRTMSF) held at Guindy Campus, University of Madras, Chennai from 19th to 23rd January, 2004.
Presented an invited talk entitled 'Structural basis of how threonyl-tRNA synthetase acts as a translational repressor and solves a crucial double discrimination problem for a faithful translation of the genetic code' in the Institute of Molecular and Cell Biology (IMCB), Singapore on the 7th July, 2003.
Presented an invited talk entitled 'How Threonyl-tRNA Synthetase Solves a Crucial Double Discrimination Problem to Ensure a High Fidelity During Translation of The Genetic Code?' in the School of Biological Sciences, Nanyang Technological University (NTU), Singapore on the 5th July, 2003.
Presented a talk entitled 'Unexpected conformational movements upon substrate binding by the class II threonyl-tRNA synthetase' in the 4th tRNA Synthetase meeting on "tRNA Synthetases in Biology, Medicine, and Evolution" held at the Asilomar Conference Center, Monterey, California, U. S. A. Janunary 13th -18th, 2002.
Presented a talk entitled 'Solution to the double discrimination
problem by the class II threonyl-tRNA synthetase' in the international
symposium on Current Trends in Drug Discovery Research (CTDDR-2001)
organized by the Central Drug Research Institute, Lucknow, India, 11th -
15th February, 2001.
Presented a talk entitled 'The fidelity in the translation of the genetic code' in a meeting on the Molecular architecture of evolution organized by the Polish Academy of Sciences in The Institute of Bio-organic chemistry, Poznan, Poland, 29th - 31st October, 2000.
Presented a talk entitled 'Zinc ion mediated amino acid recognition by threonyl-tRNA synthetase' in European Crystallographic Meeting (ECM-19), Nancy, France, 25th - 31st August, 2000.
Presented a talk entitled 'Crystal structure of threonyl-tRNA synthetase-tRNAThr complex from E. coli' in the Fifth IUPAC international symposium on Bio-organic chemistry ISBOC-5 held at National chemical laboratory, Pune, 30th Jan - 4th Feb, 2000.
Presented a talk entitled 'Structure of E. Coli Threonyl-tRNA synthetase' in the 12th Regio meeting on X-ray crystallography of Biomacromolecules, Strasbourg, France 30th Sept - 2nd October, 1998.
Presented a talk entitled 'Structural studies on Lectins' in the Asian Regional Seminar on Crystallography in Molecular Biology, University of Madras, Madras, 9th -14th December, 1993.