Our laboratory is interested in studying prokaryotic cell division (cytokinesis) and its regulation using a Gram-negative model bacterium, Escherichia coli K12 and Mycobacterium smegmatis, a surrogate model organism that is used to understand the biology of M. tuberculosis, a human pathogen that causes tuberculosis.
Garde S, Chodisetti PK and Reddy M. 2021. Peptidoglycan: structure, synthesis and regulation. EcoSalPlus doi: 10.1128/ecosalplus. ESP-0010-2020
Bahadur R, Chodisetti PK and Reddy M. 2021. Cleavage of Braun's lipoprotein Lpp from the bacterial peptidoglycan by a paralog of L,D-transpeptidases, LdtF. Proc. Natl. Acad. Sci USA 118: 19 (2).
Chodisetti PK and Reddy M. 2019. Peptidoglycan hydrolase of an unusual cross-link specificity contributes to bacterial cell wall synthesis. Proc. Natl. Acad. Sci USA 116: 7825-7830.
Singh SK, Parveen S, SaiSree L and Reddy M. 2015. Regulated proteolysis of a crosslink-specific peptidoglycan hydrolase contributes to bacterial morphogenesis. Proc. Natl. Acad. Sci USA 112: 10956-10961.
Education & Experience
|P.G:||Biochemistry ; University of Hyderabad ; 1985|
|Ph.D:||Studies of mutational mechanisms in Escherichia coli in various phases of growth: reversion analysis of mutations in the lacZ gene ; Jawaharlal Nehru University (JNU-CCMB), New Delhi ; 2001|
|Peptidoglycan: structure, synthesis and regulation||EcoSal Plus||2021|
|Structural basis for the differential regulatory roles of the PDZ domain in C-terminal processing proteases.||mBio||2019|
|Peptidoglycan hydrolase of an unusual cross-link specificity contributes to bacterial cell wall synthesis.||Proc Natl Acad Sci. USA||2019|
|A synergistic role for two predicted inner membrane proteins of Escherichia coli in cell envelope integrity.||Molecular Microbiology||2019|
|Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc.||Nature Communications||2017|
|Identification of YfiH (PgeF) as a factor contributing to the maintenance of bacterial peptidoglycan composition.||Molecular Microbiology||2017|
|Determination of Keto-deoxy-d-manno-8-octanoic acid (KDO) from Lipopolysaccharide of Escherichia coli.||Bio-protocol||2015|
|Regulated proteolysis of a crosslink-specific peptidoglycan hydrolase contributes to bacterial morphogenesis.||Proc. Natl. Acad. Sci USA||2015|
|yciM is an essential gene required for regulation of lipopolysaccharide synthesis in Escherichia coli.||Molecular Microbiology||2014|
|Three redundant murein endopeptidases catalyse an essential cleavage step in peptidoglycan synthesis of Escherichia coli K12.||Molecular Microbiology||2012|
|SufI (FtsP) is a cell division protein required for the growth of Escherichia coli during oxidative stress.||Journal of Bacteriology||2007|
|Role of FtsEX in cell division of Escherichia coli: viability of ftsEX mutants is dependent on functional SufI or high osmotic strength.||Journal of Bacteriology||2007|
|Intersubunit signaling in RecBCD enzyme, a complex protein machine regulated by Chi hotspots.||Genes & Development||2007|
|A positive selection system for identification of recombinants using alpha-complementation plasmids.||BioTechniques||2004|
|Distinct signatures for mutator sensitivity of lacZ reversions, and for spectrum of lacI/lacO forward mutations on the chromosome of nondividing Escherichia coli.||Genetics||2004|
|IS186 insertion at a hot spot in the lon promoter as a basis for Lon protease deficiency of Escherichia coli B: Identification of a consensus target sequence for IS186 transposition.||Journal of Bacteriology||2001|
|lon incompatibility associated with mutations causing SOS induction: Null uvrD alleles induce an SOS response in Escherichia coli.||Journal of Bacteriology||2000|
|Characterization of the uup locus and its role in transposon excisions and tandem repeat deletions in Escherichia coli.||Journal of Bacteriology||2000|
|A genetic strategy to demonstrate the occurrence of spontaneous mutations in nondividing cells within colonies of Escherichia coli.||Genetics||1997|
|Identification and characterization of ssb and uup mutants with increased frequency of precise excision of transposon Tn10 derivatives: nucleotide sequence of uup in Escherichia coli.||Journal of Bacteriology||1997|