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Manjula Reddy-Img

Manjula Reddy

Chief Scientist
Email: manjula@ccmb.res.in
Phone: +91-040-27192514

Research Interests

Research in our laboratory is focused towards understanding how bacteria elongate, divide, and split their cell walls during cell cycle to successfully generate two equal daughter cells. We take a multi-disciplinary approach including genetics, biochemistry, cell biology, and genomics to address these questions. We use a well-known Gram-negative rod-shaped bacterium Escherichia coli as our primary model system. Our most significant contribution in this field was identification of a rate-limiting cleavage step in the growth and synthesis of peptidoglycan, a unique constituent of bacterial cell wall. We expect that our work facilitates better understanding of fundamental aspects of bacterial physiology thereby providing novel strategies for development of alternate antimicrobial therapeutics.

Selected Publications

Garde S, Chodisetti PK and Reddy M. 2021. Peptidoglycan: structure, synthesis and regulation. EcoSalPlus doi: 10.1128/ecosalplus. ESP-0010-2020

Bahadur R, Chodisetti PK and Reddy M. 2021. Cleavage of Braun's lipoprotein Lpp from the bacterial peptidoglycan by a paralog of L,D-transpeptidases, LdtF. Proc. Natl. Acad. Sci USA 118: 19 (2).

Chodisetti PK and Reddy M. 2019. Peptidoglycan hydrolase of an unusual cross-link specificity contributes to bacterial cell wall synthesis. Proc. Natl. Acad. Sci USA 116: 7825-7830.

Singh SK, Parveen S, SaiSree L and Reddy M. 2015. Regulated proteolysis of a crosslink-specific peptidoglycan hydrolase contributes to bacterial morphogenesis. Proc. Natl. Acad. Sci USA 112: 10956-10961.

Education & Experience

Publications

Manjula Reddy-Group Pic
Manjula Reddy-Img

Manjula Reddy

Chief Scientist

2514

manjula@ccmb.res.in

G S N Reddy-Img

G S N Reddy

Principal Technical Officer

2519

gsnr@ccmb.res.in

M B Madhavi	-Img

M B Madhavi

Senior Technical Officer (2)

2519

madhavimb@ccmb.res.in

Balaji Venkataraman-Img

Balaji Venkataraman

Principal Project Associate

2519

balajiv@ccmb.res.in

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G Bhargavi Krishna Sree

Senior Research Fellow

2519

krishnasree@ccmb.res.in

Nilanjan Som-Img

Nilanjan Som

Senior Research Fellow

2521

nilanjan@ccmb.res.in

Pavan Kumar Ch-Img

Pavan Kumar Ch

Senior Project Associate

2521

pavankumarchodisetti@ccmb.res.in

Raj Bahadur-Img

Raj Bahadur

Senior Research Fellow

2521

raj-bahadur@ccmb.res.in

Shambhavi Garde-Img

Shambhavi Garde

Senior Research Fellow

2521

shambhavigarde@ccmb.res.in

Moneca Kaul-Img

Moneca Kaul

Senior Research Fellow (Project)

2519

moneca@ccmb.res.in

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Krishna Leela J

Job Contract

2519

krishnaleela@ccmb.res.in

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Suraj Kumar Meher

Junior Research Fellow

2521

surajkumar@ccmb.res.in

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Vaidehi Rajguru

Junior Research Fellow

2521

vaidehi.rajguru@ccmb.res.in

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Krishna Chaitanya N

Junior Research Fellow

2519

krishnachaitanya.n@ccmb.res.in