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CSIR - Centre for Cellular & Molecular Biology

Council of Scientific and Industrial Research
Ministry of Science & Technology, Govt. of India

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K Thangaraj

Chief Scientist
Email: thangs@ccmb.res.in
Phone: +91-040-27192634

Research Interests

Our major research interest has been in the field of human origin, health and disease. We are interested in understand the complex origin and affinities of Indian populations, using the genomics variations of contemporary populations and ancient biological remains. We are also interested in understanding the impact of endogamy on health and disease of South Asians. Our other research focus is to find the molecular basis of; male infertility, cardiovascular diseases, sex determination, and mitochondrial disorders. Some of our most significant contributions in the above field are as follows:

We discovered that the enigmatic tribal populations of Andaman Islands are the first modern humans who migrated out of Africa through southern coastal route about 65,000 years ago (Science, 2005). Subsequently, we found that the present-day Indian populations descend from two diverse groups; namely, Ancestral South Indians (ASI) and Ancestral North Indians (ANI) (Nature, 2009). Further, we found that the ASI and ANI have admixed during the past 2000 - 4000 years (American Journal of Human Genetics, 2013); followed by strict endogamy leading to population-specific recessive disease, due to founder events (Nature Genetics, 2017).

Selected Publications

Shinde V, Narasimhan VM, Rohland N, Mallick S, Mah M, Lipson M, Nakatsuka N, Adamski N, Broomandkhoshbacht N, Ferry M, Lawson AM, Michel M, Oppenheimer J, Stewardson K, Jadhav N, Kim YJ, Chatterjee M, Munshi A, Panyam A, Waghmare P, Yadav Y, Patel H, Kaushik A, Thangaraj K, Meyer M, Patterson N, Rai N, Reich D (2019) An Ancient Harappan Genome Lacks Ancestry from Steppe Pastoralists or Iranian Farmers. Cell. 179:729-735. (accompanied with Preview by Maanasa Raghavan, Hannes Schroeder, Anna-Sapfo Malaspina)

Nakatsuka N, Moorjani P, Rai N, Sarkar B, Tandon A, Patterson N, Bhavani GS, Girisha KM, Mustak MS, Srinivasan S, Kaushik A, Vahab SA, Jagadeesh SM, Satyamoorthy K, Singh L, Reich D, Thangaraj K (2017) The promise of discovering population-specific disease-associated genes in South Asia. Nature Genetics. 49: 1403-1407. (accompanied with coverpage and Editorial)

Reich D*, Thangaraj K*, Patterson N*, Price AL*, Singh L (2009) Reconstructing Indian Population History. Nature. 461: 489-494. (*equal first authors) (accompanied with coverpage and News & Views by Aravinda Chakravarty)

Dhandapany PS, Sadayappan S, Xue Y, Powell GT, Rani DS, Nallari P, Rai TS, Khullar M, Soares P, Bahl A, Tharkan JM, Vaideeswar P, Rathinavel A, Narasimhan C, Ayapati DR, Ayub Q, Mehdi SQ, Oppenheimer S, Richards M, Price A, Patterson N, Reich D, Singh L, Tyler-Smith C, Thangaraj K (2009) A common MYBPC3 (Cardiac Myosin Binding Protein C) variant associated with cardiomyopathies in South Asia. Nature Genetics. 41 187-191.

Thangaraj K, Chaubey G, Kivisild T, Reddy AG, Singh VK, Rasalkar AA, Singh L (2005) Reconstructing the origin of the Andaman Islanders. Science 308: 996. (accompanied with Perspectives by Peter Foster and Shuichi Matsumura)

 

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Publications

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K Thangaraj

Chief Scientist

2634

thangs@ccmb.res.in

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Nitin C Tupperwar

Principal Scientist

2606

nitint@ccmb.res.in

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G Mala

Principal Technical Officer

2638

mala@ccmb.res.in

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S Deepa Selvi Rani

Sr. Technical Officer(2)

2636

deepa@ccmb.res.in

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Jagamohan Chhatai

Technical Officer

2638

jagamohan@ccmb.res.in

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Purushotham V

Technical Officer

2516

purushotham@ccmb.res.in

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Narmadha

CSIR Nehru PDF

2640

narmadha@ccmb.res.in

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Sunitha Kundur

Research Associate-I

2640

sunitha.k@ccmb.res.in

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Sunil Kumar Tripathi

Senior Research Fellow

2636

sunilkumar@ccmb.res.in

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Rajan Kumar Jha

Senior Research Fellow

2637

rajanjha@ccmb.res.in

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Nipa Basak

Senior Research Fellow

2637

nipabasak@ccmb.res.in

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Jaydeep Aravindbhai Badarukhiya

Senior Research Fellow

2640

jd.aravind41@ccmb.res.in

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Lomous Kumar

Senior Research Fellow

2642

lomous.kumar@ccmb.res.in

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Umesh Kumar

Junior Research Fellow

2640

u.kumar@ccmb.res.in

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Deepak Kumar Kashyap

Junior Research Fellow

2636

deepak.kashyap@ccmb.res.in

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Sagnik Dhar

Junior Research Fellow (CSIR)

2636

sagnik@ccmb.res.in

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Pratheusa Machha

Junior Research Fellow (DBT)

2640

pratheusa@ccmb.res.in

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Usha Kabilan

Project Assistant-II

2638

ushakabilan@ccmb.res.in

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Meghana P

Project Assistant-II

2636

meghana@ccmb.res.in