Research Interests:

• Biochemical and Biophysical studies involving the interaction of different forms of DNA (double, triple and quadruplex forms) with small molecules, metals and macromolecules.
• Studies to understand the mechanism of modified, novel organic and inorganic complexes in enhancing anti-cancer/pro-apoptotic activity among cancer cells and reduce cancer cell proliferation both under in vitro and in vivo conditions,
• Research activity that brings the industry and academics together.

Selected Publications:

Magnetic bead-amplified voltammetric detection for carbohydrate antigen 125 with enzyme labels using aptamer-antigen-antibody sandwiched assay. (2020) Mohanraj Sadasivam, Arunkumar Sakthivel ??, ?Narayana Nagesh, Shekhar Hansda, Murugan Veerapandian, Subbiah Alwarappan, Pandiaraj Manickam. Sensors & Actuators: B. Chemical, 312, 127985-127991. https://doi.org/10.1016/j.snb.2020.127985. (IF 6.3).

Design,synthesis and biological evaluation of new ?-carboline bisindole compounds as DNA binding, photocleavage agents and topoisomerase inhibitors. (2018) Jeshma Kovvuri , Burri Nagaraju, V. Lakshma Nayak, Ravi kumar Akunuri, M.P.Narasimha Rao, Ayyappan Ajitha, Narayana Nagesh*, Ahmed Kamal*. European Journal of MedicinalChemistry. Volume 143, 1563-1577. (IF- 4.8).

Telomerase inhibition and human telomeric G-quadruplex DNA stabilization by a ?-carboline–benzimidazole derivative at low concentration.(2017) Kranthikumar Yadav, Penchala Narasimha Rao Meka, Sudeshna Sadhu, Sravanthi Devi Guggilapu, Jeshma Kovvuri, Ahmed Kamal, Ragampeta Srinivas, Panuganti Devayani, Bathini Nagendra Babu, and Narayana Nagesh*. ACS Biochemistry, 56 (33), 4392–4404. DOI: 10.1021/acs.biochem.7b00008. (IF-2.9).

Synthesis, DNA binding affinity and anticancer activity of novel 4Hbenzo[g][1,2,3]triazolo [5,1-c][1,4]oxazocines. (2016) K. N. Visweswara Sastry, Sunitha Routhu, Soma Gupta Datta, Narayana Nagesh,* Bathini Nagendra Babu, Jagadeesh Babu Nanubolu, C. Ganesh Kumar, Ram Awatar Maurya* and Ahmed Kamal*. Organic Biomolecular Chemistry, 14, 9294–9305. (I.F- 3.6).

Sugar-boronate ester scaffold tethered pyridyl -imine palladium(II) complexes:Synthesis and their in vitro anticancer evaluation. (2015) Eda Rami Reddy, Rajiv Trivedi*, Akella Venkata Subrahmanya Sarma, Balasubramanian Sridhar,Hasitha Shilpa Anantharaju,Dharmarajan Sriram, Perumal Yogeeswari, Narayana Nagesh* Dalton Transactions, 44,17600-17616. (IF- 4.1).

A dihydroindolizino indole derivative selectively stabilizes G quadruplex DNA and down regulates c-MYC expression in human cancer cells. (2015) Narayana Nagesh*, G. Raju, R. Srinivas, P. Ramesh, M. Damoder Reddy, Ch. Raji Reddy. Biochimica et Biophysica Acta (BBA)-General Subjects, 1850(1), 129-140. (IF-4.4).

Patents:

Title of the Patent: Synthesis of N-((1-pheny1-9H-pyrido[3,4 b]indo1-3- y1) methy1) cinnamamides as potential Anticancer Agents. File Reference No: PT-649. CSIR Ref No.: 0272NF2015. Inventors: Ahmed Kamal, Manda Sathish, Narayana Nagesh, Nagula Shankaraiah, Sabanis Chetan Dushantrao, Namballa Hari Krishna. Countries: India, US, UK, Germany, France. International Patent Classification: C07D 471/04(2006.01); A61K 31/437(2006.01). Title of the Patent: A process for preparing 2-pyrimidyl substituted-2,3-dihydro-1H naphtho[1,2-e][1,3]oxazines. Application No: 201921033132. Inventors: Rakhi Gajanan Gawali, Raghunath Bhikaji Bhosale, Sachin Pandurang Shirame, Narayana Nagesh. Countries: India.