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Mandar V Deshmukh -Img

Mandar V Deshmukh

Senior Principal Scientist
Email: mvdesh@ccmb.res.in
Phone: +91-040-27192646/2839

Research Interests

The lab of Dr. Deshmukh explores the structural and molecular basis of evolutionary divergence in the noncoding RNA mediated gene silencing pathway across organisms. He utilizes state-of-the-art biomolecular NMR techniques coupled with molecular biology, biochemistry, and biophysics to elaborate on the structure and function of several important high molecular weight proteins and nucleic acids. His lab employs an innovative biomolecular NMR approach to study inter-domain orientations and dynamics in multi-domain proteins such as RDE-4, DRB4, and DRB2. The studies performed by his group deciphered the initiation of the non-coding RNA mediated gene regulation pathway in various species. His work revealed that the subtle differences in structure and dynamics in highly homologous proteins incite the evolutionary divergence in the RNAi pathway. His work distinctively helps to extend our understanding in one of the basic biological processes that have direct implications in infection, cancer, and development.
He was invited as a speaker at prestigious biomolecular NMR meetings such as ICMRBS, Dallas, USA (2014), APNMRS, Hong Kong (2015), ICMRBS, Kyoto, Japan (2016), Indo-German Workshop, Leipzig, Germany (2017), and APNMRS, Singapore (2019).

Selected Publications

DRB4 dsRBD1 drives dsRNA recognition in Arabidopsis thaliana tasi/siRNA pathway 

C. Sai Chaitanya, Ramdas Aute, Upasana Rai, Mandar V. Deshmukh 
Nucleic Acids Research, 45(14), 8551-8563 , 2017.

Recent Excitements in Protein NMR: Large Proteins and Biologically Relevant Dynamics 
C. Sai Chaitanya and Mandar V Deshmukh
Journal of Biosciences, 41(4), 787-803, 2016.

Backbone and stereospecific 13C methyl Ile (?1), Leu and Val sidechain chemical shift assignments of Crc. 
Rakhi Sharma, B Sahu, Malay K Ray and Mandar V Deshmukh
Biomolecular NMR Assignments, 9(1), 75-9, 2015.

Structure of RDE-4 dsRBDs and mutational studies provide insights in the dsRNA recognition in C. elegans RNAi. 
C Sai Chaitanya and Mandar V Deshmukh
Biochemical Journal, 458 (1), 119-130, 2014.

Backbone and sidechain methyl Ile(?1), Leu and Val chemical shift assignments of RDE-4(1-243), an RNA interference initiation protein in C. elegans. C Sai Chaitanya, Sonu Kumar, M Udaya Kiran and Mandar V Deshmukh
Biomolecular NMR Assignments, 6(2), 143-6, 2012.

Education & Experience

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Publications

Mandar V Deshmukh -Group Pic
Mandar V Deshmukh -Img

Mandar V Deshmukh

Senior Principal Scientist

2646/2839

mvdesh@ccmb.res.in

Shiv Pratap Singh Yadav-Img

Shiv Pratap Singh Yadav

Scientist

2524/2542

shivpratap@ccmb.res.in

R Phanindranath-Img

R Phanindranath

Sr. Technical Officer(2)

2998

phanindra@ccmb.res.in

Sneha Paturi	-Img

Sneha Paturi

Senior Research Fellow

2917/2517

snehapaturi@ccmb.res.in

Jaydeep Paul	-Img

Jaydeep Paul

Senior Research Fellow

2917/2517

jaydeep@ccmb.res.in

Debadutta Patra-Img

Debadutta Patra

Junior Research Fellow

2917

debadutta@ccmb.res.in

Priti Chanda Behra-Img

Priti Chanda Behra

Junior Research Fellow

2517

pritichanda@ccmb.res.in

Aute Ramdas Annasaheb	-Img

Aute Ramdas Annasaheb

Junior Research Fellow

2917/2517

ramaute@ccmb.res.in

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Supriti Das

Junior Research Fellow

Nilam Waghela-Img

Nilam Waghela

Junior Research Fellow (DBT)

2517

nilam.waghela@ccmb.res.in