Training on Faster COVID-19 Testing
Link for downloading Admit Cards for the post of JSA(Gen./F&A/S&P) vide Advt. No.01/2025List of shortlisted and not shortlisted candidates against vide Advt.Nos: 04/2023, 05/2023 and 01/2025
List of provisionally selected candidates for the posts of Junior Stenographer advertised vide CSIR-CCMB Advt.No. 01_2023
CSIR - Centre for Cellular & Molecular Biology
Council of Scientific and Industrial Research
Ministry of Science & Technology, Govt. of India
J C Bose Fellow
Email: chandakgrc@ccmb.res.in
Phone: +91-040-27192748
Our group is interested in understanding the genetic basis of complex disorders such as type 2 diabetes mellitus and chronic pancreatitis and its interaction with various environmental factors (epigenetic basis). The major focus is on identifying various genetic and nutritional factors (and interaction between them), which influence The Thin Fat Indian Phenotype, and various intermediate traits that predict higher risk of developing diabetes and metabolic syndrome. These determinants could be both maternal and fetal in origin and we believe that the variable clinical phenotype of these complex disorders in Indians has different genetic basis that is regulated differently and is programmed in-utero (Developmental Origins of Adult Common Diseases,). The larger goal is to have comprehensive knowledge of gene-gene and gene-nutrient interaction that will enable to alleviate and/or modulate the clinical course and complications of these disorders by modification of life style and diet, especially micronutrients.
Selected Publications
C S Yajnik, G R Chandak, C Joglekar, P Katre, D S Bhat, S N Singh, C S Janipalli, H Refsum, G Krishnaveni, S Veena, C Osmond, CHD Fall. Maternal homocysteine in pregnancy and offspring birthweight: Epidemiological associations and Mendelian randomizationanalysis. Int J Epidemiology 22 July 2014. Epub ahead of print. PMID: 25052622.
[Accompanied by Editorial Commentary, Sarah J Lewis (2014). "One-carbon metabolism has major implications for fetal growth and development beyond neural tube defects" Int. J. of Epidemiol., 1-2 doi: 10.1093/ije/dyu175].
Heiko Witt, Sebastian Beer, Jonas Rosendahl, Jian-Min Chen, GirirajRatanChandak, et al. Loss-of-function mutations in CPA1 are strongly associated with early-onset chronic pancreatitis. Nature Genetics 2013 Oct;45(10):1216-20. doi: 10.1038/ng.2730. Epub 2013 Aug 18.
Ganesh Chauhan, Charles J Spurgeon, 12 more authors and G R Chandak (2010). Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC3018, HHEX, CDKN2A, IGF2BP2 AND CDKAL1 on the risk of type 2 diabetes in 5148 Indians. Diabetes ;59(8):2068-74.
P D Gluckman, P Bateson, A S Beedle, Z A Bhutta, M A Hanson, C Law, K V Anokhin, P Bougneres, G R Chandak, P Dasupta, G D Smith, P T Ellison, T Forrester, S F Gilbert, E Jablonka, H Kaplan, A M Prentice, S J Simpson, R Uauy & M J West-Eberhard (2009)."Development and human disease - a synthesis of evolutionary, medical, anthropological, and economic perspectives". Lancet 373(9675):1654-1657.
Education & Experience
| P.G: | Biochemistry ; Banaras Hindu University ; 1993 |
| Ph.D: | Genetic basis of tropical calcific pancreatitis ; Osmania University ; 2009 |
| Post.Doc: | Disease Genomics ; CSIR-CCMB ; 1994-96 |
| Experience: |
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| Invention | Countries of filing the patent | Application number | Publication number | Status | Grant Number |
|---|---|---|---|---|---|
| A kit for detection of mutations causing genetic disorders using unprocessed blood or dried blood spot | PCT | PCT/IN2020/050189 | Filed | Under process | |
| A kit for detection of mutations causing genetic disorders using unprocessed blood or dried blood spot | India | 201911038617 | Filed | Under process |
| Title | Journal | Year |
|---|---|---|
| Anaemia and iron deficiency in India: a venous blood-based survey of adolescents, adults, and the elderly in eight states. | Eur J Clin Nutr. | 2025 |
| Investigating misclassification of type 1 diabetes in a population-based cohort of British Pakistanis and Bangladeshis using polygenic risk scores. | Sci Rep | 2025 |
| HLA haplotype diversity, islet autoantibody status and discriminative ability of type 1 diabetes genetic risk score in Indians. | Diabet Med | 2025 |
| Cardiometabolic Risk factors among adults in rural, urban, and urban slum population in eight states of India. | Indian Heart J. | 2025 |
| Anaemia and iron deficiency in India: a venous blood-based survey of adolescents, adults, and the elderly in eight states | European Journal of Clinical Nutrition (Accepted) | 2024 |
| Investigating misclassification of type 1 diabetes in a population- based cohort of British Pakistanis and Bangladeshis using polygenic risk scores | Scientific Reports (Accepted) | 2024 |
| Maternal age is related to offspring DNA methylation: a meta-analysis of results from the PACE consortium | Aging Cell (Accpted) | 2024 |
| Maternal peri-conceptional vitamin B12 deficiency in Wistar rats leads to sex-specific programming for cardiometabolic disease risk in the next generation | The Journal of Nutrition (Accepted) | 2023 |
| Genetic architecture of adiposity measures among Asians: Findings from GWAS | Annals of Human Genetics | 2023 |
| DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood | Nature Communications (Accepted) | 2023 |
| Differential expression of genes influencing mitotic processes in cord blood mononuclear cells after a pre-conceptional micronutrient-based randomised controlled trial: Pune Rural Intervention in Young Adolescents (PRIYA). | J Dev Orig Health Dis. 2023, doi: 10.1017/S204017442200068X | 2023 |
| Hypoxia Inducible factors (HIF1α and HIF3α) are differentially methylated in preeclampsia placentae and are associated with birth outcomes | Molecular and Cellular Biochemistry (Accepted) | 2023 |
| Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis | Genome Biology | 2022 |
| A saturated map of common genetic vatiants associate with human height from 5.4 million individuals of diverse ancestries. | Nature. 2022 Oct;610(7933):704-712 | 2022 |
| Implicating genes, pleiotropy and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis | Genome Biology (Accepted) | 2022 |
| The PRSS3P2 and TRY7 deletion copy number variant modifies risk for chronic pancreatitis | Pancreatology | 2022 |
| DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood | bioRxiv | 2022 |
| Differential expression of genes influence mitotic processes in cord blood mononuclear cells after a pre-conceptional micronutrient-based randomized controlled trial: Pune Rural Intervention in Young Adolescents (PRIYA) | medRxiv | 2022 |
| Tissue- and ethnicity-independent hypervariable DNA methylation states show evidence of establishment in the early human embryo | Nucleic Acids Res | 2022 |
| A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids | Am J Hum Genet | 2022 |
| Evaluation of pharmacological efficacy and safety of Hydroxyurea in sickle cell disease: Study of a pediatric cohort from Chhattisgarh, India | Pediatric Hematology and Oncology | 2022 |
| Association of placental fatty acid desaturase 2 (FADS2) methylation with maternal fatty acid levels in women with preeclampsia | Prostaglandins, Leukotrienes and Essential Fatty Acids(Accepted) | 2022 |
| Sexual dimorphism in the relationship between brain complexity, volume and general intelligence (g): a cross-cohort study | Scientific Reports | 2022 |
| Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation | Nat Genet. 2022 May;54(5):560-572. doi: 10.1038/s41588-022-01058-3. Epub 2022 May 12. | 2022 |
| Author Correction: Identification of genetic effects underlying type 2 diabetes in South Asian and European populations | Commun Biol. 2022 May 5;5(1):441. doi: 10.1038/s42003-022-03404-x. | 2022 |
| Identification of genetic effects underlying type 2 diabetes in South Asian and European populations | Commun Biol. 2022 Apr 7;5(1):329. doi: 10.1038/s42003-022-03248-5. | 2022 |
| Environmentally sensitive hotspots in the methylome of the early human embryo | Elife. 2022 Feb 21;11:e72031. doi: 10.7554/eLife.72031. | 2022 |
| Babies of South Asian and European Ancestry Show Similar Associations With Genetic Risk Score for Birth Weight Despite the Smaller Size of South Asian Newborns | Diabetes. 2022 Apr 1;71(4):821-836. doi: 10.2337/db21-0479. | 2022 |
| DNA methylation signatures associated with cardiometabolic risk factors in children from India and The Gambia: results from the EMPHASIS study | Clin Epigenetics. 2022 Jan 9;14(1):6. doi: 10.1186/s13148-021-01213-3. | 2022 |
| Placental growth factor?and Fms related tyrosine kinase-1?are hypomethylated in preeclampsia placentae | Epigenomics. 2021 Feb;13(4):257-269. doi: 10.2217/epi-2020-0318. Epub 2021 Jan 20. | 2021 |
| Protocol for a cluster randomised trial evaluating a multifaceted intervention starting preconceptionally-Early Interventions to Support Trajectories for Healthy Life in India (EINSTEIN): a Healthy Life Trajectories Initiative (HeLTI) Study | BMJ Open. 2021 Feb 16;11(2):e045862. doi: 10.1136/bmjopen-2020-045862. | 2021 |
| Rapid and accurate nucleobase detection using FnCas9 and its application in COVID-19 diagnosis | Biosens Bioelectron. 2021 Jul 1;183:113207. doi: 10.1016/j.bios.2021.113207. Epub 2021 Apr 5. | 2021 |
| Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2 | Elife. 2021 Apr 20;10:e66537. doi: 10.7554/eLife.66537. | 2021 |
| Size at birth, lifecourse factors, and cognitive function in late life: findings from the MYsore study of Natal effects on Ageing and Health (MYNAH) cohort in South India | Int Psychogeriatr. 2021 Oct 20:1-14. doi: 10.1017/S1041610221001186. Online ahead of print. | 2021 |
| The power of genetic diversity in genome-wide association studies of lipids | Nature. 2021 Dec;600(7890):675-679. doi: 10.1038/s41586-021-04064-3. Epub 2021 Dec 9. | 2021 |
| Causal relationships between lipid and glycemic levels in an Indian population: A bidirectional Mendelian randomization approach | PLoS One. 2020 Jan 29;15(1):e0228269. doi: 10.1371/journal.pone.0228269. eCollection 2020. | 2020 |
| Maternal vitamin B(12) deficiency in rats alters DNA methylation in metabolically important genes in their offspring | Mol Cell Biochem. 2020 May;468(1-2):83-96. doi: 10.1007/s11010-020-03713-x. Epub 2020 Mar 18. | 2020 |
| Novel p.P298L SURF1 mutation in thiamine deficient Leigh syndrome patients compromises cytochrome c oxidase activity | Mitochondrion. 2020 Jul;53:91-98. doi: 10.1016/j.mito.2020.04.009. Epub 2020 May 4. | 2020 |
| Type 1 diabetes genetic risk score is discriminative of diabetes in non-Europeans: evidence from a study in India | Sci Rep. 2020 Jun 11;10(1):9450. doi: 10.1038/s41598-020-65317-1. | 2020 |
| Periconceptional environment predicts leukocyte telomere length in a cross-sectional study of 7-9 year old rural Gambian children | Sci Rep. 2020 Jun 15;10(1):9675. doi: 10.1038/s41598-020-66729-9. | 2020 |
| Genetic Architecture of Parkinson's Disease in the Indian Population: Harnessing Genetic Diversity to Address Critical Gaps in Parkinson's Disease Research | Front Neurol. 2020 Jun 18;11:524. doi: 10.3389/fneur.2020.00524. eCollection 2020. | 2020 |
| Effect of maternal preconceptional and pregnancy micronutrient interventions on children's DNA methylation: Findings from the EMPHASIS study | Am J Clin Nutr. 2020 Oct 1;112(4):1099-1113. doi: 10.1093/ajcn/nqaa193. | 2020 |
| Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis | Am J Gastroenterol. 2019 Jun;114(6):974-983. doi: 10.14309/ajg.0000000000000051. | 2019 |
| The REVAMP study: research exploring various aspects and mechanisms in preeclampsia: study protocol | BMC Pregnancy Childbirth. 2019 Aug 23;19(1):308. doi: 10.1186/s12884-019-2450-0. | 2019 |
| Associations of autozygosity with a broad range of human phenotypes | Nat Commun. 2019 Oct 31;10(1):4957. doi: 10.1038/s41467-019-12283-6. | 2019 |
| Vitamin B(12) supplementation influences methylation of genes associated with Type 2 diabetes and its intermediate traits | Epigenomics. 2018 Jan;10(1):71-90. doi: 10.2217/epi-2017-0102. Epub 2017 Nov 14. | 2018 |
| Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls | Sci Data. 2018 Jan 23;5:180002. doi: 10.1038/sdata.2018.2. | 2018 |
| Identification and characterization of cis-regulatory elements 'insulator and repressor' in PPARD gene | Epigenomics. 2018 May;10(5):613-627. doi: 10.2217/epi-2017-0139. Epub 2018 Mar 27. | 2018 |
| Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: a review of existing evidence in humans with specific focus on one-carbon metabolism | Int J Epidemiol. 2018 Dec 1;47(6):1910-1937. doi: 10.1093/ije/dyy153. | 2018 |
| Adult onset hereditary hemochromatosis is associated with a novel recurrent Hemojuvelin (HJV) gene mutation in north Indians | Blood Cells Mol Dis. 2018 Nov;73:14-21. doi: 10.1016/j.bcmd.2018.08.003. Epub 2018 Aug 27. | 2018 |
| GWAS identifies population-specific new regulatory variants in FUT6 associated with plasma B12 concentrations in Indians | Hum Mol Genet. 2017 Jul 1;26(13):2551-2564. doi: 10.1093/hmg/ddx071. | 2017 |
| A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk | Diabetes. 2017 Jul;66(7):2019-2032. doi: 10.2337/db16-1329. Epub 2017 Mar 24. | 2017 |
| GWAS identifies population-specific new regulatory variants in FUT6 associated with plasma B12 concentrations in Indians | Hum Mol Genet. 2017 Jul 1;26(13):2589. doi: 10.1093/hmg/ddx156. | 2017 |
| Identification of a functional enhancer variant within the chronic pancreatitis-associated SPINK1 c.101A>G (p.Asn34Ser)-containing haplotype | Hum Mutat. 2017 Aug;38(8):1014-1024. doi: 10.1002/humu.23269. Epub 2017 Jun 15. | 2017 |
| Hypermethylated CpG sites in the MTR gene promoter in preterm placenta | Epigenomics. 2017 Jul;9(7):985-996. doi: 10.2217/epi-2016-0173. Epub 2017 Jun 15. | 2017 |
| Inclusion of Population-specific Reference Panel from India to the 1000 Genomes Phase 3 Panel Improves Imputation Accuracy | Sci Rep. 2017 Jul 27;7(1):6733. doi: 10.1038/s41598-017-06905-6. | 2017 |
| Protocol for the EMPHASIS study; epigenetic mechanisms linking maternal pre-conceptional nutrition and children's health in India and Sub-Saharan Africa | BMC Nutr. 2017 Oct 30;3:81. doi: 10.1186/s40795-017-0200-0. | 2017 |
| Sequence data and association statistics from 12,940 type 2 diabetes cases and controls | Sci Data. 2017 Dec 19;4:170179. doi: 10.1038/sdata.2017.179. | 2017 |
| Association Analysis of PRSS1-PRSS2 and CLDN2-MORC4 Variants in Nonalcoholic Chronic Pancreatitis Using Tropical Calcific Pancreatitis as Model | Pancreas. 2016 Sep;45(8):1153-7. doi: 10.1097/MPA.0000000000000608. | 2016 |
| Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function | Nat Commun. 2016 Jan 21;7:10023. doi: 10.1038/ncomms10023. | 2016 |
| Lack of replication of association of THSD7A with obesity | Int J Obes (Lond). 2016 Apr;40(4):725-6. doi: 10.1038/ijo.2016.15. Epub 2016 Feb 23. | 2016 |
| No Association Between CEL-HYB Hybrid Allele and Chronic Pancreatitis in Asian Populations | Gastroenterology. 2016 Jun;150(7):1558-1560.e5. doi: 10.1053/j.gastro.2016.02.071. Epub 2016 Mar 3. | 2016 |
| The genetic architecture of type 2 diabetes | Nature. 2016 Aug 4;536(7614):41-47. doi: 10.1038/nature18642. Epub 2016 Jul 11. | 2016 |
| Identification of urinary proteins potentially associated with diabetic kidney disease | Indian J Nephrol. 2016 Nov-Dec;26(6):434-445. doi: 10.4103/0971-4065.176144. | 2016 |
| New genetic loci link adipose and insulin biology to body fat distribution | Nature. 2015 Feb 12;518(7538):187-196. doi: 10.1038/nature14132. | 2015 |
| Genetic studies of body mass index yield new insights for obesity biology | Nature. 2015 Feb 12;518(7538):197-206. doi: 10.1038/nature14177. | 2015 |
| Maternal micronutrient deficiency leads to alteration in the kidney proteome in rat pups | J Proteomics. 2015 Sep 8;127(Pt A):178-84. doi: 10.1016/j.jprot.2015.04.035. Epub 2015 May 14. | 2015 |
| Directional dominance on stature and cognition in?diverse human populations | Nature. 2015 Jul 23;523(7561):459-462. doi: 10.1038/nature14618. Epub 2015 Jul 1. | 2015 |
| New insights from monogenic diabetes for "common" type 2 diabetes | Front Genet. 2015 Aug 7;6:251. doi: 10.3389/fgene.2015.00251. eCollection 2015. | 2015 |
| Intrauterine Programming of Diabetes and Adiposity | Curr Obes Rep. 2015 Dec;4(4):418-28. doi: 10.1007/s13679-015-0175-6. | 2015 |
| Association of common variants in/near six genes (ATP2B1, CSK, MTHFR, CYP17A1, STK39 and FGF5) with blood pressure/hypertension risk in Chinese children | J Hum Hypertens. 2014 Jan;28(1):32-6. doi: 10.1038/jhh.2013.50. Epub 2013 Jun 13. | 2014 |
| Associations of genetic variants in/near body mass index-associated genes with type 2 diabetes: a systematic meta-analysis | Clin Endocrinol (Oxf). 2014 Nov;81(5):702-10. doi: 10.1111/cen.12428. Epub 2014 Mar 13. | 2014 |
| FTO gene variant and risk of hypertension: a meta-analysis of 57,464 hypertensive cases and 41,256 controls | Metabolism. 2014 May;63(5):633-9. doi: 10.1016/j.metabol.2014.02.008. Epub 2014 Feb 17. | 2014 |
| Altered methylation and expression patterns of genes regulating placental angiogenesis in preterm pregnancy | Reprod Sci. 2014 Dec;21(12):1508-17. doi: 10.1177/1933719114532838. Epub 2014 May 6. | 2014 |
| Association of common genetic variants with lipid traits in the Indian population | PLoS One. 2014 Jul 3;9(7):e101688. doi: 10.1371/journal.pone.0101688. eCollection 2014. | 2014 |
| Maternal homocysteine in pregnancy and offspring birthweight: epidemiological associations and Mendelian randomization analysis | Int J Epidemiol. 2014 Oct;43(5):1487-97. doi: 10.1093/ije/dyu132. Epub 2014 Jul 22. | 2014 |
| Chronic maternal vitamin B12 restriction induced changes in body composition & glucose metabolism in the Wistar rat offspring are partly correctable by rehabilitation | PLoS One. 2014 Nov 14;9(11):e112991. doi: 10.1371/journal.pone.0112991. eCollection 2014. | 2014 |
| Genetic and phenotypic heterogeneity in tropical calcific pancreatitis | World J Gastroenterol. 2014 Dec 14;20(46):17314-23. doi: 10.3748/wjg.v20.i46.17314. | 2014 |
| Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants | Gut. 2013 Nov;62(11):1602-6. doi: 10.1136/gutjnl-2012-302448. Epub 2012 May 12. | 2013 |
| Maternal dietary folate and/or vitamin B12 restrictions alter body composition (adiposity) and lipid metabolism in Wistar rat offspring | J Nutr Biochem. 2013 Jan;24(1):25-31. doi: 10.1016/j.jnutbio.2012.01.004. Epub 2012 Jun 14. | 2013 |
| Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk | Gut. 2013 Nov;62(11):1616-24. doi: 10.1136/gutjnl-2012-303090. Epub 2012 Sep 1. | 2013 |
| Migration and DNA methylation: a comparison of methylation patterns in type 2 diabetes susceptibility genes between indians and europeans | J Diabetes Res Clin Metab. 2013;2:6. doi: 10.7243/2050-0866-2-6. Epub 2013 Feb 6. | 2013 |
| Association study of 25 type 2 diabetes related Loci with measures of obesity in Indian sib pairs | PLoS One. 2013;8(1):e53944. doi: 10.1371/journal.pone.0053944. Epub 2013 Jan 17. | 2013 |
| Study of 11 BMI-associated loci identified in GWAS for associations with central obesity in the Chinese children | PLoS One. 2013;8(2):e56472. doi: 10.1371/journal.pone.0056472. Epub 2013 Feb 12. | 2013 |
| STK39 polymorphism is associated with essential hypertension: a systematic review and meta-analysis | PLoS One. 2013;8(3):e59584. doi: 10.1371/journal.pone.0059584. Epub 2013 Mar 18. | 2013 |
| Influence of obesity on association between genetic variants identified by genome-wide association studies and hypertension risk in Chinese children | Am J Hypertens. 2013 Aug;26(8):990-6. doi: 10.1093/ajh/hpt046. Epub 2013 Apr 16. | 2013 |
| Differential placental methylation and expression of VEGF, FLT-1 and KDR genes in human term and preterm preeclampsia | Clin Epigenetics. 2013 Apr 26;5(1):6. doi: 10.1186/1868-7083-5-6. | 2013 |
| PPAR signaling pathway is a key modulator of liver proteome in pups born to vitamin B(12) deficient rats | J Proteomics. 2013 Oct 8;91:297-308. doi: 10.1016/j.jprot.2013.07.027. Epub 2013 Aug 6. | 2013 |
| Variants in CPA1 are strongly associated with early onset chronic pancreatitis | Nat Genet. 2013 Oct;45(10):1216-20. doi: 10.1038/ng.2730. Epub 2013 Aug 18. | 2013 |
| Analysis of 32 common susceptibility genetic variants and their combined effect in predicting risk of Type 2 diabetes and related traits in Indians | Diabet Med. 2012 Jan;29(1):121-7. doi: 10.1111/j.1464-5491.2011.03438.x. | 2012 |
| Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs | Diabetologia. 2012 Feb;55(2):349-57. doi: 10.1007/s00125-011-2355-6. Epub 2011 Nov 4. | 2012 |
| Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians | Diabetologia. 2012 Apr;55(4):981-95. doi: 10.1007/s00125-011-2370-7. Epub 2011 Nov 23. | 2012 |
| LC-MS/MS analysis of differentially expressed glioblastoma membrane proteome reveals altered calcium signaling and other protein groups of regulatory functions | Mol Cell Proteomics. 2012 Jun;11(6):M111.013565. doi: 10.1074/mcp.M111.013565. Epub 2012 Jan 4. | 2012 |
| Common variants of SLAMF1 and ITLN1 on 1q21 are associated with type 2 diabetes in Indian population | J Hum Genet. 2012 Mar;57(3):184-90. doi: 10.1038/jhg.2011.150. Epub 2012 Jan 26. | 2012 |
| High resolution methylome map of rat indicates role of intragenic DNA methylation in identification of coding region | PLoS One. 2012;7(2):e31621. doi: 10.1371/journal.pone.0031621. Epub 2012 Feb 15. | 2012 |
| Presence of strong association of the major histocompatibility complex (MHC) class I allele HLA-A*26:01 with idiopathic hypoparathyroidism | J Clin Endocrinol Metab. 2012 Sep;97(9):E1820-4. doi: 10.1210/jc.2012-1328. Epub 2012 Jun 20. | 2012 |
| Common polymorphism near the MC4R gene is associated with type 2 diabetes: data from a meta-analysis of 123,373 individuals | Diabetologia. 2012 Oct;55(10):2660-2666. doi: 10.1007/s00125-012-2655-5. Epub 2012 Aug 7. | 2012 |
| Genetic analysis of an Indian family with members affected with Waardenburg syndrome and Duchenne muscular dystrophy | Mol Vis. 2012;18:2022-32. Epub 2012 Jul 20. | 2012 |
| H63D mutation in HFE gene is common in Indians and is associated with the European haplotype | J Genet. 2012 Aug;91(2):229-32. doi: 10.1007/s12041-012-0163-5. | 2012 |
| Proteins with altered levels in plasma from glioblastoma patients as revealed by iTRAQ-based quantitative proteomic analysis | PLoS One. 2012;7(9):e46153. doi: 10.1371/journal.pone.0046153. Epub 2012 Sep 28. | 2012 |
| Association between common polymorphism near the MC4R gene and obesity risk: a systematic review and meta-analysis | PLoS One. 2012;7(9):e45731. doi: 10.1371/journal.pone.0045731. Epub 2012 Sep 25. | 2012 |
| Evaluation of seven common lipid associated loci in a large Indian sib pair study | Lipids Health Dis. 2012 Nov 14;11:155. doi: 10.1186/1476-511X-11-155. | 2012 |
| What's there in a name: tropical calcific pancreatitis and idiopathic chronic pancreatitis in India | Gut. 2011 Oct;60(10):1440-1; author reply 1441-2. doi: 10.1136/gut.2010.228452. Epub 2010 Oct 27. | 2011 |
| Common variants in NOD2 and IL23R are not associated with inflammatory bowel disease in Indians | J Gastroenterol Hepatol. 2011 Apr;26(4):694-9. doi: 10.1111/j.1440-1746.2010.06533.x. | 2011 |
| Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study | Hum Mol Genet. 2011 Jun 1;20(11):2273-84. doi: 10.1093/hmg/ddr092. Epub 2011 Mar 4. | 2011 |
| Association of PON1 and APOA5 gene polymorphisms in a cohort of Indian patients having coronary artery disease with and without type 2 diabetes | Genet Test Mol Biomarkers. 2011 Jul-Aug;15(7-8):507-12. doi: 10.1089/gtmb.2010.0207. Epub 2011 Mar 25. | 2011 |
| Relationship of APOA5, PPAR? and HL gene variants with serial changes in childhood body mass index and coronary artery disease risk factors in young adulthood | Lipids Health Dis. 2011 May 8;10:68. doi: 10.1186/1476-511X-10-68. | 2011 |
| Glioblastoma cell secretome: analysis of three glioblastoma cell lines reveal 148 non-redundant proteins | J Proteomics. 2011 Sep 6;74(10):1918-25. doi: 10.1016/j.jprot.2011.05.002. Epub 2011 May 11. | 2011 |
| Assessing the pathological relevance of SPINK1 promoter variants | Eur J Hum Genet. 2011 Oct;19(10):1066-73. doi: 10.1038/ejhg.2011.79. Epub 2011 May 25. | 2011 |
| A set of five microsatellite markers linked to F8 gene can detect haemophilia A carriers across India | Haemophilia. 2011 Sep;17(5):e928-35. doi: 10.1111/j.1365-2516.2011.02584.x. Epub 2011 Jun 22. | 2011 |
| Maternal one-carbon metabolism, MTHFR and TCN2 genotypes and neural tube defects in India | Birth Defects Res A Clin Mol Teratol. 2011 Sep;91(9):848-56. doi: 10.1002/bdra.20841. Epub 2011 Jul 18. | 2011 |
| Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier | J Obes. 2011;2011:307542. doi: 10.1155/2011/307542. Epub 2011 May 17. | 2011 |
| Obscure pathogenesis of primary iron overload in Indians warrants more focused research | Indian J Gastroenterol. 2011 Jul;30(4):154-5. doi: 10.1007/s12664-011-0119-3. Epub 2011 Aug 17. | 2011 |
| Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk | Nature. 2011 Sep 11;478(7367):103-9. doi: 10.1038/nature10405. | 2011 |
| Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma | Nat Genet. 2011 Oct 16;43(11):1131-8. doi: 10.1038/ng.970. | 2011 |
| Cardiac beriberi: often a missed diagnosis | J Trop Pediatr. 2010 Aug;56(4):284-5. doi: 10.1093/tropej/fmp108. Epub 2009 Nov 24. | 2010 |
| Low prevalence of GJB2 mutations in non-syndromic hearing loss in Western India | Indian J Otolaryngol Head Neck Surg. 2010 Jan;62(1):60-3. doi: 10.1007/s12070-010-0009-5. Epub 2010 Jun 4. | 2010 |
| Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians | Diabetes. 2010 Aug;59(8):2068-74. doi: 10.2337/db09-1386. Epub 2010 Apr 27. | 2010 |
| EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda | Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18961-6. doi: 10.1073/pnas.1006108107. Epub 2010 Oct 18. | 2010 |
| FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians | Diabetologia. 2009 Feb;52(2):247-52. doi: 10.1007/s00125-008-1186-6. Epub 2008 Nov 13. | 2009 |
| Genetic mechanisms underlying the pathogenesis of tropical calcific pancreatitis | World J Gastroenterol. 2009 Jan 21;15(3):264-9. doi: 10.3748/wjg.15.264. | 2009 |
| Towards a new developmental synthesis: adaptive developmental plasticity and human disease | Lancet. 2009 May 9;373(9675):1654-7. doi: 10.1016/S0140-6736(09)60234-8. | 2009 |
| The G191R variant in the PRSS2 gene does not play a role in protection against tropical calcific pancreatitis | Gut. 2009 Jun;58(6):881-2. doi: 10.1136/gut.2008.170753. | 2009 |
| Trypsinogen copy number mutations in patients with idiopathic chronic pancreatitis | Clin Gastroenterol Hepatol. 2008 Jan;6(1):82-8. doi: 10.1016/j.cgh.2007.10.004. Epub 2007 Dec 11. | 2008 |
| High prevalence of infantile encephalitic beriberi with overlapping features of Leigh's disease | J Trop Pediatr. 2008 Oct;54(5):328-32. doi: 10.1093/tropej/fmn031. Epub 2008 May 8. | 2008 |
| Genetic landscape of the people of India: a canvas for disease gene exploration | J Genet. 2008 Apr;87(1):3-20. doi: 10.1007/s12041-008-0002-x. | 2008 |
| TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes | BMC Med Genet. 2008 Aug 16;9:80. doi: 10.1186/1471-2350-9-80. | 2008 |
| Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population | Diabetologia. 2007 Jan;50(1):63-7. doi: 10.1007/s00125-006-0502-2. Epub 2006 Nov 9. | 2007 |
| Frequency of primary iron overload and HFE gene mutations (C282Y, H63D and S65C) in chronic liver disease patients in north India | World J Gastroenterol. 2007 Jun 7;13(21):2956-9. doi: 10.3748/wjg.v13.i21.2956. | 2007 |
| Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis | World J Gastroenterol. 2007 Nov 28;13(44):5938-43. doi: 10.3748/wjg.v13.i44.5938. | 2007 |
| Evaluation of genetic markers linked to hemophilia A locus: an Indian experience | Haematologica. 2007 Dec;92(12):1725-6. doi: 10.3324/haematol.11545. | 2007 |
| Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis | Gut. 2006 Sep;55(9):1270-5. doi: 10.1136/gut.2005.087403. Epub 2006 Feb 21. | 2006 |
| Allelic drop-out may occur with a primer binding site polymorphism for the commonly used RFLP assay for the -1131T>C polymorphism of the Apolipoprotein AV gene | Lipids Health Dis. 2006 May 2;5:11. doi: 10.1186/1476-511X-5-11. | 2006 |
| Juvenile fibrocalculous pancreatopathy--a patient report | J Pediatr Endocrinol Metab. 2006 Jul;19(7):947-50. doi: 10.1515/jpem.2006.19.7.947. | 2006 |
| A novel mutation in STK11 gene is associated with Peutz-Jeghers Syndrome in Indian patients | BMC Med Genet. 2006 Sep 30;7:73. doi: 10.1186/1471-2350-7-73. | 2006 |
| Triglyceride associated polymorphisms of the APOA5 gene have very different allele frequencies in Pune, India compared to Europeans | BMC Med Genet. 2006 Oct 10;7:76. doi: 10.1186/1471-2350-7-76. | 2006 |
| Lack of significant association of an insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene with tropical calcific pancreatitis | BMC Gastroenterol. 2006 Dec 12;6:42. doi: 10.1186/1471-230X-6-42. | 2006 |
| Remarkable variation in the informativeness of RFLP markers linked to hemophilia B locus in Indian population groups: implication in the strategy for carrier detection | Dis Markers. 2006;22(5-6):327-34. doi: 10.1155/2006/947275. | 2006 |
| Mutations in anionic trypsinogen gene are not associated with tropical calcific pancreatitis | Gut. 2005 May;54(5):728-9. doi: 10.1136/gut.2004.055335. | 2005 |
| Genotype-phenotype correlation of SMN locus genes in spinal muscular atrophy patients from India | Exp Mol Med. 2005 Jun 30;37(3):147-54. doi: 10.1038/emm.2005.20. | 2005 |
| Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis | Gut. 2004 May;53(5):723-8. doi: 10.1136/gut.2003.026526. | 2004 |
| Molecular pathology of haemophilia B: identification of five novel mutations including a LINE 1 insertion in Indian patients | Haemophilia. 2004 May;10(3):259-63. doi: 10.1111/j.1365-2516.2004.00895.x. | 2004 |
| Dystrophin gene deletions in South Indian Duchenne muscular dystrophy patients | Indian J Med Sci. 2003 Jan;57(1):1-6. | 2003 |
| Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitis | J Med Genet. 2002 May;39(5):347-51. doi: 10.1136/jmg.39.5.347. | 2002 |
| Apolipoprotein E and presenilin-1 allelic variation and Alzheimer's disease in India | Hum Biol. 2002 Oct;74(5):683-93. doi: 10.1353/hub.2002.0051. | 2002 |
| Sickle cell gene haplotypes in Relli and Thurpu Kapu populations of Andhra Pradesh | Hum Biol. 2000 Jun;72(3):535-40. | 2000 |
| Fetus-in-fetu: a case report with molecular analysis | J Pediatr Surg. 1999 Apr;34(4):641-4. doi: 10.1016/s0022-3468(99)90095-7. | 1999 |
| Some atypical and rare sickle cell gene haplotypes in populations of Andhra Pradesh, India | Hum Biol. 1999 Jun;71(3):333-40. | 1999 |
2748
chandakgrc@ccmb.res.in
2653
2653
seema@ccmb.res.in
2549
suraj.nong@ccmb.res.in
2549
sumit-pal@ccmb.res.in
2653
sara.sajjadi@ccmb.res.in
2653
swati.bayyana@ccmb.res.in
2655
sankareswaran@ccmb.res.in
2607
sohail@ccmb.res.in
2653
manishaa@ccmb.res.in
2607
punyasri@ccmb.res.in
2657
archanad@ccmb.res.in
2657
akshithaj@ccmb.res.in
2657
dimple@ccmb.res.in
2655
