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CSIR - Centre for Cellular & Molecular Biology

Council of Scientific and Industrial Research
Ministry of Science & Technology, Govt. of India

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G R Chandak

Chief Scientist
Email: chandakgrc@ccmb.res.in
Phone: +91-040-27192748

Research Interests

Our group is interested in understanding the genetic basis of complex disorders such as type 2 diabetes mellitus and chronic pancreatitis and its interaction with various environmental factors (epigenetic basis). The major focus is on identifying various genetic and nutritional factors (and interaction between them), which influence The Thin Fat Indian Phenotype, and various intermediate traits that predict higher risk of developing diabetes and metabolic syndrome. These determinants could be both maternal and fetal in origin and we believe that the variable clinical phenotype of these complex disorders in Indians has different genetic basis that is regulated differently and is programmed in-utero (Developmental Origins of Adult Common Diseases,). The larger goal is to have comprehensive knowledge of gene-gene and gene-nutrient interaction that will enable to alleviate and/or modulate the clinical course and complications of these disorders by modification of life style and diet, especially micronutrients.

Selected Publications

C S Yajnik, G R Chandak, C Joglekar, P Katre, D S Bhat, S N Singh, C S Janipalli, H Refsum, G Krishnaveni, S Veena, C Osmond, CHD Fall. Maternal homocysteine in pregnancy and offspring birthweight: Epidemiological associations and Mendelian randomizationanalysis. Int J Epidemiology 22 July 2014. Epub ahead of print. PMID: 25052622. 
[Accompanied by Editorial Commentary, Sarah J Lewis (2014). "One-carbon metabolism has major implications for fetal growth and development beyond neural tube defects" Int. J. of Epidemiol., 1-2 doi: 10.1093/ije/dyu175].

Heiko Witt, Sebastian Beer, Jonas Rosendahl, Jian-Min Chen, GirirajRatanChandak, et al. Loss-of-function mutations in CPA1 are strongly associated with early-onset chronic pancreatitis. Nature Genetics 2013 Oct;45(10):1216-20. doi: 10.1038/ng.2730. Epub 2013 Aug 18.

Ganesh Chauhan, Charles J Spurgeon, 12 more authors and G R Chandak (2010). Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC3018, HHEX, CDKN2A, IGF2BP2 AND CDKAL1 on the risk of type 2 diabetes in 5148 Indians. Diabetes ;59(8):2068-74.

P D Gluckman, P Bateson, A S Beedle, Z A Bhutta, M A Hanson, C Law, K V Anokhin, P Bougneres, G R Chandak, P Dasupta, G D Smith, P T Ellison, T Forrester, S F Gilbert, E Jablonka, H Kaplan, A M Prentice, S J Simpson, R Uauy & M J West-Eberhard (2009)."Development and human disease - a synthesis of evolutionary, medical, anthropological, and economic perspectives". Lancet 373(9675):1654-1657.


G R Chandak, C S Janipalli, S Bhaskar, S R Kulkarni, P Mohankrishna, A T Hattersley, T M Frayling, C S Yajnik (2007). Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population. Diabetologia50(1):63-67. 
[This paper is accompanied by an Editorial Commentary, Zeggini E and McCarthy MI "TCF7L2: the biggest story in diabetes genetics since HLA ?" Diabetologia 50: 1-4.]

Education & Experiance

Patents


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G R Chandak

Chief Scientist

2748

chandakgrc@ccmb.res.in

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Seema Bhaskar

Principal Technical Officer

2653

seema@ccmb.res.in

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Inder Deo Mali

Lab Assistant-I

2653

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P Ashok

Lab Attendant(2)

2653

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Amitabh Biswas

Project Consultant

2607

amitabh@ccmb.res.in

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Venkateswarlu Bandi

Research Associate-I (Project)

venky@ccmb.res.in

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Ajay Deepak Verma

Project SRF/RA

2653

ajaydeepak@ccmb.res.in

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Prachand I

Senior Research Fellow

2549

prachand@ccmb.res.in

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Ashutosh Singh Tomar

Senior Research Fellow

2607

ashutosh.tomar87@ccmb.res.in

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Sara Sajjadi

Senior Research Fellow

2653

sara.sajjadi@ccmb.res.in

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Swati Bayyana

Junior Research Fellow

2653

swati.bayyana@ccmb.res.in

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Sohail Rafik Mansuri

Junior Research Fellow

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Alagu Sankareswaran

Junior Research Fellow (Project)

2655

sankareshwaran@ccmb.res.in

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Shoma Naskar

Project Assistant-II

2607

shoma@ccmb.res.in

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Mobeen Shaik

Project Assistant-II

2607

mobeenshaik@ccmb.res.in

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Manisha Arumalla

Project Assistant-II

2653

manishaa@ccmb.res.in

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P S K D B Punya Sri

Project Assistant-I

2607

punyasri@ccmb.res.in

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Shagufta Tasneem

Project Assistant-I

2655

shaguftatasneem@ccmb.res.in

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Varsha Kolaria

Project Assistant-I

2607

varshak@ccmb.res.in